Structural Classification of Proteins
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Fold: P-loop containing nucleoside triphosphate hydrolases

3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: P-loop containing nucleoside triphosphate hydrolases [52539]
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

Superfamilies:

  1. P-loop containing nucleoside triphosphate hydrolases [52540] (24)
    division into families based on beta-sheet topologies
    link to SUPERFAMILY database - Superfamily
    1. Nucleotide and nucleoside kinases [52541] (46) picpic
      parallel beta-sheet of 5 strands, order 23145
    2. Shikimate kinase (AroK) [52566] (4) picpic
      similar to the nucleotide/nucleoside kinases but acts on different substrate
    3. Chloramphenicol phosphotransferase [52569] (1) picpic
      similar to the nucleotide/nucleoside kinases but acts on different substrate
    4. Gluconate kinase [75195] (1) picpic
      similar to the nucleotide/nucleoside kinases
    5. Plasmid maintenance system epsilon/zeta, toxin zeta subunit [82395] (1) picpic
      similar to the nucleotide/nucleoside kinases; extra N- and C-terminal structures
    6. Adenosine-5'phosphosulfate kinase (APS kinase) [52572] (2) picpic
    7. ATP sulfurylase C-terminal domain [64011] (2) picpic
    8. PAPS sulfotransferase [52575] (15) picpic
      Pfam 00685
      similar to the nucleotide/nucleoside kinases but transfer sulphate group
    9. Phosphoribulokinase/pantothenate kinase [52584] (5) picpic
    10. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [52589] (2) picpic
    11. G proteins [52592] (118) picpic
      core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest
    12. Motor proteins [52641] (15) picpic
    13. Nitrogenase iron protein-like [52652] (29) picpic
      core: parallel beta-sheet of 7 strands; order 3241567
    14. RecA protein-like (ATPase-domain) [52670] (29) picpic
      core: mixed beta-sheet of 8 strands, order 32451678; strand 7 is antiparallel to the rest
    15. Bacterial cell division inhibitor SulA [89678] (1) picpic
      homologous to RecA but lacks its P-loop motif; the fold is C-terminally truncated; 5-stranded parallel beta-sheet, order: 15423
    16. ABC transporter ATPase domain-like [52686] (29) picpic
      there are two additional subdomains inserted into the central core that has a RecA-like topology
    17. Tandem AAA-ATPase domain [81268] (27) picpic
      duplication: tandem repeat of two RecA-like (AAA) domains
    18. Extended AAA-ATPase domain [81269] (34) picpic
      fold is similar to that of RecA, but lacks the last two strands, followed by a family-specific Arg-finger domain
    19. RNA helicase [52724] (3) picpic
      duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension
    20. Helicase-like "domain" of reverse gyrase [69496] (1) picpic
    21. DNA helicase UvsW [102396] (1) picpic
      contains extra N-terminal alpha+beta subdomain
    22. YjeE-like [75213] (1) picpic
      mixed beta-sheet; order 234156(0), strands 2 and 6 are antiparallel to the rest
    23. Type II thymidine kinase [117558] (3) picpic
      N-terminal part of Pfam 00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (scop_pr 52684)
    24. Atu3015-like [142332] (2) picpic
      unknown function; similar to the nucleotide/nucleoside kinases

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site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk