Structural Classification of Proteins
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Fold: Acyl-CoA N-acyltransferases (Nat)

3 layers: a/b/a; contains mixed beta-sheet

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Acyl-CoA N-acyltransferases (Nat) [55728]
    3 layers: a/b/a; contains mixed beta-sheet

Superfamilies:

  1. Acyl-CoA N-acyltransferases (Nat) [55729] (10)
    link to SUPERFAMILY database - Superfamily
    1. N-acetyl transferase, NAT [55730] (60) picpic
    2. N-myristoyl transferase, NMT [55748] (3) picpic
      duplication: consists of two NAT-like domains swapped with the C-terminal strands
    3. Autoinducer synthetase [75508] (2) picpic
      Pfam 00765
    4. FemXAB nonribosomal peptidyltransferases [82749] (3) picpic
      duplication: consists of two NAT-like domains swapped with the C-terminal strands
    5. Hypothetical protein cg14615-pa [103179] (1) picpic
      duplication: consists of two NAT-like domains swapped with the C-terminal strands
    6. LFTR-like [143711] (1) picpic
      Pfam 03588; closer relative to the nonribosomal peptidyltransferases (scop_fa 82749); deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events
    7. Ornithine decarboxylase antizyme-like [143714] (1) picpic
      Pfam 02100; may have evolved different function; putative active site maps to the same location in the common fold
    8. AstA-like [143717] (1) picpic
      Pfam 04958; contains extra C-terminal domain, similar to the double psi beta-barrel fold (scop_cf 50684) with missing one strand and untangled psi-loops
    9. Aq_1966-like [143720] (1) picpic
      Pfam 06557; DUF1122; probable biological unit is homotrimeric; may have evolved different function; putative active site maps to the same location in the common fold
    10. EF1021-like [160644] (3) picpic
      duplication: consists of two NAT domains swapped with the C-terminal strands; overall structural similarity to Mycothiol synthase and N-myristoyl transferase (NMT); the similarity to NMT extends to the participation of the protein C-terminus (after the SCP2-like C-terminal domain) in the active site

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site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk