Structural Classification of Proteins
home mail help root up expand collapse

Fold: DHS-like NAD/FAD-binding domain

3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: DHS-like NAD/FAD-binding domain [52466]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

Superfamilies:

  1. DHS-like NAD/FAD-binding domain [52467] (6)
    binds cofactor molecules in the opposite direction than classical Rossmann fold
    link to SUPERFAMILY database - Superfamily
    1. Deoxyhypusine synthase, DHS [52468] (1) picpic
    2. C-terminal domain of the electron transfer flavoprotein alpha subunit [52471] (3) picpic
      lacks strand 3; shares the FAD-binding mode with the pyruvate oxidase domain
    3. Pyruvate oxidase and decarboxylase, middle domain [52475] (12) picpic
      N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold
    4. Transhydrogenase domain III (dIII) [52484] (3) picpic
      binds NADP, shares with the pyruvate oxidase FAD-binding domain a common ADP-binding mode
    5. Sir2 family of transcriptional regulators [63984] (7) picpic
      silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain
    6. ACDE2-like [142130] (1) picpic
      Pfam 02552
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk