Structural Classification of Proteins
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Protein: Branched-chain alpha-keto acid dehydrogenase, Pyr module from Human (Homo sapiens) [TaxId: 9606]

SQ P21953 52-392

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741]
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. Protein: Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742]
  7. Species: Human (Homo sapiens) [TaxId: 9606] [88743]
    SQ P21953 52-392

PDB Entry Domains:

  1. 2bfd picpicxrefxref
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, mpd, tdp; mutant
    1. region b:2-204 [128419] picpiclink
  2. 2bff picpicxrefxref
    automatically matched to d1olsb1
    complexed with gol, k, mn, tzd
    1. region b:2-204 [128421] picpiclink
  3. 1x7y picpicxrefxref
    complexed with cl, gol, k, mn, tdp; mutant
    1. region b:14-204 [114945] picpiclink
  4. 2bfc picpicxrefxref
    automatically matched to d1olsb1
    complexed with gol, k, mn, tzd; mutant
    1. region b:2-204 [128417] picpiclink
  5. 1x7z picpicxrefxref
    complexed with cl, gol, k, mn, tdp; mutant
    1. region b:14-204 [114948] picpiclink
  6. 1x7w picpicxrefxref
    complexed with cl, gol, k, mn, tdp; mutant
    1. region b:14-204 [114939] picpiclink
  7. 2bev picpicxrefxref
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, thy
    1. region b:2-204 [128393] picpiclink
  8. 2bew picpicxrefxref
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, thw
    1. region b:2-204 [128396] picpiclink
  9. 1v16 picpicxrefxref
    complexed with bdn, cl, gol, k, mn, tdp; mutant
    1. region b:2-204 [108241] picpiclink
  10. 1wci picpicxrefxref
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, wwf
    1. region b:2-204 [120891] picpiclink
  11. 1u5b picpicxrefxref
    complexed with gol, k, mn, tdp
    1. region b:14-204 [113035] picpiclink
  12. 1v1r picpicxrefxref
    complexed with cl, gol, k, na, so4
    1. region b:2-204 [108273] picpiclink
  13. 1olu picpicxrefxref
    complexed with gol, k, mg, tdp; mutant
    1. region b:2-204 [93336] picpiclink
  14. 1v11 picpicxrefxref
    complexed with bdn, cl, gol, k, mn, tdp; mutant
    1. region b:2-204 [108228] picpiclink
  15. 1ols picpicxrefxref
    complexed with gol, k, mn, tdp
    1. region b:2-204 [93332] picpiclink
  16. 1v1m picpicxrefxref
    complexed with bdn, cl, gol, k, mn, tdp; mutant
    1. region b:2-204 [108262] picpiclink
  17. 2beu picpicxrefxref
    automatically matched to d1olsb1
    complexed with cl, gol, k, mn, so4, thv
    1. region b:2-204 [128390] picpiclink
  18. 1x80 picpicxrefxref
    complexed with cl, gol, k, mn, tdp
    1. region b:14-204 [114951] picpiclink
  19. 1x7x picpicxrefxref
    complexed with cl, gol, k, mn, tdp; mutant
    1. region b:14-204 [114942] picpiclink
  20. 1olx picpicxrefxref
    complexed with gol, k, mn, tdp; mutant
    1. region b:2-204 [93339] picpiclink
  21. 1dtw picpicxrefxref
    complexed with k, mg, tdp
    1. region b:17-204 [31828] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk