Structural Classification of Proteins
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Family: Pyruvate oxidase and decarboxylase, middle domain

N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: DHS-like NAD/FAD-binding domain [52466]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. Superfamily: DHS-like NAD/FAD-binding domain [52467]
    binds cofactor molecules in the opposite direction than classical Rossmann fold
    link to SUPERFAMILY database - Superfamily
  5. Family: Pyruvate oxidase and decarboxylase, middle domain [52475]
    N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold

Protein Domains:

  1. Pyruvate oxidase [52476]
    binds FAD
    1. Lactobacillus plantarum [TaxId: 1590] [52477] (12) picpic
    2. Aerococcus viridans [TaxId: 1377] [142122] (4) picpic
  2. Pyruvate decarboxylase [52478]
    rudiment domain with a variant fold, lacks FAD-binding
    1. Brewer's yeast (Saccharomyces), uvarum strain [TaxId: 4932] [52479] (1) picpic
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52480] (2) picpic
    3. Zymomonas mobilis [TaxId: 542] [52481] (1) picpic
  3. Indole-3-pyruvate decarboxylase [89637]
    1. Enterobacter cloacae [TaxId: 550] [89638] (1) picpic
  4. Benzoylformate decarboxylase [52482]
    1. Pseudomonas putida [TaxId: 303] [52483] (12) picpic
      SQ P20906
  5. Acetohydroxyacid synthase catalytic subunit [69463]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [69464] (6) picpic
      SQ P07342 84-687
    2. Thale cress (Arabidopsis thaliana), chloroplast [TaxId: 3702] [142123] (6) picpic
      SQ P17597 281-459
  6. Catabolic acetolactate synthase [102288]
    1. Klebsiella pneumoniae [TaxId: 573] [102289] (3) picpic
  7. Carboxyethylarginine synthase [102290]
    1. Streptomyces clavuligerus [TaxId: 1901] [102291] (11) picpic
  8. Oxalyl-CoA decarboxylase [142124]
    1. Oxalobacter formigenes [TaxId: 847] [142125] (12) picpic
      SQ P40149 195-369
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk