Structural Classification of Proteins

Fold: Acyl-CoA N-acyltransferases (Nat)

: 3 layers: a/b/a; contains mixed beta-sheet

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Acyl-CoA N-acyltransferases (Nat) [55728]
3 layers: a/b/a; contains mixed beta-sheet

Superfamilies:

Acyl-CoA N-acyltransferases (Nat) [55729] (10)
uperfamily
1. N-acetyl transferase, NAT [55730] (60)
2. N-myristoyl transferase, NMT [55748] (3)
  duplication: consists of two NAT-like domains swapped with the C-terminal strands
3. Autoinducer synthetase [75508] (2)
  Pfam 00765
4. FemXAB nonribosomal peptidyltransferases [82749] (3)
  duplication: consists of two NAT-like domains swapped with the C-terminal strands
5. Hypothetical protein cg14615-pa [103179] (1)
  duplication: consists of two NAT-like domains swapped with the C-terminal strands
6. LFTR-like [143711] (1)
  Pfam 03588; closer relative to the nonribosomal peptidyltransferases (scop_fa 82749); deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events
7. Ornithine decarboxylase antizyme-like [143714] (1)
  Pfam 02100; may have evolved different function; putative active site maps to the same location in the common fold
8. AstA-like [143717] (1)
  Pfam 04958; contains extra C-terminal domain, similar to the double psi beta-barrel fold (scop_cf 50684) with missing one strand and untangled psi-loops
9. Aq_1966-like [143720] (1)
  Pfam 06557; DUF1122; probable biological unit is homotrimeric; may have evolved different function; putative active site maps to the same location in the common fold
10. EF1021-like [160644] (3)
  duplication: consists of two NAT domains swapped with the C-terminal strands; overall structural similarity to Mycothiol synthase and N-myristoyl transferase (NMT); the similarity to NMT extends to the participation of the protein C-terminus (after the SCP2-like C-terminal domain) in the active site