Structural Classification of Proteins
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Family: Extended AAA-ATPase domain

fold is similar to that of RecA, but lacks the last two strands, followed by a family-specific Arg-finger domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: P-loop containing nucleoside triphosphate hydrolases [52539]
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. Superfamily: P-loop containing nucleoside triphosphate hydrolases [52540]
    division into families based on beta-sheet topologies
    link to SUPERFAMILY database - Superfamily
  5. Family: Extended AAA-ATPase domain [81269]
    fold is similar to that of RecA, but lacks the last two strands, followed by a family-specific Arg-finger domain

Protein Domains:

  1. gamma subunit of DNA polymerase III, N-domain [64031]
    1. Escherichia coli [TaxId: 562] [64032] (3) picpic
      SQ P06710 5-368
    2. Thermotoga maritima [TaxId: 2336] [142324] (1) picpic
      SQ Q9WZM9 11-208
  2. delta prime subunit of DNA polymerase III, N-domain [52711]
    contains additional alpha-helical domain after the family specific domains
    1. Escherichia coli [TaxId: 562] [52712] (6) picpic
      SQ P28631
  3. delta subunit of DNA polymerase III, N-domain [64033]
    1. Escherichia coli [TaxId: 562] [64034] (5) picpic
      SQ P28630
  4. Replication factor C [64035]
    contains additional alpha-helical domain after the family specific domains
    1. Archaeon Pyrococcus furiosus [TaxId: 2261] [64036] (1) picpic
  5. Chromosomal replication initiation factor DnaA [82416]
    contains TrpR-like DNA-binding domain after the family specific domains
    1. Aquifex aeolicus [TaxId: 63363] [82417] (5) picpic
  6. Holliday junction helicase RuvB [52713]
    contains "winged helix" DNA-binding domain after the family specific domains
    1. Thermus thermophilus [TaxId: 274] [52714] (3) picpic
    2. Thermotoga maritima [TaxId: 2336] [64037] (6) picpic
  7. Transcriptional activator sigm54 (NtrC1), C-terminal domain [102389]
    1. Aquifex aeolicus [TaxId: 63363] [102390] (2) picpic
  8. CDC6, N-domain [52715]
    contains "winged helix" DNA-binding domain after the family specific domains
    1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [52716] (1) picpic
  9. Hexamerization domain of N-ethylmalemide-sensitive fusion (NSF) protein [52717]
    1. Chinese hamster (Cricetulus griseus) [TaxId: 10029] [52718] (2) picpic
  10. Membrane fusion ATPase VCP/p97 [64038]
    1. Mouse (Mus musculus) [TaxId: 10090] [64039] (4) picpic
  11. AAA domain of cell division protein FtsH [82418]
    ATP-dependent protease
    1. Escherichia coli [TaxId: 562] [82419] (1) picpic
    2. Thermus thermophilus [TaxId: 274] [82420] (4) picpic
    3. Thermotoga maritima [TaxId: 2336] [142325] (12) picpic
      SQ Q9WZ49 150-402
  12. HslU [52721]
    ATPase subunit of ATP-dependent protease
    1. Escherichia coli [TaxId: 562] [52722] (10) picpic
    2. Haemophilus influenzae [TaxId: 727] [52723] (6) picpic
  13. ClpX [102391]
    ATPase subunit of ATP-dependent protease
    1. Helicobacter pylori [TaxId: 210] [102392] (1) picpic
  14. ATPase domain of protease Lon (La) [102393]
    1. Escherichia coli [TaxId: 562] [102394] (1) picpic
  15. ClpA, an Hsp100 chaperone, AAA+ modules [82421]
    duplication: two AAA+ modules; the first module is structurally similar to the CDC6 module whereas the second module to the HslU module
    1. Escherichia coli [TaxId: 562] [82422] (2) picpic
      SQ Q83LR6
  16. ClpB, AAA+ modules [75211]
    ATPase subunit of ATP-dependent protease; similar domain organization to ClpA
    1. Thermus thermophilus [TaxId: 274] [102395] (1) picpic
    2. Escherichia coli [TaxId: 562] [75212] (1) picpic
  17. ATPase subunit of magnesium chelatase, BchI [64040]
    1. Rhodobacter capsulatus [TaxId: 1061] [64041] (1) picpic
  18. Papillomavirus large T antigen helicase domain [89688]
    1. Simian virus 40 [TaxId: 10633] [89689] (16) picpic
      SQ P03070 265-627
  19. Rep 40 protein helicase domain [110564]
    1. Adeno-associated virus 2, AAV2 [TaxId: 10804] [110565] (2) picpic
      SQ P03132 225-490
  20. Replication factor C1 [110566]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110567] (1) picpic
      SQ P38630 295-696
  21. Replication factor C4 [110568]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110569] (1) picpic
      SQ P40339
  22. Replication factor C3 [110570]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110571] (1) picpic
      SQ P38629
  23. Replication factor C2 [110572]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110573] (1) picpic
      SQ P40348
  24. Replication factor C5 [110574]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110575] (1) picpic
      SQ P38251
  25. Replication protein E1 helicase domain [110576]
    1. Human papillomavirus type 18 [TaxId: 333761] [110577] (1) picpic
      SQ P06789 428-629 # structure of the origin-binding domain (210-354) is also known, 1r9w (scop_sp 103119)
  26. CDC6-like protein APE0152, N-terminal domain [117556]
    1. Aeropyrum pernix [TaxId: 56636] [117557] (2) picpic
      SQ Q9YFU8
  27. Archaeal ATPase SSO1545 [142326]
    member of Pfam 01637 family; overall structural similarity to the archael CDC6-like protein APE0102
    1. Sulfolobus solfataricus [TaxId: 2287] [142327] (2) picpic
      SQ Q97Y08 1-283
  28. CED-4, NB-ARC domain [159577]
    belongs to Pfam 00931
    1. Caenorhabditis elegans [TaxId: 6239] [159578] (1) picpic
      SQ P30429 109-385
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk