Protein: Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from Bacillus stearothermophilus [TaxId: 1422]

SQ P21874

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
   uperfamily
5. Family: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741]
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
6. Protein: Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain [117522]
7. Species: Bacillus stearothermophilus [TaxId: 1422] [117523]
   SQ P21874

PDB Entry Domains:

1. 1w85
   complexed with k, mg, peg, tdp
   1. region b:1-192 [114336]
   2. region d:1-192 [114339]
   3. region f:1-192 [114342]
   4. region h:1-192 [114345]
2. 1w88
   complexed with mg, tdp; mutant
   1. region b:1-192 [114350]
   2. region d:1-192 [114353]
   3. region f:1-192 [114356]
   4. region h:1-192 [114359]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk