Class: Membrane and cell surface proteins and peptides

Does not include proteins in the immune system

Lineage:

1. Root: scop
2. Class: Membrane and cell surface proteins and peptides [56835]
   Does not include proteins in the immune system

Folds:

1. Toxins' membrane translocation domains [56836] (5)
   multi-helical domains of various folds which is thought to unfold in the membrane
2. Family A G protein-coupled receptor-like [81322] (1)
   core: up-and-down bundle of seven transmembrane helices tilted 20 degrees with respect to the plane of the membrane
3. Single transmembrane helix [81407] (38)
   not a true fold
4. Bacterial photosystem II reaction centre, L and M subunits [81484] (1)
   five transmembrane helices forming a sheet-like structure
5. Cytochrome c oxidase subunit I-like [81443] (1)
   12 transmembrane helices in an approximate threefold rotational symmetric arrangement
6. Cytochrome c oxidase subunit III-like [81453] (1)
   core: 7 transmembrane helices organized into two bundles, one formed by the first two helices and the other by the rest
7. Transmembrane helix hairpin [81334] (5)
   two antiparallel transmembrane helices
8. F1F0 ATP synthase subunit A [81337] (1)
   core: up-and-down bundle of four transmembrane helices
9. ATP synthase B chain-like [161059] (1)
   long single helix, part of the stator subcomplex
10. ATP synthase D chain-like [161064] (1)
    non-globular, mostly helical component of the stator subcomplex
11. Aquaporin-like [81339] (1)
    core: 8 helices, 2 short helices are surrounded by 6 long transmembrane helices
12. Ammonium transporter [111351] (1)
    11 transmembrane helices; duplication: consist of 2 structural repeats of five helices each plus extra C-terminal helix
13. MFS general substrate transporter [103472] (1)
    12 transmembrane helices; duplication: the N- and C-terminal halves are structurally similar
14. SNF-like [161069] (1)
    12 transmembrane helices; duplication: consists of two structurally similar halves
15. Proton glutamate symport protein [118214] (1)
    multihelical membrane protein; partial structural duplication in the C-terminal region; oligomeric state: trimer
16. Clc chloride channel [81341] (1)
    core: 18 transmembrane helices
17. Voltage-gated potassium channels [81325] (1)
    oligomeric transmembrane alpha-helical proteins
18. Small-conductance potassium channel [81328] (1)
    oligomeric transmembrane alpha-helical protein
19. Gated mechanosensitive channel [81331] (1)
    oligomeric transmembrane alpha-helical protein
20. Neurotransmitter-gated ion-channel transmembrane pore [90111] (1)
    heteropentameric transmembrane alpha-helical protein; 4 transmembrane helices per subunit
21. Mechanosensitive channel protein MscS (YggB), transmembrane region [82860] (1)
    oligomeric fold; 3 transmembrane helices per subunit
22. Multidrug resistance efflux transporter EmrE [103480] (1)
    oligomeric fold; 3 transmembrane helices per subunit
23. V-type ATP synthase subunit C [103485] (1)
    9 transmembrane helices
24. Preprotein translocase SecY subunit [103490] (1)
    10 transmembrane helices forming of a gated channel
25. Photosystem I subunits PsaA/PsaB [81559] (1)
    core:11 transmembrane helices
26. Photosystem I reaction center subunit X, PsaK [81564] (1)
    core: hairpin of two transmembrane helices
27. Photosystem I reaction center subunit XI, PsaL [81569] (1)
    core: three transmembrane helices, bundle
28. ABC transporter involved in vitamin B12 uptake, BtuC [81346] (1)
    multihelical; complex architecture with several transmembrane helices
29. ABC transporter transmembrane region [90122] (1)
    multihelical; complex architecture with several transmembrane helices
30. Multidrug efflux transporter AcrB transmembrane domain [82865] (1)
    12 transmembrane helices; duplication: the N- and C-terminal halves of the whole proteins are structurally similar
31. a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81649] (1)
    core: three transmembrane helices, up-and-down bundle
32. Heme-binding four-helical bundle [81344] (3)
    core: four transmembrane helices, up-and-down bundle, binds one or two heme groups in between the helices
33. 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81525] (1)
    membrane-associated alpha-helical protein; no transmembrane helices
34. Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81532] (1)
    membrane-associated alpha-helical protein; no transmembrane helices
35. Mitochondrial ATP synthase coupling factor 6 [111356] (1)
    2 helices, hairpin
36. Calcium ATPase, transmembrane domain M [81666] (1)
    core: multihelical; consists of three transmembrane regions of 2, 2 and 6 helices, separated by cytoplasmic domains
37. Light-harvesting complex subunits [56917] (1)
    membrane all-alpha fold
38. Photosystem II antenna protein-like [161076] (1)
    6 transmembrane helices arranged in three antiparallel pairs (hairpins), segregated by cofactors; there can be insertions of different small subdomains in different exposed loops
39. Mitochondrial carrier [103505] (1)
    membrane all-alpha fold; 6-helical "barrel" with internal binding cavity
40. Chlorophyll a-b binding protein [103510] (1)
    membrane all-alpha fold; three transmembrane helices
41. MAPEG domain-like [161083] (1)
    4 helices, bundle; left-handed superhelix
42. MgtE membrane domain-like [161092] (1)
    5 transmembrane helices; bundle, right-handed twist
43. MetI-like [161097] (1)
    core: 5 transmembrane helices; flattened bundle
44. Rhomboid-like [144090] (1)
    6 transmembrane helices
45. Cation efflux protein transmembrane domain-like [161110] (1)
    6 transmembrane helices, bundle
46. Connexin43 [118219] (1)
    mostly unstructured; 2 helices, hairpin
47. Transmembrane beta-barrels [56924] (6)
    not a true fold, gathers together transmembrane barrels of different (n,S)
48. Outer membrane efflux proteins (OEP) [56953] (1)
    subunit fold contains tandem repeat of alpha-beta hairpin-alpha(2) motif
    trimeric fold contains barrel (n=12, S=18) formed by beta-hairpins, two from each subunit, and a bundle of helices with a channel running through it
49. HlyD-like secretion proteins [111368] (1)
    consists of three domains: beta-barrel (res. 29-38,170-259; scop_cf 50412); barrel-sandwich hybrid (39-72,135-169; scop_sf 51230) and long alpha-hairpin (73-134; scop_cf 46556)
50. Leukocidin-like [56958] (1)
    subunit fold contains beta-sandwich of Ig-like (grerk-key) topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel
51. Lipovitellin-phosvitin complex; beta-sheet shell regions [56967] (1)
    contains several large open beta-sheets
52. Aerolisin/ETX pore-forming domain [56972] (1)
    3 domains: (1) alpha+beta; (2&3) all-beta
53. Perfringolysin [56977] (1)
    2 domains: (1) alpha+beta; (2) all-beta, similar to the CalB domain fold but the two last strands are transposed
54. Viral glycoprotein, central and dimerisation domains [56982] (1)
    2 intertwined domains; all-beta and alpha+beta
55. VP4 membrane interaction domain [111378] (1)
    2 domains; d1: complexed all-beta fold; d2: coiled-coil (trimeric) helical region
56. Head and neck region of the ectodomain of NDV fusion glycoprotein [69921] (1)
    3 intertwined all-beta domains
57. OmpH-like [111383] (1)
    trimer; one subunit consists of an alpha/beta oligomerization subdomain [3-stranded parallel beta-sheet, order 213], and an antiparallel coiled coil
58. Anthrax protective antigen [56987] (1)
    4 domains; I (res. 14-225) and II (226-487) are beta-sandwiches of similar gamma-crystallin like topologies; III (488-594) has a beta-grasp like fold; IV (595-735) has an Ig-like fold

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk