Structural Classification of Proteins
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Fold: Cysteine proteinases

consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Cysteine proteinases [54000]
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Superfamilies:

  1. Cysteine proteinases [54001] (22)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
    link to SUPERFAMILY database - Superfamily
    1. Papain-like [54002] (30) picpic
    2. Avirulence protein Avrpph3 [102723] (1) picpic
    3. FMDV leader protease [54037] (1) picpic
    4. Calpain large subunit, catalytic domain (domain II) [54040] (5) picpic
    5. Transglutaminase core [54044] (6) picpic
    6. Arylamine N-acetyltransferase [54047] (4) picpic
      fold similar to that of the factor XIII catalytic domain
    7. Ubiquitin carboxyl-terminal hydrolase UCH-L [54050] (3) picpic
    8. Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (5) picpic
      Pfam 00443
    9. Adenain-like [54054] (5) picpic
      Pfam 02902; Ulp1 protease family
    10. Microbial transglutaminase [75336] (1) picpic
      inverted positions of the catalytic triad Asp and His residues
    11. Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110773] (1) picpic
      probably the same as Pfam 02338, OTU-like cysteine protease, but 1TFF (SQ Q96DC9) was not detected by the Pfam model
    12. IgG-specific endopeptidase IdeS (Sib38) [117762] (1) picpic
    13. Lpg0564-like [142864] (1) picpic
      Pfam 07313, DUF1460; contains new PDB entry 2p1g, annotated as putative xylanase
    14. Phytochelatin synthase [142867] (1) picpic
      Pfam 05023; assosiated Pfam 09328 (DUF1984) is a part of the same functional unit
    15. CHAP domain [142870] (1) picpic
      Pfam 05257
    16. NlpC/P60 [142873] (1) picpic
      Pfam 00877
    17. PMT C-terminal domain like [159843] (1) picpic
      displays a minimal thiol-protease fold and its catalytic triad; potential redox regulation: the catalytic cysteine can form a disulfide bond with an N-terminal cysteine
    18. MOA C-terminal domain-like [159846] (1) picpic
      PfamB 070855
    19. Atu2299-like [159849] (1) picpic
      Pfam 09641; DUF2026; putative Cys/Ser-His-Asp catalytic triad
    20. M48USP-like [159852] (1) picpic
      Pfam 04843; Herpesvirus tegument protein, N-terminal conserved region
    21. YiiX-like [159855] (1) picpic
      Pfam 06520; DUF1105; circularly permuted active site residues compare to papain
    22. Autophagin-like [159858] (2) picpic
      Pfam 03416

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MRC
site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk