Structural Classification of Proteins
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Family: Pyruvate oxidase and decarboxylase Pyr module

the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: Pyruvate oxidase and decarboxylase Pyr module [88724]
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology

Protein Domains:

  1. Pyruvate decarboxylase [88725]
    1. Brewer's yeast (Saccharomyces), uvarum strain [TaxId: 4932] [88726] (1) picpic
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88727] (2) picpic
    3. Zymomonas mobilis [TaxId: 542] [88728] (1) picpic
  2. Indole-3-pyruvate decarboxylase [89648]
    1. Enterobacter cloacae [TaxId: 550] [89649] (1) picpic
  3. Pyruvate oxidase [88729]
    1. Lactobacillus plantarum [TaxId: 1590] [88730] (12) picpic
    2. Aerococcus viridans [TaxId: 1377] [142203] (4) picpic
  4. Benzoylformate decarboxylase [88731]
    1. Pseudomonas putida [TaxId: 303] [88732] (12) picpic
      SQ P20906
  5. Acetohydroxyacid synthase catalytic subunit [88733]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88734] (6) picpic
      SQ P07342 84-687
    2. Thale cress (Arabidopsis thaliana), chloroplast [TaxId: 3702] [142204] (6) picpic
      SQ P17597 86-280
  6. Catabolic acetolactate synthase [102328]
    1. Klebsiella pneumoniae [TaxId: 573] [102329] (3) picpic
  7. Carboxyethylarginine synthase [102330]
    1. Streptomyces clavuligerus [TaxId: 1901] [102331] (11) picpic
  8. Oxalyl-CoA decarboxylase [142205]
    1. Oxalobacter formigenes [TaxId: 847] [142206] (12) picpic
      SQ P40149 7-194

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site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk