Family: 6-phosphogluconate dehydrogenase-like, N-terminal domain

the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
C-terminal domains also show some similarity

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: NAD(P)-binding Rossmann-fold domains [51734]
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar
4. Superfamily: NAD(P)-binding Rossmann-fold domains [51735]
   uperfamily
5. Family: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868]
   the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
   C-terminal domains also show some similarity

Protein Domains:

1. Class I ketol-acid reductoisomerase (KARI) [89532]
   1. Pseudomonas aeruginosa [TaxId: 287] [89533] (1)
2. Class II ketol-acid reductoisomerase (KARI) [51869]
   contains additional subdomain at the N-terminus, partly ordered
   1. Spinach (Spinacia oleracea) [TaxId: 3562] [51870] (2)
3. 6-phosphogluconate dehydrogenase [51871]
   1. Sheep (Ovis orientalis aries) [TaxId: 9940] [51872] (5)
   2. Trypanosoma brucei [TaxId: 5691] [51873] (1)
4. Hydroxyisobutyrate dehydrogenase [102171]
   1. Thermus thermophilus [TaxId: 274] [102172] (8)
      structural genomics
   2. Salmonella typhimurium [TaxId: 90371] [110431] (1)
      SQ Q8ZLV8
   3. Pseudomonas aeruginosa [TaxId: 287] [159424] (1)
      SQ Q9I5I6 1-162
5. Mannitol 2-dehydrogenase [82301]
   1. Pseudomonas fluorescens [TaxId: 294] [82302] (2)
6. Short chain L-3-hydroxyacyl CoA dehydrogenase [51874]
   1. Human (Homo sapiens) [TaxId: 9606] [51875] (11)
   2. Pig (Sus scrofa) [TaxId: 9823] [51876] (1)
7. Conserved hypothetical protein MTH1747 [75113]
   1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [75114] (1)
8. UDP-glucose dehydrogenase (UDPGDH) [51877]
   1. Streptococcus pyogenes [TaxId: 1314] [51878] (2)
9. GDP-mannose 6-dehydrogenase [89534]
   1. Pseudomonas aeruginosa [TaxId: 287] [89535] (3)
10. N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [51879]
    1. Arthrobacter, strain 1c [TaxId: 1663] [51880] (1)
11. Glycerol-3- phosphate dehydrogenase [51881]
    1. Trypanosome (Leishmania mexicana) [TaxId: 5665] [51882] (7)
    2. Archaeoglobus fulgidus [TaxId: 2234] [117433] (1)
       SQ O29390
12. Ketopantoate reductase PanE [69419]
    1. Escherichia coli [TaxId: 562] [69420] (5)
13. Coenzyme F420H2:NADP+ oxidoreductase (FNO) [69421]
    lacks all but the first helix of the C-terminal all-alpha domain
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [69422] (2)
14. Fatty oxidation complex alpha subunit, middle domain [110432]
    1. Pseudomonas fragi [TaxId: 296] [110433] (4)
       SQ P28793
15. Pyrroline-5-carboxylate reductase ProC [117434]
    1. Neisseria meningitidis, serogroup B [TaxId: 487] [117435] (2)
       SQ Q9K1N1
    2. Streptococcus pyogenes [TaxId: 1314] [141928] (10)
       SQ Q9A1S9 1-152
16. Prephenate dehydrogenase TyrA [141929]
    1. Aquifex aeolicus [TaxId: 63363] [141930] (4)
       SQ O67636 30-200
    2. Synechocystis sp. pcc 6803 [TaxId: 1148] [141931] (4)
       SQ P73906 1-165
    3. Haemophilus influenzae [TaxId: 727] [159425] (2)
       SQ P43902 92-243
17. 5,10-methenyltetrahydromethanopterin hydrogenase, HMD [141932]
    1. Archaeon Methanocaldococcus jannaschii [TaxId: 2190] [141933] (1)
       SQ Q58194 1-242
18. Hypothetical protein TM1727 [159426]
    ProC structural homologue
    1. Thermotoga maritima [TaxId: 2336] [159427] (2)
       SQ Q9X250 2-154

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk