Structural Classification of Proteins
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Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like

the constituent families form similar dimers
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Isocitrate/Isopropylmalate dehydrogenase-like [53658]
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like [53659]
    the constituent families form similar dimers
    link to SUPERFAMILY database - Superfamily

Families:

  1. Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (13) picpic
    the active site is between the two identical subunits
  2. PdxA-like [102656] (2) picpic
    Pfam 04166; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PlsX-like and phosphotransacetylase families
  3. PlsX-like [102660] (2) picpic
    Pfam 02504; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and phosphotransacetylase families
  4. Phosphotransacetylase [102663] (4) picpic
    Pfam 01515; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and PlsX-like families
  5. Monomeric isocitrate dehydrogenase [82526] (1) picpic
    the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk