there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules uperfamily
Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules uperfamily
TK-like Pyr module [88735] (5) different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (6) parent family to TK and PFOR heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
PFOR Pyr module [88746] (1) domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains
Pyruvate oxidase and decarboxylase PP module [88749] (12) the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology
TK-like PP module [88760] (5) different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5) parent family to TK and PFOR heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
PFOR PP module [88771] (1) domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains
uperfamily
