Structural Classification of Proteins
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Family: G proteins

core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: P-loop containing nucleoside triphosphate hydrolases [52539]
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. Superfamily: P-loop containing nucleoside triphosphate hydrolases [52540]
    division into families based on beta-sheet topologies
    link to SUPERFAMILY database - Superfamily
  5. Family: G proteins [52592]
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Protein Domains:

  1. cH-p21 Ras protein [52593]
    1. Human (Homo sapiens) [TaxId: 9606] [52594] (57) picpic
      SQ Q6P716
  2. Rac [52595]
    1. Human (Homo sapiens) [TaxId: 9606] [52596] (23) picpic
  3. Ras-related protein RalA [89662]
    1. Human (Homo sapiens) [TaxId: 9606] [89663] (7) picpic
    2. Cotton-top tamarin (Saguinus oedipus) [TaxId: 9490] [117532] (3) picpic
      SQ P63320 # 100% identical to the mouse and rat orthologs (SQ P63321 P63322)
  4. Rap1A [52597]
    1. Human (Homo sapiens) [TaxId: 9606] [52598] (2) picpic
  5. Rap2a [52599]
    1. Human (Homo sapiens) [TaxId: 9606] [52600] (3) picpic
  6. Rab3a [52601]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [52602] (2) picpic
  7. Rab5a [82399]
    1. Human (Homo sapiens) [TaxId: 9606] [82400] (11) picpic
      SQ P20339 18-182
  8. Rab5c [52603]
    1. Mouse (Mus musculus) [TaxId: 10090] [52604] (4) picpic
  9. Rab6 [52605]
    1. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [52606] (1) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [142216] (1) picpic
      SQ P20340 13-176
  10. Rab11a [102362]
    1. Human (Homo sapiens) [TaxId: 9606] [102363] (13) picpic
    2. Saccharomyces cerevisiae [TaxId: 4932] [159558] (4) picpic
  11. Rab-related protein Sec4 [52607]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52608] (5) picpic
  12. Rab-related protein ypt7p [75199]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [75200] (2) picpic
  13. Ran [52609]
    1. Dog (Canis familiaris) [TaxId: 9615] [52610] (6) picpic
      SQ P62825
    2. Human (Homo sapiens) [TaxId: 9606] [52611] (7) picpic
  14. RhoA [52612]
    1. Human (Homo sapiens) [TaxId: 9606] [52613] (14) picpic
      SQ P61586 2-181
  15. RhoE (RND3) [75201]
    1. Mouse (Mus musculus) [TaxId: 10090] [75202] (2) picpic
  16. ADP-ribosylation factor [52614]
    1. Human (Homo sapiens), ARF1 [TaxId: 9606] [52615] (14) picpic
      SQ P32889
    2. Rat (Rattus norvegicus), ARF1 [TaxId: 10116] [52616] (2) picpic
    3. Human (Homo sapiens), ARF6 [TaxId: 9606] [52617] (6) picpic
    4. Mouse (Mus musculus), ARL3 [TaxId: 10090] [52618] (2) picpic
    5. Mouse (Mus musculus), ARL2 [TaxId: 10090] [75203] (3) picpic
    6. Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId: 4932] [82401] (1) picpic
    7. Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId: 4932] [82402] (1) picpic
    8. Human (Homo sapiens), ARL1 [TaxId: 9606] [102364] (2) picpic
    9. Human (Homo sapiens), ARF4 [TaxId: 9606] [142217] (2) picpic
      SQ P18085 3-177
    10. Human (Homo sapiens), ARL5A [TaxId: 9606] [142218] (3) picpic
      SQ Q9Y689 2-178
    11. Human (Homo sapiens), ARL8A [TaxId: 9606] [142219] (1) picpic
      SQ Q96BM9 18-181
    12. Human (Homo sapiens) [TaxId: 9606] [142220] (1) picpic
      SQ P84085 6-179
    13. Human (Homo sapiens), ARL5B [TaxId: 9606] [142221] (1) picpic
      SQ Q96KC2 6-173
    14. Human(Homo sapiens), ARL8B [TaxId: 9606] [142222] (1) picpic
      SQ Q9NVJ2 18-182
  17. SAR1 [69483]
    1. Chinese hamster (Cricetulus griseus) [TaxId: 10029] [69484] (3) picpic
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82403] (2) picpic
    3. Human (Homo sapiens) [TaxId: 9606] [142223] (2) picpic
      SQ Q9NR31 13-198
  18. CDC42 [52619]
    1. Human (Homo sapiens) [TaxId: 9606] [52620] (21) picpic
    2. Mus musculus [TaxId: 10090] [159559] (2) picpic
  19. Ypt51 [52621]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52622] (1) picpic
  20. Chloroplast protein translocon GTPase Toc34 [69485]
    1. Garden pea (Pisum sativum) [TaxId: 3888] [69486] (1) picpic
  21. Signal recognition particle receptor beta-subunit [89664]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [89665] (1) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [142224] (2) picpic
      SQ P47758 63-269
  22. Transducin (alpha subunit) [52623]
    common fold is interrupted with an all-alpha domain
    1. Cow (Bos taurus) [TaxId: 9913] [52624] (15) picpic
      SQ P04896 39-388
    2. Rat (Rattus norvegicus) [TaxId: 10116] [52625] (33) picpic
      SQ P10824
    3. Mouse (Mus musculus) [TaxId: 10090] [142225] (6) picpic
      SQ P21279 38-66,184-354! SQ P27600 53-81,204-370! SQ P27601 47-75,202-372
    4. Homo sapiens [TaxId: 9606] [159560] (4) picpic
  23. Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626]
    1. Escherichia coli [TaxId: 562] [52627] (10) picpic
      SQ P02990
    2. Thermus aquaticus [TaxId: 271] [52628] (4) picpic
    3. Thermus thermophilus [TaxId: 274] [52629] (9) picpic
    4. Cow (Bos taurus), mitochondrial [TaxId: 9913] [52630] (2) picpic
      SQ P49410 56-452
  24. Elongation factor eEF-1alpha, N-terminal (G) domain [52631]
    eukaryotic and archaeal homologue of EF-Tu
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52632] (6) picpic
    2. Archaeon Sulfolobus solfataricus [TaxId: 2287] [69487] (2) picpic
      SQ P35021
  25. Elongation factor G (EF-G), N-terminal (G) domain [52633]
    has internal nucleotide exchange factor built in as an insertion subdomain
    1. Thermus thermophilus [TaxId: 274] [52634] (9) picpic
      residues 160-252 comprise insertion subdomain
    2. Thermus thermophilus, EF-G-2 [TaxId: 274] [142226] (2) picpic
      SQ Q5SI76 1-267
      TTHA1498
  26. Elongation factor 2 (eEF-2), N-terminal (G) domain [82404]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82405] (22) picpic
      SQ P32324
  27. Initiation factor IF2/eIF5b, N-terminal (G) domain [52635]
    1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [52636] (3) picpic
  28. Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204]
    includes rubredoxin-like zinc finger insert domain, res. 56-83, similar that of the Nop10-like family (scop_fa 144211)
    1. Archaeon Pyrococcus abyssi [TaxId: 29292] [75205] (5) picpic
    2. Archaeon Methanococcus jannaschii [TaxId: 2190] [102365] (1) picpic
    3. Sulfolobus solfataricus [TaxId: 2287] [142227] (6) picpic
      SQ Q980A5 2-206
  29. GTPase Era, N-terminal domain [52637]
    1. Escherichia coli [TaxId: 562] [52638] (3) picpic
    2. Thermus thermophilus [TaxId: 274] [117533] (1) picpic
      SQ Q5SM23
  30. Probable tRNA modification GTPase TrmE (MnmE), G domain [102366]
    1. Escherichia coli [TaxId: 562] [102367] (11) picpic
  31. Probable GTPase Der, N-terminal and middle domains [82406]
    member of EngA subfamily of GTPases; contains two G domains
    1. Thermotoga maritima [TaxId: 2336] [82407] (1) picpic
  32. Obg GTP-binding protein middle domain [82408]
    1. Bacillus subtilis [TaxId: 1423] [82409] (1) picpic
    2. Thermus thermophilus [TaxId: 274] [102368] (1) picpic
      TT1381
  33. YchF GTP-binding protein N-terminal domain [82410]
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [82411] (1) picpic
    2. Haemophilus influenzae [TaxId: 727] [89666] (1) picpic
      HI0393
  34. Probable GTPase EngB [89667]
    1. Escherichia coli [TaxId: 562] [89668] (1) picpic
    2. Bacillus subtilis [TaxId: 1423] [110534] (3) picpic
      SQ P38424
  35. Probable GTPase YlqF [89669]
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain
    1. Bacillus subtilis [TaxId: 1423] [89670] (1) picpic
  36. Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639]
    1. Human (Homo sapiens) [TaxId: 9606] [52640] (2) picpic
  37. Dynamin G domain [69488]
    the family common core is decorated with large insertions
    1. Dictyostelium discoideum [TaxId: 44689] [69489] (2) picpic
    2. Rat (Rattus norvegicus) [TaxId: 10116] [142228] (1) picpic
      SQ P21575 6-304
      Dynamin-1
  38. Eukaryotic peptide chain release factor ERF2, G domain [110535]
    1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [110536] (3) picpic
      SQ O74718
  39. Rab9a [110537]
    1. Dog (Canis familiaris) [TaxId: 9615] [110538] (1) picpic
      SQ P24408
    2. Human (Homo sapiens) [TaxId: 9606] [110539] (1) picpic
      SQ P51151 2-175 # 100% sequence identity do the dog protein (SQ P24408 2-175)
    3. Mouse (Mus musculus) [TaxId: 10090] [142229] (1) picpic
      SQ Q9R0M6 4-175
  40. Rab7 [110540]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [110541] (4) picpic
      SQ P09527
    2. Human (Homo sapiens) [TaxId: 9606] [142230] (5) picpic
      SQ P51149 7-182
  41. Probable GTPase EngC (YjeQ), C-terminal domain [110542]
    circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain
    1. Thermotoga maritima [TaxId: 2336] [110543] (1) picpic
      SQ Q9X242 # TM1717
    2. Bacillus subtilis [TaxId: 1423] [117534] (1) picpic
      SQ O34530
  42. GTPase Ytp1 [110544]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110545] (2) picpic
      SQ P01123
  43. Interferon-inducible GTPase [110546]
    G domain is inserted in all-alpha domain
    1. Mouse (Mus musculus) [TaxId: 10090] [110547] (5) picpic
      SQ Q9QZ85 # all-alpha domain (14-68,252-415)
  44. TrmE GTPase domain [117535]
    1. Thermotoga maritima [TaxId: 2336] [117536] (2) picpic
      SQ Q9WYA4
  45. Elongation factor SelB, N-terminal domain [117537]
    1. Methanococcus maripaludis [TaxId: 39152] [117538] (3) picpic
      SQ Q8J307
  46. Rab23 [142231]
    1. Mouse (Mus musculus) [TaxId: 10090] [142232] (2) picpic
      SQ P35288 8-171
  47. Rab18 [142233]
    1. Human (Homo sapiens) [TaxId: 9606] [142234] (1) picpic
      SQ Q9NP72 2-178
  48. Rab31 [142235]
    1. Human (Homo sapiens) [TaxId: 9606] [142236] (1) picpic
      SQ Q13636 3-167
  49. Rab11b [142237]
    1. Human (Homo sapiens) [TaxId: 9606] [142238] (2) picpic
      SQ Q15907 7-181
  50. Rab30 [142239]
    1. Human (Homo sapiens) [TaxId: 9606] [142240] (1) picpic
      SQ Q15771 5-175
  51. Rab1a [142241]
    1. Human (Homo sapiens) [TaxId: 9606] [142242] (1) picpic
      SQ P62820 7-175
  52. RhoB [142243]
    1. Human (Homo sapiens) [TaxId: 9606] [142244] (1) picpic
      SQ P62745 4-185
  53. RhoC [142245]
    1. Human (Homo sapiens) [TaxId: 9606] [142246] (2) picpic
      SQ P08134 1-179
  54. Rab4a [142247]
    1. Human (Homo sapiens) [TaxId: 9606] [142248] (5) picpic
      SQ P20338 2-172! SQ P20338 4-172! SQ P20338 4-184
  55. Centaurin gamma 1, G domain [142249]
    1. Human (Homo sapiens) [TaxId: 9606] [142250] (1) picpic
      SQ Q99490 402-576
  56. GTP-binding protein PH0525 [142251]
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. Pyrococcus horikoshii [TaxId: 53953] [142252] (1) picpic
      SQ O58261 1-319
  57. Rab-22a [142253]
    1. Mouse (Mus musculus) [TaxId: 10090] [142254] (2) picpic
      SQ P35285 2-167! SQ P35285 2-168
  58. Rac3 [142255]
    1. Human (Homo sapiens) [TaxId: 9606] [142256] (2) picpic
      SQ P60763 3-177
  59. GTP-binding protein engB [142257]
    1. Pyrococcus horikoshii [TaxId: 53953] [142258] (3) picpic
      SQ O57939 28-211
      PH0200
  60. Rab26 [142259]
    1. Human (Homo sapiens) [TaxId: 9606] [142260] (1) picpic
      SQ Q9ULW5 58-227
  61. RhoQ [142261]
    1. Human (Homo sapiens) [TaxId: 9606] [142262] (2) picpic
      SQ P17081 1-185
  62. Rab27b [142263]
    1. Human (Homo sapiens) [TaxId: 9606] [142264] (2) picpic
      SQ O00194 4-189
  63. Rab2a [142265]
    1. Human (Homo sapiens) [TaxId: 9606] [142266] (4) picpic
      SQ P61019 2-170
  64. di-Ras2 [142267]
    1. Human (Homo sapiens) [TaxId: 9606] [142268] (2) picpic
      SQ Q96HU8 6-176
  65. Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269]
    1. Pseudomonas syringae pv. tomato [TaxId: 323] [142270] (1) picpic
      SQ Q87WW1 16-237
  66. Rab14 [142271]
    1. Human (Homo sapiens) [TaxId: 9606] [142272] (2) picpic
      SQ P61106 7-174
  67. r-Ras [142273]
    1. Human (Homo sapiens) [TaxId: 9606] [142274] (1) picpic
      SQ P10301 24-196
  68. GTP-binding protein RheB [142275]
    1. Human (Homo sapiens) [TaxId: 9606] [142276] (3) picpic
      SQ Q15382 3-169
  69. di-Ras1 [142277]
    1. Human (Homo sapiens) [TaxId: 9606] [142278] (4) picpic
      SQ O95057 4-176
  70. Rab-33b [142279]
    1. Mouse (Mus musculus) [TaxId: 10090] [142280] (2) picpic
      SQ O35963 32-196
  71. r-Ras2 [142281]
    1. Human (Homo sapiens) [TaxId: 9606] [142282] (2) picpic
      SQ P62070 10-180
  72. Ras-related protein M-Ras (XRas) [142283]
    1. Mouse (Mus musculus) [TaxId: 10090] [142284] (2) picpic
      SQ O08989 10-178
  73. Rab21 [142285]
    1. Human (Homo sapiens) [TaxId: 9606] [142286] (10) picpic
      SQ Q9UL25 16-182
  74. Rab2b [142287]
    1. Human (Homo sapiens) [TaxId: 9606] [142288] (1) picpic
      SQ Q8WUD1 4-176
  75. GTP-binding protein GEM [142289]
    1. Human (Homo sapiens) [TaxId: 9606] [142290] (1) picpic
      SQ P55040 73-244
  76. Ras-like estrogen-regulated growth inhibitor, RERG [142291]
    1. Human (Homo sapiens) [TaxId: 9606] [142292] (1) picpic
      SQ Q96A58 5-172
  77. Rab8a [142293]
    1. Mouse (Mus musculus) [TaxId: 10090] [142294] (2) picpic
      SQ P55258 3-175
  78. Rad [142295]
    1. Human (Homo sapiens) [TaxId: 9606] [142296] (2) picpic
      SQ P55042 91-258
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk