Structural Classification of Proteins

Fold: Cysteine proteinases

: consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Cysteine proteinases [54000]
consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Superfamilies:

Cysteine proteinases [54001] (22)
the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
uperfamily
1. Papain-like [54002] (30)
2. Avirulence protein Avrpph3 [102723] (1)
3. FMDV leader protease [54037] (1)
4. Calpain large subunit, catalytic domain (domain II) [54040] (5)
5. Transglutaminase core [54044] (6)
6. Arylamine N-acetyltransferase [54047] (4)
  fold similar to that of the factor XIII catalytic domain
7. Ubiquitin carboxyl-terminal hydrolase UCH-L [54050] (3)
8. Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (5)
  Pfam 00443
9. Adenain-like [54054] (5)
  Pfam 02902; Ulp1 protease family
10. Microbial transglutaminase [75336] (1)
  inverted positions of the catalytic triad Asp and His residues
11. Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110773] (1)
  probably the same as Pfam 02338, OTU-like cysteine protease, but 1TFF (SQ Q96DC9) was not detected by the Pfam model
12. IgG-specific endopeptidase IdeS (Sib38) [117762] (1)
13. Lpg0564-like [142864] (1)
  Pfam 07313, DUF1460; contains new PDB entry 2p1g, annotated as putative xylanase
14. Phytochelatin synthase [142867] (1)
  Pfam 05023; assosiated Pfam 09328 (DUF1984) is a part of the same functional unit
15. CHAP domain [142870] (1)
  Pfam 05257
16. NlpC/P60 [142873] (1)
  Pfam 00877
17. PMT C-terminal domain like [159843] (1)
  displays a minimal thiol-protease fold and its catalytic triad; potential redox regulation: the catalytic cysteine can form a disulfide bond with an N-terminal cysteine
18. MOA C-terminal domain-like [159846] (1)
  PfamB 070855
19. Atu2299-like [159849] (1)
  Pfam 09641; DUF2026; putative Cys/Ser-His-Asp catalytic triad
20. M48USP-like [159852] (1)
  Pfam 04843; Herpesvirus tegument protein, N-terminal conserved region
21. YiiX-like [159855] (1)
  Pfam 06520; DUF1105; circularly permuted active site residues compare to papain
22. Autophagin-like [159858] (2)
  Pfam 03416