Structural Classification of Proteins

Superfamily: Acyl-CoA N-acyltransferases (Nat)

: uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Acyl-CoA N-acyltransferases (Nat) [55728]
3 layers: a/b/a; contains mixed beta-sheet
Superfamily: Acyl-CoA N-acyltransferases (Nat) [55729]
uperfamily

Families:

N-acetyl transferase, NAT [55730] (60)
N-myristoyl transferase, NMT [55748] (3)
duplication: consists of two NAT-like domains swapped with the C-terminal strands
Autoinducer synthetase [75508] (2)
Pfam 00765
FemXAB nonribosomal peptidyltransferases [82749] (3)
duplication: consists of two NAT-like domains swapped with the C-terminal strands
Hypothetical protein cg14615-pa [103179] (1)
duplication: consists of two NAT-like domains swapped with the C-terminal strands
LFTR-like [143711] (1)
Pfam 03588; closer relative to the nonribosomal peptidyltransferases (scop_fa 82749); deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events
Ornithine decarboxylase antizyme-like [143714] (1)
Pfam 02100; may have evolved different function; putative active site maps to the same location in the common fold
AstA-like [143717] (1)
Pfam 04958; contains extra C-terminal domain, similar to the double psi beta-barrel fold (scop_cf 50684) with missing one strand and untangled psi-loops
Aq_1966-like [143720] (1)
Pfam 06557; DUF1122; probable biological unit is homotrimeric; may have evolved different function; putative active site maps to the same location in the common fold
EF1021-like [160644] (3)
duplication: consists of two NAT domains swapped with the C-terminal strands; overall structural similarity to Mycothiol synthase and N-myristoyl transferase (NMT); the similarity to NMT extends to the participation of the protein C-terminus (after the SCP2-like C-terminal domain) in the active site