Structural Classification of Proteins
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Family: Papain-like

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Cysteine proteinases [54000]
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. Superfamily: Cysteine proteinases [54001]
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
    link to SUPERFAMILY database - Superfamily
  5. Family: Papain-like [54002]

Protein Domains:

  1. Actinidin [54003]
    1. Chinese gooseberry or kiwifruit (Actinidia chinensis) [TaxId: 3625] [54004] (2) picpic
  2. Papain [54005]
    1. Papaya (Carica papaya) [TaxId: 3649] [54006] (18) picpic
  3. Caricain (protease omega) [54007]
    1. Papaya (Carica papaya) [TaxId: 3649] [54008] (3) picpic
  4. Chymopapain [54009]
    1. Papaya (Carica papaya) [TaxId: 3649] [54010] (1) picpic
  5. Glycyl endopeptidase [54011]
    1. Papaya (Carica papaya) [TaxId: 3649] [54012] (1) picpic
  6. Proline-specific cysteine protease [54013]
    1. Ginger rhizome (Zingiber officinale) [TaxId: 94328] [54014] (1) picpic
  7. Ervatamin B [89803]
    1. Adam's apple (Ervatamia coronaria) [TaxId: 52861] [89804] (1) picpic
  8. Ervatamin C [102717]
    1. East indian rosebay (Ervatamia coronaria) [TaxId: 52861] [102718] (1) picpic
  9. Vignain (bean endopeptidase) [102719]
    1. Castor bean (Ricinus communis) [TaxId: 3988] [102720] (1) picpic
  10. Bleomycin hydrolase [54017]
    DNA-binding protease that has more insertions in the papain-like fold
    1. Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId: 4932] [54018] (3) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [54019] (2) picpic
  11. Cruzain [54020]
    1. Trypanosoma cruzi [TaxId: 5693] [54021] (17) picpic
  12. (Pro)cathepsin B [54022]
    1. Human (Homo sapiens) [TaxId: 9606] [54023] (6) picpic
    2. Rat (Rattus norvegicus) [TaxId: 10116] [54024] (4) picpic
    3. Cow (Bos taurus) [TaxId: 9913] [54025] (11) picpic
  13. Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330]
    1. Human (Homo sapiens) [TaxId: 9606] [75331] (1) picpic
    2. Rat (Rattus norvegicus) [TaxId: 10116] [82565] (1) picpic
  14. Cathepsin F [89805]
    1. Human (Homo sapiens) [TaxId: 9606] [89806] (1) picpic
  15. Cathepsin H [81637]
    also contains a disulfide-bound minicathepsin H chain
    1. Pig (Sus scrofa) [TaxId: 9823] [81636] (3) picpic
  16. (Pro)cathepsin K [54028]
    1. Human (Homo sapiens) [TaxId: 9606] [54029] (32) picpic
      SQ P43235 116-329 ! SQ P43235 115-329
    2. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [142845] (1) picpic
      SQ P43236 115-329
  17. (Pro)cathepsin L [54026]
    1. Human (Homo sapiens) [TaxId: 9606] [54027] (4) picpic
  18. (Pro)cathepsin S [82566]
    1. Human (Homo sapiens) [TaxId: 9606] [82567] (36) picpic
  19. (Pro)cathepsin V [64202]
    1. Human (Homo sapiens) [TaxId: 9606] [64203] (1) picpic
  20. (Pro)cathepsin X [54031]
    1. Human (Homo sapiens) [TaxId: 9606] [54032] (2) picpic
  21. Staphopain StpA [54033]
    1. Staphylococcus aureus [TaxId: 1280] [54034] (1) picpic
  22. Staphopain SspB [102721]
    1. Staphylococcus aureus [TaxId: 1280] [102722] (4) picpic
      SQ Q70UQ9 41-393
  23. Streptococcal pyrogenic exotoxin B [54035]
    1. Streptococcus pyogenes [TaxId: 1314] [54036] (2) picpic
      SQ P00788 31-398
  24. Falcipain 2 [142846]
    1. Plasmodium falciparum [TaxId: 5833] [142847] (6) picpic
      SQ Q9N6S8 244-484
  25. Major mite fecal allergen der p 1 [142848]
    1. House-dust mite (Dermatophagoides pteronyssinus) [TaxId: 6956] [142849] (3) picpic
      SQ P08176 19-320! SQ P08176 99-320
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk