Structural Classification of Proteins

Superfamily: MHC antigen-recognition domain

: uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: MHC antigen-recognition domain [54451]
dimeric
Superfamily: MHC antigen-recognition domain [54452]
uperfamily

Families:

MHC antigen-recognition domain [54453] (73)
1. Class II MHC alpha chain, N-terminal domain [88806]
  1. Human (Homo sapiens), HLA-DM [TaxId: 9606] [88807] (1)
  2. Human (Homo sapiens), HLA-DR1 [TaxId: 9606] [88808] (15)
    SQ P01903 28-207
  3. Human (Homo sapiens), HLA-DR2 [TaxId: 9606] [88809] (8)
  4. Human (Homo sapiens), HLA-DR3 [TaxId: 9606] [88810] (1)
  5. Human (Homo sapiens), HLA-DR4 [TaxId: 9606] [88811] (5)
  6. Human (Homo sapiens), HLA-DQ2 [TaxId: 9606] [102833] (1)
  7. Human (Homo sapiens), HLA-DQ6 [TaxId: 9606] [102834] (1)
  8. Human (Homo sapiens), HLA-DQ8 [TaxId: 9606] [88812] (1)
  9. Mouse (Mus musculus), I-AK [TaxId: 10090] [88813] (3)
  10. Mouse (Mus musculus), I-AU [TaxId: 10090] [89859] (30)
  11. Mouse (Mus musculus), I-EK [TaxId: 10090] [88814] (9)
  12. Mouse (Mus musculus), I-AB [TaxId: 10090] [88815] (2)
  13. Mouse (Mus musculus), I-AD [TaxId: 10090] [88816] (2)
  14. Mouse (Mus musculus), I-A(G7) [TaxId: 10090] [88817] (2)
  15. Mouse (Mus musculus), H2-DM [TaxId: 10090] [88818] (1)
2. Class II MHC beta chain, N-terminal domain [88819]
  1. Human (Homo sapiens), HLA-DM [TaxId: 9606] [88820] (1)
  2. Human (Homo sapiens), HLA-DR1 [TaxId: 9606] [88821] (13)
  3. Human (Homo sapiens), HLA-DR2 [TaxId: 9606] [88822] (16)
    SQ P04229 30-219
  4. Human (Homo sapiens), HLA-DR3 [TaxId: 9606] [88823] (1)
  5. Human (Homo sapiens), HLA-DR4 [TaxId: 9606] [88824] (18)
  6. Human (Homo sapiens), HLA-DQ2 [TaxId: 9606] [102835] (1)
  7. Human (Homo sapiens), HLA-DQ6 [TaxId: 9606] [102836] (1)
  8. Human (Homo sapiens), HLA-DQ8 [TaxId: 9606] [88825] (1)
  9. Mouse (Mus musculus), I-AK [TaxId: 10090] [88826] (3)
  10. Mouse (Mus musculus), I-AU [TaxId: 10090] [89860] (1)
  11. Mouse (Mus musculus), I-EK [TaxId: 10090] [88827] (9)
  12. Mouse (Mus musculus), I-AB [TaxId: 10090] [88828] (8)
  13. Mouse (Mus musculus), I-AD [TaxId: 10090] [88829] (2)
  14. Mouse (Mus musculus), I-A(G7) [TaxId: 10090] [88830] (6)
  15. Mouse (Mus musculus), H2-DM [TaxId: 10090] [88831] (1)
3. Class I MHC, alpha-1 and alpha-2 domains [54468]
  1. Human (Homo sapiens), HLA-A2 [TaxId: 9606] [54469] (1)
  2. Human (Homo sapiens), HLA-A2.1 [TaxId: 9606] [54470] (95)
    SQ P01892 25-298
  3. Human (Homo sapiens), HLA-AW68 [TaxId: 9606] [54472] (3)
  4. Human (Homo sapiens), HLA-B08 [TaxId: 9606] [54473] (7)
  5. Human (Homo sapiens), HLA-B27 [TaxId: 9606] [54471] (8)
    SQ P03989 25-300
  6. Human (Homo sapiens), HLA-BW44 [TaxId: 9606] [102837] (12)
    SQ P30481 25-300
  7. Human (Homo sapiens), HLA-B53 [TaxId: 9606] [54474] (31)
  8. Human (Homo sapiens), HLA-B35 [TaxId: 9606] [54475] (5)
    SQ P30685 25-300
  9. Human (Homo sapiens), HLA-B51 [TaxId: 9606] [54476] (2)
  10. Human (Homo sapiens), HLA-CW3 [TaxId: 9606] [54477] (1)
  11. Human (Homo sapiens), HLA-CW4 [TaxId: 9606] [54478] (2)
  12. Human (Homo sapiens), HLA-E [TaxId: 9606] [54479] (14)
  13. Mouse (Mus musculus), H-2KB [TaxId: 10090] [54481] (40)
    SQ P01901 22-299
  14. Mouse (Mus musculus), H-2DB [TaxId: 10090] [54482] (18)
  15. Mouse (Mus musculus), H-2M3 [TaxId: 10090] [54483] (1)
  16. Mouse (Mus musculus), H-2LD [TaxId: 10090] [54484] (2)
  17. Mouse (Mus musculus), H-2DD [TaxId: 10090] [54485] (36)
  18. Mouse (Mus musculus), tla(c), H-2 class [TaxId: 10090] [89861] (1)
  19. Mouse (Mus musculus), IB QA-2 [TaxId: 10090] [69680] (1)
  20. Rat (Rattus norvegicus), RT1-AA [TaxId: 10116] [54486] (3)
  21. Human (Homo sapiens), HLA-A11 [TaxId: 9606] [110840] (4)
    SQ P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
  22. Human (Homo sapiens), HLA-A1 [TaxId: 9606] [117849] (1)
    SQ P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor
  23. Rhesus monkey (Macaca mulatta) [TaxId: 9544] [160074] (2)
  24. Mouse (Mus musculus), H-2KK [TaxId: 10090] [160075] (3)
    SQ P04223 22-197
  25. Human (Homo sapiens), HLA-G [TaxId: 9606] [160076] (4)
    SQ P17693 25-205! SQ P17693 26-205
  26. Mouse (Mus musculus), H-2M10 [TaxId: 10090] [160077] (5)
  27. Mouse (Mus musculus), H-2KD [TaxId: 10090] [160078] (2)
    SQ P01902 22-202
4. Hemochromatosis protein Hfe, alpha-1 and alpha-2 domains [88832]
  1. Human (Homo sapiens) [TaxId: 9606] [54480] (2)
5. Fc (IgG) receptor, alpha-1 and alpha-2 domains [54454]
  class I MHC-related
  1. Rat (Rattus norvegicus) [TaxId: 10116] [54455] (3)
  2. Human (Homo sapiens) [TaxId: 9606] [54493] (1)
6. CD1, alpha-1 and alpha-2 domains [54456]
  Class I MHC-related
  1. Mouse (Mus musculus) [TaxId: 10090] [54457] (10)
  2. Human (Homo sapiens), CD1b [TaxId: 9606] [75378] (3)
  3. Human (Homo sapiens), CD1a [TaxId: 9606] [102838] (4)
  4. Human (Homo sapiens), CD1d [TaxId: 9606] [160079] (4)
    SQ P15813 24-201
7. Zinc-alpha-2-glycoprotein, ZAG [54487]
  fat depleting factor related to class I MHC
  1. Human (Homo sapiens) [TaxId: 9606] [54488] (7)
    SQ P25311 22-294
8. Class I MHC homolog [54489]
  gamma, delta T-cell ligand
  1. Human (Homo sapiens), Mic-a [TaxId: 9606] [54490] (2)
  2. Human (Homo sapiens), Mic-b [TaxId: 9606] [75380] (1)
  3. Mouse (Mus musculus), t22 [TaxId: 10090] [54491] (3)
  4. Mouse (Mus musculus), t10 [TaxId: 10090] [102839] (1)
9. Class I MHC-related molecule Ulbp3 [69681]
  1. Human (Homo sapiens) [TaxId: 9606] [69682] (1)
10. NK cell ligand RAE-1 beta [69683]
  1. Mouse (Mus musculus) [TaxId: 10090] [69684] (2)
11. Endothelial protein C receptor [75381]
  phospholipid-binding protein
  1. Human (Homo sapiens) [TaxId: 9606] [75382] (2)
12. Immunomodulatory protein m144, alpha-1 and alpha-2 domains [110841]
  1. Murine cytomegalovirus [TaxId: 10366] [110842] (2)
    SQ Q69G19 27-263 # 95% sequence identity