Structural Classification of Proteins

Fold: MHC antigen-recognition domain

: dimeric

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: MHC antigen-recognition domain [54451]
dimeric

Superfamilies:

MHC antigen-recognition domain [54452] (1)
uperfamily
1. MHC antigen-recognition domain [54453] (73)
  1. Class II MHC alpha chain, N-terminal domain [88806]
    1. Human (Homo sapiens), HLA-DM [TaxId: 9606] [88807] (1)
    2. Human (Homo sapiens), HLA-DR1 [TaxId: 9606] [88808] (15)
      SQ P01903 28-207
    3. Human (Homo sapiens), HLA-DR2 [TaxId: 9606] [88809] (8)
    4. Human (Homo sapiens), HLA-DR3 [TaxId: 9606] [88810] (1)
    5. Human (Homo sapiens), HLA-DR4 [TaxId: 9606] [88811] (5)
    6. Human (Homo sapiens), HLA-DQ2 [TaxId: 9606] [102833] (1)
    7. Human (Homo sapiens), HLA-DQ6 [TaxId: 9606] [102834] (1)
    8. Human (Homo sapiens), HLA-DQ8 [TaxId: 9606] [88812] (1)
    9. Mouse (Mus musculus), I-AK [TaxId: 10090] [88813] (3)
    10. Mouse (Mus musculus), I-AU [TaxId: 10090] [89859] (30)
    11. Mouse (Mus musculus), I-EK [TaxId: 10090] [88814] (9)
    12. Mouse (Mus musculus), I-AB [TaxId: 10090] [88815] (2)
    13. Mouse (Mus musculus), I-AD [TaxId: 10090] [88816] (2)
    14. Mouse (Mus musculus), I-A(G7) [TaxId: 10090] [88817] (2)
    15. Mouse (Mus musculus), H2-DM [TaxId: 10090] [88818] (1)
  2. Class II MHC beta chain, N-terminal domain [88819]
    1. Human (Homo sapiens), HLA-DM [TaxId: 9606] [88820] (1)
    2. Human (Homo sapiens), HLA-DR1 [TaxId: 9606] [88821] (13)
    3. Human (Homo sapiens), HLA-DR2 [TaxId: 9606] [88822] (16)
      SQ P04229 30-219
    4. Human (Homo sapiens), HLA-DR3 [TaxId: 9606] [88823] (1)
    5. Human (Homo sapiens), HLA-DR4 [TaxId: 9606] [88824] (18)
    6. Human (Homo sapiens), HLA-DQ2 [TaxId: 9606] [102835] (1)
    7. Human (Homo sapiens), HLA-DQ6 [TaxId: 9606] [102836] (1)
    8. Human (Homo sapiens), HLA-DQ8 [TaxId: 9606] [88825] (1)
    9. Mouse (Mus musculus), I-AK [TaxId: 10090] [88826] (3)
    10. Mouse (Mus musculus), I-AU [TaxId: 10090] [89860] (1)
    11. Mouse (Mus musculus), I-EK [TaxId: 10090] [88827] (9)
    12. Mouse (Mus musculus), I-AB [TaxId: 10090] [88828] (8)
    13. Mouse (Mus musculus), I-AD [TaxId: 10090] [88829] (2)
    14. Mouse (Mus musculus), I-A(G7) [TaxId: 10090] [88830] (6)
    15. Mouse (Mus musculus), H2-DM [TaxId: 10090] [88831] (1)
  3. Class I MHC, alpha-1 and alpha-2 domains [54468]
    1. Human (Homo sapiens), HLA-A2 [TaxId: 9606] [54469] (1)
    2. Human (Homo sapiens), HLA-A2.1 [TaxId: 9606] [54470] (95)
      SQ P01892 25-298
    3. Human (Homo sapiens), HLA-AW68 [TaxId: 9606] [54472] (3)
    4. Human (Homo sapiens), HLA-B08 [TaxId: 9606] [54473] (7)
    5. Human (Homo sapiens), HLA-B27 [TaxId: 9606] [54471] (8)
      SQ P03989 25-300
    6. Human (Homo sapiens), HLA-BW44 [TaxId: 9606] [102837] (12)
      SQ P30481 25-300
    7. Human (Homo sapiens), HLA-B53 [TaxId: 9606] [54474] (31)
    8. Human (Homo sapiens), HLA-B35 [TaxId: 9606] [54475] (5)
      SQ P30685 25-300
    9. Human (Homo sapiens), HLA-B51 [TaxId: 9606] [54476] (2)
    10. Human (Homo sapiens), HLA-CW3 [TaxId: 9606] [54477] (1)
    11. Human (Homo sapiens), HLA-CW4 [TaxId: 9606] [54478] (2)
    12. Human (Homo sapiens), HLA-E [TaxId: 9606] [54479] (14)
    13. Mouse (Mus musculus), H-2KB [TaxId: 10090] [54481] (40)
      SQ P01901 22-299
    14. Mouse (Mus musculus), H-2DB [TaxId: 10090] [54482] (18)
    15. Mouse (Mus musculus), H-2M3 [TaxId: 10090] [54483] (1)
    16. Mouse (Mus musculus), H-2LD [TaxId: 10090] [54484] (2)
    17. Mouse (Mus musculus), H-2DD [TaxId: 10090] [54485] (36)
    18. Mouse (Mus musculus), tla(c), H-2 class [TaxId: 10090] [89861] (1)
    19. Mouse (Mus musculus), IB QA-2 [TaxId: 10090] [69680] (1)
    20. Rat (Rattus norvegicus), RT1-AA [TaxId: 10116] [54486] (3)
    21. Human (Homo sapiens), HLA-A11 [TaxId: 9606] [110840] (4)
      SQ P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
    22. Human (Homo sapiens), HLA-A1 [TaxId: 9606] [117849] (1)
      SQ P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor
    23. Rhesus monkey (Macaca mulatta) [TaxId: 9544] [160074] (2)
    24. Mouse (Mus musculus), H-2KK [TaxId: 10090] [160075] (3)
      SQ P04223 22-197
    25. Human (Homo sapiens), HLA-G [TaxId: 9606] [160076] (4)
      SQ P17693 25-205! SQ P17693 26-205
    26. Mouse (Mus musculus), H-2M10 [TaxId: 10090] [160077] (5)
    27. Mouse (Mus musculus), H-2KD [TaxId: 10090] [160078] (2)
      SQ P01902 22-202
  4. Hemochromatosis protein Hfe, alpha-1 and alpha-2 domains [88832]
    1. Human (Homo sapiens) [TaxId: 9606] [54480] (2)
  5. Fc (IgG) receptor, alpha-1 and alpha-2 domains [54454]
    class I MHC-related
    1. Rat (Rattus norvegicus) [TaxId: 10116] [54455] (3)
    2. Human (Homo sapiens) [TaxId: 9606] [54493] (1)
  6. CD1, alpha-1 and alpha-2 domains [54456]
    Class I MHC-related
    1. Mouse (Mus musculus) [TaxId: 10090] [54457] (10)
    2. Human (Homo sapiens), CD1b [TaxId: 9606] [75378] (3)
    3. Human (Homo sapiens), CD1a [TaxId: 9606] [102838] (4)
    4. Human (Homo sapiens), CD1d [TaxId: 9606] [160079] (4)
      SQ P15813 24-201
  7. Zinc-alpha-2-glycoprotein, ZAG [54487]
    fat depleting factor related to class I MHC
    1. Human (Homo sapiens) [TaxId: 9606] [54488] (7)
      SQ P25311 22-294
  8. Class I MHC homolog [54489]
    gamma, delta T-cell ligand
    1. Human (Homo sapiens), Mic-a [TaxId: 9606] [54490] (2)
    2. Human (Homo sapiens), Mic-b [TaxId: 9606] [75380] (1)
    3. Mouse (Mus musculus), t22 [TaxId: 10090] [54491] (3)
    4. Mouse (Mus musculus), t10 [TaxId: 10090] [102839] (1)
  9. Class I MHC-related molecule Ulbp3 [69681]
    1. Human (Homo sapiens) [TaxId: 9606] [69682] (1)
  10. NK cell ligand RAE-1 beta [69683]
    1. Mouse (Mus musculus) [TaxId: 10090] [69684] (2)
  11. Endothelial protein C receptor [75381]
    phospholipid-binding protein
    1. Human (Homo sapiens) [TaxId: 9606] [75382] (2)
  12. Immunomodulatory protein m144, alpha-1 and alpha-2 domains [110841]
    1. Murine cytomegalovirus [TaxId: 10366] [110842] (2)
      SQ Q69G19 27-263 # 95% sequence identity