Protein: Pyruvate dehydrogenase E1-alpha, PdhA from Bacillus stearothermophilus [TaxId: 1422]

SQ P21873

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
   uperfamily
5. Family: Branched-chain alpha-keto acid dehydrogenase PP module [88766]
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
6. Protein: Pyruvate dehydrogenase E1-alpha, PdhA [117525]
7. Species: Bacillus stearothermophilus [TaxId: 1422] [117526]
   SQ P21873

PDB Entry Domains:

1. 1w85
   complexed with k, mg, peg, tdp
   1. chain a [114335]
   2. chain c [114338]
   3. chain e [114341]
   4. chain g [114344]
2. 1w88
   complexed with mg, tdp; mutant
   1. chain a [114349]
   2. chain c [114352]
   3. chain e [114355]
   4. chain g [114358]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk