Structural Classification of Proteins
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Family: Sir2 family of transcriptional regulators

silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: DHS-like NAD/FAD-binding domain [52466]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. Superfamily: DHS-like NAD/FAD-binding domain [52467]
    binds cofactor molecules in the opposite direction than classical Rossmann fold
    link to SUPERFAMILY database - Superfamily
  5. Family: Sir2 family of transcriptional regulators [63984]
    silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

Protein Domains:

  1. AF1676, Sir2 homolog (Sir2-AF1?) [63985]
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [63986] (6) picpic
  2. AF0112, Sir2 homolog (Sir2-AF2) [82380]
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [82381] (7) picpic
  3. NAD-dependent deacetylase CobB [102292]
    1. Escherichia coli [TaxId: 562] [102293] (1) picpic
  4. Sirt2 histone deacetylase [63987]
    1. Human (Homo sapiens) [TaxId: 9606] [63988] (1) picpic
  5. Hst2 [102294]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [102295] (5) picpic
      SQ P53686 1-293
  6. NAD-dependent deacetylase NpdA [142126]
    1. Thermotoga maritima [TaxId: 2336] [142127] (10) picpic
      SQ Q9WYW0 1-245
  7. NAD-dependent deacetylase sirtuin-5 [142128]
    1. Human (Homo sapiens) [TaxId: 9606] [142129] (6) picpic
      SQ Q9NXA8 36-302
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk