Family: Branched-chain alpha-keto acid dehydrogenase Pyr module

parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
   uperfamily
5. Family: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741]
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein Domains:

1. Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742]
   1. Human (Homo sapiens) [TaxId: 9606] [88743] (21)
      SQ P21953 52-392
   2. Thermus thermophilus [TaxId: 274] [102332] (4)
2. 2-oxoisovalerate dehydrogenase (E1B), Pyr module [88744]
   chain A is alpha-subunit and chain B is beta-subunit
   1. Pseudomonas putida [TaxId: 303] [88745] (5)
3. E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472]
   1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [69473] (1)
   2. Human (Homo sapiens) [TaxId: 9606] [89653] (3)
4. Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain [117522]
   1. Bacillus stearothermophilus [TaxId: 1422] [117523] (2)
      SQ P21874

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk