Family: Tandem AAA-ATPase domain

duplication: tandem repeat of two RecA-like (AAA) domains

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: P-loop containing nucleoside triphosphate hydrolases [52539]
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
4. Superfamily: P-loop containing nucleoside triphosphate hydrolases [52540]
   division into families based on beta-sheet topologies
   uperfamily
5. Family: Tandem AAA-ATPase domain [81268]
   duplication: tandem repeat of two RecA-like (AAA) domains

Protein Domains:

1. DEXX box DNA helicase [52701]
   each AAA domain contains an all-alpha insert subdomain
   1. Bacillus stearothermophilus, PcrA [TaxId: 1422] [52702] (5)
   2. Escherichia coli, RepD [TaxId: 562] [52703] (1)
2. Putative DEAD box RNA helicase [52704]
   homologous to eIF4a and UvrB
   1. Archaeon Methanococcus jannaschii [TaxId: 2190] [52705] (1)
3. Probable DEAD box RNA helicase YqfR [102383]
   1. Bacillus stearothermophilus [TaxId: 1422] [102384] (1)
4. RecQ helicase domain [102385]
   1. Escherichia coli [TaxId: 562] [102386] (2)
5. DEAD box RNA helicase rck/p54 [102387]
   1. Human (Homo sapiens) [TaxId: 9606] [102388] (1)
6. RecG helicase domain [69494]
   1. Thermotoga maritima [TaxId: 2336] [69495] (1)
7. Initiation factor 4a [52706]
   homologous to UvrB
   1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52707] (5)
   2. Human (Homo sapiens) [TaxId: 9606] [142305] (2)
      SQ P60842 21-238
      4A-I
8. Nucleotide excision repair enzyme UvrB [52708]
   contains large insertions in the first AAA domain
   1. Thermus thermophilus [TaxId: 274] [52709] (2)
   2. Bacillus caldotenax [TaxId: 1395] [52710] (7)
      SQ P56981
9. Translocation ATPase SecA, nucleotide-binding domains [82414]
   a pre-protein crosslinking domain inserted in the first AAA domain
   1. Bacillus subtilis [TaxId: 1423] [82415] (4)
      SQ P28366
   2. Mycobacterium tuberculosis [TaxId: 1773] [89687] (2)
10. Spliceosome RNA helicase BAT1 (UAP56) [110562]
    1. Human (Homo sapiens) [TaxId: 9606] [110563] (5)
       SQ Q13838 45-428
11. Exodeoxyribonuclease V beta chain (RecB), N-terminal domain [117550]
    each AAA domain contains an all-alpha insert subdomain
    1. Escherichia coli [TaxId: 562] [117551] (1)
       SQ P08394
12. Exodeoxyribonuclease V gamma chain (RecC), N-terminal domain [117552]
    each AAA domain contains an all-alpha insert subdomain
    1. Escherichia coli [TaxId: 562] [117553] (1)
       SQ P07648
13. Exodeoxyribonuclease V alpha chain (RecD) [117554]
    contains extra N-terminal alpha+beta (sub)domain (~100 residues)
    1. Escherichia coli [TaxId: 562] [117555] (1)
       SQ P04993
14. putative ATP-dependent RNA helicase VlgB [142306]
    1. Flatworm (Dugesia japonica) [TaxId: 6161] [142307] (2)
       SQ O97032 164-401
15. putative ATP-dependent RNA helicase PF2015 [142308]
    separate structures of other domains are known: the middle nuclease domain (scop_sp 89718) and the C-terminal RuvA-like HhH domain (PDB 1x2i)
    1. Pyrococcus furiosus [TaxId: 2261] [142309] (2)
       SQ Q8TZH8 2-201! SQ Q8TZH8 202-487
16. ATP-dependent RNA helicase DDX25 [142310]
    1. Human (Homo sapiens) [TaxId: 9606] [142311] (4)
       SQ Q9UHL0 307-474
17. Helicase of the SNF2/Rad54 hamily [142312]
    1. Sulfolobus solfataricus [TaxId: 2287] [142313] (8)
       SQ Q97XQ7 432-661! SQ Q97XQ7 662-802! SQ Q97XQ7 663-802
18. Probable ATP-dependent RNA helicase DDX48 [142314]
    Eukaryotic translation initiation factor 4A isoform 3
    1. Human (Homo sapiens) [TaxId: 9606] [142315] (10)
       SQ P38919 22-243! SQ P38919 244-411
19. Rad54-like, Rad54L [142316]
    1. Zebra fish (Danio rerio) [TaxId: 7955] [142317] (2)
       SQ Q7ZV09 390-735! SQ Q7ZV09 92-389
20. DNA repair protein RAD25 [142318]
    shares with the DNA helicase UvsW (scop_fa 102396) extra N-terminal alpha+beta subdomain that might be related to the DNA repair protein MutS domain I (scop_sf 55271)
    1. Archaeoglobus fulgidus [TaxId: 2234] [142319] (10)
       SQ O29889 237-436! SQ O29889 238-434! SQ O29889 3-236! SQ O29889 4-209
21. Transcription-repair coupling factor, TRCF [142320]
    similar to UvrB in the N-terminal part and DEAD helicases in the C-terminal part; also contains CarD-like domain in the middle and TRCF domain at the C-terminus
    1. Escherichia coli [TaxId: 562] [142321] (10)
       SQ P30958 2-348! SQ P30958 26-333! SQ P30958 349-465! SQ P30958 546-778! SQ P30958 779-989
22. Putative ATP-dependent RNA helicase DHH1 [142322]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [142323] (2)
       SQ P39517 252-422! SQ P39517 46-251
23. Hel308 helicase [159575]
    1. Archaeoglobus fulgidus [TaxId: 2234] [159576] (4)

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk