Structural Classification of Proteins
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Family: Tyrosine-dependent oxidoreductases

also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: NAD(P)-binding Rossmann-fold domains [51734]
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. Superfamily: NAD(P)-binding Rossmann-fold domains [51735]
    link to SUPERFAMILY database - Superfamily
  5. Family: Tyrosine-dependent oxidoreductases [51751]
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Domains:

  1. Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752]
    1. Escherichia coli [TaxId: 562] [51753] (17) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [51754] (7) picpic
    3. Trypanosoma brucei [TaxId: 5691] [89519] (5) picpic
    4. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141872] (1) picpic
      SQ P04397 11-357
      N-terminal domain of bifunctional Gal10 protein
  2. dTDP-glucose 4,6-dehydratase (RmlB) [51755]
    1. Escherichia coli [TaxId: 562] [51756] (1) picpic
    2. Salmonella enterica [TaxId: 28901] [63925] (1) picpic
    3. Streptococcus suis, serotype 2 [TaxId: 1307] [69406] (6) picpic
    4. Streptomyces venezuelae [TaxId: 54571] [102133] (2) picpic
  3. dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102]
    1. Salmonella enterica serovar typhimurium [TaxId: 90371] [75103] (4) picpic
  4. GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757]
    1. Escherichia coli [TaxId: 562] [51758] (8) picpic
  5. GDP-mannose 4,6-dehydratase [51759]
    1. Escherichia coli [TaxId: 562] [51760] (1) picpic
    2. Pseudomonas aeruginosa [TaxId: 287] [102134] (1) picpic
    3. Human (Homo sapiens) [TaxId: 9606] [102135] (1) picpic
    4. Thale-cress (Arabidopsis thaliana) [TaxId: 3702] [82289] (2) picpic
  6. ADP-L-glycero-D-mannoheptose 6-epimerase [51761]
    1. Escherichia coli [TaxId: 562] [51762] (1) picpic
  7. CDP-glucose-4,6-dehydratase [102136]
    1. Yersinia pseudotuberculosis [TaxId: 633] [102137] (1) picpic
    2. Salmonella typhimurium [TaxId: 90371] [141873] (2) picpic
      SQ P26397 2-356
  8. CDP-tyvelose-2-epimerase [102138]
    1. Salmonella typhi [TaxId: 90370] [102139] (1) picpic
  9. Phenylcoumaran benzylic ether reductase [102140]
    1. Loblolly pine (Pinus taeda) [TaxId: 3352] [102141] (1) picpic
  10. Pinoresinol-lariciresinol reductase [102142]
    1. Giant arborvitae (Thuja plicata) [TaxId: 3316] [102143] (1) picpic
  11. Sulfolipid biosynthesis protein SQD1 [51763]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [51764] (4) picpic
  12. Negative transcriptional regulator NmrA [69407]
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
    1. Aspergillus nidulans [TaxId: 162425] [69408] (29) picpic
      SQ O59919
  13. Carbonyl reductase [51765]
    1. Mouse (Mus musculus) [TaxId: 10090] [51766] (1) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [102144] (5) picpic
      dicarbonyl/L-xylulose reductase
  14. Sepiapterin reductase [51767]
    1. Mouse (Mus musculus) [TaxId: 10090] [51768] (3) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [141874] (6) picpic
      SQ P35270 5-261
  15. Dihydropteridin reductase (pteridine reductase) [51769]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [51770] (2) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [51771] (1) picpic
    3. Leishmania major [TaxId: 5664] [63926] (35) picpic
      SQ Q01782
    4. Leishmania tarentolae [TaxId: 5689] [102145] (1) picpic
    5. Trypanosoma cruzi [TaxId: 5693] [102146] (2) picpic
    6. Nematode (Caenorhabditis elegans) [TaxId: 6239] [89520] (1) picpic
  16. Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772]
    1. Human (Homo sapiens) [TaxId: 9606] [51773] (16) picpic
      SQ P14061
  17. 7-alpha-hydroxysteroid dehydrogenase [51774]
    1. Escherichia coli [TaxId: 562] [51775] (3) picpic
  18. 3-alpha,20-beta-hydroxysteroid dehydrogenase [51776]
    1. Streptomyces hydrogenans [TaxId: 1905] [51777] (2) picpic
  19. 3-alpha-hydroxysteroid dehydrogenase [51778]
    1. Comamonas testosteroni [TaxId: 285] [51779] (2) picpic
  20. 3beta/17beta hydroxysteroid dehydrogenase [82290]
    1. Comamonas testosteroni [TaxId: 285] [82291] (1) picpic
  21. Putative oxidoreductase Rv2002 [82292]
    1. Mycobacterium tuberculosis [TaxId: 1773] [82293] (3) picpic
  22. R-specific alcohol dehydrogenase [89521]
    1. Lactobacillus brevis [TaxId: 1580] [89522] (15) picpic
  23. Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780]
    1. Pseudomonas sp., lb400 [TaxId: 306] [51781] (1) picpic
  24. Drosophila alcohol dehydrogenase [51782]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [102147] (1) picpic
    2. Fly (Drosophila lebanonensis) [TaxId: 7225] [51783] (7) picpic
  25. Glucose dehydrogenase [51784]
    1. Bacillus megaterium [TaxId: 1404] [51785] (4) picpic
  26. Sorbitol dehydrogenase [102148]
    1. Rhodobacter sphaeroides [TaxId: 1063] [102149] (1) picpic
  27. meso-2,3-butanediol dehydrogenase [51786]
    1. Klebsiella pneumoniae [TaxId: 573] [51787] (1) picpic
  28. Levodione reductase [89523]
    1. Corynebacterium aquaticum [TaxId: 144185] [89524] (1) picpic
  29. Mannitol dehydrogenase [63927]
    1. Mushroom (Agaricus bisporus) [TaxId: 5341] [63928] (1) picpic
  30. (3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294]
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
    1. Rat (Rattus norvegicus) [TaxId: 10116] [82295] (1) picpic
  31. beta-keto acyl carrier protein reductase [51788]
    1. Oil seed rape (Brassica napus) [TaxId: 3708] [51789] (7) picpic
    2. Escherichia coli [TaxId: 562] [51790] (3) picpic
    3. Thermotoga maritima [TaxId: 2336] [102150] (1) picpic
      TM1169
    4. Thermus thermophilus [TaxId: 274] [117407] (1) picpic
      SQ Q5SK98
    5. Streptomyces coelicolor [TaxId: 1902] [117408] (9) picpic
      SQ P16544 #SP
    6. Mycobacterium tuberculosis [TaxId: 1773] [141875] (6) picpic
      SQ P0A5Y4 9-245! SQ P0A5Y4 9-247
    7. Thermus thermophilus, TTHB020 [TaxId: 274] [141876] (2) picpic
      SQ Q53WH2 2-242
    8. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [141877] (1) picpic
      SQ Q86RB1 54-304
  32. Enoyl-ACP reductase [51791]
    1. Oil seed rape (Brassica napus) [TaxId: 3708] [51792] (4) picpic
    2. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [82296] (27) picpic
      SQ Q9BJJ9 96-424 # fragment
    3. Mycobacterium tuberculosis, TB, gene InhA [TaxId: 1773] [51793] (44) picpic
    4. Escherichia coli [TaxId: 562] [51794] (14) picpic
    5. Helicobacter pylori [TaxId: 210] [102151] (8) picpic
    6. Thermus thermophilus [TaxId: 274] [117409] (9) picpic
      SQ Q5SLI9
  33. Tropinone reductase [51795]
    1. Jimsonweed (Datura stramonium), I [TaxId: 4076] [51796] (1) picpic
    2. Jimsonweed (Datura stramonium), II [TaxId: 4076] [51797] (4) picpic
    3. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117410] (2) picpic
      SQ Q9ASX2
  34. 1,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798]
    1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [51799] (4) picpic
  35. 1,3,6,8-tetrahydroxynaphthalene reductase [63929]
    1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [63930] (1) picpic
  36. Biliverdin IX beta reductase [63931]
    Histidine in the active site instead of the Tyr-Lys dyad
    1. Human (Homo sapiens) [TaxId: 9606] [63932] (5) picpic
  37. Type II 3-hydroxyacyl-CoA dehydrogenase [63933]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [63934] (3) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [102152] (4) picpic
      SQ Q99714
    3. Thermus thermophilus [TaxId: 274] [89525] (1) picpic
  38. Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935]
    1. Pig (Sus scrofa) [TaxId: 9823] [63936] (1) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [141878] (4) picpic
      SQ P16152 2-276
  39. Halohydrin dehalogenase HheC [102153]
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
    1. Agrobacterium tumefaciens [TaxId: 358] [102154] (23) picpic
  40. Glucose dehydrogenase (5l265) [102155]
    1. Nematode (Caenorhabditis elegans) [TaxId: 6239] [102156] (1) picpic
  41. UDP-N-acetylglucosamine 4-epimerase WbpP [110407]
    1. Pseudomonas aeruginosa [TaxId: 287] [110408] (2) picpic
      SQ Q8KN66 # list: Q8GGB8 Q9RHD6 99% identity
  42. DTDP-4-dehydrorhamnose reductase RfbD [110409]
    1. Clostridium acetobutylicum [TaxId: 1488] [110410] (1) picpic
      SQ Q97GQ1
  43. Gluconate 5-dehydrogenase [110411]
    1. Thermotoga maritima [TaxId: 2336] [110412] (1) picpic
      SQ Q9WYS2
  44. Carbonyl reductase sniffer [110413]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [110414] (1) picpic
      SQ Q9W3H4 # cg10964-pa
  45. Hypothetical protein F25D1.5 [110415]
    1. Caenorhabditis elegans [TaxId: 6239] [110416] (1) picpic
      SQ Q19774
  46. Putative dehydrogenase ARPG836 (MGC4172) [117411]
    1. Human (Homo sapiens) [TaxId: 9606] [117412] (1) picpic
      SQ Q6UWP2
  47. Aldehyde reductase II [117413]
    1. Sporobolomyces salmonicolor [TaxId: 5005] [117414] (5) picpic
      SQ Q9UUN9
  48. Hypothetical protein R05D8.7 [117415]
    1. Caenorhabditis elegans [TaxId: 6239] [117416] (1) picpic
      SQ Q9N5G4
  49. Hypothetical protein At5g02240 (T7H20_290) [117417]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117418] (7) picpic
      SQ Q94EG6
  50. Polymyxin resistance protein ArnA (PrmI) [117419]
    evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
    1. Escherichia coli [TaxId: 562] [117420] (12) picpic
      SQ P77398
  51. 2,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421]
    1. Human (Homo sapiens), [TaxId: 9606] [117422] (3) picpic
      SQ Q16698 35-328
  52. 11-beta-hydroxysteroid dehydrogenase 1 [117423]
    1. Human (Homo sapiens) [TaxId: 9606] [117424] (37) picpic
      SQ P28845
    2. Guinea pig (Cavia porcellus) [TaxId: 10141] [117425] (1) picpic
      SQ Q6QLL4 23-296
    3. Mouse (Mus musculus) [TaxId: 10090] [141879] (4) picpic
      SQ P50172 24-298
  53. 17-beta-hydroxysteroid dehydrogenase type XI [117426]
    1. Human (Homo sapiens) [TaxId: 9606] [117427] (1) picpic
      SQ Q8NBQ5 30-273
  54. UDP-glucuronate decarboxylase 1 [141880]
    1. Human (Homo sapiens) [TaxId: 9606] [141881] (1) picpic
      SQ Q8NBZ7 87-398
  55. Xylitol dehydrogenase [141882]
    1. Gluconobacter oxydans [TaxId: 442] [141883] (8) picpic
      SQ Q8GR61 3-262
  56. Peroxisomal trans 2-enoyl CoA reductase [141884]
    1. Human (Homo sapiens) [TaxId: 9606] [141885] (4) picpic
      SQ Q9BY49 7-303
  57. D(-)-3-hydroxybutyrate dehydrogenase [141886]
    1. Pseudomonas fragi [TaxId: 296] [141887] (3) picpic
      SQ Q5KST5 1-260
  58. 15-hydroxyprostaglandin dehydrogenase, PGDH [141888]
    1. Human (Homo sapiens) [TaxId: 9606] [141889] (1) picpic
      SQ P15428 3-256
  59. GDP-mannose-3', 5'-epimerase [141890]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [141891] (8) picpic
      SQ Q93VR3 13-374! SQ Q93VR3 13-375
  60. Bacterial sepiapterin reductase [141892]
    1. Chlorobium tepidum [TaxId: 1097] [141893] (4) picpic
      SQ Q8KES3 2-241
      CT0609
  61. Dehydrogenase/reductase SDR family member 6, DHRS6 [141894]
    Oxidoreductase UCPA
    1. Human (Homo sapiens) [TaxId: 9606] [141895] (4) picpic
      SQ Q9BUT1 1-245
  62. Hypothetical protein TTHA0369 [141896]
    TT0321
    1. Thermus thermophilus [TaxId: 274] [141897] (4) picpic
      SQ Q5SLC4 2-249
  63. Rhizome secoisolariciresinol dehydrogenase [141898]
    1. Mayapple (Podophyllum peltatum) [TaxId: 35933] [141899] (4) picpic
      SQ Q94KL8 11-278
  64. Peroxisomal multifunctional enzyme type 2 [141900]
    17-beta-hydroxysteroid dehydrogenase 4
    1. Human (Homo sapiens) [TaxId: 9606] [141901] (6) picpic
      SQ P51659 2-303
      the structure of C-terminal domain is also known, PDB entry 1S9C
  65. (s)-1-phenylethanol dehydrogenase [141902]
    1. Azoarcus sp. ebn1 [TaxId: 76114] [141903] (6) picpic
      SQ Q5P5I4 3-249
  66. TAT-interacting protein TIP30 [141904]
    1. Human (Homo sapiens) [TaxId: 9606] [141905] (1) picpic
      SQ Q9BUP3 5-236
    2. Mouse (Mus musculus) [TaxId: 10090] [141906] (1) picpic
      SQ Q9Z2G9 7-236
  67. Retinal dehydrogenase/reductase 3 [141907]
    1. Human (Homo sapiens) [TaxId: 9606] [141908] (16) picpic
      SQ Q9BPX1 4-253
  68. Erythromycin synthase, eryAI, 1st ketoreductase module [141909]
    tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
    1. Saccharopolyspora erythraea [TaxId: 1836] [141910] (4) picpic
      SQ Q5UNP6 1448-1656! SQ Q5UNP6 1657-1915
  69. Hypothetical protein PA4017 [141911]
    unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
    1. Pseudomonas aeruginosa [TaxId: 287] [141912] (2) picpic
      SQ Q9HX10 4-215
  70. Putative carbonyl reductase sniffer [141913]
    1. Caenorhabditis elegans [TaxId: 6239] [141914] (6) picpic
      SQ P90780 1-250
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk