Fold: Thiamin diphosphate-binding fold (THDP-binding)

3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamilies:

1. Thiamin diphosphate-binding fold (THDP-binding) [52518] (8)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
   uperfamily
   1. Pyruvate oxidase and decarboxylase Pyr module [88724] (12)
      the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
   2. TK-like Pyr module [88735] (5)
      different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
   3. Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (6)
      parent family to TK and PFOR
      heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
   4. PFOR Pyr module [88746] (1)
      domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains
   5. Pyruvate oxidase and decarboxylase PP module [88749] (12)
      the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology
   6. TK-like PP module [88760] (5)
      different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
   7. Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5)
      parent family to TK and PFOR
      heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
   8. PFOR PP module [88771] (1)
      domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk