Structural Classification of Proteins
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Family: TK-like PP module

different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: TK-like PP module [88760]
    different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Protein Domains:

  1. Transketolase (TK), PP module [88761]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88762] (7) picpic
    2. Maize (Zea mays) [TaxId: 4577] [88763] (1) picpic
    3. Escherichia coli [TaxId: 562] [89656] (7) picpic
    4. Leishmania mexicana mexicana [TaxId: 44270] [117524] (1) picpic
      SQ Q8MPM3
  2. Pyruvate dehydrogenase E1 component, PP module [88764]
    E1A and E1B fused together in a single-chain protein
    1. Escherichia coli [TaxId: 562] [88765] (14) picpic

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site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk