Structural Classification of Proteins
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Fold: TIM beta/alpha-barrel

contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: TIM beta/alpha-barrel [51350]
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites

Superfamilies:

  1. Triosephosphate isomerase (TIM) [51351] (1) picpic
    link to SUPERFAMILY database - Superfamily
  2. Ribulose-phoshate binding barrel [51366] (6) picpic
    link to SUPERFAMILY database - Superfamily
  3. Thiamin phosphate synthase [51391] (1) picpic
    link to SUPERFAMILY database - Superfamily
  4. Pyridoxine 5'-phosphate synthase [63892] (1) picpic
    link to SUPERFAMILY database - Superfamily
  5. FMN-linked oxidoreductases [51395] (1) picpic
    link to SUPERFAMILY database - Superfamily
  6. Inosine monophosphate dehydrogenase (IMPDH) [51412] (1) picpic
    The phosphate moiety of substrate binds in the 'common' phosphate-binding site
    link to SUPERFAMILY database - Superfamily
  7. PLP-binding barrel [51419] (2) picpic
    circular permutation of the canonical fold: begins with an alpha helix and ends with a beta-strand
    link to SUPERFAMILY database - Superfamily
  8. NAD(P)-linked oxidoreductase [51430] (1) picpic
    link to SUPERFAMILY database - Superfamily
  9. (Trans)glycosidases [51445] (14) picpic
    link to SUPERFAMILY database - Superfamily
  10. Metallo-dependent hydrolases [51556] (18) picpic
    the beta-sheet barrel is similarly distorted and capped by a C-terminal helix
    has transition metal ions bound inside the barrel
    link to SUPERFAMILY database - Superfamily
  11. Aldolase [51569] (8) picpic
    Common fold covers whole protein structure
    link to SUPERFAMILY database - Superfamily
  12. Enolase C-terminal domain-like [51604] (2) picpic
    binds metal ion (magnesium or manganese) in conserved site inside barrel
    N-terminal alpha+beta domain is common to this superfamily
    link to SUPERFAMILY database - Superfamily
  13. Phosphoenolpyruvate/pyruvate domain [51621] (7) picpic
    link to SUPERFAMILY database - Superfamily
  14. Malate synthase G [51645] (1) picpic
    link to SUPERFAMILY database - Superfamily
  15. RuBisCo, C-terminal domain [51649] (1) picpic
    link to SUPERFAMILY database - Superfamily
  16. Xylose isomerase-like [51658] (7) picpic
    different families share similar but non-identical metal-binding sites
    link to SUPERFAMILY database - Superfamily
  17. Bacterial luciferase-like [51679] (4) picpic
    consists of clearly related families of somewhat different folds
    link to SUPERFAMILY database - Superfamily
  18. Nicotinate/Quinolinate PRTase C-terminal domain-like [51690] (2) picpic
    incomplete beta/alpha barrel with parallel beta-sheet of 7 strands
    link to SUPERFAMILY database - Superfamily
  19. PLC-like phosphodiesterases [51695] (3) picpic
    link to SUPERFAMILY database - Superfamily
  20. Cobalamin (vitamin B12)-dependent enzymes [51703] (4) picpic
    link to SUPERFAMILY database - Superfamily
  21. tRNA-guanine transglycosylase [51713] (1) picpic
    link to SUPERFAMILY database - Superfamily
  22. Dihydropteroate synthetase-like [51717] (2) picpic
    link to SUPERFAMILY database - Superfamily
  23. UROD/MetE-like [51726] (2) picpic
    link to SUPERFAMILY database - Superfamily
  24. FAD-linked oxidoreductase [51730] (2) picpic
    distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation
    link to SUPERFAMILY database - Superfamily
  25. Monomethylamine methyltransferase MtmB [75098] (1) picpic
    link to SUPERFAMILY database - Superfamily
  26. Homocysteine S-methyltransferase [82282] (1) picpic
    link to SUPERFAMILY database - Superfamily
  27. (2r)-phospho-3-sulfolactate synthase ComA [102110] (1) picpic
    link to SUPERFAMILY database - Superfamily
  28. Radical SAM enzymes [102114] (3) picpic
    common Fe-S cluster and SAM binding sites are embedded into complete or incomplete beta/alpha-barrel
    link to SUPERFAMILY database - Superfamily
  29. GlpP-like [110391] (1) picpic
    link to SUPERFAMILY database - Superfamily
  30. CutC-like [110395] (1) picpic
    link to SUPERFAMILY database - Superfamily
  31. ThiG-like [110399] (1) picpic
    shares the common phosphate-binding site with other superfamilies
    link to SUPERFAMILY database - Superfamily
  32. TM1631-like [117396] (1) picpic
    link to SUPERFAMILY database - Superfamily
  33. EAL domain-like [141868] (1) picpic
    variant of the beta/alpha-barrel fold with strand 1 being antiparallel to the rest
    link to SUPERFAMILY database - Superfamily

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MRC
site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk