Fold: Isocitrate/Isopropylmalate dehydrogenase-like

consists of two intertwined (sub)domains related by pseudo dyad; duplication
3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Isocitrate/Isopropylmalate dehydrogenase-like [53658]
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

Superfamilies:

1. Isocitrate/Isopropylmalate dehydrogenase-like [53659] (5)
   the constituent families form similar dimers
   uperfamily
   1. Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (13)
      the active site is between the two identical subunits
   2. PdxA-like [102656] (2)
      Pfam 04166; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PlsX-like and phosphotransacetylase families
   3. PlsX-like [102660] (2)
      Pfam 02504; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and phosphotransacetylase families
   4. Phosphotransacetylase [102663] (4)
      Pfam 01515; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and PlsX-like families
   5. Monomeric isocitrate dehydrogenase [82526] (1)
      the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk