Structural Classification of Proteins
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Root: scop

Classes:

  1. All alpha proteins [46456] (284)
    1. Globin-like [46457] (2) picpic
      core: 6 helices; folded leaf, partly opened
    2. Long alpha-hairpin [46556] (20) picpic
      2 helices; antiparallel hairpin, left-handed twist
    3. Type I dockerin domain [63445] (1) picpic
      tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand
    4. LEM/SAP HeH motif [63450] (6) picpic
      helix-extended loop-helix; parallel helices
    5. SOCS box-like [158234] (1) picpic
      helix-loop-helix motif with orthogonally packed helices
    6. RPB6/omega subunit-like [63561] (1) picpic
      core: 2 helices and adjacent loops
    7. KRAB domain (Kruppel-associated box) [109639] (1) picpic
      2 helices: one short, one long; aromatic-rich iterface
    8. Cytochrome c [46625] (1) picpic
      core: 3 helices; folded leaf, opened
    9. DNA/RNA-binding 3-helical bundle [46688] (14) picpic
      core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
    10. Another 3-helical bundle [81602] (5) picpic
      topologically similar to the DNA/RNA-binding bundles; distinct packing
    11. RuvA C-terminal domain-like [46928] (9) picpic
      3 helices; bundle, right-handed twist
    12. S13-like H2TH domain [81297] (1) picpic
      core: 3-4 helices
    13. Putative DNA-binding domain [46954] (1) picpic
      core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different
    14. Spectrin repeat-like [46965] (16) picpic
      3 helices; bundle, closed, left-handed twist; up-and-down
    15. immunoglobulin/albumin-binding domain-like [46996] (11) picpic
      3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold
    16. Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1) picpic
      3 helices; bundle, closed, right-handed twist; up-and-down
    17. ChaB-like [140375] (1) picpic
      3 helices, the first one is shorter than the other two; bundle, capped by a small, C-terminal beta-hairpin
    18. Protozoan pheromone-like [47013] (2) picpic
      3 helices; bundle, closed, left-handed twist, up-and-down
    19. Acyl-CoA binding protein-like [47026] (2) picpic
      core: 3 helices; bundle, closed, left-handed twist; up-and-down
    20. YqgQ-like [158378] (1) picpic
      3 helices, bundle, left-handed twist, extended overside connection between the first and second helices
    21. Kix domain of CBP (creb binding protein) [47039] (1) picpic
      3 helices; bundle, partly opened
    22. RAP domain-like [47044] (1) picpic
      3 helices, the first one is shorter than the other two; bundle, partly opened
    23. VHP, Villin headpiece domain [47049] (1) picpic
      3 short helices; irregular array
    24. BSD domain-like [140382] (1) picpic
      core: 3 helices; triangular array; the extra N-terminal and C-terminal helices form a coiled coil structure
    25. TAF(II)230 TBP-binding fragment [47054] (1) picpic
      3 short helices; irregular array
    26. S15/NS1 RNA-binding domain [47059] (1) picpic
      3 helices; irregular array
    27. Frizzled cysteine-rich domain [63500] (1) picpic
      Core: 3 helices; irregular array; disulfide-rich
    28. T4 endonuclease V [47076] (1) picpic
      3 helices; irregular array
    29. Fertilization protein [47081] (1) picpic
      core: 3 helices; bundle, closed, right-handed twist; up-and-down
    30. PGBD-like [47089] (1) picpic
      core: 3 helices; bundle, closed, left-handed twist; parallel
    31. HMG-box [47094] (1) picpic
      3 helices; irregular array
    32. Histone-fold [47112] (1) picpic
      core: 3 helices; long middle helix is flanked at each end with shorter ones
    33. Open three-helical up-and-down bundle [47143] (7) picpic
      core: 3 helices; bundle, open
    34. beta-catenin-interacting protein ICAT [81729] (1) picpic
      core: 3 helices; irregular array
    35. DNA polymerase III theta subunit-like [116730] (1) picpic
      3 helices; irregular array
    36. Four-helical up-and-down bundle [47161] (28) picpic
      core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
    37. PTS-regulatory domain, PRD [63519] (1) picpic
      core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection
    38. Ferritin-like [47239] (6) picpic
      core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection
    39. 4-helical cytokines [47265] (1) picpic
      core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
    40. Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1) picpic
      core: 4 helices; bundle; one loop crosses over one side of the bundle
    41. Acyl carrier protein-like [47335] (3) picpic
      4 helices, bundle; helix 3 is shorter than others; up-and-down
    42. Bromodomain-like [47363] (15) picpic
      4 helices; bundle; minor mirror variant of up-and-down topology
    43. ROP-like [47379] (8) picpic
      4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist
    44. Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [47390] (1) picpic
      4 helices; bundle, closed, right-handed twist
    45. Orange domain-like [158456] (1) picpic
      4 helices; dimer of identical alpha-hairpin subunits;
    46. Soluble domain of poliovirus core protein 3a [89042] (1) picpic
      4 helices; bundle, closed, right-handed twist
    47. Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1) picpic
      4 helices; bundle, closed, right-handed twist
    48. Ectatomin subunits [47400] (1) picpic
      4 helices; bundle, closed, left-handed twist
    49. Dimerisation interlock [47405] (4) picpic
      4 helices; bundle, closed, right-handed twist
    50. lambda repressor-like DNA-binding domains [47412] (1) picpic
      core: 4 helices; folded leaf, closed
    51. Signal peptide-binding domain [47445] (1) picpic
      4 helices; orthogonal array
    52. A DNA-binding domain in eukaryotic transcription factors [47453] (1) picpic
      4 helices; the long C-terminal helix protrudes from the domain and binds to DNA
    53. HLH-like [47458] (2) picpic
      4-helices; bundle, closed, left-handed twist; 2 crossover connections
    54. HAMP domain-like [158471] (1) picpic
      dimer of helix-loop-helix segments; distict from the HLH-like fold; parallel four-helical bundle with two overside connections
    55. EF Hand-like [47472] (4) picpic
      core: 4 helices; array of 2 hairpins, opened
    56. CH domain-like [47575] (3) picpic
      core: 4 helices: bundle
    57. Domain of poly(ADP-ribose) polymerase [47586] (1) picpic
      core: 4 helices: bundle; unusual topology
    58. SWIB/MDM2 domain [47591] (1) picpic
      core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
      duplication: consists of two structural repeats
    59. Pre-protein crosslinking domain of SecA [81766] (1) picpic
      core: 4 helices: bundle; flanked by two short beta-hairpins
      duplication: consists of two structural repeats
    60. Ribbon-helix-helix [47597] (1) picpic
      core: 4 helices; array of 2 hairpins, opened
    61. GST C-terminal domain-like [47615] (1) picpic
      core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
    62. Methionine synthase domain-like [47643] (3) picpic
      4 helices; bundle, left-handed twist; right-handed superhelix
    63. KaiA/RbsU domain [101214] (1) picpic
      4 helices; bundle, right-handed twist; right-handed superhelix
    64. STAT-like [47654] (6) picpic
      4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix
    65. N-cbl like [47667] (5) picpic
      4 helices; bundle, left-handed twist; left-handed superhelix
    66. Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1) picpic
      4 helices; bundle, right-handed twist; left-handed superhelix
    67. Hypothetical protein YqbG [116914] (1) picpic
      core: 4 helices; bundle, right-handed twist; left-handed superhelix
    68. DnaD domain-like [158498] (1) picpic
      4 helices; bundle, right-handed twist; left-handed superhelix
    69. C-terminal domain of B transposition protein [47680] (1) picpic
      4 helices; irregular array
    70. HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1) picpic
      4 helices; irregular array
    71. N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1) picpic
      4 helices; irregular array
    72. Anaphylotoxins (complement system) [47685] (1) picpic
      4 helices; irregular array, disulfide-linked
    73. Cytochrome c oxidase subunit h [47693] (1) picpic
      4 helices; irregular array, disulfide-linked
    74. Crustacean CHH/MIH/GIH neurohormone [81777] (1) picpic
      4 helices; irregular array, disulfide-linked
    75. C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1) picpic
      4 helices; folded leaf; right-handed superhelix
    76. BH2638-like [158503] (1) picpic
      4 helices, folded leaf, right-handed superhelix; some similarity to the DFF-C domain fold (scop_cf 81782)
    77. Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1) picpic
      4 helices; folded leaf; right-handed superhelix
    78. p53 tetramerization domain [47718] (1) picpic
      core: 4 helices; bundle
    79. Bcr-Abl oncoprotein oligomerization domain [69035] (1) picpic
      core: 4 long helices; bundle
    80. Domain of early E2A DNA-binding protein, ADDBP [47723] (1) picpic
      4 helices; bundle, partly opened
    81. IHF-like DNA-binding proteins [47728] (1) picpic
      core: 4 helices; bundle, partly opened, capped with a beta-sheet
    82. TraM-like [140580] (1) picpic
      multihelical oligomeric protein; structure of whole subunit is not known; the N-terminal part is implicated in DNA binding, the middle region forms tetrameric parallel coiled coil, surrounded by the C-terminal helices
    83. CO dehydrogenase ISP C-domain like [47740] (1) picpic
      core: 4 helices, bundle
    84. Protein HNS-dependent expression A; HdeA [47751] (1) picpic
      4 helices; the three last helices form a bundle similar to that of the RuvA C-domain
    85. PABP domain-like [63569] (2) picpic
      4 helices; an orthogonal array
    86. Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1) picpic
      4 helices; an orthogonal array
    87. Dcp2 domain-like [140585] (1) picpic
      4 helices; orthogonal array of two alpha hairpins
    88. Type III secretion system domain [140590] (1) picpic
      core: 4 helices, orthogonal array; right-handed superhelix
    89. YugE-like [116921] (1) picpic
      4-helices; bundle; right-handed twist
    90. PWI domain [101232] (1) picpic
      4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds
    91. PAH2 domain [47761] (1) picpic
      4 helices; open up-and-down bundle; binds alpha-helical peptides
    92. Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1) picpic
      4 helices; open up-and-down bundle; flexible N-terminal tail
    93. XPC-binding domain [101237] (1) picpic
      4 helices; array
    94. DinB/YfiT-like putative metalloenzymes [109853] (1) picpic
      core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order
    95. EspA/CesA-like [116926] (1) picpic
      4 helices; bundle, closed, left ight-handed twist; interlocked (hetero)dimer of 2-helical subunits
    96. NblA-like [109858] (1) picpic
      4 helices; dimer of identical alpha-hairpin subunits; open bundle
    97. EF2947-like [140606] (1) picpic
      4 helices; "diamond" array; duplication: N-terminal and C-terminal pairs of helices are related by pseudo dyad
    98. EB1 dimerisation domain-like [140611] (1) picpic
      dimeric 4-helical bundle with a coiled coil at one end formed by the longer N-terminal helices
    99. SAM domain-like [47768] (16) picpic
      4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
    100. Retroviral matrix proteins [47835] (1) picpic
      4-5 helices; right-handed superhelix
    101. Flavivirus capsid protein C [101256] (1) picpic
      core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices
    102. Hepatitis B viral capsid (hbcag) [47851] (1) picpic
      5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle
    103. Apolipophorin-III [47856] (1) picpic
      5 helices; bundle, closed, left-handed twist
    104. Methenyltetrahydrofolate cyclohydrolase-like [101261] (1) picpic
      5 helices; bundle, closed, left-handed twist
    105. A middle domain of Talin 1 [109879] (1) picpic
      5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (scop_cf 47161)
    106. I/LWEQ domain [109884] (1) picpic
      5 helices; bundle, closed, left-handed twist
    107. RNA-binding protein She2p [116941] (1) picpic
      5 helices; bundle, closed, left-handed twist; topological similarity to the middle domain of the L-aspartase-like fold (scop_cf 48556)
    108. Hyaluronidase domain-like [140656] (3) picpic
      5 helices; bundle, closed, left-handed twist; up-and-down (meander) topology
    109. YoaC-like [140669] (1) picpic
      5 helices; bundle, one crossover connection, the arrangement of the first four helices is similar to the KaiA/RbsU domain fold (scop_cf 101214)
    110. Saposin-like [47861] (2) picpic
      5 helices; folded leaf, closed
    111. Annexin [47873] (1) picpic
      5 helices; folded leaf, closed
    112. TAFH domain-like [158552] (1) picpic
      5 helices; folded leaf, closed
    113. Transducin (alpha subunit), insertion domain [47894] (1) picpic
      5 helices; folded leaf
    114. Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1) picpic
      5 helices; irregular array; left-handed superhelix
    115. Left-handed superhelix [47916] (4) picpic
      core: 4-5 helices; bundle; left-handed superhelix
    116. ATPD N-terminal domain-like [47927] (2) picpic
      core: 5 helices; bundle
    117. ERP29 C domain-like [47932] (2) picpic
      5 helices; bundle
    118. Functional domain of the splicing factor Prp18 [47937] (1) picpic
      core: 5 helices; bundle
    119. Retrovirus capsid protein, N-terminal core domain [47942] (1) picpic
      core: 5 helices; bundle
    120. GINS helical bundle-like [158572] (1) picpic
      5 helices, staggered bundle;
    121. Jann4075-like [158586] (1) picpic
      core: 5 helices; the C-terminal helix is surrounded by the others; similarity to some EF-hand domains
    122. Cyclin-like [47953] (1) picpic
      core: 5 helices; one helix is surrounded by the others
    123. Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1) picpic
      5 helices; one helix is surrounded by the others
    124. RNase III domain-like [69064] (1) picpic
      core: 5 helices; one helix is surrounded by the others
    125. Ribosomal protein S7 [47972] (1) picpic
      core: 5 helices; contains one more helix and a beta-hairpin outside the core
    126. post-AAA+ oligomerization domain-like [48018] (1) picpic
      core: 5 helices: bundle
    127. PAP/OAS1 substrate-binding domain [81632] (1) picpic
      core: 5-helical bundle; up-and-down; right-handed twist
    128. Anti-sigma factor AsiA [69069] (1) picpic
      core: 5 helices: orthogonal array
    129. Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1) picpic
      5 helices: orthogonal array
    130. Surp module (SWAP domain) [109904] (1) picpic
      5 helices: irregular array
    131. YgfY-like [109909] (1) picpic
      5 helices; array; forms a tight dimer in crystals
    132. Hypothetical protein YhaI [109914] (1) picpic
      core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)
    133. Hypothetical protein At3g22680 [109919] (1) picpic
      5 helices; array; probable biological unit is a homodimer
    134. SP0561-like [140682] (1) picpic
      5 helices; array; includes extra N-terminal and C-terminal short strands forming parrallel beta-sheet ladder
    135. RbcX-like [158614] (1) picpic
      5 helices per subunit; irregular array of short and long helices; swapping of the C-terminal helices in the dimer
    136. YheA-like [158621] (1) picpic
      5 helices; "kinked" antiparallel coiled coil; forms flexible oligomeric assemblies via two different dimerisation interfaces
    137. RPA2825-like [158633] (1) picpic
      5 helices, array; long flexible loop between helices 1 and 2; the remaining helices are arranged similar to the PGBD-like fold (scop_cf 47089)
    138. ENT-like [158638] (1) picpic
      5 helices, irregular array, right-handed superhelix
    139. YfmB-like [140687] (1) picpic
      5 helices, array; buried N-terminal helix; some topological similarity (circular permutation?) to the Nucleotidyltransferase substrate binding subunit/domain (scop_sf 81593)
    140. N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1) picpic
      6 helices: bundle; left-handed twist, up-and-down topology
    141. IpaD-like [140692] (1) picpic
      6 helices; bundle, up-and-down; can be divided into two four-helical bundles sharing two helices (3 and 6), which are twice longer than the rest
    142. Iron-dependent repressor protein, dimerization domain [47978] (1) picpic
      6 helices, homodimer of 3-helical domains
    143. Glutamyl tRNA-reductase dimerization domain [69074] (1) picpic
      6 helices, homodimer of 3-helical domains
    144. GRIP domain [101282] (1) picpic
      6 helices, homodimer of 3-helical domains
    145. BAR/IMD domain-like [116747] (1) picpic
      6 helices, homodimer of 3-helical domains
    146. L27 domain [101287] (1) picpic
      6 helices, heterodimer of 3-helical domains
    147. Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109924] (1) picpic
      dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil
    148. Phage replication organizer domain [140712] (1) picpic
      6 helices, homodimer of 3-helical domains
    149. YejL-like [158650] (1) picpic
      6 helices; intertwined homodimer of three-helical subunits, bundle
    150. Mediator hinge subcomplex-like [140717] (1) picpic
      6 helices; heterodimer of structurally similar subunits; the N-terminal hairpins form a four-helical bundle, whereas the C-terminal helices form coiled coil structure
    151. DEATH domain [47985] (1) picpic
      6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
    152. GntR ligand-binding domain-like [48007] (1) picpic
      core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
    153. AF0941-like [140725] (1) picpic
      6 helices, arranged into two interconnected 3-helical bundles; can also be described as a 'kinked' four-helical bundle; right-handed superhelix
    154. NusB-like [48012] (1) picpic
      6 helices: bundle; one central helix is surrounded by 5 others
    155. YutG-like [101306] (1) picpic
      core: 6 helices; bundle; one central helix is surrounded by 5 others
    156. N-terminal domain of DnaB helicase [48023] (1) picpic
      6 helices: array
    157. Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1) picpic
      6 helices: orthogonal array
    158. MtlR-like [158667] (1) picpic
      multihelical; 8-helical up-and-down bundle
    159. Guanido kinase N-terminal domain [48033] (1) picpic
      irregular array of 6 short helices
    160. Scaffolding protein gpD of bacteriophage procapsid [48044] (1) picpic
      core: 6 helices; one central helix is surrounded by 5 others
    161. Hemocyanin, N-terminal domain [48049] (1) picpic
      6 helices; bundle; one central helix is surrounded by 5 others
    162. Sama2622-like [158674] (1) picpic
      core: 6 helices; bundle; one central helix is surrounded by 5 others
    163. Di-copper centre-containing domain [48055] (1) picpic
      multihelical
    164. DBL homology domain (DH-domain) [48064] (1) picpic
      multihelical; core: 5-helical bundle
    165. LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1) picpic
      multihelical; contains compact array of 6 short helices
    166. RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1) picpic
      multihelical; irregular array of long and short helices
    167. Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1) picpic
      multihelical bundle; contains buried central helix
    168. YcfC-like [101321] (1) picpic
      multihelical; contains two buried central helices
    169. PA2201 C-terminal domain-like [140730] (1) picpic
      multihelical; seven-helical bundle with buried central helix
    170. Rv1873-like [140735] (1) picpic
      multihelical; contains unusually short buried central helix
    171. RUN domain-like [140740] (1) picpic
      multihelical; 3-helical bundle similar to one half of the DEATH domain fold is flanked by two alpha-hairpins forming a four-helical bundle; the axes of the three-helical and four-helical bundles are aproximately orthogonal to each other
    172. SipA N-terminal domain-like [140745] (1) picpic
      multihelical; bundle; the last helix is buried inside the bundle
    173. Transcription factor STAT-4 N-domain [48091] (1) picpic
      multihelical; can be divided into two subdomains
    174. TerB-like [158681] (1) picpic
      multihelical; contains two central helices; duplication: there are two three-helical repeats related by pseudo twofold symmetry
    175. Regulator of G-protein signaling, RGS [48096] (1) picpic
      multihelical; consists of two all-alpha subdomains
      contains a 4-helical bundle with left-handed twist and up-and-down topology
    176. SopE-like GEF domain [81831] (1) picpic
      multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist
    177. Variable surface antigen VlsE [74747] (1) picpic
      multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology
    178. YgfB-like [101326] (1) picpic
      multihelical; consists of two tightly associated 3-helical bundles with different twists
    179. Hypothetical protein MTH393 [101331] (1) picpic
      multihelical; consists of two all-alpha subdomains; dimer
    180. PG0816-like [140752] (1) picpic
      multihelical; comprises two helical bundles, both are topologically similar to the RuvA C-terminal domain-like fold (scop_cf 46928)
    181. UraD-like [158693] (1) picpic
      multihelical; irregular array of long and short helices
    182. Sec63 N-terminal domain-like [158701] (1) picpic
      multihelical; consists of two helical subdomains
    183. Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1) picpic
      multihelical; consists of two all-alpha subdomains
      possible duplication: subdomains have similar topologies
    184. Heme-dependent peroxidases [48112] (1) picpic
      multihelical; consists of two all-alpha domains
    185. Ribosomal protein L19 (L19e) [48139] (1) picpic
      multihelical; consists of two different 3-helical domains connected by a long, partly helical linker
    186. PSPTO4464-like [158709] (1) picpic
      multihelical; consists of two subdomains at the ends of a long connecting helix
    187. GatB/YqeY motif [89094] (1) picpic
      multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)
    188. YfbU-like [116959] (1) picpic
      multihelical; consist of two subdomains; forms 24-mer with the N-terminal sudbomains packing around the 4-fold axis and the C-terminal domains interacting at the 2-fold and 3-fold axes
    189. MG296-like [158714] (1) picpic
      multihelical; in crystal forms helical polymers by swapping the two N-terminal helices to the next subunit in polymer; three subunits per turn of polymer helix
    190. Hypothetical protein MPN330 [116964] (1) picpic
      multihelical; consists of three different 4-helical bundles
    191. HD-domain/PDEase-like [109603] (1) picpic
      multihelical; consists of two different alpha-helical bundles
    192. Superantigen MAM [101343] (1) picpic
      multihelical; consists of two different alpha-helical bundles
    193. Influenza virus matrix protein M1 [48144] (1) picpic
      multihelical; consists of two different all-alpha subdomains, 4 helices each
    194. DNA-glycosylase [48149] (1) picpic
      multihelical; consists of two all-alpha domains
    195. An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1) picpic
      multihelical; consists of two all-alpha domains
    196. Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1) picpic
      multihelical; consists of two all-alpha subdomains
    197. R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1) picpic
      multihelical consists of two all-alpha subdomains
      subdomain 1 (residues 10-100) is a 4-helical bundle
    198. BEACH domain [81836] (1) picpic
      multihelical, complex architecture
    199. Cryptochrome/photolyase FAD-binding domain [48172] (1) picpic
      multihelical; consists of two all-alpha subdomains
    200. 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1) picpic
      multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
    201. Uteroglobin-like [48200] (1) picpic
      multihelical
    202. alpha/alpha toroid [48207] (6) picpic
      multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
    203. Citrate synthase [48255] (1) picpic
      multihelical; consists of two all-alpha domains
    204. Cytochrome P450 [48263] (1) picpic
      multihelical
    205. Flagellar transcriptional activator FlhD [63591] (1) picpic
      multihelical; forms intertwined dimer of identical 5-helical subunits
    206. HP0242-like [158751] (1) picpic
      multihelical; intertwined homodimer of four-helical subunits, forming catenated triangular ring-like structures; pseudo knot
    207. SMc04008-like [158756] (1) picpic
      multihelcal; intertwined homodimer; there are 4 core helices in each subunits; contains putative metal ion-binding motif MxxxxxCxxC in the conserved surface site
    208. Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1) picpic
      multihelical; intertwined tetramer
    209. Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1) picpic
      multihelical; intertwined trimer of identical 3-helical subunits
    210. Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1) picpic
      multihelical; consists of two all-alpha domains
    211. Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1) picpic
      multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix
    212. BRCA2 helical domain [81871] (1) picpic
      multihelical; contains a 3-helical bundle surrounded by several shorter helices
    213. BRCA2 tower domain [81877] (1) picpic
      multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices
    214. H-NS histone-like proteins [81274] (1) picpic
      multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains
    215. Sigma2 domain of RNA polymerase sigma factors [88945] (1) picpic
      multihelical; consists of a conserved 4-helical core and a variable insert subdomain
    216. DNA repair protein MutS, domain III [48333] (1) picpic
      multihelical; consists of 2 all-alpha subdomains
    217. Helical scaffold and wing domains of SecA [81885] (1) picpic
      multihelical; consists of 2 all-alpha subdomains
    218. all-alpha NTP pyrophosphatases [101385] (1) picpic
      multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer
    219. Hsp90 co-chaperone CDC37 [101390] (1) picpic
      multihelical; consists of 2 all-alpha subdomains connected by a long helix
    220. Nop domain [89123] (1) picpic
      multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain
    221. YidB-like [140803] (1) picpic
      multihelical; three strings of short helices are packed across one longer helix
    222. Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1) picpic
      multihelical; bundle of longer and shorter helices
    223. A virus capsid protein alpha-helical domain [48344] (1) picpic
      multihelical; three-helical bundle in the core is surrounded by non-conserved helices
    224. P40 nucleoprotein [101398] (1) picpic
      multihelical; consists of two subdomains
    225. Rhabdovirus nucleoprotein-like [140808] (1) picpic
      multihelical, consist of two helical domains; each domain contains a buried helix
    226. GTPase activation domain, GAP [48349] (1) picpic
      multihelical
    227. Ras GEF [48365] (1) picpic
      multihelical
    228. Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1) picpic
      multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain
    229. Poly A polymerase C-terminal region-like [81890] (1) picpic
      multihelical; can be divided into three subdomains (neck, body and tail)
    230. alpha-alpha superhelix [48370] (24) picpic
      multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
    231. GUN4-like [140868] (1) picpic
      multihelical; open array, trapping inside an extended region before the C-terminal helix
    232. Lipoxigenase [48483] (1) picpic
      multihelical
      large nearly all-alpha domain
    233. gene 59 helicase assembly protein [48492] (1) picpic
      multihelical; consists of two all-alpha subdomains
    234. Tetracyclin repressor-like, C-terminal domain [48497] (1) picpic
      multihelical; interlocked (homo)dimer
    235. Skp1 dimerisation domain-like [81384] (1) picpic
      multihelical; interlocked heterodimer with F-box proteins
    236. F-box domain [81385] (1) picpic
      multihelical; interlocked heterodimer with the Skp1 dimerisation domain
    237. Nuclear receptor ligand-binding domain [48507] (1) picpic
      multihelical; 3 layers or orthogonally packed helices
    238. Phospholipase C/P1 nuclease [48536] (1) picpic
      multihelical
    239. ATP-dependent DNA ligase DNA-binding domain [117017] (1) picpic
      multihelical; duplication: contains two intertwined structural repeats related by pseudo twofold symmetry
    240. DNA primase DnaG, C-terminal domain [117022] (1) picpic
      multihelical; segment-swapped dimer
    241. PriB N-terminal domain-like [140913] (1) picpic
      multihelical bundle; contains buried central helix; also includes the PriA interface-forming insert subdomain (alpha+beta)
    242. VPS9 domain [109992] (1) picpic
      multihelical; consist of two subdomains
    243. Triger factor/SurA peptide-binding domain-like [109997] (1) picpic
      multihelical; irregular array of long and short helices
    244. DNA terminal protein [140918] (1) picpic
      multihelical, open array; contains the C-terminal four-helical bundle, left-handed superhelix
    245. Glycolipid transfer protein, GLTP [110003] (1) picpic
      multihelical; 2 layers or orthogonally packed helices
    246. Hypothetical protein MG354 [110008] (1) picpic
      multihelical bundle; contains buried central helix
    247. Duffy binding domain-like [140923] (1) picpic
      consist of two subdomains, each containing a three-helical bundle
    248. Fic-like [140930] (1) picpic
      multihelical; one central helix is surrounded by seven helices
    249. Her-1 [110013] (1) picpic
      multihelical; consists of two topologically similar alpha-helical bundles
    250. ERO1-like [110018] (1) picpic
      multihelical; consists of 2 four-helical bundles
    251. Serum albumin-like [48551] (1) picpic
      multihelical; one domain consists of two similar disulfide-linked subdomains
    252. L-aspartase-like [48556] (1) picpic
      multihelical, consists of three all-alpha domains
    253. Formin homology 2 domain (FH2 domain) [101446] (1) picpic
      multihelical, consists of three all-alpha domains
    254. Terpenoid synthases [48575] (1) picpic
      multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers
    255. GroEL equatorial domain-like [48591] (1) picpic
      multihelical; 8 helices arranged in 2 parallel layers
    256. TorD-like [89154] (1) picpic
      multihelical; bundle
    257. Chorismate mutase II [48599] (1) picpic
      multihelical; core: 6 helices, bundle
    258. Peridinin-chlorophyll protein [48607] (1) picpic
      multihelical: forms a boat-shaped protein shell around cofactors
    259. Heme oxygenase-like [48612] (1) picpic
      multihelical; bundle
    260. Indolic compounds 2,3-dioxygenase-like [140958] (1) picpic
      multihelical; bundle, contains interrupted helices
    261. AhpD-like [69117] (1) picpic
      multihelical; contains 4-helical bundle and 2-helical arm
    262. Double Clp-N motif [81922] (1) picpic
      multihelical; array
    263. Orange carotenoid protein, N-terminal domain [81929] (1) picpic
      multihelical; array
    264. DhaL-like [101472] (1) picpic
      multihelical; bundle
    265. ADP-ribosylglycohydrolase [101477] (1) picpic
      multihelical; bundle
    266. Topoisomerase V catalytic domain-like [140978] (1) picpic
      multihelical; irregular array; contains small amount of beta-structure and a 3-helical bundle with a variant homeofomain-like fold and HTH motif (scop_cf 46688)
    267. PTPA-like [140983] (1) picpic
      multihelical
    268. Tex N-terminal region-like [158831] (1) picpic
      multihelical; irregular array of long and short helices; can be divided into several subdomains
    269. AGR_C_984p-like [158836] (1) picpic
      multihelical, consists of two subdomains; duplication: there are two 5-helical structural repeats, one in each subdomain
    270. PMT central region-like [158841] (1) picpic
      multihelical; comprises two four-helical bundles of different topologies and an irregular helical array packed against a small beta-sheet
    271. FtsH protease domain-like [140989] (1) picpic
      array of 6 helices and a 2-stranded beta-ribbon
    272. Gametocyte protein Pfg27 [89161] (1) picpic
      multihelical; bundle
    273. N-terminal domain of bifunctional PutA protein [81934] (1) picpic
      multihelical; array
    274. Cysteine alpha-hairpin motif [47071] (1) picpic
      core: alpha-hairpin crosslinked with two disulfides
    275. Phospholipase A2, PLA2 [48618] (1) picpic
      common core: 2 helices, disulfide-linked, and a calcium-binding loop
    276. Fungal elicitin [48646] (1) picpic
      5 helices: irregular disulfide-linked array; also contains a small beta-hairpin
    277. Tetraspanin [48651] (1) picpic
      5 helices: irregular disulfide-linked array; form homodimer
    278. GDNF receptor-like [110034] (1) picpic
      5 helices: irregular disulfide-linked array; topological similarity to the Fungal elicitin fold (scop_cf 48646)
    279. FinO-like [48656] (1) picpic
      6 helices: irregular non-globular array; also contains two small beta-hairpins
    280. Nuclear receptor coactivator interlocking domain [69124] (1) picpic
      3 helices, non-globular array; forms interlocked heterodimers with its targets
    281. Hermes dimerisation domain [140995] (1) picpic
      multihelical, intertwinned dimer of two 4-helical strings
    282. Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101488] (1) picpic
      5 helices, non-globular array; wraps around the N-terminal tail of its target
    283. Non-globular all-alpha subunits of globular proteins [48661] (14) picpic
      not a true fold
    284. Multiheme cytochromes [48694] (1) picpic
      variable number of helices and little beta structure; not a true fold
  2. All beta proteins [48724] (174)
    1. Immunoglobulin-like beta-sandwich [48725] (28) picpic
      sandwich; 7 strands in 2 sheets; greek-key
      some members of the fold have additional strands
    2. Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (10) picpic
      sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
    3. Prealbumin-like [49451] (7) picpic
      sandwich; 7 strands in 2 sheets, greek-key
      variations: some members have additional 1-2 strands to common fold
    4. HSP40/DnaJ peptide-binding domain [49492] (1) picpic
      sandwich; 6 strands in 2 sheets
    5. Penicillin-binding protein associated domain [69188] (1) picpic
      sandwich; 6 strands in 2 sheets
    6. alpha-Amylase inhibitor tendamistat [49497] (1) picpic
      sandwich; 6 strands in 2 sheets
    7. C-terminal domain of mollusc hemocyanin [81278] (1) picpic
      six-stranded beta-sandwich, jelly-roll/greek-key topology
    8. HPA-like [141085] (1) picpic
      sandwich, 6 strands in 2 sheets; jelly-roll (truncated); also includes the pending PCSK9 V domain-like superfamily (the C-terminal domains of 2p4e and 2pmw)
    9. L21p-like [141090] (1) picpic
      core: sandwich, 6 strands in 2 sheets
    10. Cupredoxin-like [49502] (2) picpic
      sandwich; 7 strands in 2 sheets, greek-key
      variations: some members have additional 1-2 strands
    11. Ctag/Cox11 [110110] (1) picpic
      sandwich; 7 strands in 2 sheets, greek-key; permutation of the immunoglobulin-like fold
    12. Atu1913-like [141098] (1) picpic
      sandwich; 7 strands in two sheets, greek-key/jelly-roll; forms segment swapped dimers, swapping is probably facilitated by the helix insertion after strand 3
    13. C2 domain-like [49561] (5) picpic
      sandwich; 8 strands in 2 sheets; greek-key
    14. TRAF domain-like [49598] (1) picpic
      sandwich; 8 strands in 2 sheets; greek-key
    15. Neurophysin II [49605] (1) picpic
      sandwich; 8 strands in 2 sheets; meander
    16. N-utilization substance G protein NusG, insert domain [82003] (1) picpic
      sandwich; 8 strands in 2 sheets; meander
    17. Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7) picpic
      sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
      characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
    18. gamma-Crystallin-like [49694] (1) picpic
      sandwich; 8 strands in 2 sheets; greek-key
      duplication: has internal pseudo twofold symmetry
    19. Lipase/lipooxygenase domain (PLAT/LH2 domain) [49722] (1) picpic
      sandwich; 8 strands in 2 sheets; complex topology
      duplication: has weak internal pseudo twofold symmetry
    20. Calpain large subunit, middle domain (domain III) [49757] (1) picpic
      sandwich; 8 strands in 2 sheets; jelly-roll
    21. Supernatant protein factor (SPF), C-terminal domain [101575] (1) picpic
      sandwich; 8 strands in 2 sheets; jelly-roll; similarity to the Nucleoplasmin-like/VP fold
    22. Hypothetical protein TM1070 [89231] (1) picpic
      sandwich; 8 strands in 2 sheets; jelly-roll
    23. Olfactory marker protein [63696] (1) picpic
      sandwich; 8 strands in 2 sheets; jelly-roll
    24. HSP20-like chaperones [49763] (1) picpic
      sandwich; 8 strands in 2 sheets; greek-key
    25. Heat shock protein 70kD (HSP70), peptide-binding domain [100919] (1) picpic
      beta-sandwich: 8 strands in 2 sheets
    26. Ecotin, trypsin inhibitor [49771] (1) picpic
      sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
    27. PEBP-like [49776] (1) picpic
      sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
    28. Ganglioside M2 (gm2) activator [63706] (1) picpic
      sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
    29. Nicotinic receptor ligand binding domain-like [63711] (1) picpic
      sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
    30. Beta-galactosidase LacA, domain 3 [117099] (1) picpic
      sandwich; 8 strands in 2 sheets
    31. Galactose-binding domain-like [49784] (1) picpic
      sandwich; 9 strands in 2 sheets; jelly-roll
    32. Viral protein domain [49817] (1) picpic
      sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
    33. Calcium-mediated lectin [82025] (1) picpic
      sandwich; 9 strands in 2 sheets; greek-key
    34. Dextranase, N-terminal domain [101595] (1) picpic
      sandwich; 9 strands in 2 sheets; greek-key
    35. Smp-1-like [101600] (1) picpic
      sandwich; 9 strands in 2 sheets; greek-key/jelly-roll
    36. Superantigen (mitogen) Ypm [101605] (1) picpic
      sandwich; 9 strands in 2 sheets; jelly-roll
    37. ENV polyprotein, receptor-binding domain [49829] (1) picpic
      sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
    38. BTV NS2-like ssRNA-binding domain [110131] (1) picpic
      sandwich; 9 strands in 2 sheets; unusual topology with 2 crossover loops
    39. WSSV envelope protein-like [158973] (1) picpic
      beta-sandwich; 9 strands in 2 sheets; greek-key
    40. Virus attachment protein globular domain [49834] (1) picpic
      sandwich, 10 strands in 2 sheets; greek-key
    41. TNF-like [49841] (1) picpic
      sandwich, 10 strands in 2 sheets; jelly-roll
    42. CUB-like [49853] (3) picpic
      sandwich, 10 strands in 2 sheets; jelly-roll
    43. Hyaluronate lyase-like, C-terminal domain [49862] (1) picpic
      sandwich, 10 strands in 2 sheets; "folded meander"
    44. Cytolysin/lectin [63723] (1) picpic
      sandwich, 10 strands in 2 sheets;
    45. Putative glucosidase YicI, C-terminal domain [117124] (1) picpic
      sandwich; 10 strands in two sheets
    46. CsrA-like [117129] (1) picpic
      sandwich; 10 strands in 2 sheets; intertwined dimer (segment-swapped, 5-stranded greek-key sandwich?)
    47. Osmotin, thaumatin-like protein [49869] (1) picpic
      sandwich; 11 strands in 2 sheets
    48. SMAD/FHA domain [49878] (1) picpic
      sandwich; 11 strands in 2 sheets; greek-key
    49. Soluble secreted chemokine inhibitor, VCCI [49888] (1) picpic
      sandwich; 11 strands in 2 sheets; greek-key
    50. Baculovirus p35 protein [49893] (1) picpic
      sandwich; 14 strands in 2 sheets; greek-key
    51. Concanavalin A-like lectins/glucanases [49898] (1) picpic
      sandwich; 12-14 strands in 2 sheets; complex topology
    52. Supersandwich [49993] (3) picpic
      sandwich; 18 strands in 2 sheets
    53. Leukotriene A4 hydrolase N-terminal domain [63736] (1) picpic
      duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
    54. EV matrix protein [50011] (1) picpic
      consists of two beta-sandwich domains of similar topologies
    55. Viral chemokine binding protein m3 [82045] (1) picpic
      consists of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds
    56. gp9 [50016] (1) picpic
      consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
    57. Flagellar hook protein flgE [117142] (1) picpic
      consists of two different domains; d1: [complex fold made of bifurcated beta-sheets]; d2 (inserted into d1): [beta-sandwich; 8 strands in 2 sheets]
    58. ISP domain [50021] (1) picpic
      consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
    59. Trm112p-like [158996] (1) picpic
      similar to the small domain of the ISP (scop_cf 50021)
    60. YopX-like [159005] (1) picpic
      consists of two domains: the N-terminal dimerisation domain of variable structure and the C-terminal domain with similarity to the SH3-like fold
    61. Obg-fold [82050] (1) picpic
      this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
      these regions form six left-handed collagen-like helices packed and H-bonded together
    62. SH3-like barrel [50036] (21) picpic
      barrel, partly opened; n*=4, S*=8; meander
      the last strand is interrupted by a turn of 3-10 helix
    63. GroES-like [50128] (2) picpic
      contains barrel, partly opened; n*=4, S*=8; meander
    64. PDZ domain-like [50155] (1) picpic
      contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
    65. N-terminal domains of the minor coat protein g3p [50175] (1) picpic
      core: barrel, in some members open; n*=4, S*=8; meander
    66. Sm-like fold [50181] (5) picpic
      core: barrel, open; n*=4, S*=8; meander; SH3-like topology
    67. SspB-like [101737] (1) picpic
      core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
    68. Rof/RNase P subunit-like [101743] (1) picpic
      core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
    69. Hydrophobin II, HfbII [101750] (1) picpic
      core: barrel, closed; n=4, S=8; complex topology; helix-containing crossover connection
    70. Ribosomal protein L14 [50192] (1) picpic
      barrel, closed; n=5, S=8, meander
    71. OB-fold [50198] (16) picpic
      barrel, closed or partly opened n=5, S=10 or S=8; greek-key
    72. PRC-barrel domain [50345] (1) picpic
      core: barrel, partly opened; n*=5, S*=8; meander
    73. beta-Trefoil [50352] (8) picpic
      barrel, closed; n=6, S=12; and a hairpin triplet; meander
      duplication: has internal pseudo threefold symmetry
    74. Reductase/isomerase/elongation factor common domain [50412] (4) picpic
      barrel, closed; n=6, S=10; greek-key
    75. Elongation factor/aminomethyltransferase common domain [50464] (2) picpic
      barrel, closed; n=6, S=10; greek-key
    76. Split barrel-like [50474] (3) picpic
      barrel; n=6, S=10; greek-key
    77. Phage tail proteins [69278] (1) picpic
      core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
    78. Surface presentation of antigens (SPOA) [101800] (1) picpic
      segment-swapped dimer forming two identical conjoint barrels (n=6, S=10) topologically similar to the FMN-binding split barrel
    79. FMT C-terminal domain-like [50485] (1) picpic
      barrel, open; n*=6, S*=10; greek-key
    80. Trypsin-like serine proteases [50493] (1) picpic
      barrel, closed; n=6, S=8; greek-key
      duplication: consists of two domains of the same fold
    81. Replicase NSP9 [101815] (1) picpic
      barrel; n=6, S=8, greek-key; similar to one trypsin-like protease barrel
    82. mu transposase, C-terminal domain [50609] (1) picpic
      barrel; n=6, S=8, greek-key
    83. Domain of alpha and beta subunits of F1 ATP synthase-like [50614] (3) picpic
      barrel, closed; n=6, S=8; greek-key
    84. Small protein B (SmpB) [74981] (1) picpic
      barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
    85. Acid proteases [50629] (1) picpic
      barrel, closed; n=6, S=10, complex topology
    86. ValRS/IleRS/LeuRS editing domain [50676] (1) picpic
      core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
    87. Urease metallochaperone UreE, N-terminal domain [69286] (1) picpic
      barrel, closed; n=6, S=8; a crossover loop topology
    88. Double psi beta-barrel [50684] (2) picpic
      barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
    89. Ribosomal protein L25-like [50714] (1) picpic
      barrel, closed; n=6, S=10; complex topology
    90. Core binding factor beta, CBF [50722] (1) picpic
      barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
    91. NifT/FixU barrel-like [159202] (1) picpic
      barrel, closed, n=6, S=10; meander
    92. PH domain-like barrel [50728] (2) picpic
      barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
    93. Transcription factor IIA (TFIIA), beta-barrel domain [50783] (1) picpic
      barrel, closed; n=6, S=12; mixed beta-sheet
    94. Hcp1-like [141451] (1) picpic
      barrel, closed; n=6, S=12; contains extra, non-barrel strand 7 at the C-terminus
    95. YopT-like [159221] (1) picpic
      beta-sheet barrel, closed, n=6, S=12, capped at both ends by helices; intertwined dimer of beta-alpha-beta(2) subinits;
    96. Herpes virus serine proteinase, assemblin [50788] (1) picpic
      core: barrel, closed; n=7, S=8; complex topology
    97. PK beta-barrel domain-like [50799] (1) picpic
      barrel, closed; n=7, S=10; complex topology
    98. XRCC4, N-terminal domain [50808] (1) picpic
      barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
    99. HesB-like domain [89359] (1) picpic
      barrel, closed; n=7, S=10; complex topology
    100. Bacterial fluorinating enzyme, C-terminal domain [101851] (1) picpic
      barrel, closed; n=7, S=10; greek-key topology; one overside connection
    101. SPOC domain-like [100938] (1) picpic
      barrel, closed; n=7, S=10; complex topology
    102. BH3618-like [141456] (1) picpic
      barrel, closed; n=7, S=10; meander
    103. FAS1 domain [82152] (1) picpic
      core: barrel, closed; n=7, S=12; meander
    104. Lipocalins [50813] (1) picpic
      barrel, closed or opened; n=8, S=12; meander
    105. Streptavidin-like [50875] (8) picpic
      barrel, closed; n=8, S=10; meander
    106. FomD barrel-like [159233] (1) picpic
      barrel, closed; n=8, S=12; meander; similar topology to the AOC barrel-like fold (reversed to the lipocalin barrel topology)
    107. AOC barrel-like [141492] (2) picpic
      barrel, closed; n=8, S=10; meander; mirrored (reversed) topology to the Spreptavidin-like and Lipocalin-like folds
    108. AttH-like [159244] (1) picpic
      duplication: two flattened beta-barrels of lipocalin-like topology are orthogonally packed with a pseudo twofold symmetry
    109. Cyclophilin-like [50890] (1) picpic
      barrel, closed; n=8, S=10; complex topology
    110. Oncogene products [50903] (1) picpic
      barrel, closed; n=8, S=10; one overside connection
    111. L,D-transpeptidase catalytic domain-like [141522] (1) picpic
      barrel, closed; n=8, S=10; one overside connection
    112. Sortase [63816] (1) picpic
      barrel, closed; n=8, S=10; mixed sheet; two overside connections
    113. PTSIIA/GutA-like [141529] (1) picpic
      barrel, closed; n=8, S=12; mixed sheet; two overside connections; duplication: consists of two intertwinned structural repeats
    114. Mannose 6-phosphate receptor domain [50910] (1) picpic
      barrel, partly open; n*=8, S*=10; one psi loop
    115. triple barrel [50915] (1) picpic
      dimer of two non-identical subunits; forms two similar barrels, n=8, S=10 each, that are fused together with the formation of third barrel, n=6, S=8
    116. 4-bladed beta-propeller [50922] (1) picpic
      consists of four 4-stranded beta-sheet motifs; meander
    117. 5-bladed beta-propeller [50933] (3) picpic
      consists of five 4-stranded beta-sheet motifs; meander
    118. 6-bladed beta-propeller [50938] (11) picpic
      consists of six 4-stranded beta-sheet motifs; meander
    119. 7-bladed beta-propeller [50964] (14) picpic
      consists of seven 4-stranded beta-sheet motifs; meander
    120. 8-bladed beta-propeller [50997] (3) picpic
      consists of eight 4-stranded beta-sheet motifs; meander
      also found in some members of the WD40-repeat superfamily
    121. Glycosyl hydrolase domain [51010] (1) picpic
      folded sheet; greek-key
    122. WW domain-like [51044] (3) picpic
      core: 3-stranded meander beta-sheet
    123. Head domain of nucleotide exchange factor GrpE [51063] (1) picpic
      small mixed beta-sheet, 4 "generalized" strands
    124. Coronavirus RNA-binding domain [110303] (1) picpic
      coiled antiparallel beta-sheet of 5 strands, order 51324; complex topology, crossing loops
    125. Ribonuclease domain of colicin E3 [63839] (1) picpic
      twisted meander beta-sheet of 6 strands
    126. NAC domain [101940] (1) picpic
      core: twisted 7-stranded beta-sheet (half-barrel)
    127. At5g01610-like [141561] (1) picpic
      contains large meander beta-sheet bent into a scoop-like shape
    128. Carbonic anhydrase [51068] (1) picpic
      single sheet; 10 strands
    129. LolA-like prokaryotic lipoproteins and lipoprotein localization factors [89391] (1) picpic
      11 stranded sheet partly folded in a corner-like structure filled with a few short helices
    130. YmcC-like [159269] (1) picpic
      12-stranded meander beta-sheet, folded into a deformed beta-barrel; topological similarity to the LolA-like fold (scop_cf 89391)
    131. Spiral beta-roll [159274] (1) picpic
      a large 15-stranded beta-sheet rolled about a single helix core; overlapping edges form a sandwich-like structure; topological similarity to the LolA-like fold (scop_cf 89391)
    132. Bacteriochlorophyll A protein [51080] (1) picpic
      single sheet; 16 strands; meander
    133. open-sided beta-meander [51086] (2) picpic
      single sheet formed by beta-hairpin repeats; exposed on both sides in the middle
    134. beta-Prism I [51091] (3) picpic
      consists of 3 4-stranded sheets; strands are parallel to the 3-fold axis
      duplication: has internal pseudo threefold symmetry
    135. beta-Prism II [51109] (1) picpic
      consists of 3 4-stranded sheets; strands are perpendicular to the 3-fold axis
      duplication: consists of two domains of this fold
    136. Single-stranded right-handed beta-helix [51125] (8) picpic
      superhelix turns are made of parallel beta-strands and (short) turns
    137. Single-stranded left-handed beta-helix [51160] (4) picpic
      superhelix turns are made of parallel beta-strands and (short) turns
    138. Double-stranded beta-helix [51181] (7) picpic
      one turn of helix is made by two pairs of antiparallel strands linked with short turns
      has appearance of a sandwich of distinct architecture and jelly-roll topology
    139. Triple-stranded beta-helix [69348] (1) picpic
      (homo)trimer; each chain donates 3 beta-strands per turn of the helix
    140. Triple beta-spiral [51224] (1) picpic
      trimer formed by the interlocking beta-hairpin repeat units
    141. Trimeric adhesin [101998] (1) picpic
      trimer; contains two different beta-prism-like domains connected by an linker subdomain of less regular structure
    142. beta-hairpin stack [69359] (1) picpic
      Trp-rich beta-hairpin repeat units form helical structures of 3 units per turn
    143. Barrel-sandwich hybrid [51229] (4) picpic
      sandwich of half-barrel shaped beta-sheets
    144. beta-clip [51268] (7) picpic
      double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
    145. PheT/TilS domain [56036] (1) picpic
      core: 3 layers; contains beta-sandwich of unusual topology
    146. C-terminal autoproteolytic domain of nucleoporin nup98 [82214] (1) picpic
      multisheet protein with a mixture of beta-sandwich and beta-prism features
    147. Pseudo beta-prism [141657] (1) picpic
      beta-sandwich with one regular beta-sheet and the other beta-sheet bent in the middle with a set of aligned beta-bulges
    148. SARS ORF9b-like [141665] (1) picpic
      complex dimeric fold with three intersubunit beta-sheets packed around a single core
    149. Adsorption protein p2 [89427] (1) picpic
      multisheet protein containing partial beta-propeller and beta-sandwich regions
    150. Baseplate structural protein gp8 [89432] (1) picpic
      multisheet protein with a mixture of beta-sandwich and beta-barrel features
    151. Hedgehog/intein (Hint) domain [51293] (1) picpic
      complex fold made of five beta-hairpin units and a b-ribbon arc
    152. LexA/Signal peptidase [51305] (1) picpic
      complex fold made of several coiled beta-sheets; contains an SH3-like barrel
    153. Cloacin translocation domain [69368] (1) picpic
      complex fold made of several coiled beta-sheets
    154. Mss4-like [51315] (1) picpic
      complex fold made of several coiled beta-sheets
    155. Cyanovirin-N [51321] (1) picpic
      complex fold
    156. Tp47 lipoprotein, N-terminal domain [82219] (1) picpic
      complex fold; consists of two intertwined subdomains
    157. Methuselah ectodomain [63876] (1) picpic
      complex fold
    158. Head-binding domain of phage P22 tailspike protein [51326] (1) picpic
      complex fold made of bifurcated and partly folded beta-sheet
    159. E2 regulatory, transactivation domain [51331] (1) picpic
      complex fold made of bifurcated and coiled beta-sheets
    160. MoeA N-terminal region -like [63881] (1) picpic
      complex fold made of bifurcated and coiled b-sheets
    161. MOSC N-terminal domain-like [141672] (1) picpic
      complex fold; comprises a beta-hairpin and a meander 3-stranded sheet packed against beta-barrel: closed, n=5, S=8; contains three short helices
    162. MAL13P1.257-like [141677] (1) picpic
      complex fold; duplication: consists of two intertwinned structural repeats related by pseudo dyad
    163. Composite domain of metallo-dependent hydrolases [51337] (1) picpic
      pseudobarrel; mixed sheet of 7 strand folded upon itself and "buckled" by two beta-turns
    164. Epsilon subunit of F1F0-ATP synthase N-terminal domain [51343] (1) picpic
      pseudobarrel: sandwich of two sheets packed at a positive interstrand angle and interconnected with many short turns
    165. N-terminal domain of MutM-like DNA repair proteins [81625] (1) picpic
      pseudobarrel; capped on both ends by alpha-helices
    166. Hypothetical protein YojF [89441] (1) picpic
      pseudobarrel; capped at one end by an alpha-helix
    167. DNA-binding pseudobarrel domain [101935] (1) picpic
      core: barrel, open; n=7, S*=10; capped with helices at both ends; partial similarity to the AbrB/MazE/MraZ-like fold (scop_cf 89446)
    168. Double-split beta-barrel [89446] (2) picpic
      pseudobarrel; capped on both ends by alpha-helices
    169. PUA domain-like [88696] (1) picpic
      pseudobarrel; mixed folded sheet of 5 strands; order 13452; strand 1 and 3 are parallel to each other
    170. AXH domain [102030] (1) picpic
      pseudobarrel; some similarity to OB-fold
    171. FimD N-terminal domain-like [141728] (1) picpic
      pseudo barrel, capped by an alpha-helix; some topological similarity to the PRC-barrel domain (scop_sf 50346) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
    172. HisI-like [141733] (1) picpic
      pseudo barrel, capped by an alpha-helix; contains a beta-triangle structure on one side; some topological similarity to the Ribosomal protein L25-like fold (scop_cf 50714) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
    173. MFPT repeat-like [141738] (1) picpic
      consists of two similar pseudo barrel subdomains with structural similarity to a circularly permuted SAND domain (scop_fa 63764)
    174. P-domain of calnexin/calreticulin [63886] (1) picpic
      non-globular proline-rich hairpin
  3. Alpha and beta proteins (a/b) [51349] (147)
    Mainly parallel beta sheets (beta-alpha-beta units)
    1. TIM beta/alpha-barrel [51350] (33) picpic
      contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
      the first seven superfamilies have similar phosphate-binding sites
    2. NAD(P)-binding Rossmann-fold domains [51734] (1) picpic
      core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
      The nucleotide-binding modes of this and the next two folds/superfamilies are similar
    3. FAD/NAD(P)-binding domain [51904] (1) picpic
      core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
    4. Nucleotide-binding domain [51970] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
    5. MurCD N-terminal domain [51983] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; incomplete Rossmann-like fold; binds UDP group
    6. 7-stranded beta/alpha barrel [51988] (3) picpic
      variant of beta/alpha barrel; parallel beta-sheet barrel, closed, n=7, S=8; strand order 1234567; some members may have fewer strands
    7. PFL-like glycyl radical enzymes [51997] (1) picpic
      contains: barrel, closed; n=10, S=10; accommodates a hairpin loop inside the barrel
    8. The "swivelling" beta/beta/alpha domain [52008] (10) picpic
      3 layers: b/b/a; the central sheet is parallel, and the other one is antiparallel; there are some variations in topology
      this domain is thought to be mobile in most multi-domain proteins known to contain it
    9. Barstar-like [52037] (2) picpic
      2 layers, a/b; parallel beta-sheet of 3 strands, order 123
    10. MurF and HprK N-domain-like [63417] (2) picpic
      core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1234; structural similarity of the MurF and HprK extends beyond the core.
    11. Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [52046] (3) picpic
      2 curved layers, a/b; parallel beta-sheet; order 1234...N; there are sequence similarities between different superfamilies
    12. Ribosomal proteins L15p and L18e [52079] (1) picpic
      core: three turns of irregular (beta-beta-alpha)n superhelix
    13. SpoIIaa-like [52086] (2) picpic
      core: 4 turns of a (beta-alpha)n superhelix
    14. ClpP/crotonase [52095] (1) picpic
      core: 4 turns of (beta-beta-alpha)n superhelix
    15. BRCT domain [52112] (1) picpic
      3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    16. Lumazine synthase [52120] (1) picpic
      3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    17. Uracil-DNA glycosylase-like [52140] (1) picpic
      3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    18. Creatininase [102214] (1) picpic
      3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    19. DNA polymerase III psi subunit [102219] (1) picpic
      3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
    20. Initiation factor IF2/eIF5b, domain 3 [52155] (1) picpic
      3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    21. Aminoacid dehydrogenase-like, N-terminal domain [53222] (1) picpic
      core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134
    22. Toprim domain [110454] (1) picpic
      3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
    23. AtpF-like [159467] (1) picpic
      3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
    24. Ribosomal protein L13 [52160] (1) picpic
      3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 3214
    25. Ribosomal protein L4 [52165] (1) picpic
      3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 1423
    26. Nqo1 FMN-binding domain-like [142018] (1) picpic
      3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
    27. Flavodoxin-like [52171] (15) picpic
      3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345
    28. Methylglyoxal synthase-like [52334] (1) picpic
      3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
    29. Ferredoxin reductase-like, C-terminal NADP-linked domain [52342] (1) picpic
      3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
    30. Adenine nucleotide alpha hydrolase-like [52373] (3) picpic
      core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145
    31. Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [52417] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
    32. Cryptochrome/photolyase, N-terminal domain [52424] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
    33. DsrEFH-like [75168] (1) picpic
      3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 43215
    34. PIN domain-like [88722] (1) picpic
      3 layers, a/b/a; core: parallel beta-sheet of 5 strands, order 32145
    35. Ribose/Galactose isomerase RpiB/AlsB [89622] (1) picpic
      3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 21354; topological similarity to a part of the arginase/deacetylase fold
    36. EreA/ChaN-like [159500] (1) picpic
      Core: 3 layers: a/b/a; parallel beta-sheet of 5 strands, order:51423;
    37. alpha/beta knot [75216] (1) picpic
      core: 3 layers: a/b/a, parallel beta-sheet of 5 strands, order 21435; contains a deep trefoil knot
    38. PreATP-grasp domain [52439] (1) picpic
      3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
      possible rudiment form of Rossmann-fold domain
    39. DHS-like NAD/FAD-binding domain [52466] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
    40. Tubulin nucleotide-binding domain-like [52489] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    41. Isochorismatase-like hydrolases [52498] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    42. Dipeptide transport protein [63991] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; also contains a C-terminal alpha+beta subdomain
    43. Homo-oligomeric flavin-containing Cys decarboxylases, HFCD [52506] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    44. HAD-like [56783] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    45. NagB/RpiA/CoA transferase-like [100949] (1) picpic
      core: 3 layers: a/b/a; parallel or mixed beta-sheet of 6 strands, order 321456
    46. Hypothetical protein MTH777 (MT0777) [75180] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
    47. Thiamin pyrophosphokinase, catalytic domain [63998] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 432156
    48. Undecaprenyl diphosphate synthase [64004] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 342156
    49. F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) [102323] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213456
    50. Thiamin diphosphate-binding fold (THDP-binding) [52517] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
    51. P-loop containing nucleoside triphosphate hydrolases [52539] (1) picpic
      3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
    52. PTS IIb component [52727] (1) picpic
      3 layers: a/b/a, parallel beta-sheet of 6 strands, order 324156
    53. DNA polymerase III chi subunit [102399] (1) picpic
      3 layers, a/b/a; parallel beta-sheet of 7 strands, order 7165243
    54. Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) [52732] (1) picpic
      3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567
    55. CofD-like [142337] (1) picpic
      3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567; topological similarity to the CobT-like fold (scop_cf 52732)
    56. MCP/YpsA-like [102404] (1) picpic
      3 layers: a/b/a, parallel beta-sheet of 7 strands, order 4321567
    57. Methylesterase CheB, C-terminal domain [52737] (1) picpic
      3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3421567
    58. Subtilisin-like [52742] (1) picpic
      3 layers: a/b/a, parallel beta-sheet of 7 strands, order 2314567; left-handed crossover connection between strands 2 & 3
    59. Indigoidine synthase A-like [110580] (1) picpic
      core: 3 layers, a/b/a; parallel beta-sheet of 7 strands, order 2134756
    60. Arginase/deacetylase [52767] (1) picpic
      3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456
    61. Alpha-2,3/8-sialyltransferase CstII [102413] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 8 strands, order 54321678
    62. Cell-division inhibitor MinC, N-terminal domain [64042] (1) picpic
      beta(2)-(alpha-beta)2-beta; 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 1 & 5 are antiparallel to the rest
    63. DTD-like [69499] (1) picpic
      beta(2)-(alpha-beta)2-beta(3); 3 layers, a/b/b; some topological similarity to the N-terminal domain of MinC
    64. CoA-dependent acyltransferases [52776] (1) picpic
      core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest
    65. Phosphotyrosine protein phosphatases I-like [52787] (2) picpic
      3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134
    66. (Phosphotyrosine protein) phosphatases II [52798] (1) picpic
      core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
    67. Rhodanese/Cell cycle control phosphatase [52820] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
    68. Thioredoxin fold [52832] (2) picpic
      core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
    69. Peptidyl-tRNA hydrolase II [102461] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 4 strands, order 2143, strand 4 is antiparallel to the rest
    70. TK C-terminal domain-like [52921] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 5 strands, order 13245, strand 1 is antiparallel to the rest
    71. Pyruvate kinase C-terminal domain-like [52934] (2) picpic
      3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145, strand 5 is antiparallel to the rest
    72. Anticodon-binding domain-like [52953] (6) picpic
      3 layers: a/b/a; mixed beta-sheet of five strands, order 21345; strand 4 is antiparallel to the rest
    73. MTH938-like [64075] (1) picpic
      core: 3 layers, b+a/b/a ; the central mixed sheet of 5 strands: order 21534; strand 2 is antiparallel to the rest
    74. Restriction endonuclease-like [52979] (4) picpic
      core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest
    75. Resolvase-like [53040] (2) picpic
      Core: 3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
    76. PTS system fructose IIA component-like [53061] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
    77. Ribonuclease H-like motif [53066] (7) picpic
      3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest
    78. Phosphorylase/hydrolase-like [53162] (8) picpic
      core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
    79. Molybdenum cofactor biosynthesis proteins [53217] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 5 strands; order: 21354, strand 5 is antiparallel to the rest; permutation of the Phosphorylase/hydrolase-like fold
    80. CobE/GbiG C-terminal domain-like [159663] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32154; strand 5 is antiparallel to the rest
    81. CbiG N-terminal domain-like [159671] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 6 strands, order 213456, strand 5 is antiparallel to the rest
    82. Bacterial fluorinating enzyme, N-terminal domain [102521] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 6 strands; order: 213546, strand 5 is antiparallel to the rest; topological similarity to the MogA-like family fold
    83. Caspase-like [52128] (1) picpic
      3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest
    84. Macro domain-like [52948] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest
    85. MurD-like peptide ligases, peptide-binding domain [53243] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 6 strands, order 126345; strand 1 is antiparallel to the rest
    86. Phosphoglycerate mutase-like [53253] (1) picpic
      core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 324156; strand 5 is antiparallel to the rest
    87. PRTase-like [53270] (1) picpic
      core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
    88. vWA-like [53299] (1) picpic
      core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
    89. Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [53322] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 6 strands, order 231456; strand 3 is antiparallel to the rest
    90. RbsD-like [102545] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 6 strands, order 251634; strand 6 is antiparallel to the rest
    91. FabD/lysophospholipase-like [52150] (1) picpic
      core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 432156; strand 4 is antiparallel to the rest
    92. L-sulfolactate dehydrogenase-like [89732] (1) picpic
      core: 3 layers, a/b/a; mixed sheet of 7 strands, order 1237456; strands 1, 6 and 7 are antiparallel to the rest
    93. Formyltransferase [53327] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214567; strand 6 is antiparallel to the rest
    94. S-adenosyl-L-methionine-dependent methyltransferases [53334] (1) picpic
      core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
    95. LmbE-like [102587] (1) picpic
      3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest; topological similarity to SAM-dependent methyltransferases
    96. PLP-dependent transferase-like [53382] (3) picpic
      main domain: 3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3245671; strand 7 is antiparallel to the rest
    97. Nucleotide-diphospho-sugar transferases [53447] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214657; strand 6 is antiparallel to the rest
    98. RibA-like [142694] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 7 strands, order 1235467, strands 1 and 3 are antiparallel to the rest; partial topological similarity to some alpha/beta hydrolases (scop_cf 53473)
    99. Activating enzymes of the ubiquitin-like proteins [69571] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
    100. alpha/beta-Hydrolases [53473] (1) picpic
      core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
    101. Nucleoside hydrolase [53589] (1) picpic
      core: 3 layers, a/b/a ; mixed beta-sheet of 8 strands, order 32145687; strand 7 is antiparallel to the rest
    102. Dihydrofolate reductase-like [53596] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
    103. Ribokinase-like [53612] (3) picpic
      core: 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
      potential superfamily: members of this fold have similar functions but different ATP-binding sites
    104. YjeF N-terminal domain-like [64152] (1) picpic
      3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 32145678; strand 8 is antiparallel to the rest
    105. Carbamate kinase-like [53632] (1) picpic
      3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 34215786; strand 8 is antiparallel to the rest
    106. 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain [64157] (1) picpic
      core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 45321678, strands 4 and 5 are antiparallel to the rest
    107. Alkaline phosphatase-like [53648] (1) picpic
      core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest
    108. TTHA0583/YokD-like [110709] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 8 strands, order 78612354; strands 3, 4 and 8 are antiparallel to the rest
    109. Glycerol-3-phosphate (1)-acyltransferase [69592] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 9 strands, order 918736452; strands 1, 2 and 8 are antiparallel to the rest
    110. AraD/HMP-PK domain-like [53638] (1) picpic
      3 layers: a/b/a; mixed (mostly antiparallel) beta-sheet of 9 strands, order 432159876; left-handed crossover between strands 4 and 5
    111. SurE-like [64166] (1) picpic
      3 layers: a/b/a; mixed beta-sheet of 9 strands, order 342156798; strands 3, 8 and 9 are antiparallel to the rest; left-handed crossover connection between strands 6 and 7
    112. YerB-like [159773] (1) picpic
      3 layers: b/b/a; central mixed beta-sheet of 9 strands, order 541329678; strands 3 and 7 are antiparallel to the rest; an unusual "over the other end" connection between strands 3 and 4
    113. CdCA1 repeat-like [159778] (1) picpic
      contains two parallel beta-strands of four strands each; the sheets contact each other with edges at a right angle
    114. Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1) picpic
      consists of two intertwined (sub)domains related by pseudo dyad; duplication
      3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
    115. Amidase signature (AS) enzymes [75303] (1) picpic
      possible duplication: the topologies of N- and C-terminal halves are similar; 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213549A867 (A=10); strands from 5 to 9 are antiparallel to the rest
    116. ATC-like [53670] (2) picpic
      consists of two similar domains related by pseudo dyad; duplication
      core: 3 layers, a/b/a, parallel beta-sheet of 4 strands, order 2134
    117. Tryptophan synthase beta subunit-like PLP-dependent enzymes [53685] (1) picpic
      consists of two similar domains related by pseudo dyad; duplication
      core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
    118. SIS domain [53696] (1) picpic
      3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345
    119. Formate dehydrogenase/DMSO reductase, domains 1-3 [53705] (1) picpic
      contains of two similar intertwined domains related by pseudo dyad; duplication
      core: 3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
    120. ALDH-like [53719] (1) picpic
      consists of two similar domains with 3 layers (a/b/a) each; duplication
      core: parallel beta-sheet of 5 strands, order 32145
    121. NadA-like [142753] (1) picpic
      duplication; consists of three similar domains related by pseudo threefold symmetry; 3 layers, a/b/a; parallel beta sheet, order: 2134
    122. Aconitase iron-sulfur domain [53731] (1) picpic
      consists of three similar domains with 3 layers (a/b/a) each; duplication
      core: parallel beta-sheet of 5 strands, order 32145
    123. Phosphoglucomutase, first 3 domains [53737] (1) picpic
      consists of three similar domains with 3 layers (a/b/a) each; duplication
      core: mixed beta-sheet of 4 strands, order 2134, strand 4 is antiparallel to the rest
    124. FucI/AraA N-terminal and middle domains [53742] (1) picpic
      consists of two domains of similar topology, 3 layers (a/b/a) each
      Domain 1 (1-173) has parallel beta-sheet of 5 strands, order 21345
      Domain 2 (174-355) has parallel beta-sheet of 4 strands, order 2134
    125. YgbK-like [142763] (1) picpic
      consists of two domains with partial topological similarity to the P-loop kinases but without the P-loop motif; the domain association results in the formation of a single mixed beta-sheet of 15 strands
    126. Phosphoglycerate kinase [53747] (1) picpic
      consists of two non-similar domains, 3 layers (a/b/a) each
      Domain 1 has parallel beta-sheet of 6 strands, order 342156
      Domain 2 has parallel beta-sheet of 6 strands, order 321456
    127. UDP-Glycosyltransferase/glycogen phosphorylase [53755] (1) picpic
      consists of two non-similar domains with 3 layers (a/b/a) each
      domain 1: parallel beta-sheet of 7 strands, order 3214567
      domain 2: parallel beta-sheet of 6 strands, order 321456
    128. Glutaminase/Asparaginase [53773] (1) picpic
      consists of two non-similar alpha/beta domains, 3 layers (a/b/a) each
      Domain 1 has mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest; left-handed crossover connection between strands 4 and 5
      Domain 2 has parallel beta-sheet of 4 strands, order 1234
    129. Phosphofructokinase [53783] (1) picpic
      consists of two non-similar domains, 3 layers (a/b/a) each
      Domain 1 has mixed sheet of 7 strands, order 3214567; strands 3 & 7 are antiparallel to the rest
      Domain 2 has parallel sheet of 4 strands, order 2314
    130. Tetrapyrrole methylase [53789] (1) picpic
      consists of two non-similar domains
      Domain 1 has parallel sheet of 5 strands, order 32415
      Domain 2 has mixed sheet of 5 strands, order 12534; strands 4 & 5 are antiparallel to the rest
    131. GckA/TtuD-like [82543] (1) picpic
      consists of two non-similar domains
      Domain 1 has parallel sheet of 6 strands, order 321456, Rossmann-like topology
      Domain 2 has mixed sheet of 6 strands, order 126345; strands 5 and 6 are antiparallel to the rest; some similarity to CbiF Domain 2
    132. DAK1/DegV-like [82548] (1) picpic
      2 different domains; d1: [core: 3 layers, a/b/a; parallel sheet of 5 strands, order: 2134]; D2: [2 layers, a/b; mixed sheet of 6 strands, order 321645; strands 2 and 6 are antiparallel to the rest]
    133. DHH phosphoesterases [64181] (1) picpic
      consists of two non-similar domains
      Domain 1 has parallel sheet of 6 strands, order 321456
      Domain 2 has mixed sheet of 5 strands, order 12345; strands 1 & 4 are antiparallel to the rest
    134. Glycerate kinase I [110737] (1) picpic
      consists of two different alpha/beta domains; (1) of the Flavodoxin-like fold (scop_cf 52171); (2) similar to the Restriction endonuclease-like fold (scop_cf 52979), inserted into domain 1
    135. PEP carboxykinase-like [53794] (1) picpic
      contains a P-loop NTP-binding motif; mixed beta-sheet folds into a barrel-like structure with helices packed on one side
    136. PEP carboxykinase N-terminal domain [68922] (1) picpic
      contains mixed beta-sheets; topology is partly similar to that of the catalytic C-terminal domain
    137. Chelatase-like [53799] (3) picpic
      duplication: tandem repeat of two domains; 3 layers (a/b/a); parallel beta-sheet of 4 strands, order 2134
    138. HemD-like [69617] (1) picpic
      duplication: consists of two similar 'swapped' domain with 3 layers (a/b/a) each; parallel beta-sheet of 5 strands, order 21345
    139. CAC2185-like [142794] (1) picpic
      consists of two non-similar domains, 3 layers (a/b/a) each; d1 has parallel sheet of 4 strands, order 2134; d2 has parallel sheet of 5 strands, order 21345, and antiparallel meander sheet of 3 strands
    140. Periplasmic binding protein-like I [53821] (1) picpic
      consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
      parallel beta-sheet of 6 strands, order 213456
    141. Periplasmic binding protein-like II [53849] (1) picpic
      consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
      mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest
    142. Thiolase-like [53900] (1) picpic
      consists of two similar domains related by pseudo dyad; duplication
      3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32451; strand 5 is antiparallel to the rest
    143. NIF3 (NGG1p interacting factor 3)-like [102704] (1) picpic
      consist of two intertwined domains; duplication: contains two structural repeats of alpha-beta-(beta-alpha)3 motif with mixed beta-sheet, order: 1432, strand 1 is antiparallel to the rest
    144. Fe-only hydrogenase [53919] (1) picpic
      consist of two intertwined domains; contains partial duplication
    145. ComB-like [142822] (1) picpic
      contains of two similar intertwined domains related by pseudo dyad; duplication; core: 3 layers: a/b/a; parallel beta-sheet of 4 strands, order 1423
    146. CoA-transferase family III (CaiB/BaiF) [89795] (1) picpic
      consist of two different alpha/beta domains; N-terminal domain has a SurE-like topology with a left-handed beta-alpha-beta unit
    147. Cytidine deaminase-like [53926] (2) picpic
      core: alpha-beta(2)-(alpha-beta)2; 3 layers (a/b/a); mixed beta-sheet of 4 strands, order 2134; strand 1 is antiparallel to the rest
  4. Alpha and beta proteins (a+b) [53931] (376)
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
    1. Microbial ribonucleases [53932] (1) picpic
      single helix packs against antiparallel beta-sheet
    2. Lysozyme-like [53954] (1) picpic
      common alpha+beta motif for the active site region
    3. Cysteine proteinases [54000] (1) picpic
      consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
    4. His-Me finger endonucleases [54059] (1) picpic
      core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
    5. RNase A-like [54075] (1) picpic
      contains long curved beta-sheet and 3 helices
    6. EndoU-like [142876] (1) picpic
      comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (scop_cf 54075)
    7. Prion-like [54097] (1) picpic
      beta-alpha-beta-alpha(2); antiparallel beta-ribbon
    8. LysM domain [54105] (1) picpic
      beta-alpha(2)-beta; antiparallel strands
    9. gpW/XkdW-like [64209] (2) picpic
      alpha-beta(2)-alpha; antiparallel hairpin
    10. Hypothetical protein MTH677 [110782] (1) picpic
      alpha-beta(2)-alpha; 2 layers a/b; antiparallel beta-hairpin
    11. GTF2I-like repeat [117772] (1) picpic
      alpha(2)-beta-alpha-beta-alpha; 2 layers: a/b; antiparallel beta-ribbon
    12. Urease, gamma-subunit [54110] (1) picpic
      alpha(3)-beta(2); antiparallel hairpin
    13. IL8-like [54116] (2) picpic
      beta(3)-alpha
    14. DNA-binding domain [54170] (1) picpic
      beta(3)-alpha; 2 layers: alpha/beta
    15. Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54183] (1) picpic
      alpha1-beta3; 2 layers: alpha/beta; order 132
    16. Dodecin subunit-like [88797] (6) picpic
      beta-alpha-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 132
    17. Ribosomal proteins S24e, L23 and L15e [54188] (1) picpic
      beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
    18. Ribosome binding domain-like [100965] (2) picpic
      beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e
    19. TFB5-like [142896] (1) picpic
      beta-alpha-beta(2)-alpha; 2 layers, a/b; antiparallel sheet, order: 132; dimerises in solution (PDB 2jnj) via extended N-terminal strand
    20. Obg GTP-binding protein C-terminal domain [102740] (1) picpic
      beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other
    21. HIT-like [54196] (2) picpic
      alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
    22. Secretion chaperone-like [69634] (5) picpic
      alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta
    23. DNA-binding domain of intron-encoded endonucleases [64495] (1) picpic
      beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix
    24. MotA C-terminal domain-like [69651] (1) picpic
      alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta
    25. YktB/PF0168-like [142912] (1) picpic
      alpha-beta(4)-alpha-beta(2)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order: 1234756; half-barrel shape; topological similarity to the MotA C-terminal domain-like fold (scop_cf 69651) and the Secretion chaperone-like fold (scop_cf 69634)
    26. Mago nashi protein [89816] (1) picpic
      beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, order: 651234
    27. WGR domain-like [142920] (1) picpic
      beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure
    28. PH1570-like [159901] (1) picpic
      duplication: two beta(4)-alpha structural repeats, related by pseudo twofold symmetry; two extra helices in the linker region; single 8-standed antiparallel beta-sheet, order: 12348765
    29. Ribosomal protein S5 domain 2-like [54210] (1) picpic
      core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
    30. beta-Grasp (ubiquitin-like) [54235] (14) picpic
      core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
    31. MM3350-like [159940] (1) picpic
      beta(2)-alpha-beta(4); antiparallel beta-sheet; order: 216534; similar to a ubiquitin-like fold with the extra C-terminal strand inserted in the middle of the beta-sheet
    32. WWE domain [117838] (1) picpic
      beta(2)-alpha-beta(4); antiparallel folded beta-sheet (half-barrel), order 216543
    33. FAD-linked reductases, C-terminal domain [54372] (1) picpic
      alpha+beta sandwich
    34. Cystatin-like [54402] (7) picpic
      Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
    35. Nuclease A inhibitor (NuiA) [82601] (1) picpic
      alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432
    36. Colicin D/E5 nuclease domain [102823] (1) picpic
      alpha(2)-beta(4)-alpha, 2 layers: alpha/beta, antiparallel beta sheet, meander
    37. RelE-like [143010] (1) picpic
      beta-alpha(2)-beta(4), 2 layers; a/b, antiparallel beta-sheet; order 15432
    38. Hypothetical protein SAV1430 [110835] (1) picpic
      beta(3)-alpha-beta(2)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet, order: 12543
    39. Ns1 effector domain-like [143020] (1) picpic
      beta-X-beta(5)-alpha-beta-alpha; 2 layers: a/b; bifurcated beta-sheet; order 23654[1,7]
    40. YbaB-like [82606] (1) picpic
      core: alpha-beta(3)-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123
    41. Kinetochore globular domain-like [143025] (1) picpic
      core: alpha-beta(3)-alpha; variant: alpha-beta(4)-alpha(2)
    42. L35p-like [143033] (1) picpic
      core: alpha-beta(3)-alpha; 2layers a/b
    43. Cell division protein ZapA-like [102828] (1) picpic
      core: beta(2)-alpha(2), 2 layers: alpha/beta; long C-terminal helix forms dimeric parallel and tetrameric antiparallel coiled coils
    44. ssDNA-binding transcriptional regulator domain [54446] (1) picpic
      helix-swapped dimer of beta(4)-alpha motifs
    45. Photosystem I subunit PsaD [64233] (1) picpic
      beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
    46. GINS/PriA/YqbF domain [160058] (1) picpic
      beta(4)-alpha-beta; 3-stranded antiparallel beta-sheet (strands 4,1 and 5) are covered on the same side by the helix and beta hairpin of strands 2 and 3; similarity to the L9 N-domain-like fold (scop_cf 55657) and the PsaD fold (scop_sf 64243)
    47. MHC antigen-recognition domain [54451] (1) picpic
      dimeric
    48. UBC-like [54494] (1) picpic
      alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
    49. SAND domain-like [63762] (1) picpic
      core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold
    50. NRDP1 C-terminal domain-like [160087] (1) picpic
      alpha-beta-alpha(3)-beta(3); a pseudo barrel beta-sheet of an SH3-like topology, surrounded by helices
    51. Coronavirus NSP8-like [143075] (1) picpic
      core: alpha-beta(2)-alpha-beta(4)-alpha-beta; bifurcated barrel-like beta-sheet
    52. ParB/Sulfiredoxin [110848] (1) picpic
      beta*-alpha-beta(2)-alpha-beta-alpha; mixed beta sheet forms a partly open barrel: (n*=4, S*=8)
    53. Gamma-glutamyl cyclotransferase-like [110856] (1) picpic
      beta-alpha-beta(4)-alpha-beta(2); contains beta-sheet barrel (n=5, S=8)
    54. BB1717-like [143080] (1) picpic
      complex fold with a bifurcated beta-sheet structure surrounded by helices; contains beta-sheet barrel, closed (n=5, S=8)
    55. SARS Nsp1-like [160098] (1) picpic
      complex alpha+beta fold; contains mixed beta-sheet barrel, n=6, S=10
    56. Acetoacetate decarboxylase-like [160103] (1) picpic
      complex fold: contains a 3-layer beta-sheet structure, which is folded in two conjoint barrels capped by helices; one rounded barrel has 7 strands, the other flattened barrel has 9 strands
    57. AF0104/ALDC/Ptd012-like [117855] (1) picpic
      duplication: consists of two similar beta-alpha-beta(4) motifs
    58. NSFL1 (p97 ATPase) cofactor p47, SEP domain [102847] (1) picpic
      beta(3)-alpha(2)-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other
    59. TTHA1013/TTHA0281-like [143099] (1) picpic
      beta(3)-alpha-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other; topological similarity to the SEP domain fold (scop_cf 102847); dimerises via the long C-terminal strand with the formation of a single beta-sheet
    60. YegP-like [160112] (1) picpic
      comprises two subunits or tandem repeats of beta(3)-alpha-beta motifs; these assemble with the formation of a single beta-sheet and swapping of the C-terminal strands
    61. Diaminopimelate epimerase-like [54505] (1) picpic
      mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
    62. GFP-like [54510] (1) picpic
      beta-sheet folds into a barrel (n=11, S=14) around the central helix
    63. Tubby C-terminal domain-like [54517] (1) picpic
      beta-sheet folds into a barrel (n=12, S=12) around the central helix
    64. Pili subunits [54522] (1) picpic
      contains very long N-terminal helix, which end is packed against beta-sheet
    65. Mitochondrial glycoprotein MAM33-like [54528] (1) picpic
      core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain
    66. NAP-like [143112] (1) picpic
      core: central meander 4-stranded beta-sheet (order: 1234) transversed by a C-terminal helix
    67. Polo-box domain [82614] (1) picpic
      beta(6)-alpha; antiparallel beta-sheet, meander
    68. mRNA decapping enzyme DcpS N-terminal domain [102859] (1) picpic
      beta(3)-alpha-beta(3)-alpha; 3 layers a/b/a
    69. Inhibitor of vertebrate lysozyme, Ivy [89871] (1) picpic
      alpha(2)-beta(5)-alpha(2); 3 layers a/b/a; meander beta-sheet
    70. FKBP-like [54533] (3) picpic
      core: beta(2)-alpha-beta(2); antiparallel beta-sheet
    71. Ribosomal protein S16 [54564] (1) picpic
      beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234
    72. Ribosomal protein S19 [54569] (1) picpic
      alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123
    73. YefM-like [143119] (1) picpic
      core: beta-alpha(2)-beta(2)-alpha; mixed beta-sheet, order:123, strands 1 and 2 are parallel; forms compact dimer with a single beta-sheet;
    74. Ribosomal protein L31e [54574] (1) picpic
      beta-alpha-beta-(alpha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342
    75. Allophycocyanin linker chain (domain) [54579] (1) picpic
      beta(2)-alpha-beta; 2 layers: alpha/beta
    76. Cdc48 domain 2-like [54584] (1) picpic
      beta-alpha-beta(3); 2 layers: alpha/beta
    77. Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1) picpic
      beta-alpha-beta(3); 2 layers: alpha/beta
    78. Chromosomal protein MC1 [102874] (1) picpic
      beta(2)-alpha-beta(3); 2 layers: alpha/beta
    79. CPE0013-like [160147] (1) picpic
      beta(2)-alpha-beta(3); mixed, mostly antiparallel beta-sheet, folded in a half-barrel; order:31254; strand 3 is parallel to strand 1 and is shorter than the rest
    80. beta-hairpin-alpha-hairpin repeat [74651] (2) picpic
      multiple repeats of beta(2)-alpha(2) motif
    81. Proguanylin [89889] (1) picpic
      beta(2)-alpha(3)-beta; two layers: alpha/beta; antiparallel sheet: order 213
    82. SecB-like [54610] (1) picpic
      beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432
    83. MesJ substrate recognition domain-like [82828] (1) picpic
      beta-alpha(2)-beta(3); 2 layers: a/b; antiparallel beta-sheet, order:1432
    84. FYSH domain [89894] (1) picpic
      beta(2)-alpha(2)-beta(2)-alpha-beta; two layers: alpha/beta; antiparallel sheet: order 51234
    85. VSV matrix protein [75403] (1) picpic
      beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154
    86. DNA-binding domain of Mlu1-box binding protein MBP1 [54615] (1) picpic
      beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465
    87. Heme-binding protein A (HasA) [54620] (1) picpic
      beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432
    88. Chalcone isomerase [54625] (1) picpic
      beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567
    89. Coproporphyrinogen III oxidase [102885] (1) picpic
      alpha-beta(6)-alpha(2)-beta-alpha(n); 3 layers alpha/beta/alpha; antiparallel sheet: order 1234567
    90. Hypothetical protein Ta1206 [102890] (1) picpic
      beta(4)-alpha-beta(2)-alpha(2); mixed, predominately antiparallel beta-sheet, order: 123465, strands 4 and 5 are parallel to each other
    91. CBS-domain pair [54630] (1) picpic
      duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences; 4 layers: a/b/b/a
    92. Thioesterase/thiol ester dehydrase-isomerase [54636] (1) picpic
      core: beta-alpha-beta(4); 2 layers: alpha/beta
    93. DLC [54647] (1) picpic
      core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342
    94. CI-2 family of serine protease inhibitors [54653] (1) picpic
      alpha+beta sandwich; loop across free side of beta-sheet
    95. Integrin beta tail domain [69686] (1) picpic
      alpha-beta-loop-beta(3); loop across free side of beta-sheet
    96. YcgL-like [160190] (1) picpic
      beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet, order:3124
    97. alpha/beta-Hammerhead [54664] (5) picpic
      core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
    98. POZ domain [54694] (1) picpic
      core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143
    99. EF-Ts domain-like [54712] (2) picpic
      beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123
    100. Fe,Mn superoxide dismutase (SOD), C-terminal domain [54718] (1) picpic
      alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213
    101. ClpS-like [54735] (1) picpic
      beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta
    102. Hypothetical protein MTH1880 [75411] (1) picpic
      beta-alpha-beta(2)-alpha(2); 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
    103. Ribosomal L11/L12e N-terminal domain [54746] (1) picpic
      beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
    104. Anti-LPS factor/recA domain [54751] (2) picpic
      alpha-beta(3)-alpha(2); 2 layers, alpha/beta
    105. Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54761] (1) picpic
      (beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta
    106. dsRBD-like [54767] (5) picpic
      alpha-beta(3)-alpha; 2 layers: alpha/beta
    107. 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain [110920] (1) picpic
      duplication: consists of two beta(3)-alpha repeats; 3 layers, beta/alpha/beta
    108. NMB0488-like [160206] (1) picpic
      duplication: two beta(3)-alpha motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456, shaped into a half-barrel; helical linker region
    109. SRP19 [69694] (1) picpic
      beta-alpha-beta(2)-alpha; 2 layers: alpha/beta
    110. SufE/NifU [82648] (1) picpic
      alpha(2)-beta(3)-alpha(3); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
    111. FlaG-like [160213] (1) picpic
      alpha(2)-beta(3)-alpha; 2 layers: a/b; antiparallel beta-sheet, order: 123; partial similatity to the dsRBD-like fold(sop_cf 54767)
    112. AMPKBI-like [160218] (1) picpic
      comprises 3 short helices and 3-stranded meander beta-sheet; makes extensive intermolecular interactions
    113. DNA-binding protein Tfx [89914] (1) picpic
      alpha(3)-beta-alpha(2)-beta(2); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
    114. Eukaryotic type KH-domain (KH-domain type I) [54790] (1) picpic
      beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta
    115. Alpha-lytic protease prodomain-like [54805] (10) picpic
      core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta
    116. Nucleotidyltransferase [81302] (1) picpic
      core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123
    117. Nqo5-like [143242] (1) picpic
      core: alpha-beta(2)-alpha-beta(3); 2 layers, a/b; mixed beta-sheet, order 12534, strands 2 and 5 are parallel
    118. Ribosomal protein S3 C-terminal domain [54820] (1) picpic
      alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143
    119. Transcription factor NusA, N-terminal domain [69704] (1) picpic
      alpha-beta(3)-alpha-beta-alpha; bifurcated coiled beta-sheet
    120. Enolase N-terminal domain-like [54825] (1) picpic
      beta(3)-alpha(3); meander and up-and-down bundle
    121. Ribosomal protein L22 [54842] (1) picpic
      beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation
    122. Prokaryotic ribosomal protein L17 [64262] (1) picpic
      alpha-beta-alpha(3)-beta(2); 2 layers: alpha/beta;
    123. GroEL-intermediate domain like [54848] (1) picpic
      3-helical bundle packed against 3-stranded mixed beta-sheet
    124. PX domain [64267] (1) picpic
      beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch
    125. Shew3726-like [160271] (1) picpic
      beta(3)-alpha(n)-beta; 2 layers, a/b; mixed beta-sheet, order 1234, strands 3 and 4 are parallel with a left-handed crossover connection
    126. DsrC, the gamma subunit of dissimilatory sulfite reductase [69720] (1) picpic
      beta(3)-alpha(5); meander beta-sheet packed against array of helices
    127. DNA damage-inducible protein DinI [54856] (1) picpic
      beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops
    128. HSP90 C-terminal domain [110941] (1) picpic
      alpha-beta(3)-alpha(3); 2 layers, a/b; mixed beta-sheet, order:132; crossing loops
    129. Ferredoxin-like [54861] (59) picpic
      alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
    130. PurS-like [109622] (1) picpic
      consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
    131. RplX-like [160373] (1) picpic
      beta(2)-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 213; some structural similarity to the PurS subunit/repeat (scop_cf 109622)
    132. Dystroglycan, domain 2 [111005] (1) picpic
      beta-alpha-beta-X-beta(2)-alpha(2)-beta; antiparallel beta-sheet, order 24153; topological similarity to the ferredoxin-like fold (scop_cf 54861)
    133. Pseudouridine synthase [100877] (1) picpic
      consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
    134. SP0830-like [160378] (1) picpic
      duplication: two beta-alpha-beta(2)-alpha-beta-alpha motifs are organized in ferredoxin-like subdomains swapped with the extra C-terminal helices
    135. Folate-binding domain [103024] (1) picpic
      duplication: consists of two beta(2)-alpha-beta(3)-alpha subdomains swapped with the first strands
    136. THUMP domain [143436] (1) picpic
      contains mixed 8-stranded beta-sheet, folded into a half-barrel and covered with 4 helices on the outside; order 32148756; strands 5, 6 and 7 are parallel
    137. AMMECR1-like [143446] (1) picpic
      duplication; contains two beta(2)-alpha-beta(2) structural repeats, swapped with C-terminal strands; extra N-terminal helix and C-terminal strand
    138. NosL/MerB-like [160386] (1) picpic
      unusual fold; comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets; probable duplication
    139. YehU-like [118000] (1) picpic
      beta-alpha(2)-beta(2)-alpha; 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
    140. Hypothetical protein YwqG [103031] (1) picpic
      duplication: contains two similar beta-x-beta(4) motifs swapped with the first strands
    141. VC0467-like [143455] (1) picpic
      complex fold; contains bifurcated beta-sheet structure folded into pseudo barrel
    142. Lesion bypass DNA polymerase (Y-family), little finger domain [100878] (1) picpic
      beta-alpha-beta(2)-alpha-beta; antiparallel beta-sheet: order 1423; "reversed" ferredoxin-like topology
    143. ImmE5-like [143468] (1) picpic
      alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order 213
    144. Ribosomal protein L30p/L7e [55128] (1) picpic
      core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity to the ferredoxin-like fold
    145. Chorismate lyase-like [64287] (1) picpic
      duplication of alpha(2)-beta(3) motif; antiparallel beta sheet, order 123654
    146. YdfO-like [160418] (1) picpic
      duplication: two alpha(2)-beta(3) motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456
    147. TM1622-like [143476] (1) picpic
      alpha-beta(3)-alpha-beta(4)-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 1237654
    148. BH3703-like [160423] (1) picpic
      alpha-beta(3)-alpha-beta(2)-alpha(2); antiparallel beta-sheet, order:32145; duplication: two alpha-beta(2) structural repeats are arranged with pseudo twofold symmetry
    149. Probable bacterial effector-binding domain [55135] (1) picpic
      duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12)
    150. CheC-like [103038] (1) picpic
      duplication: tandem repeat of two intertwined alpha-beta-(X)-beta(2) motifs
    151. LigT-like [55143] (1) picpic
      duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III
    152. Pepsin inhibitor-3 [55148] (1) picpic
      duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure
    153. CYTH-like phosphatases [55153] (1) picpic
      duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it
    154. Antiparallel beta/alpha barrel (PT-barrel) [143491] (1) picpic
      tandem repeat of five alpha(2)-beta(2) motifs; antiparallel beta-sheet barrel, closed; n=10, S=10; order 123456789A; there is a channel along the barrel axis
    155. eIF1-like [55158] (2) picpic
      beta(2)-alpha-beta(2)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet: order 51243
    156. Hedgehog/DD-peptidase [55165] (1) picpic
      alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
    157. Alpha-L RNA-binding motif [55173] (1) picpic
      alpha(2)-beta(2)-loop-beta; 2 layers: alpha/beta
    158. RRF/tRNA synthetase additional domain-like [55185] (4) picpic
      core: alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
    159. LuxS/MPP-like metallohydrolase [63410] (1) picpic
      core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta
    160. IF3-like [55199] (8) picpic
      beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest
    161. PUG domain-like [143502] (1) picpic
      alpha(2)-beta-alpha(2)-beta(2)-alpha; cluster of helices with a small antiparallel beta-sheet on one side; order 132; topological similarity to the fold of an extended R3H domain (PDB 1whr)
    162. PG1857-like [160447] (1) picpic
      alpha-beta-alpha-beta(2)-alpha(3); 3 layers, a/b/a; antiparallel beta-sheet, order: 132
    163. PB2 C-terminal domain-like [160452] (1) picpic
      alpha-beta-alpha-X-alpha-beta(2); 3 layers, a/b/a; antiparallel beta-sheet, order 132; connection between helices 2 and 3 runs over the edge of the beta-sheet
    164. Ribosome binding protein Y (YfiA homologue) [69753] (1) picpic
      beta-alpha-beta(3)-alpha; 2 layers; mixed sheet 1234, strand 3 is antiparallel to the rest
    165. TolA/TonB C-terminal domain [74652] (1) picpic
      beta(2)-alpha-beta; 2 layers, alpha/beta; left-handed beta-alpha-beta unit in non-swapped monomer
    166. Yeast killer toxins [55220] (1) picpic
      beta-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta; left-handed crossover connection
    167. Cell division protein MinE topological specificity domain [55228] (1) picpic
      dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
    168. Hypothetical protein YoaG [103062] (1) picpic
      dimer of beta(2)-alpha motifs ; 2 layers, alpha/beta; reverse MinE topology
    169. BLRF2-like [160458] (1) picpic
      homodimer of alpha(2)-beta motif; also includes extra N-terminal helix of variable position
    170. Nucleocapsid protein dimerization domain [103067] (1) picpic
      dimer of alpha-beta(2)-alpha motifs ; 2 layers, alpha/beta
    171. Cyanase C-terminal domain [55233] (1) picpic
      intertwined dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
    172. Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains [82713] (1) picpic
      Intertwined pseudo hexamer of an alpha+beta motif
    173. RuBisCO, small subunit [55238] (1) picpic
      alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
    174. DCoH-like [55247] (5) picpic
      beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
    175. TRCF domain-like [143516] (1) picpic
      beta-alpha(3)-beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed beta sheet, order 12354, strands 1 and 2 are parallel; some topological similarity to the DCoH-like fold (scop_cf 55247)
    176. NMB0513-like [160471] (1) picpic
      alpha(3)-beta(2)-alpha-beta(2); some similarity to the "winged helix" DNA-binding domain fold
    177. PA1123-like [160476] (1) picpic
      irregular array of short helices and two three-stranded beta-sheets
    178. Hypothetical protein Yml108w [100886] (1) picpic
      beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta; mixed beta-sheet 2143, strands 1 and 4 are parallel
    179. MutS N-terminal domain-like [55266] (2) picpic
      beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
    180. GYF/BRK domain-like [55276] (2) picpic
      beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
    181. GTP cyclohydrolase I feedback regulatory protein, GFRP [69760] (1) picpic
      beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta, antiparallel beta-sheet: order 342165
    182. RL5-like [55281] (1) picpic
      beta-alpha-beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet: order 231654
    183. RPB5-like RNA polymerase subunit [55286] (1) picpic
      core: beta-alpha-beta-alpha-beta(2); 2 layers, alpha/beta
    184. Bacillus chorismate mutase-like [55297] (9) picpic
      core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest
    185. YjbQ-like [111037] (1) picpic
      beta(2)-alpha-beta(2)-alpha(2)-beta(3); contains a beta-sandwich: 7 strands in 2 sheets; trimerizes with orthogonally packed beta-sheets
    186. Tautomerase/MIF [55330] (1) picpic
      (beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet
      generally forms trimers with three closely packed beta-sheets
    187. FwdE/GAPDH domain-like [55346] (4) picpic
      core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1
    188. Ava3019-like [160531] (1) picpic
      alpha(2)-beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order: 32145; similarity to the insert domain of Glucose 6-phosphate dehydrogenase-like family (sop_fa 55376)
    189. Hypothetical protein PF0899 [111056] (1) picpic
      alpha-beta-alpha-beta(4); 2 layers: a/b; mixed beta-sheet, order 23145, strands 1 and 3 are parallel; similar to the GAPDH C-terminal domain-like fold (scop_cf 55346)
    190. Major capsid protein gp5 [56562] (1) picpic
      unusual fold; contains PF0899-like core, decorated with additional structure
    191. MK0786-like [143559] (1) picpic
      alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order 1234 (meander)
    192. YkuJ-like [143566] (1) picpic
      alpha-beta(4)-alpha; 2 layers a/b; antiparallel beta-sheet, order 1234
    193. N domain of copper amine oxidase-like [55382] (5) picpic
      alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet
    194. Aha1/BPI domain-like [55393] (2) picpic
      core: [beta]-alpha-beta(5)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, meander
    195. SpoVG-like [160536] (1) picpic
      beta(5)-alpha; comprises a coiled antiparallel beta-sheet (order: 12345) packed against the C-terminal helix; the extensions of strands 4 and 5 form an isolated beta-hairpin
    196. Subtilisin inhibitor [55398] (1) picpic
      alpha+beta sandwich
    197. RNA bacteriophage capsid protein [55404] (1) picpic
      6-standed beta-sheet followed with 2 helices; meander
    198. eIF4e-like [55417] (1) picpic
      beta(2)-alpha-beta(2)-alpha-beta(2)-alpha-beta-2; 2 layers: alpha/beta; antiparallel sheet: 21356478
    199. CO dehydrogenase flavoprotein C-domain-like [55423] (2) picpic
      core: beta(3,4)-alpha(3); alpha+beta sandwich
    200. SRF-like [55454] (1) picpic
      alpha-beta(2)-alpha; dimer; 3 layers a/b/a; antiparallel beta-sheet
    201. Origin of replication-binding domain, RBD-like [55463] (1) picpic
      alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel sheet 41325
    202. SARS receptor-binding domain-like [143586] (1) picpic
      core: 3 layers, a/b/a; antiparallel beta-sheet of 5 strands, order 13542
    203. Hut operon positive regulatory protein HutP [111063] (1) picpic
      alpha(2)-beta-alpha(2)-beta(3); 3 layers: a/b/a; antiparallel beta-sheet: order 1234
    204. Hypothetical protein yfbM [111068] (1) picpic
      beta-alpha(2)-beta-alpha(2)-beta(2)-alpha(n)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 21543
    205. TTHA1528-like [143591] (1) picpic
      beta-alpha-beta(3)-alpha-beta-alpha(2)-beta; 3 layers: a/b/a; mixed beta-sheet, order: 143256, parallel strands' pairs are 1-4 and 2-5
    206. YojJ-like [143596] (1) picpic
      alpha-beta-X-beta-alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; 7-stranded mixed beta-sheet, order 2431567; strands 1 and 3 are parallel to each other
    207. STIV B116-like [143601] (1) picpic
      subunit fold consists of mixed 5-stranded beta-sheet, order:31452, strand 5 is antiparallel to the rest, with 3 helices on one side; dimerises with the formation of a single 10-stranded beta-sheet; strand 2 is in the dimer interface
    208. Bacillus phage protein [111073] (1) picpic
      alpa-beta(3)-alpha-beta(3)-alpha; 3 layers: b/a/b, 3-helical bundle flanked by two 3-stranded meander beta-sheets
    209. FMN-dependent nitroreductase-like [55468] (1) picpic
      core: (alpha-beta-alpha-beta)2; 3 layers a/b/a; antiparallel beta-sheet: 1243
    210. N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 [55480] (1) picpic
      alpha-beta-alpha(2)-beta(3)-alpha; 3 layers a/b/a; antiparallel beta-sheet: 4123
    211. EscU C-terminal domain-like [160543] (1) picpic
      alpha-beta(3)-alpha-beta-alpha(2); 3 layers, a/b/a; mixed beta-sheet, order: 4123, strand 2 is antiparallel to the rest
    212. Zincin-like [55485] (2) picpic
      contains mixed beta sheet with connection over free side of the sheet
    213. SH2-like [55549] (1) picpic
      3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
    214. HPr-like [55593] (2) picpic
      beta-alpha-beta(2)-alpha-beta-alpha; 2 layers: a/b; antiparallel sheet 1423
    215. TrkA C-terminal domain-like [116725] (1) picpic
      beta-X-beta(2)-X-beta-alpha; pseudo barrel capped by helix at one end; topological similarity to the HPr-like fold
    216. Hypothetical protein YjiA, C-terminal domain [90001] (1) picpic
      beta-alpha-beta(4)-alpha; 2 layers: a/b; antiparallel sheet 15234; topological similarity to the HPr-like fold
    217. YggU-like [69785] (1) picpic
      beta(2)-loop-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243; some similarity to the Homing endonuclease-like fold
    218. Homing endonuclease-like [55603] (2) picpic
      alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243
    219. T-fold [55619] (2) picpic
      beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
      tunnel-shaped: its known members form wide oligomeric barrels different sizes
    220. Cell cycle regulatory proteins [55636] (1) picpic
      beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243
      can form strand-exchange dimers
    221. YonK-like [160569] (1) picpic
      intertwined dimer of beta(3)-alpha-beta subunits; assembles further in octamer with formation of a wide 16-stranded beta-barrel
    222. BLIP-like [55647] (2) picpic
      alpha(2)-beta(4); 2 layers: alpha/beta
    223. Ribosomal protein L9 C-domain [55652] (1) picpic
      alpha-beta-alpha(2)-beta(2); 2 layers: alpha/beta
    224. MbtH/L9 domain-like [55657] (2) picpic
      beta(2)-alpha-beta-alpha; 3 layers: alpha/beta/alpha
    225. Tombusvirus P19 core protein, VP19 [103144] (1) picpic
      beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel sheet: order 2134
    226. Ribonuclease PH domain 2-like [55665] (1) picpic
      beta(2)-alpha-beta(2)-alpha; 3 layers: alpha/beta/alpha; antiparallel sheet: order 2134
    227. Regulatory factor Nef [55670] (1) picpic
      alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha
    228. CytB endotoxin-like [55675] (1) picpic
      core: beta-alpha(2)-beta-alpha(2)-beta(4); 3 layers: a/b/a
    229. Class II aaRS and biotin synthetases [55680] (1) picpic
      contains large mixed beta-sheet
    230. Subdomain of clathrin and coatomer appendage domain [55710] (1) picpic
      beta-alpha-beta-alpha-beta(4)-alpha; 3 layers: a/b/a; bifurcated antiparallel beta-sheet
    231. SCP-like [55717] (1) picpic
      alpha-beta(3)-(crossover)-beta-(alpha)-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 32145
    232. Ta1353-like [103164] (1) picpic
      core: beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 51423;
    233. Mog1p/PsbP-like [55723] (1) picpic
      (beta-hairpin)-beta(3)-alpha-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet of 7 strands; order: 1237654
    234. SMI1/KNR4-like [160630] (1) picpic
      alpha(4)-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet, order 1234(meander)
    235. Acyl-CoA N-acyltransferases (Nat) [55728] (1) picpic
      3 layers: a/b/a; contains mixed beta-sheet
    236. Gelsolin-like [55752] (3) picpic
      3 layers: a/b/a; contains mixed beta-sheet
    237. PHP14-like [143723] (1) picpic
      beta(3)-alpha-beta(2)-alpha-beta; 3 layers, a/b/a; mixed beta-sheet, half-barrel, order: 132456; strands 2 and 5 are antiparallel to the rest
    238. Profilin-like [55769] (10) picpic
      core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha
    239. Ligand-binding domain in the NO signalling and Golgi transport [111125] (1) picpic
      an N-terminal helical bundle and the C-terminal alpha-beta(2)-alpha-beta(2) subdomain enclose a ligand-binding cavity
    240. Phage tail protein-like [143748] (1) picpic
      alpha-beta-X-beta(2)-alpha-beta(2); 2 layers: a/b; mixed beta-sheet: order 12354, strands 1 and 2 are parallel
    241. PR-1-like [55796] (1) picpic
      alpha-beta-alpha-beta-alpha(2)-beta(2); 3 layers, alpha/beta/alpha; mixed sheet: order 1342
    242. Phoshotransferase/anion transport protein [55803] (1) picpic
      beta-alpha(2)-beta(3)-alpha(3); 3 layers, alpha/beta/alpha; mixed sheet: order 1342; loop crossing
    243. Nudix [55810] (1) picpic
      beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
      contains beta-grasp motif
    244. 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain [55815] (1) picpic
      core: alpha-beta(2)-alpha-beta(2)-alpha-beta; 3 layers; mixed sheet: order 31425
    245. YrdC/RibB [55820] (1) picpic
      core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers; mixed twisted sheet of 7 strands; order 7126354; strands 7 and 1 are parallel to each other
    246. GIY-YIG endonuclease [82770] (1) picpic
      beta(2)-alpha(2)-beta-alpha-(beta); strand 4 is very short; 3 layers; antiparallel (mixed) beta-sheet; order 312(4)
    247. YbaK/ProRS associated domain [55825] (1) picpic
      core: alpha-beta-alpha-beta(2)-(alpha-beta)2-alpha-beta(2)-alpha-beta; 3 layers; bifurcated mixed sheet
    248. Thymidylate synthase/dCMP hydroxymethylase [55830] (1) picpic
      contains large mixed beta-sheet
    249. Thymidylate synthase-complementing protein Thy1 [69795] (1) picpic
      complex alpha+beta fold; contains antiparallel 5-stranded beta-sheet: order 12354
    250. N-acetylmuramoyl-L-alanine amidase-like [55845] (1) picpic
      contains mixed beta-sheet
    251. Cytochrome b5-like heme/steroid binding domain [55855] (1) picpic
      beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 1532(4)
    252. BTG domain-like [160695] (1) picpic
      alpha(2)-beta-alpha(2)-beta(3); four-helical bundle, capped at one end by an antiparallel beta-sheet, order:1234
    253. DUSP-like [143790] (1) picpic
      alpha-beta-alpha-X-beta-alpha-beta; three-helical bundle capped at one end by antiparallel beta-sheet, order: 213
    254. DNA topoisomerase I domain [55868] (1) picpic
      beta(2)-alpha-beta-(alpha)-beta(2); left-handed crossover between strands 2 & 3
    255. ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1) picpic
      8-stranded mixed beta-sheet; 2 layers: alpha/beta
    256. YehR-like [160703] (1) picpic
      beta(3)-alpha-beta(2)-alpha(3)-beta; 2 layers, a/b; antiparallel beta-sheet, order: 612354
    257. Sporulation response regulatory protein Spo0B [55889] (1) picpic
      core: alpha-beta-alpha-beta(2)-(alpha)-beta(2)
    258. Ribonuclease Rh-like [55894] (1) picpic
      alpha+beta fold
    259. YlxR-like [64375] (1) picpic
      alpha+beta fold; could have evolved from a glucocorticoid receptor-like zinc finger domain
    260. YggX-like [111147] (1) picpic
      beta(2)-alpha(3); contains zinc-less 'zinc finger'-like fold (scop_cf 57715; see also scop_cf 64375)
    261. L28p-like [143799] (1) picpic
      unusual fold consisting of three beta-hairpins, that form a paper clip-like structure, and two helices; could have evolved from a glucocorticoid receptor-like zinc finger domain (scop_cf 57715)
    262. YqaI-like [160712] (1) picpic
      dimeric zinc-less 'zinc finger'-like fold; similar to the C-terminal strand-swapped B-box domain (scop_cf 57844)
    263. Ornithine decarboxylase C-terminal domain [55903] (1) picpic
      complex alpha+beta motif
    264. Pentein, beta/alpha-propeller [55908] (1) picpic
      duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis
    265. Creatinase/aminopeptidase [55919] (1) picpic
      duplication: composed of two very similar alpha+beta folds
    266. gpW/gp25-like [160718] (1) picpic
      alpha(2)-beta(3); similar to one structural repeat of the Creatinase/aminopeptidase family and the C-terminal subdomain of PanC
    267. Glutamine synthetase/guanido kinase [55930] (1) picpic
      duplication: common core consists of two beta-alpha-beta2-alpha repeats
    268. TBP-like [55944] (11) picpic
      beta-alpha-beta(4)-alpha
    269. XisI-like [143846] (1) picpic
      alpha-beta(4)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order 1234, meander; the open side of beta-sheet provides dimerization interface
    270. S-adenosylmethionine synthetase [55972] (1) picpic
      duplication: consists of 3 similar intertwined domains
      structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
    271. DNA clamp [55978] (1) picpic
      contains two helices and two beta sheets
      duplication: fold has internal pseudo two-fold symmetry
    272. Hypothetical protein TM0160 [103255] (1) picpic
      duplication: consists of two beta(3)-alpha(2) structural repeats; single barrel-like beta-sheet
    273. TTHC002-like [160760] (1) picpic
      alpha-beta-alpha-beta(3); forms dimer with a single beta-sheet, folded in a barrel-like shape
    274. Molybdenum cofactor-binding domain [56002] (1) picpic
      beta(2)-alpha-beta-alpha-beta; 2 layers: a/b; mixed sheet: order 1243: crossing loops
    275. NE1680-like [160765] (1) picpic
      beta(2)-alpha-beta-alpha-beta; 2 layers, a/b; antiparallel sheet, order 3124
    276. Nitrite and sulphite reductase 4Fe-4S domain-like [56013] (1) picpic
      beta-alpha-beta-alpha-beta(3)-alpha(2,3); mixed sheet: order 12345; left-handed crossover connection between strands 1 and 2
    277. DeoB insert domain-like [143855] (1) picpic
      alpha-beta-X-beta(2)-alpha-beta(2); 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 2 and 5 are antiparallel to the rest
    278. The spindle assembly checkpoint protein mad2 [56018] (1) picpic
      core: alpha(2)-beta(2)-alpha-beta; mixed sheet: order 213
    279. Phospholipase D/nuclease [56023] (1) picpic
      beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234
    280. CorA soluble domain-like [143864] (1) picpic
      beta(2)-alpha-beta-alpha(2)-beta(4)-alpha(3); 3 layers: a/b/a; mixed beta-sheet, order 2137654; strands 3 and 7 are parallel
    281. Monooxygenase (hydroxylase) regulatory protein [56028] (1) picpic
      corner-like structure formed by two sheets and filled in with 2-3 helices
    282. PurM C-terminal domain-like [56041] (1) picpic
      3 layers: alpha/beta/alpha; partial topological similarity to the ferredoxin-like fold
    283. PF0523-like [143869] (1) picpic
      beta-alpha-beta-alpha(3)-beta-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order 4132; some similarity to the PurM C-terminal domain-like fold (scop_cf 56041)
    284. Chorismate synthase, AroC [103262] (1) picpic
      duplication: consists of two DCoH-like beta(2)-alpha-beta(2)-alpha structural repeats; 3 layers, beta/alpha/beta
    285. Hsp33 domain [64396] (1) picpic
      3 layers: beta/alpha/beta; buried helix
    286. MTH1598-like [69818] (1) picpic
      beta(2)-alpha-beta-alpha-beta(4); 3 layers: beta/alpha/beta; some similarity to the Hsp33 fold
    287. Protein-L-isoaspartyl O-methyltransferase, C-terminal domain [68929] (1) picpic
      beta-alpha-beta(4)-alpha-beta(2); 3 layers: beta/alpha/beta; buried helix
    288. OsmC-like [82783] (1) picpic
      swapped dimer of beta(3)-alpha-beta(2)-alpha(2)-beta subunits; mixed beta-sheet; order: 321[4][5][6]; buried helix
    289. Hypothetical protein HI1480 [103276] (1) picpic
      beta-alpha(4)-beta-alpha-beta; segregated alpha-helical and beta-sheet subdomains; dimeric beta-sheet barrel: n=6, S=10
    290. ERH-like [143874] (1) picpic
      beta(2)-alpha(2)-beta(2)-alpha; antiparallel beta-sheet, order:2134; helices are arranged in a bundle rather than packed agains beta-sheet; dimerises via with the formation of a flattened beta-barel: closed n=8, S=10
    291. Ribosomal protein S8 [56046] (1) picpic
      consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a
    292. Ribosomal protein L6 [56052] (1) picpic
      consists of two beta-sheets and one alpha-helix packed around single core
    293. NE0471 N-terminal domain-like [143879] (1) picpic
      beta(3)-alpha(n)-beta(3)-alpha; the two meander beta-sheets and helices are packed against the same core
    294. Lp2179-like [160799] (1) picpic
      beta(2)-alpha-beta(4)-alpha-beta; contains two antiparallel beta-sheets (orders: 127 and 3456) packed against the longer C-terminal helix
    295. RGC domain-like [143884] (1) picpic
      consists of two beta-sheets and four helices eclosing a cental cavity
    296. Smc hinge domain [75552] (1) picpic
      consists of 2 different alpha+beta subdomains; forms subdomain-swapped dimers
    297. DNA mismatch repair protein MutL [118115] (1) picpic
      consists of two different alpha+beta (sub)domains; d1: [beta(3)-alpha-(insert of d2)-alpha(2)-beta; 2 layers, a/b; antiparallel sheet, order: 1234]; d2: [beta-alpha-beta(2)-alpha(2); 2 layers, a/b; antiparallel sheet, order: 132]
    298. ATP-grasp [56058] (2) picpic
      Consists of two subdomains with different alpha+beta folds
      shares functional and structural similarities with the PIPK and protein kinase superfamilies
    299. SAICAR synthase-like [56103] (1) picpic
      consists of two alpha+beta subdomains
    300. Protein kinase-like (PK-like) [56111] (1) picpic
      consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
    301. FAD-binding/transporter-associated domain-like [56175] (1) picpic
      consists of two alpha+beta subdomains
    302. Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain [56193] (1) picpic
      consists of two alpha+beta subdomains
    303. Methenyltetrahydromethanopterin cyclohydrolase [56198] (1) picpic
      consists of two alpha+beta subdomains
    304. Prim-pol domain [56746] (1) picpic
      consists of two alpha+beta domains
    305. Hect, E3 ligase catalytic domain [56203] (1) picpic
      consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit; conformational flexibility of domain orientation
    306. Nitrile hydratase alpha chain [56208] (1) picpic
      4 layers a/b/b/a; inside is a sandwich of two 2-stranded beta-sheets
    307. 4'-phosphopantetheinyl transferase [56213] (1) picpic
      beta-alpha(3)-beta(2) motif
    308. DNase I-like [56218] (1) picpic
      contains beta-sandwich; duplication of alpha+beta motif
    309. Aldehyde ferredoxin oxidoreductase, N-terminal domain [56227] (1) picpic
      contains sandwich; duplication of alpha+beta motif with single mixed sheet
      motif: beta(2)-alpha-beta(3)-alpha-beta; strand order 216345, strands 1 and 6 are parallel
    310. Ntn hydrolase-like [56234] (2) picpic
      4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
    311. DmpA/ArgJ-like [56265] (1) picpic
      duplication of beta(3)-alpha-beta-alpha motif; 4 layers: alpha/beta/beta/alpha
    312. Pyruvoyl-dependent histidine and arginine decarboxylases [56270] (1) picpic
      duplication of beta-alpha-beta(2) motif; 4 layers: alpha/beta/beta/alpha; contains "silk" beta-sandwich
    313. S-adenosylmethionine decarboxylase [56275] (1) picpic
      duplication of beta-alpha-beta(4)-alpha-beta-alpha-beta(2) motif; 4 layers a/b/b/a; antiparallel beta-sheets: order 23451687
    314. Metallo-hydrolase/oxidoreductase [56280] (1) picpic
      duplication of beta(4)-alpha-beta-alpha motif; 4 layers a/b/b/a; mixed beta-sheets
    315. PP2C-like [81607] (1) picpic
      4 layers: alpha/beta/beta/alpha; antiparallel beta sheets
    316. Metallo-dependent phosphatases [56299] (1) picpic
      4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
    317. Carbon-nitrogen hydrolase [56316] (1) picpic
      4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
    318. CNF1/YfiH-like putative cysteine hydrolases [64437] (1) picpic
      4 layers: alpha/beta/beta/alpha; mixed beta sheets
    319. ADC synthase [56321] (1) picpic
      duplication: contains four repeats of alpha-beta(2)-beta motif arranged in a 4 layer core structure: alpha/beta/beta/alpha; orthogonally packed beta-sheets
    320. Sulfolobus fructose-1,6-bisphosphatase-like [111248] (1) picpic
      4 layers: a/b/b/a; antiparallel beta sheets; similarities to ferredoxin-like fold (scop_cf 54861) in the N-terminal part (1-120) and to the Bacterial S-adenosylmethionine decarboxylase subunit (scop_fa 997656) in the C-terminal part (121-340)
    321. LDH C-terminal domain-like [56326] (1) picpic
      unusual fold, defines family
    322. DNA breaking-rejoining enzymes [56348] (1) picpic
      core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
    323. Replication modulator SeqA, C-terminal DNA-binding domain [82807] (1) picpic
      consists of seven alpha-helices and three-stranded beta-sheet
    324. SMAD MH1 domain [56365] (1) picpic
      consists of four alpha-helices and three beta-ribbons
    325. YopH tyrosine phosphatase N-terminal domain [64448] (1) picpic
      consists of four alpha-helices and two beta-hairpins
    326. Rotavirus NSP2 fragment, N-terminal domain [75573] (1) picpic
      consists of six alpha-helices and two beta-hairpins
    327. Rv2827c C-terminal domain-like [160886] (1) picpic
      multihelical array flanked by two three-stranded mixed beta-sheets
    328. Phosphoprotein oligomerization domain-like [160891] (1) picpic
      intertwinned homodimer of beta(2)-alpha-beta(2) motifs; 3 layers: b/a/b; each antiparallel beta-sheet is formed by the N-terminal beta-hairpin of one subunit and the C-terminal beta-hairpin of the other subunit; order 1243
    329. Taf5 N-terminal domain-like [160896] (1) picpic
      multihelical cluster with a C-terminal beta-alpha(2)-beta motif; one central buried helix; parallel beta-ribbon
    330. Jann2411-like [160903] (1) picpic
      unusual fold; consists of seven alpha-helices and three beta-hairpins
    331. ATP12-like [160908] (1) picpic
      contains an N-terminal beta-sheet that forms a beta-triangle structure; the remainder is a multihelical array of long and short helices
    332. Ribosome inactivating proteins (RIP) [56370] (1) picpic
      contains mixed beta-sheet
    333. ADP-ribosylation [56398] (1) picpic
      unusual fold
    334. Peptide deformylase [56419] (1) picpic
      alpha-beta(5)-alpha; 3 layers: a/b/a; meander beta-sheet wraps around the C-terminal alpha-helix
    335. LCCL domain [69847] (1) picpic
      unusual fold
    336. Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [56424] (1) picpic
      unusual fold
    337. C-type lectin-like [56435] (1) picpic
      unusual fold
    338. Hemolytic lectin CEL-III, C-terminal domain [111264] (1) picpic
      unusual fold
    339. SRCR-like [56486] (2) picpic
      unusual fold; disulfide-rich; core: beta-x-alpha-beta-loop-beta
    340. Fibrinogen C-terminal domain-like [56495] (1) picpic
      unusual fold
    341. gp120 core [56501] (1) picpic
      unusual fold
    342. Methionine synthase activation domain-like [56506] (1) picpic
      unusual fold; core: beta-alpha(2)-beta(2)-alpha(2)-beta-alpha-beta; antiparallel beta-sheet: order 12354
    343. UbiD C-terminal domain-like [143967] (1) picpic
      alpha-beta(2)-alpha-beta-alpha-beta(2); 3 layers, a/b/a; mixed beta-sheet, order: 12354, strands 2,3 and 5 are parallel to each other
    344. Hypothetical protein TM0875 [90063] (1) picpic
      unusual fold; core: beta(2)-loop-beta(2)-alpha-beta; mixed beta-sheet: order 51243; parallel strands 2 and 4
    345. Metal cation-transporting ATPase, ATP-binding domain N [81661] (1) picpic
      unusual fold; core: beta-alpha(2)-beta(3)-alpha(2)-beta(2); 6-stranded antiparallel beta-sheet, order: 165432
    346. Suppressor of Fused, N-terminal domain [103358] (1) picpic
      unusual fold; bifurcated beta-sheet; left-handed beta-alpha-beta unit
    347. Nitric oxide (NO) synthase oxygenase domain [56511] (1) picpic
      unusual fold
    348. Penicillin binding protein dimerisation domain [56518] (1) picpic
      unusual fold
    349. Oxidoreductase molybdopterin-binding domain [56523] (1) picpic
      unusual fold; contains 3 layers of beta-sheet structure and a beta-grasp like motif
    350. FAH [56528] (1) picpic
      unusual fold; contains 3 layers of beta-sheet structure
    351. Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [56533] (1) picpic
      unusual fold
    352. Substrate-binding domain of HMG-CoA reductase [56541] (1) picpic
      unusual fold
    353. Argininosuccinate synthetase, C-terminal domain [69863] (1) picpic
      unusual fold
    354. Hypothetical protein PH1602 [103364] (1) picpic
      complex alpha+beta fold; contains a region of similarity to the ferredoxin-like fold
    355. IlvD/EDD N-terminal domain-like [143974] (1) picpic
      contains a large cluster of helices and a mixed beta-sheet of 4 strands; order 2134, strands 3 and 4 are parallel
    356. DNA methylase specificity domain [116733] (1) picpic
      comprises the N-terminal, double beta-helix like structure and C-terminal alpha-hairpin
    357. GCM domain [90072] (1) picpic
      consists of two different alpha+beta subdomains; 2 zinc-binding sites
    358. Conserved core of transcriptional regulatory protein vp16 [56547] (1) picpic
      unusual fold
    359. Insert subdomain of RNA polymerase alpha subunit [56552] (1) picpic
      unusual fold; contains a left-handed beta-alpha-beta unit
    360. Baseplate structural protein gp11 [56557] (1) picpic
      unusual fold; trimer
    361. Receptor-binding domain of short tail fibre protein gp12 [88873] (1) picpic
      unusual fold; trimer
    362. Outer capsid protein sigma 3 [64464] (1) picpic
      unusual fold
    363. Phosphoprotein M1, C-terminal domain [118172] (1) picpic
      consists of 6 helices and one beta-hairpin
    364. L,D-transpeptidase pre-catalytic domain-like [143984] (1) picpic
      unusual fold, made of four helices and four 2-3 stranded beta-sheets
    365. YbiA-like [143989] (1) picpic
      consists of six alpha-helices and two two-stranded beta-sheets
    366. NinB [103369] (1) picpic
      unusual fold; intertwined dimer; consists of two different structural domains
    367. AF2331-like [143994] (1) picpic
      interlocked dimer of beta-alpha-beta(2)-alpha-beta-(alpha) subunits; 3 layers: b/b/a
    368. SSo0622-like [111277] (1) picpic
      alpha(2)-beta(2)-alpha-beta-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel beta-sheet: order 21354; strands 1,3 and 5 and the C-terminal helix are longer than other secondary structures
    369. Putative modulator of DNA gyrase, PmbA/TldD [111282] (1) picpic
      consists of two different alpha+beta domains; d1: [duplication of alpha-beta(3)-alpha motif; 2 layers: a/b; antiparallel beta-sheet, order: 321456; strands 1, 2, 4 and 5 are twice longer than other secondary structures]; d2 [ complex fold; contains beta-barrel (n=5, S=10)]
    370. PSTPO5379-like [160919] (1) picpic
      complex fold; consists of two alpha+beta subdomains, one is inserted in the other
    371. PG1388-like [160924] (1) picpic
      consists of 2 alpha+beta subdomains, each having a meander beta-sheet; d1: alpha(2)-beta(7); d2: alpha(2)-beta(2)-alpha(2)-beta(2)
    372. Oxysterol-binding protein-like [143999] (1) picpic
      core: large meander beta-sheet of 12 strands wrapped around the N-terminal (distorted) alpha-hairpin; some similarity to transmembrane beta-barrel proteins
    373. ORC1-binding domain [144004] (1) picpic
      complex fold, composed of an alpha hairpin, meander beta-sheet and a five-stranded barrel of unusual topology
    374. CofE-like [144009] (1) picpic
      consists of two different domains; d1: beta-alpha-beta-alpha-beta(2)-alpha-beta, mixed sheet of 5 strands, order:15234, strands 2 and 3 are parralel; d2 is inserted in d1 after strand 2 and comprises a helix-turn-helix motif and two 3-stranded sheets
    375. Peptidoglycan deacetylase N-terminal noncatalytic region [144014] (1) picpic
      consists of two different domains, d1: [alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; mixed beta-sheet, order 12345, strands 2 and 3 are parallel to each other with a left-handed crossover connection], d2: alpha-beta(3)-alpha; 2 layers; antiparallel beta-sheet, order 123]
    376. Non-globular alpha+beta subunits of globular proteins [56567] (1) picpic
      not a true fold
  5. Multi-domain proteins (alpha and beta) [56572] (66)
    Folds consisting of two or more domains belonging to different classes
    1. Serpins [56573] (1) picpic
      contains a cluster of helices and a beta-sandwich
    2. FdhE-like [144019] (1) picpic
      consists on the N-terminal five-helical bundle, a tandem repeat of two rubredoxin-like domains and the C-terminal helix packed together
    3. FlhC-like [160929] (1) picpic
      3 domains; d1 & d2 are similar three-helical bundles, with d1 containing an HTH motif; d3: zinc finger of a rubredoxin-like fold
    4. Replication terminator protein (Tus) [56595] (1) picpic
      contains a cluster of helices and a beta-sandwich
    5. VPA0735-like [160934] (1) picpic
      consists of a cluster of helices and two beta-sandwich domains of similar topology; probable duplication
    6. 2-methylcitrate dehydratase PrpD [103377] (1) picpic
      consists of an all-alpha and alpha+beta domains
    7. Antivirulence factor [103382] (1) picpic
      contains a helical bundle with a buried helix and an alpha+beta insert domain
    8. Api92-like [160939] (1) picpic
      2 domains; d1: [alpha+beta with similarity to ferredoxin-like fold]; d2: [6 helices, bundle, one buried central helix], inserted into d1
    9. PH0156-like [160944] (1) picpic
      2 (sub)domains; d1: [alpha/beta with central mixed beta-sheet, order: 23415876, similarity to the G protein but no P-loop]; d2: [all-alpha, 5 helices, provides dimerization interface]
    10. YacF-like [160949] (1) picpic
      2 domains; d1: kinked four-helical bundle, inserted in d2: beta-sandwich of 7 strands in two sheets
    11. Virulence-associated V antigen [103387] (1) picpic
      consists of an all-alpha and alpha+beta domains connected by antiparallel coiled coil
    12. Heme-dependent catalase-like [56633] (1) picpic
      contains an (8,10) beta-barrel and an all-alpha domain
    13. Acyl-CoA dehydrogenase NM domain-like [56644] (1) picpic
      2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology
    14. Carbohydrate phosphatase [56654] (1) picpic
      N-terminal domain is an alpha+beta, C-terminal domain is an alpha/beta with mixed beta-sheet
    15. DNA/RNA polymerases [56671] (1) picpic
      divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
    16. beta and beta-prime subunits of DNA dependent RNA-polymerase [64483] (1) picpic
      Multidomain subunits of complex domain organization
    17. Poly(A) polymerase catalytic subunit-like [160956] (1) picpic
      3 domains; d1: all-alpha, contains HhH motif; d2: alpha+beta of nucleotidyltransferase fold (scop_cf 81302); d3: [alpha+beta; beta(3)-alpha-beta(3)-alpha(2); 3 layers: a/b/a; mixed beta-sheet of 6 strands, order 123654, strands 2 and 5 are antiparallel to the rest
    18. Adenylylcyclase toxin (the edema factor) [81299] (1) picpic
      3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha
    19. Prokaryotic type I DNA topoisomerase [56711] (1) picpic
      4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8
    20. Type II DNA topoisomerase [56718] (1) picpic
      4 domains: (1) toprim alpha/beta; (2) "winged helix"-like; (3) alpha+beta; (4) all-alpha
    21. DNA topoisomerase IV, alpha subunit [56725] (1) picpic
      2 domains: (1) toprim alpha/beta; (2) "winged helix"-like
    22. DNA primase core [56730] (1) picpic
      2 domains: (1) alpha+beta; (2) toprim alpha/beta
    23. Recombination protein RecR [111303] (1) picpic
      consists of three domains: alpha-helical dimerisation domain (res. 1-53) with HhH motif; 'treble cleft' C4 zinc-finger domain (54-76); and Toprim domain (76-199; segment-swapped dimer)
    24. Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1) picpic
      2 domains: alpha+beta and all-beta
    25. D-aminoacid aminotransferase-like PLP-dependent enzymes [56751] (1) picpic
      2 domains: (1) alpha+beta: beta3-alpha2-beta2; (2) alpha/beta, a part of its mixed sheet forms barrel: n=6, S=8
    26. HydB/Nqo4-like [56761] (1) picpic
      3 domains: (1) all-alpha; (2&3) alpha+beta
    27. HydA/Nqo6-like [56769] (1) picpic
      2 domains: (1) alpa/beta; (2) Fe-S cluster-bound
    28. Dehydroquinate synthase-like [56795] (1) picpic
      2 domains: (1) alpha/beta of a Rossmann-fold topology, binds NAD (2) multihelical array
    29. Siroheme synthase middle domains-like [75614] (1) picpic
      2 domains: (1) alpha+beta, 2 layers; (2) 3/4-helical bundle, right-handed twist, left-handed superhelix
    30. Acetyl-CoA synthetase-like [56800] (1) picpic
      4 domains: (1&2) duplication: share the same alpha/beta fold; (3) beta-barrel; (4) alpha+beta
    31. Ribosomal protein L1 [56807] (1) picpic
      2 domains: (1) alpha+beta; (2) alpha/beta (interrupts domain 1)
    32. Release factor [75619] (1) picpic
      4 domains: (1) 3-helical bundle; (2) alpha+beta of ferredoxin-like fold (3 and 4) alpha+beta of dsRDB-like fold
    33. YaeB-like [118195] (1) picpic
      2 domains; d1: [beta-barrel (n=6, S=10), similar to the Reductase/isomerase/elongation factor common domain fold (scop_cf 50412), provides homodimerisation interface]; d2: [alpha+beta (disordered)]
    34. MalF N-terminal region-like [160963] (1) picpic
      consists of 3 N-terminal transmembrane helices, an alpha+beta linker domain and a beta-barrel (n=7; S=8) with one overside loop
    35. YebC-like [75624] (1) picpic
      3 domains: (1) 3-helical bundle; (2 and 3 ) alpha+beta of different folds: domain 3 has a ferredoxin-like fold and is inserted in domain 2
    36. Cullin homology domain [75631] (1) picpic
      3 domains: (1) 4-helical bundle; (2) alpha+beta; (3) "winged helix"-like
    37. Sec1/munc18-like (SM) proteins [56814] (1) picpic
      3 domains: (1 and 2) alpha+beta; (3) mostly alpha, inserted in domain 2
    38. Prismane protein-like [56820] (1) picpic
      3 domains: (1) spectrin repeat-like 3-helical bundle; (2 and 3) alpha/beta: Rossmann-fold topology
    39. Subunits of heterodimeric actin filament capping protein Capz [90095] (1) picpic
      3 domains: (1) protozoan pheromone-like alpha-helical bundle; (2) rubredoxin-like domain lacking metal-binding site; (3) alpha+beta heterodimerisation domain: alpha-beta(5)-alpha
    40. beta-lactamase/transpeptidase-like [56600] (1) picpic
      contains a cluster of helices and an alpha+beta sandwich
    41. Upper collar protein gp10 (connector protein) [56825] (1) picpic
      2 domains: (1) alpha-helical bundle; (2) beta-barrel (n=5, S=8)
    42. AF1531-like [160974] (1) picpic
      2 domains; d1: incomplete barrel similar to the OB-fold domain of ribosomal L2 protein, d2: six helices, array
    43. Phase 1 flagellin [64517] (1) picpic
      3 domains: (1) alpha-helical bundle; (2&3) complex all-beta folds
    44. 39 kda initiator binding protein, IBP39, C-terminal domains [103408] (1) picpic
      2 closely associated domains: (1) all-alpha, EF-hand like; (2) alpha+beta, Frataxin-like
    45. AF1104-like [111320] (1) picpic
      2 domains; d1: [all-alpha; 3-helical bundle, similar to the immunoglobulin/albumin-binding domain-like fold (scop_cf 46996)]; d2: [alpha/beta; 3 layers, a/b/a; 6-stranded mixed beta-sheet, order: 321456, strand 6 is antiparallel to the rest]
    46. SSO1389-like [160979] (1) picpic
      2 domains; d1: [alpha/beta, central parallel beta-sheet of 6 strands, order 321456, Rossmann-like]; d2: [alpha+beta, cluster of helices and a small 4-stranded beta-sheet]
    47. Urocanase [111325] (1) picpic
      3 domains; d1: alpha+beta [alpha(2)-beta(3); mixed sheet: 213]; d2: alpha/beta of the NAD(P)-binding Rossmann-fold superfamily (scop_sf 51735, most similar to scop_fa 51883 and scop_fa 51736); d3: alpha+beta of the glutamine synthetase/guanido kinase fold (scop_cf 55930); d1 and d3 form a single beta-sheet
    48. NAD kinase/diacylglycerol kinase-like [111330] (1) picpic
      2 domains: d1 [alpha/beta; related to the PFK N-terminal domain (scop_sf 53784)]; d2 [all-beta; atypical beta-sandwich made of 4 structural repeats of beta(3) unit]
    49. QueA-like [111336] (1) picpic
      2 domains; d1 (1-64,174-335) [alpha/beta; 3 layers, a/b/a; mixed beta sheet of 9 strands, order: 219863457; strands 1, 5 and 8 are antiparallel to the rest]; d2 (65-142) [all-beta; barrel, closed (n=6, S=10); greek-key; topologically similar to the split barrel fold (scop_cf 50474)
    50. CbiD-like [111341] (1) picpic
      2 domains; (1) alpha+beta (res 1-192), a circularly permuted rS5 domain 2-like fold (scop_cf 54210); (2) alpha/beta with parallel beta-sheet of 4 strands, order 2134
    51. Rap/Ran-GAP [111346] (1) picpic
      consists of two domains; d1: alpha+beta (78-190; alpha-beta(4)-alpha-beta-alpha; 3 layers; antiparallel beta-sheet of 5 strands; order 51234); d2: alpha/beta similar to the G-domain fold (191-381; scop_fa 52592)
    52. Vacuolar ATP synthase subunit C [118202] (1) picpic
      2 alpha+beta (sub)domains [each has a ferredoxin-like fold; scop_cf 54861], connected with 3-helical bundle; duplication: two repeats of beta-alpha-beta-[alpha coiled-coil]-beta-alpha-beta motif
    53. Thermophilic metalloprotease-like [144051] (1) picpic
      consists of two domains; d1: alpha/beta (3 layers, a/b/a; parralel beta-sheet, order 2134); d2: pseudo beta-barrel capped by helices
    54. ImpE-like [144058] (1) picpic
      consists of two domains; d1: right-handed superhelix of five helices; d2: pseudo beta-barrel containing structurally similar part to the "Histone-like" proteins from archaea (scop_fa 54161)
    55. CV3147-like [160990] (1) picpic
      2 domains; d1: [alpha/beta; 3 layers, a/b/a, mixed beta-sheet of 8 strands, order 12543876, strands 1, 7 and 8 are antiparallel to the rest]; d2: [pseudo beta-barrel of 6 strands, meander]
    56. Heme iron utilization protein-like [144063] (1) picpic
      2 domains; d1 - 3-helical bundle similar to the homeodomain-like fold; d2 - 6-stranded beta-barrel capped by two helices at one end, similar topology to the PH-like fold
    57. HI0933 insert domain-like [160995] (1) picpic
      2 domains; d1: barrel, closed, n=6, S=12, greek-key; d2: four-helical bundle, inserted in d1
    58. NSP3 homodimer [69902] (1) picpic
      2 domains: (1) all-alpha, (2) alpha+beta; asymmetric homodimer with each domain intertwining with its counterpart
    59. E2F-DP heterodimerization region [144073] (1) picpic
      heterodimeric fold with the N-terminal long helices of both chains forming a parallel coiled coil and their C-terminal folded beta-hairpins interlocking together in a beta-sandwich
    60. Membrane penetration protein mu1 [69907] (1) picpic
      4 domains: three intertwined predominately alpha domains and one jelly-roll beta-sandwich
    61. Flu NP-like [161002] (1) picpic
      consists of alpha+beta and all-alpha domains; biological unit is a trimer
    62. Viral glycoprotein ectodomain-like [161007] (1) picpic
      complex fold; contains three rigid, mostly-beta domains and an alpha-helical region, acting as a conformatiomal switch ("fusion stalk")
    63. Reovirus inner layer core protein p3 [56830] (1) picpic
      large protein without apparent domain division; has a number of all-alpha regions and one all beta domain near the C-end
    64. L-A virus major coat protein [82855] (1) picpic
      large protein without apparent domain division
    65. Major capsid protein VP5 [103416] (1) picpic
      large protein without apparent domain division
    66. Viral ssDNA binding protein [118207] (1) picpic
      2 domains; d1: [large alpha+beta domain subdivided into the 'head', 'neck' and 'shoulders' regions; in the 'neck', there is an OB-fold interrupted by large insertions]; d2: [all-alpha, 6 helices; orthogonal array]
  6. Membrane and cell surface proteins and peptides [56835] (58)
    Does not include proteins in the immune system
    1. Toxins' membrane translocation domains [56836] (5) picpic
      multi-helical domains of various folds which is thought to unfold in the membrane
    2. Family A G protein-coupled receptor-like [81322] (1) picpic
      core: up-and-down bundle of seven transmembrane helices tilted 20 degrees with respect to the plane of the membrane
    3. Single transmembrane helix [81407] (38) picpic
      not a true fold
    4. Bacterial photosystem II reaction centre, L and M subunits [81484] (1) picpic
      five transmembrane helices forming a sheet-like structure
    5. Cytochrome c oxidase subunit I-like [81443] (1) picpic
      12 transmembrane helices in an approximate threefold rotational symmetric arrangement
    6. Cytochrome c oxidase subunit III-like [81453] (1) picpic
      core: 7 transmembrane helices organized into two bundles, one formed by the first two helices and the other by the rest
    7. Transmembrane helix hairpin [81334] (5) picpic
      two antiparallel transmembrane helices
    8. F1F0 ATP synthase subunit A [81337] (1) picpic
      core: up-and-down bundle of four transmembrane helices
    9. ATP synthase B chain-like [161059] (1) picpic
      long single helix, part of the stator subcomplex
    10. ATP synthase D chain-like [161064] (1) picpic
      non-globular, mostly helical component of the stator subcomplex
    11. Aquaporin-like [81339] (1) picpic
      core: 8 helices, 2 short helices are surrounded by 6 long transmembrane helices
    12. Ammonium transporter [111351] (1) picpic
      11 transmembrane helices; duplication: consist of 2 structural repeats of five helices each plus extra C-terminal helix
    13. MFS general substrate transporter [103472] (1) picpic
      12 transmembrane helices; duplication: the N- and C-terminal halves are structurally similar
    14. SNF-like [161069] (1) picpic
      12 transmembrane helices; duplication: consists of two structurally similar halves
    15. Proton glutamate symport protein [118214] (1) picpic
      multihelical membrane protein; partial structural duplication in the C-terminal region; oligomeric state: trimer
    16. Clc chloride channel [81341] (1) picpic
      core: 18 transmembrane helices
    17. Voltage-gated potassium channels [81325] (1) picpic
      oligomeric transmembrane alpha-helical proteins
    18. Small-conductance potassium channel [81328] (1) picpic
      oligomeric transmembrane alpha-helical protein
    19. Gated mechanosensitive channel [81331] (1) picpic
      oligomeric transmembrane alpha-helical protein
    20. Neurotransmitter-gated ion-channel transmembrane pore [90111] (1) picpic
      heteropentameric transmembrane alpha-helical protein; 4 transmembrane helices per subunit
    21. Mechanosensitive channel protein MscS (YggB), transmembrane region [82860] (1) picpic
      oligomeric fold; 3 transmembrane helices per subunit
    22. Multidrug resistance efflux transporter EmrE [103480] (1) picpic
      oligomeric fold; 3 transmembrane helices per subunit
    23. V-type ATP synthase subunit C [103485] (1) picpic
      9 transmembrane helices
    24. Preprotein translocase SecY subunit [103490] (1) picpic
      10 transmembrane helices forming of a gated channel
    25. Photosystem I subunits PsaA/PsaB [81559] (1) picpic
      core:11 transmembrane helices
    26. Photosystem I reaction center subunit X, PsaK [81564] (1) picpic
      core: hairpin of two transmembrane helices
    27. Photosystem I reaction center subunit XI, PsaL [81569] (1) picpic
      core: three transmembrane helices, bundle
    28. ABC transporter involved in vitamin B12 uptake, BtuC [81346] (1) picpic
      multihelical; complex architecture with several transmembrane helices
    29. ABC transporter transmembrane region [90122] (1) picpic
      multihelical; complex architecture with several transmembrane helices
    30. Multidrug efflux transporter AcrB transmembrane domain [82865] (1) picpic
      12 transmembrane helices; duplication: the N- and C-terminal halves of the whole proteins are structurally similar
    31. a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81649] (1) picpic
      core: three transmembrane helices, up-and-down bundle
    32. Heme-binding four-helical bundle [81344] (3) picpic
      core: four transmembrane helices, up-and-down bundle, binds one or two heme groups in between the helices
    33. 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81525] (1) picpic
      membrane-associated alpha-helical protein; no transmembrane helices
    34. Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81532] (1) picpic
      membrane-associated alpha-helical protein; no transmembrane helices
    35. Mitochondrial ATP synthase coupling factor 6 [111356] (1) picpic
      2 helices, hairpin
    36. Calcium ATPase, transmembrane domain M [81666] (1) picpic
      core: multihelical; consists of three transmembrane regions of 2, 2 and 6 helices, separated by cytoplasmic domains
    37. Light-harvesting complex subunits [56917] (1) picpic
      membrane all-alpha fold
    38. Photosystem II antenna protein-like [161076] (1) picpic
      6 transmembrane helices arranged in three antiparallel pairs (hairpins), segregated by cofactors; there can be insertions of different small subdomains in different exposed loops
    39. Mitochondrial carrier [103505] (1) picpic
      membrane all-alpha fold; 6-helical "barrel" with internal binding cavity
    40. Chlorophyll a-b binding protein [103510] (1) picpic
      membrane all-alpha fold; three transmembrane helices
    41. MAPEG domain-like [161083] (1) picpic
      4 helices, bundle; left-handed superhelix
    42. MgtE membrane domain-like [161092] (1) picpic
      5 transmembrane helices; bundle, right-handed twist
    43. MetI-like [161097] (1) picpic
      core: 5 transmembrane helices; flattened bundle
    44. Rhomboid-like [144090] (1) picpic
      6 transmembrane helices
    45. Cation efflux protein transmembrane domain-like [161110] (1) picpic
      6 transmembrane helices, bundle
    46. Connexin43 [118219] (1) picpic
      mostly unstructured; 2 helices, hairpin
    47. Transmembrane beta-barrels [56924] (6) picpic
      not a true fold, gathers together transmembrane barrels of different (n,S)
    48. Outer membrane efflux proteins (OEP) [56953] (1) picpic
      subunit fold contains tandem repeat of alpha-beta hairpin-alpha(2) motif
      trimeric fold contains barrel (n=12, S=18) formed by beta-hairpins, two from each subunit, and a bundle of helices with a channel running through it
    49. HlyD-like secretion proteins [111368] (1) picpic
      consists of three domains: beta-barrel (res. 29-38,170-259; scop_cf 50412); barrel-sandwich hybrid (39-72,135-169; scop_sf 51230) and long alpha-hairpin (73-134; scop_cf 46556)
    50. Leukocidin-like [56958] (1) picpic
      subunit fold contains beta-sandwich of Ig-like (grerk-key) topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel
    51. Lipovitellin-phosvitin complex; beta-sheet shell regions [56967] (1) picpic
      contains several large open beta-sheets
    52. Aerolisin/ETX pore-forming domain [56972] (1) picpic
      3 domains: (1) alpha+beta; (2&3) all-beta
    53. Perfringolysin [56977] (1) picpic
      2 domains: (1) alpha+beta; (2) all-beta, similar to the CalB domain fold but the two last strands are transposed
    54. Viral glycoprotein, central and dimerisation domains [56982] (1) picpic
      2 intertwined domains; all-beta and alpha+beta
    55. VP4 membrane interaction domain [111378] (1) picpic
      2 domains; d1: complexed all-beta fold; d2: coiled-coil (trimeric) helical region
    56. Head and neck region of the ectodomain of NDV fusion glycoprotein [69921] (1) picpic
      3 intertwined all-beta domains
    57. OmpH-like [111383] (1) picpic
      trimer; one subunit consists of an alpha/beta oligomerization subdomain [3-stranded parallel beta-sheet, order 213], and an antiparallel coiled coil
    58. Anthrax protective antigen [56987] (1) picpic
      4 domains; I (res. 14-225) and II (226-487) are beta-sandwiches of similar gamma-crystallin like topologies; III (488-594) has a beta-grasp like fold; IV (595-735) has an Ig-like fold
  7. Small proteins [56992] (90)
    Usually dominated by metal ligand, heme, and/or disulfide bridges
    1. Insulin-like [56993] (1) picpic
      nearly all-alpha
      can be classified as disulfide-rich
    2. Knottins (small inhibitors, toxins, lectins) [57015] (19) picpic
      disulfide-bound fold; contains beta-hairpin with two adjacent disulfides
    3. PMP inhibitors [57282] (1) picpic
      disulfide-rich fold; all-beta: 3 antiparallel strands
    4. Midkine [57287] (1) picpic
      disulfide-rich fold; all-beta: 3 antiparallel strands
    5. TSP-1 type 1 repeat [82894] (1) picpic
      disulfide-rich fold; all-beta: 3 antiparallel strands
    6. Amb V allergen [57295] (1) picpic
      disulfide-rich; alpha+beta: 3 antiparallel strands followed by a short alpha helix
    7. Snake toxin-like [57301] (1) picpic
      disulfide-rich fold: nearly all-beta
    8. BPTI-like [57361] (1) picpic
      disulfide-rich alpha+beta fold
    9. Defensin-like [57391] (1) picpic
      Disulfide-rich fold, nearly all-beta
    10. Hairpin loop containing domain-like [57413] (1) picpic
      alpha+beta fold with two crossing loops
    11. Neurotoxin III (ATX III) [57418] (1) picpic
      disulfide-rich fold
    12. LDL receptor-like module [57423] (1) picpic
      disulfide-rich calcium-binding fold
    13. Crambin-like [57428] (1) picpic
      disulfide-rich alpha+beta fold
    14. Kringle-like [57439] (1) picpic
      disulfide-rich fold; nearly all-beta
    15. Kazal-type serine protease inhibitors [100894] (1) picpic
    16. Plant proteinase inhibitors [100896] (1) picpic
      disulfide-rich small alpha+beta fold; topological similarity to the Ovomucoid domain III
    17. Trefoil/Plexin domain-like [57491] (3) picpic
      disulfide-rich fold; common core is alpha+beta with two conserved disulfides
    18. Necrosis inducing protein 1, NIP1 [103579] (1) picpic
      disulfide-rich fold; all-beta; duplication: contains two structural repeats
    19. Cystine-knot cytokines [57500] (1) picpic
      disulfide-rich fold; common core is all-beta
    20. Complement control module/SCR domain [57534] (1) picpic
      disulfide-rich all-beta fold
    21. Crisp domain-like [57545] (1) picpic
      disulfide-rich all-alpha fold
    22. Blood coagulation inhibitor (disintegrin) [57551] (1) picpic
      small disulfide-rich
    23. Methylamine dehydrogenase, L chain [57560] (1) picpic
      disulfide-rich; nearly all-beta
    24. Serine protease inhibitors [57566] (1) picpic
      disulfide-rich; nearly all-beta
    25. TB module/8-cys domain [57580] (1) picpic
      disulfide-rich; alpha+beta
    26. TNF receptor-like [57585] (1) picpic
      duplication: consists of three similar disulfide-rich domains
    27. Heparin-binding domain from vascular endothelial growth factor [57592] (1) picpic
      duplication: consists of two similar disulfide-rich domains, alpha+beta
    28. Antifungal protein (AGAFP) [57597] (1) picpic
      disulfide-rich; all-beta: open barrel, 5 strands; OB-fold-like
    29. FnI-like domain [57602] (1) picpic
      disulfide-rich, all-beta
    30. Thyroglobulin type-1 domain [57609] (1) picpic
      disulfide-rich, alpha+beta
    31. Type X cellulose binding domain, CBDX [57614] (1) picpic
      disulfide-rich, alpha+beta
    32. Cellulose docking domain, dockering [64570] (1) picpic
      disulfide-rich, alpha+beta
    33. Carboxypeptidase inhibitor [57619] (1) picpic
      disulfide-rich, alpha+beta
    34. Invertebrate chitin-binding proteins [57624] (1) picpic
      disulfide-rich
    35. Pheromone ER-23 [69963] (1) picpic
      disulfide-rich, all-alpha
    36. Mollusk pheromone [90182] (1) picpic
      disulfide-rich; all-alpha
    37. Apical membrane antigen 1 [82909] (1) picpic
      disulfide-rich, alpha+beta
    38. Somatomedin B domain [90187] (1) picpic
      disulfide-rich
    39. Notch domain [90192] (1) picpic
      disulfide-rich; all-alpha; calcium-binding
    40. Mini-collagen I, C-terminal domain [103588] (1) picpic
      disulfide-rich
    41. Hormone receptor domain [111417] (1) picpic
      disulfide-rich all-beta fold; contains beta sandwich of 5 strands
    42. Resistin [111422] (1) picpic
      disulfide-rich six-stranded beta-sandwich; jelly-roll
    43. YAP1 redox domain [111429] (1) picpic
      bipartite cysteine-rich all-alpha domain; a single helix in the N-terminal part (chain A) is linked by disulfides to the C-terminal part (chain B) [3-helical bundle of the RuvA C-terminal domain-like fold (scop_cf 46928)
    44. Toxic hairpin [57006] (4) picpic
      disulfide crosslinked alpha-helical hairpin
    45. Tim10-like [144121] (1) picpic
      alpha-hairpin crosslinked by two disulfides; assembles into a heterohexameric ring-like structure
    46. Cysteine zipper [144128] (1) picpic
      string of helices that contain cysteines at almost every turn; folds upon itself and is crosslnked by multiple disulfides
    47. GLA-domain [57629] (1) picpic
      Calcium ion-bound
    48. Cholecystokinin A receptor, N-domain [57641] (1) picpic
      a few helical turns and a disulfide-crosslinked loop
    49. HIV-1 VPU cytoplasmic domain [57646] (1) picpic
      a few helical turns assembled without a hydrophobic core?
    50. HIPIP (high potential iron protein) [57651] (1) picpic
      folds around 4Fe-4S cluster
    51. Ferredoxin thioredoxin reductase (FTR), catalytic beta chain [57661] (1) picpic
      folds around 4Fe-4S cluster
    52. beta-beta-alpha zinc fingers [57666] (1) picpic
      simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC
    53. Zn2/Cys6 DNA-binding domain [57700] (1) picpic
      all-alpha dimetal(zinc)-bound fold
    54. Glucocorticoid receptor-like (DNA-binding domain) [57715] (1) picpic
      alpha+beta metal(zinc)-bound fold
    55. SBT domain [103611] (1) picpic
      consist of two different zn-binding subdomains, each subdomain resembles a distorted glucocorticoid receptor-like fold
    56. Retrovirus zinc finger-like domains [57755] (1) picpic
      metal(zinc)-bound fold
    57. Rubredoxin-like [57769] (17) picpic
      metal(zinc or iron)-bound fold; sequence contains two CX(n)C motifs, in most cases n = 2
    58. Ribosomal protein L36 [57839] (1) picpic
      zinc-bound beta-ribbon motif
    59. Zinc-binding domain of translation initiation factor 2 beta [75688] (1) picpic
      zinc-bound beta-ribbon motif
    60. WRKY DNA-binding domain [118289] (1) picpic
      zinc-bound 4-stranded meander beta-sheet, distinct from the beta-ribbon motifs
    61. B-box zinc-binding domain [57844] (1) picpic
      zinc-bound alpha+beta motif
    62. RING/U-box [57849] (1) picpic
      dimetal(zinc)-bound alpha+beta motif; structurally diverse
    63. ArfGap/RecO-like zinc finger [57862] (1) picpic
      zinc-bound alpha+beta motif
    64. Metallothionein [57867] (1) picpic
      metal(iron)-bound fold
      duplication: consists of clear structural/sequence repeats
    65. Zinc domain conserved in yeast copper-regulated transcription factors [57878] (1) picpic
      metal(zinc)-bound alpha+beta fold
    66. Ada DNA repair protein, N-terminal domain (N-Ada 10) [57883] (1) picpic
      metal(zinc)-bound alpha+beta fold
    67. Cysteine-rich domain [57888] (1) picpic
      dimetal(zinc)-bound alpha+beta fold
    68. AN1-like Zinc finger [118309] (1) picpic
      dimetal(zinc)-bound alpha+beta fold; partial similarity to the Cysteine-rich domain fold (scop_cf 57888)
    69. HIT/MYND zinc finger-like [144231] (1) picpic
      dimetal(zinc)-bound alpha+beta fold; structural similarity to members of the Cysteine-rich domain fold (scop_cf 57888)
    70. CHY zinc finger-like [161218] (1) picpic
      trimetal-bound fold; integration of HIT/MYND-like and rubredoxin-like fingers
    71. FYVE/PHD zinc finger [57902] (1) picpic
      dimetal(zinc)-bound alpha+beta fold
    72. Zn-binding domains of ADDBP [57916] (1) picpic
      metal(zinc)-bound alpha+beta fold
    73. Inhibitor of apoptosis (IAP) repeat [57923] (1) picpic
      metal(zinc)-bound alpha+beta fold
    74. CCCH zinc finger [90228] (1) picpic
      metal(zinc)-bound alpha+beta fold
    75. E6 C-terminal domain-like [161228] (1) picpic
      alpha+beta zinc-binding fold with topological similarity to the fold of lambda cro protein
    76. E7 C-terminal domain-like [161233] (1) picpic
      alpha+beta zinc-binding domain; beta(2)-alpha(2)
    77. Zinc finger domain of DNA polymerase-alpha [90233] (1) picpic
      Zn-binding, all-alpha fold
    78. TAZ domain [57932] (1) picpic
      all-alpha fold; Zn-binding sites are in the loops connecting helices
    79. T-antigen specific domain-like [161239] (1) picpic
      all-alpha zinc-binding domain; there are two zinc ion-binding sites with a common CxCxxC motif but different fourth ligands
    80. Cysteine-rich DNA binding domain, (DM domain) [82926] (1) picpic
      alpha-helical fold with two Zn-binding sites
    81. Coronavirus NSP10-like [144245] (1) picpic
      binds two zinc ion per subunit; forms a dodecameric shell
    82. Zinc hairpin stack [161244] (1) picpic
      stack of beta-hairpins; in the middle hairpins, there is HCxxCxxC motif, the first and the last residues of which contribute to the zinc-binding site on one side of hairpin, whereas the middle residues contribute to the zinc-binding site on the other side
    83. DnaJ/Hsp40 cysteine-rich domain [57937] (1) picpic
      metal(zinc)-bound extended beta-hairpin fold
    84. HSP33 redox switch-like [118351] (1) picpic
      alpha+beta zinc-binding domain; alpha(2)-beta(2)-alpha
    85. CCHHC domain [103636] (1) picpic
      metal(zinc)-bound fold
    86. Sec-C motif [103641] (1) picpic
      metal(zinc)-bound fold
    87. Viral leader polypeptide zinc finger [144250] (1) picpic
      consists of small beta-hairpin with CxH motif and short helix with CxxC motif
    88. TSP type-3 repeat [103646] (1) picpic
      metal(calcium)-bound fold
    89. Expressed protein At2g23090/F21P24.15 [118358] (1) picpic
      not assigned; partly disordered
    90. Intrinsically disordered proteins [144255] (1) picpic
      not a true fold
  8. Coiled coil proteins [57942] (7)
    Not a true class
    1. Parallel coiled-coil [57943] (34) picpic
      this is not a true fold; includes oligomers of shorter identical helices
    2. Tetramerization domain of the Mnt repressor [58058] (1) picpic
    3. Stalk segment of viral fusion proteins [58063] (3) picpic
      core: trimeric coiled coil
    4. Antiparallel coiled-coil [58086] (17) picpic
      this is not a true fold; contains at least two very long antiparallel helices
    5. Apolipoprotein A-I [58112] (1) picpic
      tetrameric antiparallel coiled coil, closed in a circuit
    6. Apolipoprotein A-II [82935] (1) picpic
      segmented tetrameric parallel coiled coil
    7. Synuclein [118374] (1) picpic
  9. Low resolution protein structures [58117] (26)
    Not a true class
    1. Ribosome and ribosomal fragments [58118] (1) picpic
    2. Collagen fibre [144296] (1) picpic
    3. Fatty acid synthase [144301] (1) picpic
    4. Helicase [58135] (1) picpic
    5. ATP synthase [58140] (1) picpic
    6. Membrane ion ATPase [82940] (1) picpic
    7. Multidrug resistance ABC transporter [64606] (1) picpic
    8. Electron transport chains [58146] (1) picpic
    9. Photosystems [58155] (1) picpic
    10. Viruses and virus-receptor complexes [58162] (1) picpic
    11. Reovirus components [58175] (1) picpic
    12. Virus envelope proteins [75718] (1) picpic
    13. Bacteriophage HK97 procapsid (prohead II) [64611] (1) picpic
    14. Bacteriophage T4 3D cryo-EM reconstruction [103674] (1) picpic
    15. RNA polymerase [58180] (1) picpic
    16. Blood clotting [58187] (1) picpic
    17. Microtubule complexes [58193] (1) picpic
    18. Muscle protein complexes [64616] (1) picpic
    19. Ep-cadherin [103681] (1) picpic
    20. Transferrin receptor-transferrin complex [103686] (1) picpic
    21. Signal recognition particle (SRP) complex [103691] (1) picpic
    22. GroE chaperon [69998] (1) picpic
    23. clathrin assemblies [111484] (1) picpic
    24. anthrax toxin protective antigen-receptor complex [111489] (1) picpic
    25. Computational models partly based on experimental data [58198] (1) picpic
    26. Proteins of incorrect, partial and unknown sequence [58207] (1) picpic
  10. Peptides [58231] (121)
    Peptides and fragments. Not a true class
    1. Membrane ion channel-forming peptide antibiotics containing D-aminoacids [58232] (1) picpic
    2. Lantibiotic peptides [58243] (1) picpic
      peptide antibiotic
    3. Leucocin-like bacteriocin [100898] (1) picpic
      consists of a conserved, disulfide-containing N-terminal region (forming a beta-sheet) and a C-terminal helix
    4. Antimicrobial beta-hairpin [58251] (1) picpic
      contains beta-hairpin crosslinked by disulfide bridge(s)
    5. Antimicrobial helix [58268] (1) picpic
      antibiotic peptide
    6. Macrocyclic bacteriocins [58278] (1) picpic
      macrocyclic antimicrobial peptide; bacteriocin
    7. Peptide hormones [58283] (1) picpic
      contains one alpha-helix
    8. Angiotensin [90269] (1) picpic
    9. delta toxin-like [58307] (3) picpic
      single alpha helix
    10. PSP1-like [58312] (1) picpic
    11. Arg-rich RNA binding peptides [58321] (7) picpic
    12. DNA-binding domains of HMG-I(Y) [58348] (1) picpic
    13. VPR protein fragments [58353] (1) picpic
    14. Inactivation gate of potassium and sodium channels [58358] (1) picpic
    15. Coagulation factor VIII, membrane-binding peptide [58368] (1) picpic
    16. Phosphocholine cytidylyltransferase membrane-binding peptides [58373] (1) picpic
    17. Parathyroid hormone fragments (residues between 1 and 39) [58378] (1) picpic
    18. Corticotropin releasing hormone [58384] (1) picpic
    19. Liposaccharide-binding protein CAP18 (residues 106-137) [58389] (1) picpic
    20. Polymorphic antigen SPAM-H1 (residues 90-127) [58394] (1) picpic
    21. Insect toxins [58399] (1) picpic
    22. Tertiapin [58404] (1) picpic
      small disulfide-rich peptide
    23. Antifreeze polypeptide HPLC-6 [58409] (1) picpic
    24. Troponin I fragments [58414] (1) picpic
    25. Pilin fragments [58420] (1) picpic
    26. RP71935 [58427] (1) picpic
    27. Atrial natriuretic peptide [58432] (1) picpic
    28. Compstatin [58437] (1) picpic
    29. Membrane-bound antimicrobial peptides [58442] (1) picpic
    30. Endothelin-like [58449] (1) picpic
      small disulfide-rich
    31. Heat-stable enterotoxin (HSE) [58457] (1) picpic
    32. Conotoxins [58464] (1) picpic
      disulfide-rich fold
    33. Conantokin [58494] (1) picpic
    34. Contryphan-R [58502] (1) picpic
    35. Kappa-hefutoxin-like [58507] (2) picpic
      hairpin of two short helices crosslinked with two disulfides
    36. Penaeidin-3a [103726] (1) picpic
    37. Bradykinin [58512] (1) picpic
    38. Transmembrane helical fragments [58517] (1) picpic
    39. Topogenic peptides [58555] (4) picpic
    40. Phospholamban fragments [58568] (1) picpic
    41. Influenza hemagglutinin fragments [64631] (1) picpic
    42. Fragments of bowman-birk inhibitor [58574] (1) picpic
    43. Fragments of apolipoproteins [58579] (1) picpic
    44. Transactivation protein TAT [58593] (1) picpic
    45. Proline pipe [58599] (1) picpic
    46. Amyloid peptides [58604] (1) picpic
    47. Gelsolin fragment (residues 150-169) [58609] (1) picpic
    48. Acetylcholine receptor fragment (residues alpha 67-76) [58614] (1) picpic
    49. Thrombomodulin EGF domain fragment (residues 409-426) [58619] (1) picpic
    50. C-terminal fragment of thermolysin [63387] (1) picpic
    51. Capsid protein major homology region peptide analog [58629] (1) picpic
    52. CD4 and CD8 receptor regions [58635] (1) picpic
    53. Proto-oncogene tyrosine-protein kinase lck CD4/CD8 interacting region [103748] (1) picpic
    54. Heparin binding site of non collagenous domain I (nc1) of collagen facit xiv [58640] (1) picpic
    55. GroES fragments [58645] (1) picpic
    56. cAMP and cGMP phosphodiesterase (PDE) fragments [58650] (1) picpic
    57. HIV-1 Nef protein fragments [58657] (1) picpic
    58. HIV-1 envelope gp120 protein fragments [58662] (1) picpic
    59. HIV-1 gp41 fragments [70010] (1) picpic
    60. Hepatitis C virus N-terminal capsid protein fragment 2-45 [58667] (1) picpic
    61. P27(KIP1) fragment 22-106 [58672] (1) picpic
    62. Transducin alpha-1 subunit rhodopsin binding domain (res. 340-350) [58677] (1) picpic
    63. Transducin gamma-t1 subunit rhodopsin bound fragment (res. 60-71) [90290] (1) picpic
    64. alpha-lactalbumin peptide model [58682] (1) picpic
    65. Coat protein-binding domain of bacteriophage P22 scaffolding protein [58687] (1) picpic
    66. Immunoreceptor tyrosine kinase activation motif, ITAM [58692] (1) picpic
    67. Integrin fragments [58697] (1) picpic
    68. Human glutathione reductase (HGR) inhibitor [58702] (1) picpic
    69. Small subunit C-terminal inhibitory peptide of ribonucleotide reductase [58707] (1) picpic
    70. Histone H3 C-terminal fragment 130-135 [58712] (1) picpic
    71. Smad-binding domain of Sara [58717] (1) picpic
    72. Transactivation domain [81275] (1) picpic
    73. Nuclear receptor coactivator Src-1 [100901] (1) picpic
    74. TBP-binding domain of the transcription factor IIIb Brf1 subunit [90297] (1) picpic
    75. BRCA2 BRC4 repeat [82985] (1) picpic
    76. Peptide derived from p-21 activated kinase [58722] (1) picpic
    77. pak1 autoregulatory domain [58728] (1) picpic
    78. Translocated intimin receptor (tir) intimin-binding domain [58733] (1) picpic
    79. Fragments of the L-type calcium channel alpha subunit Cav.1 (dihydropyridine receptor) [58738] (1) picpic
    80. Tumor suppressor p53 fragments [58743] (1) picpic
    81. FxFG nucleoporin repeats [58748] (1) picpic
    82. beta-Catenine bound non-globular protein regions [58753] (1) picpic
    83. Synaptobrevin-II fragments [58758] (1) picpic
    84. VMIP-II fragment [58763] (1) picpic
    85. Papillomavirus e6-interacting peptide of e6ap [58768] (1) picpic
    86. Isolated insulin B-chain [58773] (1) picpic
    87. N-terminal hairpin of ubiquitin (residues 1-17) [58778] (1) picpic
    88. alpha-helical hairpin of p8mtcp1 [58783] (1) picpic
    89. Syndecan-4 cytoplasmic domain [64638] (1) picpic
    90. Actin-binding peptides [70017] (1) picpic
    91. Pituitary adenylate cyclase activating polypeptide, pacap21 [64643] (1) picpic
    92. Rack1 interaction site of the CAMP-specific phosphodiesterase pde4d5. [70022] (1) picpic
    93. Prepeptide of 5-ALAS [70027] (1) picpic
    94. Cholecystokinin receptor fragments [64648] (1) picpic
    95. the cytoplasmic N-terminus of the bk beta-subunit kcnmb2 [70032] (1) picpic
    96. Trypsin inhibitor SFTIf-1 [64653] (1) picpic
    97. Prion protein fragments [70037] (1) picpic
    98. Tumor suppressor protein p19-ARF fragment [70042] (1) picpic
    99. Antennapedia homeodomain fragments [70047] (1) picpic
    100. Sheep myeloid antimicrobial peptide SMAP29 based peptides [75751] (1) picpic
    101. alpha-2a adrenergic receptor pepride t3-i2 [75756] (1) picpic
    102. Catestatin fragment from chromogranin A [75761] (1) picpic
    103. Bhpbr3, the Baff-binding loop of br3 embedded in a beta-hairpin peptide [82992] (1) picpic
    104. N-terminal fragment of gastric H/K-ATPase [82997] (1) picpic
    105. Barstar fragment [83002] (1) picpic
    106. Cannabinoid receptor 1 (CB1) fragment [83007] (1) picpic
    107. Ribosomal protein L10 [64658] (1) picpic
    108. Ubiquitin interacting motif (UIM) [90302] (1) picpic
    109. Metal-binding peptide from MerP [103758] (1) picpic
    110. Marinostatin, MstI [103763] (1) picpic
    111. Cross-reactive peptides from 60S acidic ribosomal protein p2 [103768] (1) picpic
    112. NTR, cyclotide processing element [111516] (1) picpic
    113. HMG-box transcription factor 1 fragments [111523] (1) picpic
    114. MAD protein fragments [111528] (1) picpic
    115. Fragments of TNF receptors [111533] (1) picpic
    116. Ezrin-radixin-moesin binding phosphoprotein 50 (ebp50) fragments [111538] (1) picpic
    117. Ribosomal protein L34p [144320] (1) picpic
      non-globular, mainly alpha-helical
    118. Ribosomal protein S21p [161307] (1) picpic
      non-globular, mainly alpha-helical
    119. Retinoblastoma-associated protein RB1 fragments [144325] (1) picpic
    120. Genome linked protein vpg [144330] (1) picpic
    121. Programmed cell death protein 5 fragments [144335] (1) picpic
  11. Designed proteins [58788] (44)
    Experimental structures of proteins with essentially non-natural sequences. Not a true class
    1. New fold designs [103774] (1) picpic
    2. In vitro evolution products [103779] (1) picpic
    3. Hybrid and chimeric proteins [58789] (1) picpic
    4. Amphiphilic (amphipathic) alpha helix [58798] (1) picpic
    5. Collagen-like peptides [58805] (1) picpic
    6. Coiled serine [58812] (1) picpic
    7. Designed trimeric coiled-coil [100903] (1) picpic
    8. Designed heterodimeric coiled-coil [58822] (1) picpic
    9. Thermostable heterotrimeric coiled coil [58827] (1) picpic
    10. Designed four-helix bundle protein [58832] (1) picpic
    11. Designed single chain three-helix bundle [58839] (1) picpic
      not a true fold: both possible topologies are created
    12. Peptide f (amphiphilic octadecapeptide) [58846] (1) picpic
    13. Retro-GCN4 leucine zipper [58851] (1) picpic
    14. Glytm1bzip [70053] (1) picpic
    15. Zinc finger design [58856] (1) picpic
    16. Protein A Ig(Fc)-binding domain mimics [58863] (1) picpic
    17. Zinc finger based beta-beta-alpha motif [58868] (1) picpic
    18. helix-turn-helix motif [58877] (1) picpic
    19. alpha2d [58882] (1) picpic
    20. Right-handed coiled coil [58887] (1) picpic
    21. TPR domain-based design [90307] (1) picpic
    22. Erythropoietin (EPO) mimetic peptides [58892] (1) picpic
    23. IL-1 receptor type 1 antagonist peptide AF10847 [58897] (1) picpic
    24. Octreotide (Sandostatine), a somatostatine analogue [58902] (1) picpic
    25. Calmodulin [58907] (1) picpic
    26. WW domain-based designs [58912] (1) picpic
    27. Artificial ankyrin repeat proteins [83017] (1) picpic
    28. Carboxypeptidase A prodomain-based design [103789] (1) picpic
    29. Ubiquitin [144344] (1) picpic
    30. Cro lambda fold design [144349] (1) picpic
    31. Scorpion toxin-based designs [58917] (1) picpic
    32. TH (toxin hand)-motif beta-sheet mini-protein designs [64673] (1) picpic
    33. Inhibitor of mammalian ribonucleotide reductase [58925] (1) picpic
    34. Integrin-binding RGD peptide [64682] (1) picpic
    35. Peptide antagonists of IGF-1 [64687] (1) picpic
    36. beta-hairpin design [64692] (1) picpic
    37. Trp-cage miniprotein [75769] (1) picpic
    38. Synthetic high affinity IgE receptor antagonists [64703] (1) picpic
    39. IFN mimetic syr6 [75779] (1) picpic
    40. TAZ (CH) Zn-binding domain based design [75784] (1) picpic
    41. Beta-sheet designs [75789] (1) picpic
    42. PW2, a tryptophan-rich anticocidial peptide [75796] (1) picpic
    43. Designed EF-hand type cation-binding loop [111554] (1) picpic
    44. Metalloporphyrin-binding designed peptides [90314] (1) picpic

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