Structural Classification of Proteins

Fold: Nuclear receptor ligand-binding domain

: multihelical; 3 layers or orthogonally packed helices

Lineage:

Root: scop
Class: All alpha proteins [46456]
Fold: Nuclear receptor ligand-binding domain [48507]
multihelical; 3 layers or orthogonally packed helices

Superfamilies:

Nuclear receptor ligand-binding domain [48508] (1)
uperfamily
1. Nuclear receptor ligand-binding domain [48509] (44)
  1. Retinoid-X receptor alpha (RXR-alpha) [48510]
    1. Human (Homo sapiens) [TaxId: 9606] [48511] (21)
      SQ P19793 227-458
    2. Mouse (Mus musculus) [TaxId: 10090] [48512] (2)
      SQ P28700 232-463
  2. Retinoid-X receptor beta (RXR-beta) [74792]
    1. Human (Homo sapiens) [TaxId: 9606] [74793] (2)
      SQ P28702 298-528
  3. Retinoic acid receptor alpha (RAR-alpha) [48513]
    1. Human (Homo sapiens) [TaxId: 9606] [48514] (1)
  4. Retinoic acid receptor gamma (RAR-gamma) [48515]
    1. Human (Homo sapiens) [TaxId: 9606] [48516] (9)
  5. Glucocorticoid receptor [89140]
    1. Human (Homo sapiens) [TaxId: 9606] [89141] (4)
  6. Orphan nuclear receptor NURR1 [89142]
    1. Human (Homo sapiens) [TaxId: 9606] [89143] (1)
  7. Nuclear hormone receptor HR38 [89144]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [89145] (1)
  8. Progesterone receptor [48517]
    1. Human (Homo sapiens) [TaxId: 9606] [48518] (8)
      SQ P06401 679-932
  9. Estrogen receptor alpha [48519]
    1. Human (Homo sapiens) [TaxId: 9606] [48520] (36)
      SQ P03372 307-551
  10. Estrogen receptor beta [48521]
    1. Human (Homo sapiens) [TaxId: 9606] [48522] (36)
    2. Rat (Rattus norvegicus) [TaxId: 10116] [48523] (4)
  11. Androgen receptor [63621]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [63622] (7)
    2. Human (Homo sapiens) [TaxId: 9606] [63623] (36)
      SQ P10275 671-919
    3. Chimpanzee (Pan troglodytes) [TaxId: 9598] [109986] (8)
      SQ O97775 661-910 # 100% sequence identity to human sequence (SQ P10275 669-918)
  12. Peroxisome proliferator activated receptor alpha, PPAR-alpha [69109]
    1. Human (Homo sapiens) [TaxId: 9606] [69110] (5)
  13. Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524]
    1. Human (Homo sapiens) [TaxId: 9606] [48525] (72)
      SQ P37231 232-505
  14. Peroxisome proliferator-activated receptor delta, PPAR-DELTA [48526]
    1. Human (Homo sapiens) [TaxId: 9606] [48527] (18)
  15. Pregnane x receptor, PXR [63624]
    1. Human (Homo sapiens) [TaxId: 9606] [63625] (6)
  16. Vitamin D nuclear receptor [48528]
    1. Human (Homo sapiens) [TaxId: 9606] [48529] (13)
    2. Rat (Rattus norvegicus) [TaxId: 10116] [101432] (12)
  17. Thyroid hormone receptor beta (TR-beta) [48530]
    1. Human (Homo sapiens) [TaxId: 9606] [48531] (11)
      SQ P10828 202-460
  18. Thyroid hormone receptor alpha1 (TR-alpha1) [48532]
    1. Human (Homo sapiens) [TaxId: 9606] [88962] (1)
  19. Ultraspiracle protein, usp [48534]
    the ortholog of RXRs in insects
    1. Drosophila melanogaster [TaxId: 7227] [48535] (1)
    2. Heliothis virescens [TaxId: 7102] [63626] (4)
  20. Orphan nuclear receptor ROR-alpha [81914]
    1. Human (Homo sapiens) [TaxId: 9606] [81915] (2)
  21. Orphan nuclear receptor ROR-beta [74794]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [74795] (3)
  22. Orphan nuclear receptor ERR3 [81916]
    1. Human (Homo sapiens) [TaxId: 9606] [81917] (26)
      SQ O75454 233-458
  23. Hepatocyte nuclear factor 4-gamma [81918]
    1. Human (Homo sapiens) [TaxId: 9606] [81919] (1)
  24. Hepatocyte nuclear factor 4-alpha [109605]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [89146] (1)
    2. Human (Homo sapiens) [TaxId: 9606] [109987] (1)
      SQ P41235 139-369
  25. Orphan nuclear receptor NR5a2 (LRH-1) [89147]
    1. Mouse (Mus musculus) [TaxId: 10090] [89148] (1)
  26. Oxysterols receptor LXR-beta [89149]
    1. Human (Homo sapiens) [TaxId: 9606] [89150] (6)
      SQ P55055 219-461
  27. Bile acid receptor FXR [101433]
    1. Human (Homo sapiens) [TaxId: 9606] [101434] (5)
    2. Rat (Rattus norvegicus) [TaxId: 10116] [101435] (2)
  28. Ecdysone receptor [101436]
    1. Noctuid moth (Heliothis virescens) [TaxId: 7102] [101437] (3)
  29. Oxysterols receptor LXR-alpha [109988]
    1. Human (Homo sapiens) [TaxId: 9606] [109989] (1)
      SQ Q13133 207-445
    2. Mouse (Mus musculus) [TaxId: 10090] [158810] (4)
      SQ Q9Z0Y9 203-443
  30. Steroid hormone receptor ERR1 [109990]
    1. Human (Homo sapiens) [TaxId: 9606] [109991] (3)
      SQ P11474 289-516
  31. Retinoic acid receptor beta (RAR-beta) [117011]
    1. Mouse (Mus musculus) [TaxId: 10090] [117012] (1)
      SQ P22605 209-453
    2. Human (Homo sapiens) [TaxId: 9606] [117013] (1)
      SQ P10826 182-416
  32. Orphan nuclear receptor NR1I3 (CAR) [117014]
    1. Mouse (Mus musculus) [TaxId: 10090] [117015] (2)
      SQ O35627 109-358
    2. Human (Homo sapiens) [TaxId: 9606] [117016] (2)
      SQ Q14994 103-352
  33. Orphan nuclear receptor NR4A1 [158811]
    1. Human (Homo sapiens) [TaxId: 9606] [158812] (4)
      SQ P22736 363-595