Fold: alpha/beta knot

core: 3 layers: a/b/a, parallel beta-sheet of 5 strands, order 21435; contains a deep trefoil knot

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: alpha/beta knot [75216]
   core: 3 layers: a/b/a, parallel beta-sheet of 5 strands, order 21435; contains a deep trefoil knot

Superfamilies:

1. alpha/beta knot [75217] (8)
   known or predicted SAM-dependent methytransferases including the SPOUT 'sequence' superfamily
   all known members have dimeric structures
   uperfamily
   1. YbeA-like [82371] (4)
      Pfam 02590
   2. tRNA(m1G37)-methyltransferase TrmD [89629] (3)
      fold and dimerisation mode are similar to those of the YbeA-like family; contains additional C-terminal all-alpha subdomain
   3. SpoU-like RNA 2'-O ribose methyltransferase [75218] (4)
      contains extra strand (3) in the parallel beta-sheet, order 321546
   4. Hypothetical protein MTH1 (MT0001), dimerisation domain [75221] (1)
      contains extra strand (3) in the parallel beta-sheet, order 321546; interrupted by an insert OB-fold domain
   5. YggJ C-terminal domain-like [89632] (3)
      contains extra strand (3) in the parallel beta-sheet, order 321546; similar dimerisation to the MTH1 domain
   6. EMG1/NEP1-like [159513] (2)
      Pfam 03587; structurally most similar to the AF1056-like family, but more decorated
   7. AF1056-like [159518] (2)
      Pfam 04013; DUF358
   8. AF0751-like [159523] (1)
      Pfam 01994; DUF127

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk