Family: Monomeric isocitrate dehydrogenase

the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Isocitrate/Isopropylmalate dehydrogenase-like [53658]
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
4. Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like [53659]
   the constituent families form similar dimers
   uperfamily
5. Family: Monomeric isocitrate dehydrogenase [82526]
   the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion

Protein Domains:

1. Monomeric isocitrate dehydrogenase [82527]
   1. Azotobacter vinelandii [TaxId: 354] [82528] (1)
      the insert region spans residues 150-404
      1. 1itw
         complexed with ici, mn
         1. chain a [76793]
         2. chain b [76794]
         3. chain c [76795]
         4. chain d [76796]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk