Structural Classification of Proteins

Fold: SH2-like

: 3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: SH2-like [55549]
3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

Superfamilies:

SH2 domain [55550] (1)
uperfamily
1. SH2 domain [55551] (39)
  Pfam 00017
  1. p56-lck tyrosine kinase [55552]
    1. Human (Homo sapiens) [TaxId: 9606] [55553] (16)
  2. Carboxyl-terminal src kinase (csk) [75498]
    1. Human (Homo sapiens) [TaxId: 9606] [75499] (1)
  3. c-src tyrosine kinase [55556]
    1. Human (Homo sapiens) [TaxId: 9606] [55557] (42)
    2. Chicken (Gallus gallus) [TaxId: 9031] [55558] (3)
    3. Rous sarcoma virus [TaxId: 11886] [69782] (13)
  4. Tyrosine kinase Fyn [55559]
    1. Human (Homo sapiens) [TaxId: 9606] [55560] (3)
  5. Tyrosine phosphatase Syp [55561]
    1. Mouse (Mus musculus) [TaxId: 10090] [55562] (4)
  6. Growth factor receptor-bound protein 2 (GRB2) [55563]
    1. Human (Homo sapiens) [TaxId: 9606] [55564] (25)
  7. Hemopoetic cell kinase Hck [55565]
    1. Human (Homo sapiens) [TaxId: 9606] [55566] (4)
  8. Crk proto-oncogen [82741]
    1. Human (Homo sapiens) [TaxId: 9606] [82742] (3)
  9. Shc adaptor protein [55567]
    1. Human (Homo sapiens) [TaxId: 9606] [55568] (2)
  10. Phosphatidylinositol 3-kinase, p85-alpha subunit [55569]
    1. Cow (Bos taurus) [TaxId: 9913] [55570] (7)
    2. Human (Homo sapiens) [TaxId: 9606] [55571] (2)
    3. Rat (Rattus norvegicus) [TaxId: 10116] [55572] (2)
  11. Proto-oncogen tyrosine kinase [55573]
    1. Human (Homo sapiens) [TaxId: 9606] [55574] (2)
  12. Syk tyrosine kinase [55575]
    1. Human (Homo sapiens) [TaxId: 9606] [55576] (3)
  13. Growth factor receptor-bound protein 10, GRB10 [89994]
    1. Human (Homo sapiens) [TaxId: 9606] [89995] (1)
  14. Growth factor receptor-bound protein 7 [103135]
    1. Human (Homo sapiens) [TaxId: 9606] [103136] (5)
  15. Tyrosine-protein kinase zap-70 [89996]
    1. Human (Homo sapiens) [TaxId: 9606] [89997] (3)
  16. Phospholipase C-gamma-1 [55577]
    1. Cow (Bos taurus) [TaxId: 9913] [55578] (3)
  17. P55 Blk protein tyrosine kinase [55579]
    1. Mouse (Mus musculus) [TaxId: 10090] [55580] (2)
  18. Itk/tsk protein tyrosine kinase [82743]
    1. Mouse (Mus musculus) [TaxId: 10090] [82744] (6)
  19. Abl tyrosine kinase [55581]
    1. Human (Homo sapiens) [TaxId: 9606] [55582] (1)
    2. Mouse (Mus musculus) [TaxId: 10090] [89998] (2)
  20. Csk homologous kinase Chk [64345]
    1. Human (Homo sapiens) [TaxId: 9606] [64346] (1)
  21. STAT-1 [55583]
    1. Human (Homo sapiens) [TaxId: 9606] [55584] (1)
  22. STAT3b [55585]
    1. Mouse (Mus musculus) [TaxId: 10090] [55586] (1)
  23. STAT homologue [103137]
    1. Dictyostelium discoideum [TaxId: 44689] [103138] (2)
  24. Cbl [55587]
    1. Human (Homo sapiens) [TaxId: 9606] [55588] (12)
  25. Tyrosine phoshatase shp-2 [55589]
    1. Human (Homo sapiens) [TaxId: 9606] [55590] (1)
  26. The Xlp protein Sap [55591]
    1. Human (Homo sapiens) [TaxId: 9606] [55592] (6)
  27. Ews/fli1 activated transcript 2, Eat2 [89999]
    1. Mouse (Mus musculus) [TaxId: 10090] [90000] (1)
  28. Adaptor protein Aps [103139]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [103140] (2)
  29. Tyrosine-protein kinase 6 (Breast tumor kinase, Brk) [111084]
    1. Human (Homo sapiens) [TaxId: 9606] [111085] (1)
      SQ Q13882 75-174
  30. GRB2-related adaptor protein 2 (MONA, GRID) [111086]
    1. Mouse (Mus musculus) [TaxId: 10090] [111087] (3)
      SQ O89100 53-147
  31. Beta-chimaerin, N-terminal domain [118052]
    includes N-terminal tail and the linker to the next domain
    1. Human (Homo sapiens) [TaxId: 9606] [118053] (1)
      SQ P52757 23-468
  32. Hematopoietic SH2 domain containing protein HSH2D [143623]
    1. Human (Homo sapiens) [TaxId: 9606] [143624] (1)
      SQ Q96JZ2 24-129
  33. Suppressor of cytokine signaling 2, SOCS-2 [160562]
    1. Human (Homo sapiens) [TaxId: 9606] [160563] (1)
      SQ O14508 32-134
  34. Suppressor of cytokine signaling 4, SOCS-4 [160564]
    1. Human (Homo sapiens) [TaxId: 9606] [160565] (1)
      SQ Q8WXH5 274-385