Structural Classification of Proteins

Fold: alpha/beta-Hydrolases

: core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: alpha/beta-Hydrolases [53473]
core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

Superfamilies:

alpha/beta-Hydrolases [53474] (41)
many members have left-handed crossover connection between strand 8 and additional strand 9
uperfamily
1. Acetylcholinesterase-like [53475] (11)
2. Carboxylesterase [53487] (9)
3. Mycobacterial antigens [53491] (4)
4. Hypothetical protein TT1662 [102616] (1)
5. PepX catalytic domain-like [69581] (4)
6. Prolyl oligopeptidase, C-terminal domain [53496] (1)
  N-terminal domain is a 7-bladed beta-propeller
7. DPP6 catalytic domain-like [82497] (3)
  N-terminal domain is a 8-bladed beta-propeller
8. Serine carboxypeptidase-like [53499] (5)
9. Gastric lipase [53506] (2)
10. Proline iminopeptidase-like [53509] (3)
11. Acetyl xylan esterase-like [82504] (2)
  Pfam 05448; AXE1
12. Haloalkane dehalogenase [53513] (3)
13. Dienelactone hydrolase [53518] (2)
14. Carbon-carbon bond hydrolase [53522] (4)
  closely related to the Proline iminopeptidase-like family
15. Biotin biosynthesis protein BioH [82509] (1)
16. Aclacinomycin methylesterase RdmC [102620] (1)
17. Carboxylesterase/lipase [102623] (1)
18. Epoxide hydrolase [53525] (4)
19. Haloperoxidase [53531] (7)
20. Thioesterases [53542] (3)
21. Carboxylesterase/thioesterase 1 [53547] (5)
22. Ccg1/TafII250-interacting factor B (Cib) [75285] (1)
23. A novel bacterial esterase [53552] (1)
24. Lipase [53555] (1)
25. Fungal lipases [53558] (12)
26. Bacterial lipase [53570] (7)
  lack the first two strands of the common fold
27. Pancreatic lipase, N-terminal domain [53577] (6)
28. Hydroxynitrile lyase-like [53585] (3)
29. Thioesterase domain of polypeptide, polyketide and fatty acid synthases [69584] (4)
  Pfam 00975
30. Cutinase-like [52260] (3)
  minimal alpha/beta hydrolase lacking peripheral secondary structures; similar to a flavodoxin-like fold
31. YdeN-like [110699] (1)
  Pfam 06821; DUF1234; lack the first two strands of the common fold
32. Putative serine hydrolase Ydr428c [110702] (1)
33. Acylamino-acid-releasing enzyme, C-terminal donain [117711] (1)
  closely related to the prolyl peptidase and DPP6 domains (scop_fa 53496 and 82497)
34. Hypothetical esterase YJL068C [117714] (1)
  part of Pfam 00756
35. Hypothetical protein VC1974 [117717] (1)
36. Atu1826-like [159742] (2)
37. PHB depolymerase-like [159747] (1)
38. IroE-like [159750] (1)
39. TTHA1544-like [159753] (1)
  minimal hydrolase fold (one strand less than the cutinase-like family); there is neither catalytic triad, nor nucleopilic residue in the elbow motif
40. O-acetyltransferase [159756] (3)
41. 2,6-dihydropseudooxynicotine hydrolase-like [159762] (1)
  Pfam 06500; DUF1100