Structural Classification of Proteins
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Protein: Pyruvate dehydrogenase E1 component, PP module from Escherichia coli [TaxId: 562]

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: TK-like PP module [88760]
    different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
  6. Protein: Pyruvate dehydrogenase E1 component, PP module [88764]
    E1A and E1B fused together in a single-chain protein
  7. Species: Escherichia coli [TaxId: 562] [88765]

PDB Entry Domains:

  1. 2iea picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, tdp
    1. region a:56-470 [137295] picpiclink
  2. 2iea picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, tdp
    1. region b:56-470 [137298] picpiclink
  3. 2qta picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, tdp; mutant
    1. region a:56-470 [151334] picpiclink
  4. 2qta picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, tdp; mutant
    1. region b:56-470 [151337] picpiclink
  5. 2qtc picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, tdk; mutant
    1. region a:56-470 [151344] picpiclink
  6. 2qtc picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, tdk; mutant
    1. region b:56-470 [151347] picpiclink
  7. 1l8a picpicxrefxref
    complexed with mg, tdp
    1. region a:56-470 [73677] picpiclink
    2. region b:56-470 [73680] picpiclink
  8. 2g28 picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, tdk
    1. region a:56-470 [134530] picpiclink
  9. 2g28 picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, tdk
    1. region b:56-470 [134533] picpiclink
  10. 2g25 picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, po4, tdk
    1. region a:56-470 [134524] picpiclink
  11. 2g25 picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    complexed with mg, po4, tdk
    1. region b:56-470 [134527] picpiclink
  12. 1rp7 picpicxrefxref
    complexed with mg, tzd
    1. region a:56-470 [97703] picpiclink
    2. region b:56-470 [97706] picpiclink
  13. 2g67 picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    1. region a:56-470 [134696] picpiclink
  14. 2g67 picpicxrefxrefxrefxref
    automatically matched to d1l8aa1
    1. region b:56-470 [134699] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk