Structural Classification of Proteins

Fold: P-loop containing nucleoside triphosphate hydrolases

: 3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: P-loop containing nucleoside triphosphate hydrolases [52539]
3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

Superfamilies:

P-loop containing nucleoside triphosphate hydrolases [52540] (24)
division into families based on beta-sheet topologies
uperfamily
1. Nucleotide and nucleoside kinases [52541] (46)
  parallel beta-sheet of 5 strands, order 23145
2. Shikimate kinase (AroK) [52566] (4)
  similar to the nucleotide/nucleoside kinases but acts on different substrate
3. Chloramphenicol phosphotransferase [52569] (1)
  similar to the nucleotide/nucleoside kinases but acts on different substrate
4. Gluconate kinase [75195] (1)
  similar to the nucleotide/nucleoside kinases
5. Plasmid maintenance system epsilon/zeta, toxin zeta subunit [82395] (1)
  similar to the nucleotide/nucleoside kinases; extra N- and C-terminal structures
6. Adenosine-5'phosphosulfate kinase (APS kinase) [52572] (2)
7. ATP sulfurylase C-terminal domain [64011] (2)
8. PAPS sulfotransferase [52575] (15)
  Pfam 00685
  similar to the nucleotide/nucleoside kinases but transfer sulphate group
9. Phosphoribulokinase/pantothenate kinase [52584] (5)
10. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [52589] (2)
11. G proteins [52592] (118)
  core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest
12. Motor proteins [52641] (15)
13. Nitrogenase iron protein-like [52652] (29)
  core: parallel beta-sheet of 7 strands; order 3241567
14. RecA protein-like (ATPase-domain) [52670] (29)
  core: mixed beta-sheet of 8 strands, order 32451678; strand 7 is antiparallel to the rest
15. Bacterial cell division inhibitor SulA [89678] (1)
  homologous to RecA but lacks its P-loop motif; the fold is C-terminally truncated; 5-stranded parallel beta-sheet, order: 15423
16. ABC transporter ATPase domain-like [52686] (29)
  there are two additional subdomains inserted into the central core that has a RecA-like topology
17. Tandem AAA-ATPase domain [81268] (27)
  duplication: tandem repeat of two RecA-like (AAA) domains
18. Extended AAA-ATPase domain [81269] (34)
  fold is similar to that of RecA, but lacks the last two strands, followed by a family-specific Arg-finger domain
19. RNA helicase [52724] (3)
  duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension
20. Helicase-like "domain" of reverse gyrase [69496] (1)
21. DNA helicase UvsW [102396] (1)
  contains extra N-terminal alpha+beta subdomain
22. YjeE-like [75213] (1)
  mixed beta-sheet; order 234156(0), strands 2 and 6 are antiparallel to the rest
23. Type II thymidine kinase [117558] (3)
  N-terminal part of Pfam 00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (scop_pr 52684)
24. Atu3015-like [142332] (2)
  unknown function; similar to the nucleotide/nucleoside kinases