Structural Classification of Proteins

Fold: NAD(P)-binding Rossmann-fold domains

: core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: NAD(P)-binding Rossmann-fold domains [51734]
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamilies:

NAD(P)-binding Rossmann-fold domains [51735] (12)
uperfamily
1. Alcohol dehydrogenase-like, C-terminal domain [51736] (28)
  N-terminal all-beta domain defines family
2. Tyrosine-dependent oxidoreductases [51751] (108)
  also known as short-chain dehydrogenases and SDR family
  parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
3. Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (52)
  family members also share a common alpha+beta fold in C-terminal domain
4. Formate/glycerate dehydrogenases, NAD-domain [51830] (14)
  this domain interrupts the other domain which defines family
5. Siroheme synthase N-terminal domain-like [75110] (2)
6. LDH N-terminal domain-like [51848] (33)
7. 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (26)
  the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
  C-terminal domains also show some similarity
8. Aminoacid dehydrogenase-like, C-terminal domain [51883] (24)
  extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
9. Potassium channel NAD-binding domain [63944] (4)
10. Transcriptional repressor Rex, C-terminal domain [102174] (1)
11. CoA-binding domain [51900] (7)
12. Ornithine cyclodeaminase-like [110436] (2)
  Pfam 02423; contains additional alpha+beta dimerisation subdomain mostly formed by the N-terminal meander beta-sheet