Structural Classification of Proteins
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Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like

multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178]
    multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

Superfamilies:

  1. 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (12)
    N-terminal domain is Rossmann-fold with a family-specific C-terminal extension
    link to SUPERFAMILY database - Superfamily
    1. Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain [48180] (5) picpic
      Hydroxyisobutyrate dehydrogenase domain is similar to one structural repeat in the 6-phosphogluconate dehydrogenase domain
    2. Mannitol 2-dehydrogenase [81843] (1) picpic
    3. Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) [48184] (2) picpic
    4. HCDH C-domain-like [48187] (3) picpic
    5. Conserved hypothetical protein MTH1747 [74762] (1) picpic
    6. UDP-glucose/GDP-mannose dehydrogenase dimerisation domain [48191] (2) picpic
    7. N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [48194] (1) picpic
    8. Glycerol-3-phosphate dehydrogenase [48197] (2) picpic
    9. Ketopantoate reductase PanE [69084] (1) picpic
    10. ProC C-terminal domain-like [116984] (3) picpic
      similar dimer to the class I KARI
    11. HMD dimerization domain-like [140777] (1) picpic
      dimer similar to those of the GDP-mannose 6-dehydrogenase and class I KARI domains
    12. TyrA dimerization domain-like [140780] (3) picpic
      new dimerisation mode with swapping of C-terminal helices
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk