Lysozyme-like [53954] (1) common alpha+beta motif for the active site region
Cysteine proteinases [54000] (1) consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
His-Me finger endonucleases [54059] (1) core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
RNase A-like [54075] (1) contains long curved beta-sheet and 3 helices
EndoU-like [142876] (1) comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (scop_cf 54075)
Ribosome binding domain-like [100965] (2) beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e
TFB5-like [142896] (1) beta-alpha-beta(2)-alpha; 2 layers, a/b; antiparallel sheet, order: 132; dimerises in solution (PDB 2jnj) via extended N-terminal strand
Obg GTP-binding protein C-terminal domain [102740] (1) beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other
DNA-binding domain of intron-encoded endonucleases [64495] (1) beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix
WGR domain-like [142920] (1) beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure
PH1570-like [159901] (1) duplication: two beta(4)-alpha structural repeats, related by pseudo twofold symmetry; two extra helices in the linker region; single 8-standed antiparallel beta-sheet, order: 12348765
MM3350-like [159940] (1) beta(2)-alpha-beta(4); antiparallel beta-sheet; order: 216534; similar to a ubiquitin-like fold with the extra C-terminal strand inserted in the middle of the beta-sheet
WWE domain [117838] (1) beta(2)-alpha-beta(4); antiparallel folded beta-sheet (half-barrel), order 216543
Photosystem I subunit PsaD [64233] (1) beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
GINS/PriA/YqbF domain [160058] (1) beta(4)-alpha-beta; 3-stranded antiparallel beta-sheet (strands 4,1 and 5) are covered on the same side by the helix and beta hairpin of strands 2 and 3; similarity to the L9 N-domain-like fold (scop_cf 55657) and the PsaD fold (scop_sf 64243)
Acetoacetate decarboxylase-like [160103] (1) complex fold: contains a 3-layer beta-sheet structure, which is folded in two conjoint barrels capped by helices; one rounded barrel has 7 strands, the other flattened barrel has 9 strands
AF0104/ALDC/Ptd012-like [117855] (1) duplication: consists of two similar beta-alpha-beta(4) motifs
TTHA1013/TTHA0281-like [143099] (1) beta(3)-alpha-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other; topological similarity to the SEP domain fold (scop_cf 102847); dimerises via the long C-terminal strand with the formation of a single beta-sheet
YegP-like [160112] (1) comprises two subunits or tandem repeats of beta(3)-alpha-beta motifs; these assemble with the formation of a single beta-sheet and swapping of the C-terminal strands
YefM-like [143119] (1) core: beta-alpha(2)-beta(2)-alpha; mixed beta-sheet, order:123, strands 1 and 2 are parallel; forms compact dimer with a single beta-sheet;
CPE0013-like [160147] (1) beta(2)-alpha-beta(3); mixed, mostly antiparallel beta-sheet, folded in a half-barrel; order:31254; strand 3 is parallel to strand 1 and is shorter than the rest
FYSH domain [89894] (1) beta(2)-alpha(2)-beta(2)-alpha-beta; two layers: alpha/beta; antiparallel sheet: order 51234
VSV matrix protein [75403] (1) beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154
Coproporphyrinogen III oxidase [102885] (1) alpha-beta(6)-alpha(2)-beta-alpha(n); 3 layers alpha/beta/alpha; antiparallel sheet: order 1234567
Hypothetical protein Ta1206 [102890] (1) beta(4)-alpha-beta(2)-alpha(2); mixed, predominately antiparallel beta-sheet, order: 123465, strands 4 and 5 are parallel to each other
CBS-domain pair [54630] (1) duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences; 4 layers: a/b/b/a
alpha/beta-Hammerhead [54664] (5) core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
NMB0488-like [160206] (1) duplication: two beta(3)-alpha motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456, shaped into a half-barrel; helical linker region
PX domain [64267] (1) beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch
Shew3726-like [160271] (1) beta(3)-alpha(n)-beta; 2 layers, a/b; mixed beta-sheet, order 1234, strands 3 and 4 are parallel with a left-handed crossover connection
Ferredoxin-like [54861] (59) alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
PurS-like [109622] (1) consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
RplX-like [160373] (1) beta(2)-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 213; some structural similarity to the PurS subunit/repeat (scop_cf 109622)
Dystroglycan, domain 2 [111005] (1) beta-alpha-beta-X-beta(2)-alpha(2)-beta; antiparallel beta-sheet, order 24153; topological similarity to the ferredoxin-like fold (scop_cf 54861)
Pseudouridine synthase [100877] (1) consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
SP0830-like [160378] (1) duplication: two beta-alpha-beta(2)-alpha-beta-alpha motifs are organized in ferredoxin-like subdomains swapped with the extra C-terminal helices
Folate-binding domain [103024] (1) duplication: consists of two beta(2)-alpha-beta(3)-alpha subdomains swapped with the first strands
THUMP domain [143436] (1) contains mixed 8-stranded beta-sheet, folded into a half-barrel and covered with 4 helices on the outside; order 32148756; strands 5, 6 and 7 are parallel
AMMECR1-like [143446] (1) duplication; contains two beta(2)-alpha-beta(2) structural repeats, swapped with C-terminal strands; extra N-terminal helix and C-terminal strand
NosL/MerB-like [160386] (1) unusual fold; comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets; probable duplication
Ribosomal protein L30p/L7e [55128] (1) core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity to the ferredoxin-like fold
Chorismate lyase-like [64287] (1) duplication of alpha(2)-beta(3) motif; antiparallel beta sheet, order 123654
YdfO-like [160418] (1) duplication: two alpha(2)-beta(3) motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456
CheC-like [103038] (1) duplication: tandem repeat of two intertwined alpha-beta-(X)-beta(2) motifs
LigT-like [55143] (1) duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III
Pepsin inhibitor-3 [55148] (1) duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure
CYTH-like phosphatases [55153] (1) duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it
Antiparallel beta/alpha barrel (PT-barrel) [143491] (1) tandem repeat of five alpha(2)-beta(2) motifs; antiparallel beta-sheet barrel, closed; n=10, S=10; order 123456789A; there is a channel along the barrel axis
IF3-like [55199] (8) beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest
PUG domain-like [143502] (1) alpha(2)-beta-alpha(2)-beta(2)-alpha; cluster of helices with a small antiparallel beta-sheet on one side; order 132; topological similarity to the fold of an extended R3H domain (PDB 1whr)
PB2 C-terminal domain-like [160452] (1) alpha-beta-alpha-X-alpha-beta(2); 3 layers, a/b/a; antiparallel beta-sheet, order 132; connection between helices 2 and 3 runs over the edge of the beta-sheet
TRCF domain-like [143516] (1) beta-alpha(3)-beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed beta sheet, order 12354, strands 1 and 2 are parallel; some topological similarity to the DCoH-like fold (scop_cf 55247)
NMB0513-like [160471] (1) alpha(3)-beta(2)-alpha-beta(2); some similarity to the "winged helix" DNA-binding domain fold
PA1123-like [160476] (1) irregular array of short helices and two three-stranded beta-sheets
Hypothetical protein Yml108w [100886] (1) beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta; mixed beta-sheet 2143, strands 1 and 4 are parallel
Bacillus chorismate mutase-like [55297] (9) core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest
YjbQ-like [111037] (1) beta(2)-alpha-beta(2)-alpha(2)-beta(3); contains a beta-sandwich: 7 strands in 2 sheets; trimerizes with orthogonally packed beta-sheets
Tautomerase/MIF [55330] (1) (beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet generally forms trimers with three closely packed beta-sheets
FwdE/GAPDH domain-like [55346] (4) core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1
Ava3019-like [160531] (1) alpha(2)-beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order: 32145; similarity to the insert domain of Glucose 6-phosphate dehydrogenase-like family (sop_fa 55376)
Hypothetical protein PF0899 [111056] (1) alpha-beta-alpha-beta(4); 2 layers: a/b; mixed beta-sheet, order 23145, strands 1 and 3 are parallel; similar to the GAPDH C-terminal domain-like fold (scop_cf 55346)
Major capsid protein gp5 [56562] (1) unusual fold; contains PF0899-like core, decorated with additional structure
SpoVG-like [160536] (1) beta(5)-alpha; comprises a coiled antiparallel beta-sheet (order: 12345) packed against the C-terminal helix; the extensions of strands 4 and 5 form an isolated beta-hairpin
TTHA1528-like [143591] (1) beta-alpha-beta(3)-alpha-beta-alpha(2)-beta; 3 layers: a/b/a; mixed beta-sheet, order: 143256, parallel strands' pairs are 1-4 and 2-5
YojJ-like [143596] (1) alpha-beta-X-beta-alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; 7-stranded mixed beta-sheet, order 2431567; strands 1 and 3 are parallel to each other
STIV B116-like [143601] (1) subunit fold consists of mixed 5-stranded beta-sheet, order:31452, strand 5 is antiparallel to the rest, with 3 helices on one side; dimerises with the formation of a single 10-stranded beta-sheet; strand 2 is in the dimer interface
Bacillus phage protein [111073] (1) alpa-beta(3)-alpha-beta(3)-alpha; 3 layers: b/a/b, 3-helical bundle flanked by two 3-stranded meander beta-sheets
TrkA C-terminal domain-like [116725] (1) beta-X-beta(2)-X-beta-alpha; pseudo barrel capped by helix at one end; topological similarity to the HPr-like fold
T-fold [55619] (2) beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234 tunnel-shaped: its known members form wide oligomeric barrels different sizes
Cell cycle regulatory proteins [55636] (1) beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243 can form strand-exchange dimers
YonK-like [160569] (1) intertwined dimer of beta(3)-alpha-beta subunits; assembles further in octamer with formation of a wide 16-stranded beta-barrel
YrdC/RibB [55820] (1) core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers; mixed twisted sheet of 7 strands; order 7126354; strands 7 and 1 are parallel to each other
GIY-YIG endonuclease [82770] (1) beta(2)-alpha(2)-beta-alpha-(beta); strand 4 is very short; 3 layers; antiparallel (mixed) beta-sheet; order 312(4)
L28p-like [143799] (1) unusual fold consisting of three beta-hairpins, that form a paper clip-like structure, and two helices; could have evolved from a glucocorticoid receptor-like zinc finger domain (scop_cf 57715)
YqaI-like [160712] (1) dimeric zinc-less 'zinc finger'-like fold; similar to the C-terminal strand-swapped B-box domain (scop_cf 57844)
gpW/gp25-like [160718] (1) alpha(2)-beta(3); similar to one structural repeat of the Creatinase/aminopeptidase family and the C-terminal subdomain of PanC
XisI-like [143846] (1) alpha-beta(4)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order 1234, meander; the open side of beta-sheet provides dimerization interface
S-adenosylmethionine synthetase [55972] (1) duplication: consists of 3 similar intertwined domains structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
DNA clamp [55978] (1) contains two helices and two beta sheets duplication: fold has internal pseudo two-fold symmetry
Hypothetical protein TM0160 [103255] (1) duplication: consists of two beta(3)-alpha(2) structural repeats; single barrel-like beta-sheet
TTHC002-like [160760] (1) alpha-beta-alpha-beta(3); forms dimer with a single beta-sheet, folded in a barrel-like shape
DeoB insert domain-like [143855] (1) alpha-beta-X-beta(2)-alpha-beta(2); 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 2 and 5 are antiparallel to the rest
Hypothetical protein HI1480 [103276] (1) beta-alpha(4)-beta-alpha-beta; segregated alpha-helical and beta-sheet subdomains; dimeric beta-sheet barrel: n=6, S=10
ERH-like [143874] (1) beta(2)-alpha(2)-beta(2)-alpha; antiparallel beta-sheet, order:2134; helices are arranged in a bundle rather than packed agains beta-sheet; dimerises via with the formation of a flattened beta-barel: closed n=8, S=10
Ribosomal protein S8 [56046] (1) consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a
Ribosomal protein L6 [56052] (1) consists of two beta-sheets and one alpha-helix packed around single core
NE0471 N-terminal domain-like [143879] (1) beta(3)-alpha(n)-beta(3)-alpha; the two meander beta-sheets and helices are packed against the same core
Lp2179-like [160799] (1) beta(2)-alpha-beta(4)-alpha-beta; contains two antiparallel beta-sheets (orders: 127 and 3456) packed against the longer C-terminal helix
RGC domain-like [143884] (1) consists of two beta-sheets and four helices eclosing a cental cavity
Smc hinge domain [75552] (1) consists of 2 different alpha+beta subdomains; forms subdomain-swapped dimers
DNA mismatch repair protein MutL [118115] (1) consists of two different alpha+beta (sub)domains; d1: [beta(3)-alpha-(insert of d2)-alpha(2)-beta; 2 layers, a/b; antiparallel sheet, order: 1234]; d2: [beta-alpha-beta(2)-alpha(2); 2 layers, a/b; antiparallel sheet, order: 132]
ATP-grasp [56058] (2) Consists of two subdomains with different alpha+beta folds shares functional and structural similarities with the PIPK and protein kinase superfamilies
Prim-pol domain [56746] (1) consists of two alpha+beta domains
Hect, E3 ligase catalytic domain [56203] (1) consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit; conformational flexibility of domain orientation
DNase I-like [56218] (1) contains beta-sandwich; duplication of alpha+beta motif
Aldehyde ferredoxin oxidoreductase, N-terminal domain [56227] (1) contains sandwich; duplication of alpha+beta motif with single mixed sheet motif: beta(2)-alpha-beta(3)-alpha-beta; strand order 216345, strands 1 and 6 are parallel
Ntn hydrolase-like [56234] (2) 4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
DmpA/ArgJ-like [56265] (1) duplication of beta(3)-alpha-beta-alpha motif; 4 layers: alpha/beta/beta/alpha
ADC synthase [56321] (1) duplication: contains four repeats of alpha-beta(2)-beta motif arranged in a 4 layer core structure: alpha/beta/beta/alpha; orthogonally packed beta-sheets
Sulfolobus fructose-1,6-bisphosphatase-like [111248] (1) 4 layers: a/b/b/a; antiparallel beta sheets; similarities to ferredoxin-like fold (scop_cf 54861) in the N-terminal part (1-120) and to the Bacterial S-adenosylmethionine decarboxylase subunit (scop_fa 997656) in the C-terminal part (121-340)
Phosphoprotein oligomerization domain-like [160891] (1) intertwinned homodimer of beta(2)-alpha-beta(2) motifs; 3 layers: b/a/b; each antiparallel beta-sheet is formed by the N-terminal beta-hairpin of one subunit and the C-terminal beta-hairpin of the other subunit; order 1243
Taf5 N-terminal domain-like [160896] (1) multihelical cluster with a C-terminal beta-alpha(2)-beta motif; one central buried helix; parallel beta-ribbon
Jann2411-like [160903] (1) unusual fold; consists of seven alpha-helices and three beta-hairpins
ATP12-like [160908] (1) contains an N-terminal beta-sheet that forms a beta-triangle structure; the remainder is a multihelical array of long and short helices
UbiD C-terminal domain-like [143967] (1) alpha-beta(2)-alpha-beta-alpha-beta(2); 3 layers, a/b/a; mixed beta-sheet, order: 12354, strands 2,3 and 5 are parallel to each other
Hypothetical protein TM0875 [90063] (1) unusual fold; core: beta(2)-loop-beta(2)-alpha-beta; mixed beta-sheet: order 51243; parallel strands 2 and 4
Hypothetical protein PH1602 [103364] (1) complex alpha+beta fold; contains a region of similarity to the ferredoxin-like fold
IlvD/EDD N-terminal domain-like [143974] (1) contains a large cluster of helices and a mixed beta-sheet of 4 strands; order 2134, strands 3 and 4 are parallel
DNA methylase specificity domain [116733] (1) comprises the N-terminal, double beta-helix like structure and C-terminal alpha-hairpin
GCM domain [90072] (1) consists of two different alpha+beta subdomains; 2 zinc-binding sites
SSo0622-like [111277] (1) alpha(2)-beta(2)-alpha-beta-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel beta-sheet: order 21354; strands 1,3 and 5 and the C-terminal helix are longer than other secondary structures
Putative modulator of DNA gyrase, PmbA/TldD [111282] (1) consists of two different alpha+beta domains; d1: [duplication of alpha-beta(3)-alpha motif; 2 layers: a/b; antiparallel beta-sheet, order: 321456; strands 1, 2, 4 and 5 are twice longer than other secondary structures]; d2 [ complex fold; contains beta-barrel (n=5, S=10)]
PSTPO5379-like [160919] (1) complex fold; consists of two alpha+beta subdomains, one is inserted in the other
PG1388-like [160924] (1) consists of 2 alpha+beta subdomains, each having a meander beta-sheet; d1: alpha(2)-beta(7); d2: alpha(2)-beta(2)-alpha(2)-beta(2)
Oxysterol-binding protein-like [143999] (1) core: large meander beta-sheet of 12 strands wrapped around the N-terminal (distorted) alpha-hairpin; some similarity to transmembrane beta-barrel proteins
ORC1-binding domain [144004] (1) complex fold, composed of an alpha hairpin, meander beta-sheet and a five-stranded barrel of unusual topology
CofE-like [144009] (1) consists of two different domains; d1: beta-alpha-beta-alpha-beta(2)-alpha-beta, mixed sheet of 5 strands, order:15234, strands 2 and 3 are parralel; d2 is inserted in d1 after strand 2 and comprises a helix-turn-helix motif and two 3-stranded sheets
Peptidoglycan deacetylase N-terminal noncatalytic region [144014] (1) consists of two different domains, d1: [alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; mixed beta-sheet, order 12345, strands 2 and 3 are parallel to each other with a left-handed crossover connection], d2: alpha-beta(3)-alpha; 2 layers; antiparallel beta-sheet, order 123]
