Family: TK-like PP module

different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
   uperfamily
5. Family: TK-like PP module [88760]
   different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Protein Domains:

1. Transketolase (TK), PP module [88761]
   1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88762] (7)
   2. Maize (Zea mays) [TaxId: 4577] [88763] (1)
   3. Escherichia coli [TaxId: 562] [89656] (7)
   4. Leishmania mexicana mexicana [TaxId: 44270] [117524] (1)
      SQ Q8MPM3
2. Pyruvate dehydrogenase E1 component, PP module [88764]
   E1A and E1B fused together in a single-chain protein
   1. Escherichia coli [TaxId: 562] [88765] (14)

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk