Structural Classification of Proteins

Fold: Nucleotidyltransferase

: core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Nucleotidyltransferase [81302]
core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123

Superfamilies:

Nucleotidyltransferase [81301] (14)
uperfamily
1. Catalytic subunit of bi-partite nucleotidyltransferase [102932] (3)
  insert X in the core is an alpha-helix; minimal nucleotidyltransferase fold
2. Kanamycin nucleotidyltransferase (KNTase), N-terminal domain [56708] (1)
  insert X in the core is a beta-strand ; mixed 4-stranded sheet, order: 1243
3. Poly(A) polymerase, PAP, N-terminal domain [81589] (2)
  insert X in the core is an alpha-beta(2) unit; mixed 5-stranded sheet, order: 12543
4. 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain [102937] (1)
  similar overall structure to the first two domains of poly(A) polymerase, PAP
5. Archaeal tRNA CCA-adding enzyme catalytic domain [102940] (1)
  similar overall structure to poly(A) polymerase, PAP
6. DNA polymerase beta-like [81300] (5)
  insert X in the core is an alpha-beta(2) unit; mixed 5-stranded sheet, order: 12543; contains extra C-terminal alpha+beta subdomain
7. Poly A polymerase head domain-like [82661] (3)
  overlaps with the N-terminal part of Pfam 01743; this family is distinct from eukaryotic PAPs
  insert X in the core is an alpha-beta(2) unit; contains two extra C-terminal strands; mixed 7-stranded sheet, order: 7612543
8. RelA/SpoT domain [102945] (2)
  Pfam 04607; ppGpp-synthetase
9. GlnE-like domain [110933] (1)
  Pfam 03710; Pfam coverage excludes the extra N-terminal subdomain but includes a short segment of the next domain 2
10. RNA editing terminal uridyl transferase 2, RET2, catalytic domain [143236] (1)
  contains insert domain of a ferredoxin-like fold
11. TM1012-like [143239] (1)
  insert X in the core is an alpha-beta(2) unit; contains extra C-terminal structures; mixed 7-stranded sheet, order: 6712543;
12. Iojap/YbeB-like [160252] (2)
  Pfam 02410, probably has evolved a different function; closer relationship to the GrpB-like family
13. AadK N-terminal domain-like [160257] (1)
  N-terminal part of Pfam 04439; Streptomycin adenylyltransferase; insert X is alpha-beta(2) unit; overall domain architecture is similar to Kanamycin nucleotidyltransferase
14. GrpB-like [160260] (1)
  Pfam 04229, different set of active-site residues