Structural Classification of Proteins

Class: Alpha and beta proteins (a+b)

: Mainly antiparallel beta sheets (segregated alpha and beta regions)

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)

Folds:

Microbial ribonucleases [53932] (1)
single helix packs against antiparallel beta-sheet
1. Microbial ribonucleases [53933] (3)
  uperfamily
Lysozyme-like [53954] (1)
common alpha+beta motif for the active site region
1. Lysozyme-like [53955] (11)
  uperfamily
Cysteine proteinases [54000] (1)
consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
1. Cysteine proteinases [54001] (22)
  the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  uperfamily
His-Me finger endonucleases [54059] (1)
core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
1. His-Me finger endonucleases [54060] (6)
  common motif contains conserved histidine residue and metal-binding site
  uperfamily
RNase A-like [54075] (1)
contains long curved beta-sheet and 3 helices
1. RNase A-like [54076] (1)
  can be classified as disulfide-rich
  uperfamily
EndoU-like [142876] (1)
comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (scop_cf 54075)
1. EndoU-like [142877] (2)
  similarity to the RNase A-like superfamily (scop_sf 54076) extends to the active site location and architecture; the two structural cores of the RNase A and EndoU superfamilies are interrelated by a topological permutation - transposition of two pereferial beta-strands, suggesting possible distant homology of the two superfamilies (and their unification in a hyperfamily)
  uperfamily
Prion-like [54097] (1)
beta-alpha-beta-alpha(2); antiparallel beta-ribbon
1. Prion-like [54098] (1)
  uperfamily
LysM domain [54105] (1)
beta-alpha(2)-beta; antiparallel strands
1. LysM domain [54106] (1)
  uperfamily
gpW/XkdW-like [64209] (2)
alpha-beta(2)-alpha; antiparallel hairpin
1. Head-to-tail joining protein W, gpW [64210] (1)
  uperfamily
2. XkdW-like [159865] (1)
  different packing of secondary structures than in gpW
Hypothetical protein MTH677 [110782] (1)
alpha-beta(2)-alpha; 2 layers a/b; antiparallel beta-hairpin
1. Hypothetical protein MTH677 [110783] (1)
  uperfamily
GTF2I-like repeat [117772] (1)
alpha(2)-beta-alpha-beta-alpha; 2 layers: a/b; antiparallel beta-ribbon
1. GTF2I-like repeat [117773] (1)
  uperfamily
Urease, gamma-subunit [54110] (1)
alpha(3)-beta(2); antiparallel hairpin
1. Urease, gamma-subunit [54111] (1)
  uperfamily
IL8-like [54116] (2)
beta(3)-alpha
1. Interleukin 8-like chemokines [54117] (1)
  form dimers with different dimerisation modes
  uperfamily
2. PhtA domain-like [142887] (1)
  contains extra N-terminal beta-hairpin, like structurally similar archaeal "histone-like" proteins (scop_fa 54161), but does not adopt its SH3-like barrel fold
  uperfamily
DNA-binding domain [54170] (1)
beta(3)-alpha; 2 layers: alpha/beta
1. DNA-binding domain [54171] (4)
  uperfamily
Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54183] (1)
alpha1-beta3; 2 layers: alpha/beta; order 132
1. Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54184] (1)
  duplication: consists of 2 subdomains of this fold
  uperfamily
Dodecin subunit-like [88797] (6)
beta-alpha-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 132
1. Dodecin-like [89807] (1)
  uperfamily
2. Amyloid beta a4 protein copper binding domain (domain 2) [89811] (1)
  uperfamily
3. N-terminal, heterodimerisation domain of RBP7 (RpoE) [88798] (1)
  uperfamily
4. D-lysine 5,6-aminomutase beta subunit KamE, N-terminal domain [117778] (1)
  uperfamily
5. YbjQ-like [117782] (1)
  pentamer, beta/alpha-propeller; additional short beta-strands promote oligomeric assembly
  uperfamily
6. YdgH-like [159871] (1)
  extra N-terminal structures: short strand and short helix; topological similarity to the YbjQ-like superfamily
Ribosomal proteins S24e, L23 and L15e [54188] (1)
beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
1. Ribosomal proteins S24e, L23 and L15e [54189] (3)
  uperfamily
Ribosome binding domain-like [100965] (2)
beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e
1. Trigger factor ribosome-binding domain [102735] (1)
  uperfamily
2. Translation initiation factor 2 beta, aIF2beta, N-terminal domain [100966] (1)
  uperfamily
TFB5-like [142896] (1)
beta-alpha-beta(2)-alpha; 2 layers, a/b; antiparallel sheet, order: 132; dimerises in solution (PDB 2jnj) via extended N-terminal strand
1. TFB5-like [142897] (1)
  uperfamily
Obg GTP-binding protein C-terminal domain [102740] (1)
beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other
1. Obg GTP-binding protein C-terminal domain [102741] (1)
  uperfamily
HIT-like [54196] (2)
alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
1. HIT-like [54197] (4)
  uperfamily
2. Rotavirus NSP2 fragment, C-terminal domain [75347] (1)
  uperfamily
Secretion chaperone-like [69634] (5)
alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta
1. Type III secretory system chaperone-like [69635] (2)
  uperfamily
2. Arp2/3 complex subunits [69645] (1)
  uperfamily
3. YjbR-like [142906] (1)
  overall similar to the Type III secretory system chaperone subunits; different shape of the beta-sheet
  uperfamily
4. YdhG-like [159888] (1)
  some similarity to YjbR-like (scop_sf 136320)
5. YgaC/TfoX-N like [159894] (2)
  overall similar to the Type III secretory system chaperone subunits; different shape of the beta-sheet
DNA-binding domain of intron-encoded endonucleases [64495] (1)
beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix
1. DNA-binding domain of intron-encoded endonucleases [64496] (1)
  uperfamily
MotA C-terminal domain-like [69651] (1)
alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta
1. DNA-binding C-terminal domain of the transcription factor MotA [69652] (1)
  uperfamily
YktB/PF0168-like [142912] (1)
alpha-beta(4)-alpha-beta(2)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order: 1234756; half-barrel shape; topological similarity to the MotA C-terminal domain-like fold (scop_cf 69651) and the Secretion chaperone-like fold (scop_cf 69634)
1. YktB/PF0168-like [142913] (2)
  uperfamily
Mago nashi protein [89816] (1)
beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, order: 651234
1. Mago nashi protein [89817] (1)
  uperfamily
WGR domain-like [142920] (1)
beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure
1. WGR domain-like [142921] (1)
  uperfamily
PH1570-like [159901] (1)
duplication: two beta(4)-alpha structural repeats, related by pseudo twofold symmetry; two extra helices in the linker region; single 8-standed antiparallel beta-sheet, order: 12348765
1. PH1570-like [159902] (1)
Ribosomal protein S5 domain 2-like [54210] (1)
core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
1. Ribosomal protein S5 domain 2-like [54211] (12)
  uperfamily
beta-Grasp (ubiquitin-like) [54235] (14)
core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
1. Ubiquitin-like [54236] (8)
  uperfamily
2. CAD & PB1 domains [54277] (2)
  contain extra helix; similar heterodimerization modes; possibly related to the ubiquitin-like superfamily
  uperfamily
3. MoaD/ThiS [54285] (4)
  possible link between the ubiquitin-like and 2Fe-2S ferredoxin-like superfamilies
  uperfamily
4. TGS-like [81271] (2)
  possibly related to the ubiquitin-like and MoaD/ThiS superfamilies; some similarity to the alpha-L RNA-binding motif
  uperfamily
5. 2Fe-2S ferredoxin-like [54292] (2)
  uperfamily
6. Staphylokinase/streptokinase [54328] (1)
  uperfamily
7. Doublecortin (DC) [89837] (1)
  possibly related to the ubiquitin-like superfamily
  uperfamily
8. Superantigen toxins, C-terminal domain [54334] (1)
  uperfamily
9. Immunoglobulin-binding domains [54358] (1)
  uperfamily
10. Translation initiation factor IF3, N-terminal domain [54364] (1)
  uperfamily
11. Glutamine synthetase, N-terminal domain [54368] (1)
  uperfamily
12. TmoB-like [110814] (1)
  possibly related to the ubiquitin-like and/or 2Fe-2S ferredoxin-like superfamilies
  uperfamily
13. Nqo1 middle domain-like [142984] (1)
  possibly evolved from 2Fe-2S ferredoxins; contains no iron-sulfur cluster
  uperfamily
14. NSP3A-like [159936] (1)
  short helical inserions in the common fold
MM3350-like [159940] (1)
beta(2)-alpha-beta(4); antiparallel beta-sheet; order: 216534; similar to a ubiquitin-like fold with the extra C-terminal strand inserted in the middle of the beta-sheet
1. MM3350-like [159941] (1)
WWE domain [117838] (1)
beta(2)-alpha-beta(4); antiparallel folded beta-sheet (half-barrel), order 216543
1. WWE domain [117839] (1)
  uperfamily
FAD-linked reductases, C-terminal domain [54372] (1)
alpha+beta sandwich
1. FAD-linked reductases, C-terminal domain [54373] (7)
  N-terminal domain is beta/beta/alpha common fold
  uperfamily
Cystatin-like [54402] (7)
Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
1. Cystatin/monellin [54403] (6)
  has a additional strand at the N-terminus
  uperfamily
2. Amine oxidase N-terminal region [54416] (1)
  uperfamily
3. DsbC/DsbG N-terminal domain-like [54423] (1)
  uperfamily
4. NTF2-like [54427] (30)
  has a beta-alpha(2)-beta insertion after the main helix
  uperfamily
5. Uracil-DNA glycosylase inhibitor protein [54441] (1)
  has an additional strand at the C-terminus and a helix inserted after the first strand
  uperfamily
6. Putative dsDNA mimic [102816] (1)
  elaborated with additional structures; some similarity to Uracil-DNA glycosylase (UGI) and Nuclease A (NuiA) inhibitors
  uperfamily
7. Pre-PUA domain [88802] (5)
  this domain is found in association with the PUA domain in the C-terminal region of Archaeosine tRNA-guanine transglycosylase and related stand-alone proteins
  uperfamily
Nuclease A inhibitor (NuiA) [82601] (1)
alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432
1. Nuclease A inhibitor (NuiA) [82602] (1)
  some structural similarity to Uracil-DNA glycosylase inhibitor and putative dsDNA mimic HI1450 of the cystatin-like fold
  uperfamily
Colicin D/E5 nuclease domain [102823] (1)
alpha(2)-beta(4)-alpha, 2 layers: alpha/beta, antiparallel beta sheet, meander
1. Colicin D/E5 nuclease domain [102824] (2)
  uperfamily
RelE-like [143010] (1)
beta-alpha(2)-beta(4), 2 layers; a/b, antiparallel beta-sheet; order 15432
1. RelE-like [143011] (2)
  Toxin component of plasmid stabilisation system
  uperfamily
Hypothetical protein SAV1430 [110835] (1)
beta(3)-alpha-beta(2)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet, order: 12543
1. Hypothetical protein SAV1430 [110836] (1)
  uperfamily
Ns1 effector domain-like [143020] (1)
beta-X-beta(5)-alpha-beta-alpha; 2 layers: a/b; bifurcated beta-sheet; order 23654[1,7]
1. Ns1 effector domain-like [143021] (1)
  uperfamily
YbaB-like [82606] (1)
core: alpha-beta(3)-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123
1. YbaB-like [82607] (1)
  forms tight dimer of a 3-layer structure: beta/alpha/beta
  uperfamily
Kinetochore globular domain-like [143025] (1)
core: alpha-beta(3)-alpha; variant: alpha-beta(4)-alpha(2)
1. Kinetochore globular domain [143026] (2)
  swapped heterodimer with the N-terminal helices; Spc24-like subunits have the core fold, whereas Spc25-like subunits have a variant fold
  uperfamily
L35p-like [143033] (1)
core: alpha-beta(3)-alpha; 2layers a/b
1. L35p-like [143034] (1)
  uperfamily
Cell division protein ZapA-like [102828] (1)
core: beta(2)-alpha(2), 2 layers: alpha/beta; long C-terminal helix forms dimeric parallel and tetrameric antiparallel coiled coils
1. Cell division protein ZapA-like [102829] (1)
  uperfamily
ssDNA-binding transcriptional regulator domain [54446] (1)
helix-swapped dimer of beta(4)-alpha motifs
1. ssDNA-binding transcriptional regulator domain [54447] (4)
  uperfamily
Photosystem I subunit PsaD [64233] (1)
beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
1. Photosystem I subunit PsaD [64234] (1)
  uperfamily
GINS/PriA/YqbF domain [160058] (1)
beta(4)-alpha-beta; 3-stranded antiparallel beta-sheet (strands 4,1 and 5) are covered on the same side by the helix and beta hairpin of strands 2 and 3; similarity to the L9 N-domain-like fold (scop_cf 55657) and the PsaD fold (scop_sf 64243)
1. PriA/YqbF domain [160059] (4)
  associated with known or presumed DNA-binding domains; this superfamily also includes the C-terminal domain of PriA (PDB entry 1zt2)
MHC antigen-recognition domain [54451] (1)
dimeric
1. MHC antigen-recognition domain [54452] (1)
  uperfamily
UBC-like [54494] (1)
alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
1. UBC-like [54495] (4)
  uperfamily
SAND domain-like [63762] (1)
core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold
1. SAND domain-like [63763] (2)
  uperfamily
NRDP1 C-terminal domain-like [160087] (1)
alpha-beta-alpha(3)-beta(3); a pseudo barrel beta-sheet of an SH3-like topology, surrounded by helices
1. NRDP1 C-terminal domain-like [160088] (1)
Coronavirus NSP8-like [143075] (1)
core: alpha-beta(2)-alpha-beta(4)-alpha-beta; bifurcated barrel-like beta-sheet
1. Coronavirus NSP8-like [143076] (1)
  uperfamily
ParB/Sulfiredoxin [110848] (1)
beta*-alpha-beta(2)-alpha-beta-alpha; mixed beta sheet forms a partly open barrel: (n*=4, S*=8)
1. ParB/Sulfiredoxin [110849] (4)
  uperfamily
Gamma-glutamyl cyclotransferase-like [110856] (1)
beta-alpha-beta(4)-alpha-beta(2); contains beta-sheet barrel (n=5, S=8)
1. Gamma-glutamyl cyclotransferase-like [110857] (1)
  uperfamily
BB1717-like [143080] (1)
complex fold with a bifurcated beta-sheet structure surrounded by helices; contains beta-sheet barrel, closed (n=5, S=8)
1. BB1717-like [143081] (1)
  uperfamily
SARS Nsp1-like [160098] (1)
complex alpha+beta fold; contains mixed beta-sheet barrel, n=6, S=10
1. SARS Nsp1-like [160099] (1)
Acetoacetate decarboxylase-like [160103] (1)
complex fold: contains a 3-layer beta-sheet structure, which is folded in two conjoint barrels capped by helices; one rounded barrel has 7 strands, the other flattened barrel has 9 strands
1. Acetoacetate decarboxylase-like [160104] (1)
AF0104/ALDC/Ptd012-like [117855] (1)
duplication: consists of two similar beta-alpha-beta(4) motifs
1. AF0104/ALDC/Ptd012-like [117856] (3)
  characteristic metal ion (zinc)-binding motif in the putative active site
  uperfamily
NSFL1 (p97 ATPase) cofactor p47, SEP domain [102847] (1)
beta(3)-alpha(2)-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other
1. NSFL1 (p97 ATPase) cofactor p47, SEP domain [102848] (1)
  uperfamily
TTHA1013/TTHA0281-like [143099] (1)
beta(3)-alpha-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other; topological similarity to the SEP domain fold (scop_cf 102847); dimerises via the long C-terminal strand with the formation of a single beta-sheet
1. TTHA1013/TTHA0281-like [143100] (2)
  uperfamily
YegP-like [160112] (1)
comprises two subunits or tandem repeats of beta(3)-alpha-beta motifs; these assemble with the formation of a single beta-sheet and swapping of the C-terminal strands
1. YegP-like [160113] (1)
Diaminopimelate epimerase-like [54505] (1)
mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
1. Diaminopimelate epimerase-like [54506] (4)
  duplication: consists of two similar domain swapped with C-terminal strands
  uperfamily
GFP-like [54510] (1)
beta-sheet folds into a barrel (n=11, S=14) around the central helix
1. GFP-like [54511] (2)
  uperfamily
Tubby C-terminal domain-like [54517] (1)
beta-sheet folds into a barrel (n=12, S=12) around the central helix
1. Tubby C-terminal domain-like [54518] (2)
  uperfamily
Pili subunits [54522] (1)
contains very long N-terminal helix, which end is packed against beta-sheet
1. Pili subunits [54523] (7)
  bacterial filament proteins
  uperfamily
Mitochondrial glycoprotein MAM33-like [54528] (1)
core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain
1. Mitochondrial glycoprotein MAM33-like [54529] (1)
  uperfamily
NAP-like [143112] (1)
core: central meander 4-stranded beta-sheet (order: 1234) transversed by a C-terminal helix
1. NAP-like [143113] (1)
  uperfamily
Polo-box domain [82614] (1)
beta(6)-alpha; antiparallel beta-sheet, meander
1. Polo-box domain [82615] (2)
  Serine/threonine protein kinase-associated motif embedded in two distinct folds
  uperfamily
mRNA decapping enzyme DcpS N-terminal domain [102859] (1)
beta(3)-alpha-beta(3)-alpha; 3 layers a/b/a
1. mRNA decapping enzyme DcpS N-terminal domain [102860] (1)
  forms swapped dimer with two 6-stranded antiparallel beta sheets; order 1236[5][4]
  uperfamily
Inhibitor of vertebrate lysozyme, Ivy [89871] (1)
alpha(2)-beta(5)-alpha(2); 3 layers a/b/a; meander beta-sheet
1. Inhibitor of vertebrate lysozyme, Ivy [89872] (1)
  uperfamily
FKBP-like [54533] (3)
core: beta(2)-alpha-beta(2); antiparallel beta-sheet
1. FKBP-like [54534] (3)
  uperfamily
2. Colicin E3 immunity protein [54552] (1)
  uperfamily
3. Chitinase insertion domain [54556] (1)
  uperfamily
Ribosomal protein S16 [54564] (1)
beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234
1. Ribosomal protein S16 [54565] (1)
  uperfamily
Ribosomal protein S19 [54569] (1)
alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123
1. Ribosomal protein S19 [54570] (1)
  uperfamily
YefM-like [143119] (1)
core: beta-alpha(2)-beta(2)-alpha; mixed beta-sheet, order:123, strands 1 and 2 are parallel; forms compact dimer with a single beta-sheet;
1. YefM-like [143120] (1)
  uperfamily
Ribosomal protein L31e [54574] (1)
beta-alpha-beta-(alpha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342
1. Ribosomal protein L31e [54575] (1)
  uperfamily
Allophycocyanin linker chain (domain) [54579] (1)
beta(2)-alpha-beta; 2 layers: alpha/beta
1. Allophycocyanin linker chain (domain) [54580] (1)
  uperfamily
Cdc48 domain 2-like [54584] (1)
beta-alpha-beta(3); 2 layers: alpha/beta
1. Cdc48 domain 2-like [54585] (1)
  uperfamily
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1)
beta-alpha-beta(3); 2 layers: alpha/beta
1. Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54593] (10)
  uperfamily
Chromosomal protein MC1 [102874] (1)
beta(2)-alpha-beta(3); 2 layers: alpha/beta
1. Chromosomal protein MC1 [102875] (1)
  uperfamily
CPE0013-like [160147] (1)
beta(2)-alpha-beta(3); mixed, mostly antiparallel beta-sheet, folded in a half-barrel; order:31254; strand 3 is parallel to strand 1 and is shorter than the rest
1. CPE0013-like [160148] (1)
beta-hairpin-alpha-hairpin repeat [74651] (2)
multiple repeats of beta(2)-alpha(2) motif
1. Ankyrin repeat [48403] (1)
  repeats organized in elongated structures
  uperfamily
2. Plakin repeat [75399] (1)
  repeats associate forming globular subdomains
  uperfamily
Proguanylin [89889] (1)
beta(2)-alpha(3)-beta; two layers: alpha/beta; antiparallel sheet: order 213
1. Proguanylin [89890] (1)
  uperfamily
SecB-like [54610] (1)
beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432
1. SecB-like [54611] (2)
  uperfamily
MesJ substrate recognition domain-like [82828] (1)
beta-alpha(2)-beta(3); 2 layers: a/b; antiparallel beta-sheet, order:1432
1. MesJ substrate recognition domain-like [82829] (1)
  uperfamily
FYSH domain [89894] (1)
beta(2)-alpha(2)-beta(2)-alpha-beta; two layers: alpha/beta; antiparallel sheet: order 51234
1. FYSH domain [89895] (2)
  uperfamily
VSV matrix protein [75403] (1)
beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154
1. VSV matrix protein [75404] (1)
  uperfamily
DNA-binding domain of Mlu1-box binding protein MBP1 [54615] (1)
beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465
1. DNA-binding domain of Mlu1-box binding protein MBP1 [54616] (1)
  has some topological similarity to the "winged helix" DNA-binding domain, to B1 and B5 domains of PheRS-beta (1PYS CH B) and to methyl-CpG-binding domain
  uperfamily
Heme-binding protein A (HasA) [54620] (1)
beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432
1. Heme-binding protein A (HasA) [54621] (1)
  uperfamily
Chalcone isomerase [54625] (1)
beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567
1. Chalcone isomerase [54626] (1)
  uperfamily
Coproporphyrinogen III oxidase [102885] (1)
alpha-beta(6)-alpha(2)-beta-alpha(n); 3 layers alpha/beta/alpha; antiparallel sheet: order 1234567
1. Coproporphyrinogen III oxidase [102886] (1)
  uperfamily
Hypothetical protein Ta1206 [102890] (1)
beta(4)-alpha-beta(2)-alpha(2); mixed, predominately antiparallel beta-sheet, order: 123465, strands 4 and 5 are parallel to each other
1. Hypothetical protein Ta1206 [102891] (1)
  can be divided into an N-terminal, tetramerisation all-beta subdomain and a C-terminal alpha+beta subdomain related by a circular permutation to the Y-family DNA-polymerase 'fingers' subdomain
  uperfamily
CBS-domain pair [54630] (1)
duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences; 4 layers: a/b/b/a
1. CBS-domain pair [54631] (1)
  uperfamily
Thioesterase/thiol ester dehydrase-isomerase [54636] (1)
core: beta-alpha-beta(4); 2 layers: alpha/beta
1. Thioesterase/thiol ester dehydrase-isomerase [54637] (8)
  uperfamily
DLC [54647] (1)
core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342
1. DLC [54648] (1)
  uperfamily
CI-2 family of serine protease inhibitors [54653] (1)
alpha+beta sandwich; loop across free side of beta-sheet
1. CI-2 family of serine protease inhibitors [54654] (1)
  uperfamily
Integrin beta tail domain [69686] (1)
alpha-beta-loop-beta(3); loop across free side of beta-sheet
1. Integrin beta tail domain [69687] (1)
  uperfamily
YcgL-like [160190] (1)
beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet, order:3124
1. YcgL-like [160191] (1)
alpha/beta-Hammerhead [54664] (5)
core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
1. CO dehydrogenase molybdoprotein N-domain-like [54665] (1)
  uperfamily
2. Nicotinate/Quinolinate PRTase N-terminal domain-like [54675] (2)
  uperfamily
3. Pyrimidine nucleoside phosphorylase C-terminal domain [54680] (1)
  uperfamily
4. Ribosomal protein L16p/L10e [54686] (2)
  uperfamily
5. Molybdopterin synthase subunit MoaE [54690] (1)
  uperfamily
POZ domain [54694] (1)
core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143
1. POZ domain [54695] (2)
  uperfamily
EF-Ts domain-like [54712] (2)
beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123
1. Elongation factor Ts (EF-Ts), dimerisation domain [54713] (1)
  comprises two structural repeats of this fold
  uperfamily
2. Band 7/SPFH domain [117892] (1)
  beta(2)-alpha(3)-beta
  uperfamily
Fe,Mn superoxide dismutase (SOD), C-terminal domain [54718] (1)
alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213
1. Fe,Mn superoxide dismutase (SOD), C-terminal domain [54719] (1)
  uperfamily
ClpS-like [54735] (1)
beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta
1. ClpS-like [54736] (2)
  uperfamily
Hypothetical protein MTH1880 [75411] (1)
beta-alpha-beta(2)-alpha(2); 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
1. Hypothetical protein MTH1880 [75412] (1)
  uperfamily
Ribosomal L11/L12e N-terminal domain [54746] (1)
beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
1. Ribosomal L11/L12e N-terminal domain [54747] (1)
  uperfamily
Anti-LPS factor/recA domain [54751] (2)
alpha-beta(3)-alpha(2); 2 layers, alpha/beta
1. RecA protein, C-terminal domain [54752] (1)
  uperfamily
2. Anti-lipopolysaccharide factor [54757] (1)
  uperfamily
Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54761] (1)
(beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta
1. Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54762] (1)
  uperfamily
dsRBD-like [54767] (5)
alpha-beta(3)-alpha; 2 layers: alpha/beta
1. dsRNA-binding domain-like [54768] (3)
  uperfamily
2. Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain [54782] (1)
  uperfamily
3. YcfA/nrd intein domain [54786] (3)
  uperfamily
4. Peptidyl-tRNA hydrolase domain-like [110916] (1)
  uperfamily
5. Rv2632c-like [143212] (1)
  lacks the N-terminal helix; dimerises via the N-terminal strand and the C-terminal helix with the formation of a single beta-sheet wrapped around an antiparallel coiled coil
  uperfamily
2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain [110920] (1)
duplication: consists of two beta(3)-alpha repeats; 3 layers, beta/alpha/beta
1. 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain [110921] (1)
  uperfamily
NMB0488-like [160206] (1)
duplication: two beta(3)-alpha motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456, shaped into a half-barrel; helical linker region
1. NMB0488-like [160207] (1)
SRP19 [69694] (1)
beta-alpha-beta(2)-alpha; 2 layers: alpha/beta
1. SRP19 [69695] (1)
  uperfamily
SufE/NifU [82648] (1)
alpha(2)-beta(3)-alpha(3); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
1. SufE/NifU [82649] (3)
  iron-sulfur cluster assembly proteins
  uperfamily
FlaG-like [160213] (1)
alpha(2)-beta(3)-alpha; 2 layers: a/b; antiparallel beta-sheet, order: 123; partial similatity to the dsRBD-like fold(sop_cf 54767)
1. FlaG-like [160214] (1)
AMPKBI-like [160218] (1)
comprises 3 short helices and 3-stranded meander beta-sheet; makes extensive intermolecular interactions
1. AMPKBI-like [160219] (1)
DNA-binding protein Tfx [89914] (1)
alpha(3)-beta-alpha(2)-beta(2); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
1. DNA-binding protein Tfx [89915] (1)
  uperfamily
Eukaryotic type KH-domain (KH-domain type I) [54790] (1)
beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta
1. Eukaryotic type KH-domain (KH-domain type I) [54791] (1)
  Prokaryotic and eukaryotic domains share a KH-motif but have different topologies
  uperfamily
Alpha-lytic protease prodomain-like [54805] (10)
core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta
1. Alpha-lytic protease prodomain [54806] (1)
  uperfamily
2. GMP synthetase C-terminal dimerisation domain [54810] (1)
  uperfamily
3. Prokaryotic type KH domain (KH-domain type II) [54814] (1)
  Prokaryotic and eukaryotic domains share a KH-motif but have different topologies
  uperfamily
4. Probable GTPase Der, C-terminal domain [82653] (1)
  possible distant relative of the Era C-terminal domain lacking the KH motif
  uperfamily
5. Ribosome-binding factor A, RbfA [89919] (1)
  possible distant homologue of the type I KH domain lacking the KH motif
  uperfamily
6. YhbC-like, N-terminal domain [75420] (1)
  uperfamily
7. BolA-like [82657] (1)
  uperfamily
8. Fe-S cluster assembly (FSCA) domain-like [117916] (2)
  similar putative active site with a conserved cysteine residue
  uperfamily
9. Cation efflux protein cytoplasmic domain-like [160240] (1)
10. EspE N-terminal domain-like [160246] (1)
  contains extra C-terminal helix that packs against shorter N-terminal helix
Nucleotidyltransferase [81302] (1)
core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123
1. Nucleotidyltransferase [81301] (14)
  uperfamily
Nqo5-like [143242] (1)
core: alpha-beta(2)-alpha-beta(3); 2 layers, a/b; mixed beta-sheet, order 12534, strands 2 and 5 are parallel
1. Nqo5-like [143243] (1)
  uperfamily
Ribosomal protein S3 C-terminal domain [54820] (1)
alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143
1. Ribosomal protein S3 C-terminal domain [54821] (1)
  uperfamily
Transcription factor NusA, N-terminal domain [69704] (1)
alpha-beta(3)-alpha-beta-alpha; bifurcated coiled beta-sheet
1. Transcription factor NusA, N-terminal domain [69705] (1)
  uperfamily
Enolase N-terminal domain-like [54825] (1)
beta(3)-alpha(3); meander and up-and-down bundle
1. Enolase N-terminal domain-like [54826] (1)
  uperfamily
Ribosomal protein L22 [54842] (1)
beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation
1. Ribosomal protein L22 [54843] (1)
  some topological similarity to prokaryotic ribosomal protein L17
  uperfamily
Prokaryotic ribosomal protein L17 [64262] (1)
alpha-beta-alpha(3)-beta(2); 2 layers: alpha/beta;
1. Prokaryotic ribosomal protein L17 [64263] (1)
  some topological similarity to ribosomal protein L22
  uperfamily
GroEL-intermediate domain like [54848] (1)
3-helical bundle packed against 3-stranded mixed beta-sheet
1. GroEL-intermediate domain like [54849] (2)
  uperfamily
PX domain [64267] (1)
beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch
1. PX domain [64268] (1)
  uperfamily
Shew3726-like [160271] (1)
beta(3)-alpha(n)-beta; 2 layers, a/b; mixed beta-sheet, order 1234, strands 3 and 4 are parallel with a left-handed crossover connection
1. Shew3726-like [160272] (1)
DsrC, the gamma subunit of dissimilatory sulfite reductase [69720] (1)
beta(3)-alpha(5); meander beta-sheet packed against array of helices
1. DsrC, the gamma subunit of dissimilatory sulfite reductase [69721] (1)
  uperfamily
DNA damage-inducible protein DinI [54856] (1)
beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops
1. DNA damage-inducible protein DinI [54857] (1)
  uperfamily
HSP90 C-terminal domain [110941] (1)
alpha-beta(3)-alpha(3); 2 layers, a/b; mixed beta-sheet, order:132; crossing loops
1. HSP90 C-terminal domain [110942] (1)
  uperfamily
Ferredoxin-like [54861] (59)
alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
1. 4Fe-4S ferredoxins [54862] (6)
  uperfamily
2. Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain [54893] (1)
  uperfamily
3. Protease propeptides/inhibitors [54897] (3)
  uperfamily
4. Dimeric alpha+beta barrel [54909] (23)
  dimerizes through the beta-sheet; forms beta-sheet barrel, closed (n=8, S=12); dimers may assemble in higher oligomers
  uperfamily
5. GlnB-like [54913] (5)
  form timeric structures with the orthogonally packed beta-sheets
  uperfamily
6. SEA domain [82671] (1)
  uperfamily
7. Nucleoside diphosphate kinase, NDK [54919] (1)
  uperfamily
8. RNA-binding domain, RBD [54928] (5)
  uperfamily
9. Viral DNA-binding domain [54957] (1)
  uperfamily
10. RuBisCO, large subunit, small (N-terminal) domain [54966] (1)
  C-terminal domain is beta/alpha barrel
  uperfamily
11. Acylphosphatase/BLUF domain-like [54975] (2)
  uperfamily
12. EF-G C-terminal domain-like [54980] (3)
  uperfamily
13. eEF-1beta-like [54984] (1)
  uperfamily
14. eEF1-gamma domain [89942] (1)
  elaborated with additional structures
  uperfamily
15. Anticodon-binding domain of PheRS [54991] (1)
  uperfamily
16. Ribosomal protein S6 [54995] (1)
  uperfamily
17. Ribosomal protein S10 [54999] (1)
  uperfamily
18. N-utilization substance G protein NusG, N-terminal domain [82679] (1)
  uperfamily
19. PAP/Archaeal CCA-adding enzyme, C-terminal domain [55003] (2)
  uperfamily
20. HMA, heavy metal-associated domain [55008] (1)
  uperfamily
21. Urease metallochaperone UreE, C-terminal domain [69737] (1)
  uperfamily
22. ACT-like [55021] (14)
  regulatory domain linked to a wide range of metabolic enzymes
  uperfamily
23. Bacterial exopeptidase dimerisation domain [55031] (1)
  uperfamily
24. NAD-binding domain of HMG-CoA reductase [55035] (1)
  uperfamily
25. Molybdenum cofactor biosynthesis protein C, MoaC [55040] (1)
  uperfamily
26. TRADD, N-terminal domain [55044] (1)
  uperfamily
27. Probable ACP-binding domain of malonyl-CoA ACP transacylase [55048] (1)
  uperfamily
28. CheY-binding domain of CheA [55052] (1)
  uperfamily
29. D-ribose-5-phosphate isomerase (RpiA), lid domain [75445] (1)
  uperfamily
30. Killer toxin KP6 alpha-subunit [55056] (1)
  uperfamily
31. Hypothetical protein VC0424 [89946] (1)
  uperfamily
32. Hypothetical protein TT1725 [103007] (1)
  uperfamily
33. Mechanosensitive channel protein MscS (YggB), C-terminal domain [82689] (1)
  the last strand of the fold is flipped away and involved in oligomerisation
  uperfamily
34. GHMP Kinase, C-terminal domain [55060] (7)
  common fold is elaborated with additional secondary structures
  uperfamily
35. Translational regulator protein regA [55064] (1)
  common fold is elaborated with additional secondary structures
  uperfamily
36. Peptide methionine sulfoxide reductase [55068] (1)
  common fold is elaborated with additional secondary structures
  uperfamily
37. Nucleotide cyclase [55073] (2)
  common fold is elaborated with additional secondary structures
  uperfamily
38. 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK [55083] (1)
  common fold is elaborated with additional secondary structures
  uperfamily
39. Glutamyl tRNA-reductase catalytic, N-terminal domain [69742] (1)
  common fold is elaborated with additional secondary structures
  uperfamily
40. MTH1187/YkoF-like [89957] (2)
  uperfamily
41. Methyl-coenzyme M reductase subunits [55088] (2)
  each of the three different subunits, alpha, beta and gamma, contains this fold decorated with additional secondary structures
  uperfamily
42. FAD-linked oxidases, C-terminal domain [55103] (4)
  duplication: contains two subdomains of this fold
  uperfamily
43. Formylmethanofuran:tetrahydromethanopterin formyltransferase [55112] (1)
  duplication: contains two subdomains of this fold
  uperfamily
44. Formiminotransferase domain of formiminotransferase-cyclodeaminase. [55116] (1)
  duplication: contains two subdomains of this fold
  uperfamily
45. Nitrite/Sulfite reductase N-terminal domain-like [55124] (2)
  duplication: contains two subdomains of this fold
  uperfamily
46. Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains [82693] (1)
  duplication: the N- and C-terminal halves of the whole proteins are structurally similar; each half contains two domains of this fold
  uperfamily
47. YajQ-like [89963] (1)
  duplication: consists of two domains of this fold swapped with their N-terminal strands
  uperfamily
48. eIF-2-alpha, C-terminal domain [110993] (1)
  uperfamily
49. Sporulation related repeat [110997] (1)
  duplication: one domain contains two repeats of similar sequence and structure
  uperfamily
50. CRISPR-associated protein [117987] (1)
  duplication: contains two subdomains of this fold
  uperfamily
51. YbeD/HP0495-like [117991] (2)
  uperfamily
52. DOPA-like [143410] (1)
  probable biological unit is homodimer; the extra C-terminal strand, adjacent and antiparallel to strand 4, contributes to the dimerisation interface
  uperfamily
53. CcmK-like [143414] (1)
  contains extra C-terminal helix; forms compact hexameric 'tiles' of hexagonal shape
  uperfamily
54. Transposase IS200-like [143422] (1)
  contains extra N-terminal hairpin and C-terminal helix, both are involved in dimerization; there can be helix-swapping in the dimer
  uperfamily
55. TTP0101/SSO1404-like [143430] (1)
  contains extra C-terminal beta-strand that integrates into the beta-sheet of the other subunit in the homodimer, a probable biological unit of this superfamily
  uperfamily
56. Rnp2-like [160350] (1)
  contains extra C-terminal helix
57. Bacterial polysaccharide co-polymerase-like [160355] (1)
  Decorated common fold with extra helical regions, which facilitate oligomerization
58. MTH889-like [160363] (1)
  assembles into hexameric ring-like structures with the formation of a singe beta-barrel sheet of 24 strands
59. Ribosomal protein L10-like [160369] (1)
  consists of globular N-terminal domain, structurally similar to NDK, and the L7/L12-binding C-terminal alpha-helical tail
PurS-like [109622] (1)
consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
1. PurS-like [82697] (2)
  segment-swapped dimer: the swapped segment is made of the first helix and second strand; a single long strand is formed by strands 2 and 3 of each subunit
  uperfamily
RplX-like [160373] (1)
beta(2)-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 213; some structural similarity to the PurS subunit/repeat (scop_cf 109622)
1. RplX-like [160374] (1)
  similar structural motif to the Ribosomal S24e family (scop_fa 117786); possible structural permutation
Dystroglycan, domain 2 [111005] (1)
beta-alpha-beta-X-beta(2)-alpha(2)-beta; antiparallel beta-sheet, order 24153; topological similarity to the ferredoxin-like fold (scop_cf 54861)
1. Dystroglycan, domain 2 [111006] (1)
  uperfamily
Pseudouridine synthase [100877] (1)
consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
1. Pseudouridine synthase [55120] (4)
  the active site is the most conserved structural region of the superfamily and is located between the subdomains
  uperfamily
SP0830-like [160378] (1)
duplication: two beta-alpha-beta(2)-alpha-beta-alpha motifs are organized in ferredoxin-like subdomains swapped with the extra C-terminal helices
1. SP0830-like [160379] (1)
Folate-binding domain [103024] (1)
duplication: consists of two beta(2)-alpha-beta(3)-alpha subdomains swapped with the first strands
1. Folate-binding domain [103025] (2)
  some topological similarity to Formylmethanofuran:tetrahydromethanopterin formyltransferase
  uperfamily
THUMP domain [143436] (1)
contains mixed 8-stranded beta-sheet, folded into a half-barrel and covered with 4 helices on the outside; order 32148756; strands 5, 6 and 7 are parallel
1. THUMP domain-like [143437] (3)
  predicted RNA-binding function
  uperfamily
AMMECR1-like [143446] (1)
duplication; contains two beta(2)-alpha-beta(2) structural repeats, swapped with C-terminal strands; extra N-terminal helix and C-terminal strand
1. AMMECR1-like [143447] (1)
  uperfamily
NosL/MerB-like [160386] (1)
unusual fold; comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets; probable duplication
1. NosL/MerB-like [160387] (2)
YehU-like [118000] (1)
beta-alpha(2)-beta(2)-alpha; 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
1. YehU-like [118001] (1)
  uperfamily
Hypothetical protein YwqG [103031] (1)
duplication: contains two similar beta-x-beta(4) motifs swapped with the first strands
1. Hypothetical protein YwqG [103032] (1)
  uperfamily
VC0467-like [143455] (1)
complex fold; contains bifurcated beta-sheet structure folded into pseudo barrel
1. VC0467-like [143456] (1)
  uperfamily
Lesion bypass DNA polymerase (Y-family), little finger domain [100878] (1)
beta-alpha-beta(2)-alpha-beta; antiparallel beta-sheet: order 1423; "reversed" ferredoxin-like topology
1. Lesion bypass DNA polymerase (Y-family), little finger domain [100879] (1)
  uperfamily
ImmE5-like [143468] (1)
alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order 213
1. ImmE5-like [143469] (1)
  uperfamily
Ribosomal protein L30p/L7e [55128] (1)
core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity to the ferredoxin-like fold
1. Ribosomal protein L30p/L7e [55129] (1)
  uperfamily
Chorismate lyase-like [64287] (1)
duplication of alpha(2)-beta(3) motif; antiparallel beta sheet, order 123654
1. Chorismate lyase-like [64288] (3)
  uperfamily
YdfO-like [160418] (1)
duplication: two alpha(2)-beta(3) motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456
1. YdfO-like [160419] (1)
TM1622-like [143476] (1)
alpha-beta(3)-alpha-beta(4)-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 1237654
1. TM1622-like [143477] (1)
  uperfamily
BH3703-like [160423] (1)
alpha-beta(3)-alpha-beta(2)-alpha(2); antiparallel beta-sheet, order:32145; duplication: two alpha-beta(2) structural repeats are arranged with pseudo twofold symmetry
1. BH3703-like [160424] (1)
Probable bacterial effector-binding domain [55135] (1)
duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12)
1. Probable bacterial effector-binding domain [55136] (4)
  uperfamily
CheC-like [103038] (1)
duplication: tandem repeat of two intertwined alpha-beta-(X)-beta(2) motifs
1. CheC-like [103039] (1)
  uperfamily
LigT-like [55143] (1)
duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III
1. LigT-like [55144] (4)
  uperfamily
Pepsin inhibitor-3 [55148] (1)
duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure
1. Pepsin inhibitor-3 [55149] (1)
  uperfamily
CYTH-like phosphatases [55153] (1)
duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it
1. CYTH-like phosphatases [55154] (2)
  uperfamily
Antiparallel beta/alpha barrel (PT-barrel) [143491] (1)
tandem repeat of five alpha(2)-beta(2) motifs; antiparallel beta-sheet barrel, closed; n=10, S=10; order 123456789A; there is a channel along the barrel axis
1. Prenyltransferase-like [143492] (1)
  the barrel channel harbours the substrate-binding site
  uperfamily
eIF1-like [55158] (2)
beta(2)-alpha-beta(2)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet: order 51243
1. eIF1-like [55159] (1)
  uperfamily
2. TM1457-like [118010] (1)
  forms a homodimer via alpha-helical interface
  uperfamily
Hedgehog/DD-peptidase [55165] (1)
alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
1. Hedgehog/DD-peptidase [55166] (5)
  zinc-binding motif
  uperfamily
Alpha-L RNA-binding motif [55173] (1)
alpha(2)-beta(2)-loop-beta; 2 layers: alpha/beta
1. Alpha-L RNA-binding motif [55174] (5)
  common motif in otherwise different folds
  uperfamily
RRF/tRNA synthetase additional domain-like [55185] (4)
core: alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
1. ThrRS/AlaRS common domain [55186] (2)
  putative editing domain found in the N-terminal part of ThrRS, the C-terminal of AlaRS, and as a stand-alone protein; probable circular permutation of LuxS (d.185.1.2)
  uperfamily
2. Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain [55190] (1)
  uperfamily
3. Ribosome recycling factor, RRF [55194] (1)
  uperfamily
4. General secretion pathway protein M, EpsM [103054] (1)
  uperfamily
LuxS/MPP-like metallohydrolase [63410] (1)
core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta
1. LuxS/MPP-like metallohydrolase [63411] (2)
  Share the same "active site motif" HxxEH located in the first core helix, but differ in one of the zinc-binding residues
  uperfamily
IF3-like [55199] (8)
beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest
1. Translation initiation factor IF3, C-terminal domain [55200] (1)
  uperfamily
2. YhbY-like [75471] (1)
  uperfamily
3. SirA-like [64307] (1)
  uperfamily
4. AlbA-like [82704] (2)
  uperfamily
5. C-terminal domain of ProRS [64586] (1)
  contains a metal (zinc)-binding site
  uperfamily
6. R3H domain [82708] (1)
  possibly lacks the N-terminal strand of the common fold
  uperfamily
7. EPT/RTPC-like [55205] (2)
  uperfamily
8. SMR domain-like [160443] (1)
PUG domain-like [143502] (1)
alpha(2)-beta-alpha(2)-beta(2)-alpha; cluster of helices with a small antiparallel beta-sheet on one side; order 132; topological similarity to the fold of an extended R3H domain (PDB 1whr)
1. PUG domain-like [143503] (1)
  uperfamily
PG1857-like [160447] (1)
alpha-beta-alpha-beta(2)-alpha(3); 3 layers, a/b/a; antiparallel beta-sheet, order: 132
1. PG1857-like [160448] (1)
PB2 C-terminal domain-like [160452] (1)
alpha-beta-alpha-X-alpha-beta(2); 3 layers, a/b/a; antiparallel beta-sheet, order 132; connection between helices 2 and 3 runs over the edge of the beta-sheet
1. PB2 C-terminal domain-like [160453] (1)
Ribosome binding protein Y (YfiA homologue) [69753] (1)
beta-alpha-beta(3)-alpha; 2 layers; mixed sheet 1234, strand 3 is antiparallel to the rest
1. Ribosome binding protein Y (YfiA homologue) [69754] (1)
  uperfamily
TolA/TonB C-terminal domain [74652] (1)
beta(2)-alpha-beta; 2 layers, alpha/beta; left-handed beta-alpha-beta unit in non-swapped monomer
1. TolA/TonB C-terminal domain [74653] (2)
  uperfamily
Yeast killer toxins [55220] (1)
beta-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta; left-handed crossover connection
1. Yeast killer toxins [55221] (2)
  uperfamily
Cell division protein MinE topological specificity domain [55228] (1)
dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
1. Cell division protein MinE topological specificity domain [55229] (1)
  uperfamily
Hypothetical protein YoaG [103062] (1)
dimer of beta(2)-alpha motifs ; 2 layers, alpha/beta; reverse MinE topology
1. Hypothetical protein YoaG [103063] (1)
  uperfamily
BLRF2-like [160458] (1)
homodimer of alpha(2)-beta motif; also includes extra N-terminal helix of variable position
1. BLRF2-like [160459] (1)
Nucleocapsid protein dimerization domain [103067] (1)
dimer of alpha-beta(2)-alpha motifs ; 2 layers, alpha/beta
1. Nucleocapsid protein dimerization domain [103068] (2)
  uperfamily
Cyanase C-terminal domain [55233] (1)
intertwined dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
1. Cyanase C-terminal domain [55234] (1)
  uperfamily
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains [82713] (1)
Intertwined pseudo hexamer of an alpha+beta motif
1. Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains [82714] (1)
  duplication: the N- and C-terminal halves of the whole proteins are structurally similar
  uperfamily
RuBisCO, small subunit [55238] (1)
alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
1. RuBisCO, small subunit [55239] (1)
  uperfamily
DCoH-like [55247] (5)
beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
1. PCD-like [55248] (1)
  has additional alpha helix at the N-terminus
  uperfamily
2. C-terminal domain of arginine repressor [55252] (1)
  forms trimers with three closely packed beta-sheets
  uperfamily
3. RBP11-like subunits of RNA polymerase [55257] (2)
  form homo and heterodimers
  uperfamily
4. GAD domain-like [55261] (2)
  uperfamily
5. PH0987 N-terminal domain-like [160467] (1)
TRCF domain-like [143516] (1)
beta-alpha(3)-beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed beta sheet, order 12354, strands 1 and 2 are parallel; some topological similarity to the DCoH-like fold (scop_cf 55247)
1. TRCF domain-like [143517] (1)
  uperfamily
NMB0513-like [160471] (1)
alpha(3)-beta(2)-alpha-beta(2); some similarity to the "winged helix" DNA-binding domain fold
1. NMB0513-like [160472] (1)
PA1123-like [160476] (1)
irregular array of short helices and two three-stranded beta-sheets
1. PA1123-like [160477] (1)
Hypothetical protein Yml108w [100886] (1)
beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta; mixed beta-sheet 2143, strands 1 and 4 are parallel
1. Hypothetical protein Yml108w [89975] (1)
  uperfamily
MutS N-terminal domain-like [55266] (2)
beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
1. tRNA-intron endonuclease N-terminal domain-like [55267] (1)
  uperfamily
2. DNA repair protein MutS, domain I [55271] (1)
  uperfamily
GYF/BRK domain-like [55276] (2)
beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
1. GYF domain [55277] (1)
  uperfamily
2. BRK domain-like [160481] (1)
GTP cyclohydrolase I feedback regulatory protein, GFRP [69760] (1)
beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta, antiparallel beta-sheet: order 342165
1. GTP cyclohydrolase I feedback regulatory protein, GFRP [69761] (1)
  uperfamily
RL5-like [55281] (1)
beta-alpha-beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet: order 231654
1. RL5-like [55282] (2)
  uperfamily
RPB5-like RNA polymerase subunit [55286] (1)
core: beta-alpha-beta-alpha-beta(2); 2 layers, alpha/beta
1. RPB5-like RNA polymerase subunit [55287] (1)
  uperfamily
Bacillus chorismate mutase-like [55297] (9)
core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest
1. YjgF-like [55298] (2)
  forms trimers with three closely packed beta-sheets; possibly related to the IspF (d.79.5) and 4'-phosphopantetheinyl transferase superfamilies (d.150.1)
  uperfamily
2. IpsF-like [69765] (1)
  forms trimers with three closely packed beta-sheets; possible link between the YjgF-like (d.79.1) and 4'-phosphopantetheinyl transferase superfamilies (d.150.1)
  uperfamily
3. Tubulin C-terminal domain-like [55307] (1)
  uperfamily
4. L30e-like [55315] (3)
  uperfamily
5. PurM N-terminal domain-like [55326] (1)
  uperfamily
6. Holliday junction resolvase RusA [103084] (1)
  uperfamily
7. OmpA-like [103088] (1)
  uperfamily
8. YueI-like [160515] (1)
9. BB2672-like [160519] (1)
  contains extra N-terminal strand and a beta-hairpin insertion between strands 3 and 4 that packs against the main beta-sheet
YjbQ-like [111037] (1)
beta(2)-alpha-beta(2)-alpha(2)-beta(3); contains a beta-sandwich: 7 strands in 2 sheets; trimerizes with orthogonally packed beta-sheets
1. YjbQ-like [111038] (1)
  uperfamily
Tautomerase/MIF [55330] (1)
(beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet
generally forms trimers with three closely packed beta-sheets
1. Tautomerase/MIF [55331] (6)
  uperfamily
FwdE/GAPDH domain-like [55346] (4)
core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1
1. Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain [55347] (5)
  N-terminal domain is the classic Rossmann-fold
  uperfamily
2. Serine metabolism enzymes domain [143548] (2)
  contains extra C-terminal beta-hairpin
  uperfamily
3. FwdE-like [143555] (1)
  contains extra N-terminal and C-terminal structures
  uperfamily
4. V-type ATPase subunit E-like [160527] (1)
  extra N-terminal helix and extra C-terminal helix form dimerisation subdomain
Ava3019-like [160531] (1)
alpha(2)-beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order: 32145; similarity to the insert domain of Glucose 6-phosphate dehydrogenase-like family (sop_fa 55376)
1. Ava3019-like [160532] (1)
Hypothetical protein PF0899 [111056] (1)
alpha-beta-alpha-beta(4); 2 layers: a/b; mixed beta-sheet, order 23145, strands 1 and 3 are parallel; similar to the GAPDH C-terminal domain-like fold (scop_cf 55346)
1. Hypothetical protein PF0899 [111057] (1)
  possibly related to Major capsid protein gp5 (scop_sf 56563)63566
  uperfamily
Major capsid protein gp5 [56562] (1)
unusual fold; contains PF0899-like core, decorated with additional structure
1. Major capsid protein gp5 [56563] (1)
  possibly related to the hypothetical protein PF0899 superfamily (scop_sf 111057)
  uperfamily
MK0786-like [143559] (1)
alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order 1234 (meander)
1. MK0786-like [143560] (1)
  probable biological unit is a teramer; all subunit interfaces are provided by helices
  uperfamily
YkuJ-like [143566] (1)
alpha-beta(4)-alpha; 2 layers a/b; antiparallel beta-sheet, order 1234
1. YkuJ-like [143567] (1)
  uperfamily
N domain of copper amine oxidase-like [55382] (5)
alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet
1. Copper amine oxidase, domain N [55383] (1)
  uperfamily
2. Frataxin/Nqo15-like [55387] (2)
  uperfamily
3. Hypothetical protein c14orf129, hspc210 [103107] (1)
  uperfamily
4. GAS2 domain-like [143575] (1)
  this superfamily may include the most C-terminal domain of IBP39 (scop_fa 103410); the preceeding (middle) domain of IBP39 may be split and reassigned to the EF-hand superfamily (scop_sf 47473)
  uperfamily
5. GK1464-like [143579] (1)
  dimer; pseudo barrel; the true dimeric barrel formation requires swapping of the C-ternimal beta-alpha units
  uperfamily
Aha1/BPI domain-like [55393] (2)
core: [beta]-alpha-beta(5)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, meander
1. Activator of Hsp90 ATPase, Aha1 [103111] (1)
  consists of a single domain of this fold
  uperfamily
2. Bactericidal permeability-increasing protein, BPI [55394] (1)
  duplication: consists of two clear structural repeats of this fold also containing an extra C-terminal beta-hairpin
  uperfamily
SpoVG-like [160536] (1)
beta(5)-alpha; comprises a coiled antiparallel beta-sheet (order: 12345) packed against the C-terminal helix; the extensions of strands 4 and 5 form an isolated beta-hairpin
1. SpoVG-like [160537] (1)
  probable biological unit is a hexamer (trimer of dimers)
Subtilisin inhibitor [55398] (1)
alpha+beta sandwich
1. Subtilisin inhibitor [55399] (1)
  uperfamily
RNA bacteriophage capsid protein [55404] (1)
6-standed beta-sheet followed with 2 helices; meander
1. RNA bacteriophage capsid protein [55405] (1)
  uperfamily
eIF4e-like [55417] (1)
beta(2)-alpha-beta(2)-alpha-beta(2)-alpha-beta-2; 2 layers: alpha/beta; antiparallel sheet: 21356478
1. eIF4e-like [55418] (2)
  uperfamily
CO dehydrogenase flavoprotein C-domain-like [55423] (2)
core: beta(3,4)-alpha(3); alpha+beta sandwich
1. FAD/NAD-linked reductases, dimerisation (C-terminal) domain [55424] (1)
  both first two domains are of same beta/beta/alpha fold
  uperfamily
2. CO dehydrogenase flavoprotein C-terminal domain-like [55447] (1)
  uperfamily
SRF-like [55454] (1)
alpha-beta(2)-alpha; dimer; 3 layers a/b/a; antiparallel beta-sheet
1. SRF-like [55455] (1)
  uperfamily
Origin of replication-binding domain, RBD-like [55463] (1)
alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel sheet 41325
1. Origin of replication-binding domain, RBD-like [55464] (5)
  uperfamily
SARS receptor-binding domain-like [143586] (1)
core: 3 layers, a/b/a; antiparallel beta-sheet of 5 strands, order 13542
1. SARS receptor-binding domain-like [143587] (1)
  uperfamily
Hut operon positive regulatory protein HutP [111063] (1)
alpha(2)-beta-alpha(2)-beta(3); 3 layers: a/b/a; antiparallel beta-sheet: order 1234
1. Hut operon positive regulatory protein HutP [111064] (1)
  uperfamily
Hypothetical protein yfbM [111068] (1)
beta-alpha(2)-beta-alpha(2)-beta(2)-alpha(n)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 21543
1. Hypothetical protein yfbM [111069] (1)
  uperfamily
TTHA1528-like [143591] (1)
beta-alpha-beta(3)-alpha-beta-alpha(2)-beta; 3 layers: a/b/a; mixed beta-sheet, order: 143256, parallel strands' pairs are 1-4 and 2-5
1. TTHA1528-like [143592] (1)
  uperfamily
YojJ-like [143596] (1)
alpha-beta-X-beta-alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; 7-stranded mixed beta-sheet, order 2431567; strands 1 and 3 are parallel to each other
1. YojJ-like [143597] (1)
  uperfamily
STIV B116-like [143601] (1)
subunit fold consists of mixed 5-stranded beta-sheet, order:31452, strand 5 is antiparallel to the rest, with 3 helices on one side; dimerises with the formation of a single 10-stranded beta-sheet; strand 2 is in the dimer interface
1. STIV B116-like [143602] (1)
  uperfamily
Bacillus phage protein [111073] (1)
alpa-beta(3)-alpha-beta(3)-alpha; 3 layers: b/a/b, 3-helical bundle flanked by two 3-stranded meander beta-sheets
1. Bacillus phage protein [111074] (1)
  uperfamily
FMN-dependent nitroreductase-like [55468] (1)
core: (alpha-beta-alpha-beta)2; 3 layers a/b/a; antiparallel beta-sheet: 1243
1. FMN-dependent nitroreductase-like [55469] (2)
  uperfamily
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 [55480] (1)
alpha-beta-alpha(2)-beta(3)-alpha; 3 layers a/b/a; antiparallel beta-sheet: 4123
1. N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 [55481] (1)
  uperfamily
EscU C-terminal domain-like [160543] (1)
alpha-beta(3)-alpha-beta-alpha(2); 3 layers, a/b/a; mixed beta-sheet, order: 4123, strand 2 is antiparallel to the rest
1. EscU C-terminal domain-like [160544] (1)
Zincin-like [55485] (2)
contains mixed beta sheet with connection over free side of the sheet
1. Metalloproteases ("zincins"), catalytic domain [55486] (17)
  uperfamily
2. beta-N-acetylhexosaminidase-like domain [55545] (3)
  contains similar fold but lacks its catalytic centre
  uperfamily
SH2-like [55549] (1)
3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
1. SH2 domain [55550] (1)
  uperfamily
HPr-like [55593] (2)
beta-alpha-beta(2)-alpha-beta-alpha; 2 layers: a/b; antiparallel sheet 1423
1. HPr-like [55594] (1)
  uperfamily
2. Putative transcriptional regulator TM1602, C-terminal domain [75500] (1)
  uperfamily
TrkA C-terminal domain-like [116725] (1)
beta-X-beta(2)-X-beta-alpha; pseudo barrel capped by helix at one end; topological similarity to the HPr-like fold
1. TrkA C-terminal domain-like [116726] (1)
  uperfamily
Hypothetical protein YjiA, C-terminal domain [90001] (1)
beta-alpha-beta(4)-alpha; 2 layers: a/b; antiparallel sheet 15234; topological similarity to the HPr-like fold
1. Hypothetical protein YjiA, C-terminal domain [90002] (1)
  uperfamily
YggU-like [69785] (1)
beta(2)-loop-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243; some similarity to the Homing endonuclease-like fold
1. YggU-like [69786] (1)
  uperfamily
Homing endonuclease-like [55603] (2)
alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243
1. Glucose permease domain IIB [55604] (1)
  uperfamily
2. Homing endonucleases [55608] (2)
  uperfamily
T-fold [55619] (2)
beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
tunnel-shaped: its known members form wide oligomeric barrels different sizes
1. Tetrahydrobiopterin biosynthesis enzymes-like [55620] (4)
  bind purine or pterin in topologically similar sites between subunits
  uperfamily
2. ApbE-like [143631] (2)
  duplication: contains two differently decorated beta(2)-alpha(2)-beta(2) subdomains, similar to other T-fold domains; probably does not form the tunnel-shaped oligomers
  uperfamily
Cell cycle regulatory proteins [55636] (1)
beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243
can form strand-exchange dimers
1. Cell cycle regulatory proteins [55637] (1)
  uperfamily
YonK-like [160569] (1)
intertwined dimer of beta(3)-alpha-beta subunits; assembles further in octamer with formation of a wide 16-stranded beta-barrel
1. YonK-like [160570] (1)
  (Pro)phage and phage-related proteins
BLIP-like [55647] (2)
alpha(2)-beta(4); 2 layers: alpha/beta
1. beta-lactamase-inhibitor protein, BLIP [55648] (1)
  uperfamily
2. BT0923-like [160574] (1)
  Duplication: tandem repeat of two similar structural subdomains, which associate like the BLIP repeats but differ from them by transposition of the helices
Ribosomal protein L9 C-domain [55652] (1)
alpha-beta-alpha(2)-beta(2); 2 layers: alpha/beta
1. Ribosomal protein L9 C-domain [55653] (1)
  uperfamily
MbtH/L9 domain-like [55657] (2)
beta(2)-alpha-beta-alpha; 3 layers: alpha/beta/alpha
1. L9 N-domain-like [55658] (2)
  uperfamily
2. MbtH-like [160582] (1)
  the first helix is replaced with an extended loop; contains extra C-terminal helix of variable position
Tombusvirus P19 core protein, VP19 [103144] (1)
beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel sheet: order 2134
1. Tombusvirus P19 core protein, VP19 [103145] (1)
  uperfamily
Ribonuclease PH domain 2-like [55665] (1)
beta(2)-alpha-beta(2)-alpha; 3 layers: alpha/beta/alpha; antiparallel sheet: order 2134
1. Ribonuclease PH domain 2-like [55666] (1)
  uperfamily
Regulatory factor Nef [55670] (1)
alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha
1. Regulatory factor Nef [55671] (1)
  uperfamily
CytB endotoxin-like [55675] (1)
core: beta-alpha(2)-beta-alpha(2)-beta(4); 3 layers: a/b/a
1. CytB endotoxin-like [55676] (1)
  uperfamily
Class II aaRS and biotin synthetases [55680] (1)
contains large mixed beta-sheet
1. Class II aaRS and biotin synthetases [55681] (4)
  uperfamily
Subdomain of clathrin and coatomer appendage domain [55710] (1)
beta-alpha-beta-alpha-beta(4)-alpha; 3 layers: a/b/a; bifurcated antiparallel beta-sheet
1. Subdomain of clathrin and coatomer appendage domain [55711] (2)
  uperfamily
SCP-like [55717] (1)
alpha-beta(3)-(crossover)-beta-(alpha)-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 32145
1. SCP-like [55718] (4)
  uperfamily
Ta1353-like [103164] (1)
core: beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 51423;
1. Ta1353-like [103165] (1)
  uperfamily
Mog1p/PsbP-like [55723] (1)
(beta-hairpin)-beta(3)-alpha-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet of 7 strands; order: 1237654
1. Mog1p/PsbP-like [55724] (4)
  uperfamily
SMI1/KNR4-like [160630] (1)
alpha(4)-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet, order 1234(meander)
1. SMI1/KNR4-like [160631] (1)
Acyl-CoA N-acyltransferases (Nat) [55728] (1)
3 layers: a/b/a; contains mixed beta-sheet
1. Acyl-CoA N-acyltransferases (Nat) [55729] (10)
  uperfamily
Gelsolin-like [55752] (3)
3 layers: a/b/a; contains mixed beta-sheet
1. Actin depolymerizing proteins [55753] (2)
  uperfamily
2. C-terminal, gelsolin-like domain of Sec23/24 [82754] (1)
  uperfamily
3. FLJ32549 C-terminal domain-like [160651] (1)
  alpha-beta(2)-alpha-beta(3)-alpha; similar to the Roadblock/LC7 domain
PHP14-like [143723] (1)
beta(3)-alpha-beta(2)-alpha-beta; 3 layers, a/b/a; mixed beta-sheet, half-barrel, order: 132456; strands 2 and 5 are antiparallel to the rest
1. PHP14-like [143724] (2)
  uperfamily
Profilin-like [55769] (10)
core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha
1. Profilin (actin-binding protein) [55770] (1)
  alpha-beta(2)-alpha-beta(5)-alpha
  uperfamily
2. GAF domain-like [55781] (4)
  alpha(2)-beta(3)-alpha-beta(3)-alpha; antiparallel beta-sheet: order 321654
  uperfamily
3. PYP-like sensor domain (PAS domain) [55785] (7)
  alpha-beta(2)-alpha(2)-beta(3)
  uperfamily
4. Pheromone-binding domain of LuxR-like quorum-sensing transcription factors [75516] (1)
  alpha(2)-beta(2)-alpha(2)-beta(3)-alpha; possibly related to the PAS domain
  uperfamily
5. Sensory domain-like [103190] (3)
  alpha(2)-beta(2)-alpha(2)-beta(3); possibly related to the PAS domain
  uperfamily
6. SNARE-like [64356] (4)
  beta(2)-alpha-beta(3)-alpha(2)
  uperfamily
7. Roadblock/LC7 domain [103196] (1)
  alpha-beta(2)-alpha-beta(3)-alpha; structurally most similar to the SNARE-like superfamily with a circular permutation of the terminal helices
  uperfamily
8. YeeU-like [143737] (1)
  beta(2)-alpha-beta(3); 2 layers, a/b; there is an oligomerization interface instead of the 'missing' helical layer
  uperfamily
9. GlcG-like [143744] (1)
  alpha-beta(2)-alpha(3)-beta(2)-alpha; similar to the Roadblock/LC7 domain
  uperfamily
10. YNR034W-A-like [160683] (1)
Ligand-binding domain in the NO signalling and Golgi transport [111125] (1)
an N-terminal helical bundle and the C-terminal alpha-beta(2)-alpha-beta(2) subdomain enclose a ligand-binding cavity
1. Ligand-binding domain in the NO signalling and Golgi transport [111126] (3)
  uperfamily
Phage tail protein-like [143748] (1)
alpha-beta-X-beta(2)-alpha-beta(2); 2 layers: a/b; mixed beta-sheet: order 12354, strands 1 and 2 are parallel
1. Phage tail protein-like [143749] (2)
  Can form ring, tube-like oligomers, where the subunit beta-sheets are joined in a single beta-sheet (or barrel)
  uperfamily
PR-1-like [55796] (1)
alpha-beta-alpha-beta-alpha(2)-beta(2); 3 layers, alpha/beta/alpha; mixed sheet: order 1342
1. PR-1-like [55797] (1)
  uperfamily
Phoshotransferase/anion transport protein [55803] (1)
beta-alpha(2)-beta(3)-alpha(3); 3 layers, alpha/beta/alpha; mixed sheet: order 1342; loop crossing
1. Phoshotransferase/anion transport protein [55804] (2)
  uperfamily
Nudix [55810] (1)
beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
contains beta-grasp motif
1. Nudix [55811] (7)
  uperfamily
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain [55815] (1)
core: alpha-beta(2)-alpha-beta(2)-alpha-beta; 3 layers; mixed sheet: order 31425
1. 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain [55816] (1)
  uperfamily
YrdC/RibB [55820] (1)
core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers; mixed twisted sheet of 7 strands; order 7126354; strands 7 and 1 are parallel to each other
1. YrdC/RibB [55821] (2)
  uperfamily
GIY-YIG endonuclease [82770] (1)
beta(2)-alpha(2)-beta-alpha-(beta); strand 4 is very short; 3 layers; antiparallel (mixed) beta-sheet; order 312(4)
1. GIY-YIG endonuclease [82771] (1)
  uperfamily
YbaK/ProRS associated domain [55825] (1)
core: alpha-beta-alpha-beta(2)-(alpha-beta)2-alpha-beta(2)-alpha-beta; 3 layers; bifurcated mixed sheet
1. YbaK/ProRS associated domain [55826] (1)
  uperfamily
Thymidylate synthase/dCMP hydroxymethylase [55830] (1)
contains large mixed beta-sheet
1. Thymidylate synthase/dCMP hydroxymethylase [55831] (1)
  uperfamily
Thymidylate synthase-complementing protein Thy1 [69795] (1)
complex alpha+beta fold; contains antiparallel 5-stranded beta-sheet: order 12354
1. Thymidylate synthase-complementing protein Thy1 [69796] (1)
  uperfamily
N-acetylmuramoyl-L-alanine amidase-like [55845] (1)
contains mixed beta-sheet
1. N-acetylmuramoyl-L-alanine amidase-like [55846] (1)
  uperfamily
Cytochrome b5-like heme/steroid binding domain [55855] (1)
beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 1532(4)
1. Cytochrome b5-like heme/steroid binding domain [55856] (2)
  uperfamily
BTG domain-like [160695] (1)
alpha(2)-beta-alpha(2)-beta(3); four-helical bundle, capped at one end by an antiparallel beta-sheet, order:1234
1. BTG domain-like [160696] (1)
DUSP-like [143790] (1)
alpha-beta-alpha-X-beta-alpha-beta; three-helical bundle capped at one end by antiparallel beta-sheet, order: 213
1. DUSP-like [143791] (1)
  uperfamily
DNA topoisomerase I domain [55868] (1)
beta(2)-alpha-beta-(alpha)-beta(2); left-handed crossover between strands 2 & 3
1. DNA topoisomerase I domain [55869] (1)
  uperfamily
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1)
8-stranded mixed beta-sheet; 2 layers: alpha/beta
1. ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (4)
  uperfamily
YehR-like [160703] (1)
beta(3)-alpha-beta(2)-alpha(3)-beta; 2 layers, a/b; antiparallel beta-sheet, order: 612354
1. YehR-like [160704] (1)
Sporulation response regulatory protein Spo0B [55889] (1)
core: alpha-beta-alpha-beta(2)-(alpha)-beta(2)
1. Sporulation response regulatory protein Spo0B [55890] (1)
  Histidine kinase-like fold lacking the kinase ATP-binding site
  uperfamily
Ribonuclease Rh-like [55894] (1)
alpha+beta fold
1. Ribonuclease Rh-like [55895] (1)
  uperfamily
YlxR-like [64375] (1)
alpha+beta fold; could have evolved from a glucocorticoid receptor-like zinc finger domain
1. YlxR-like [64376] (1)
  uperfamily
YggX-like [111147] (1)
beta(2)-alpha(3); contains zinc-less 'zinc finger'-like fold (scop_cf 57715; see also scop_cf 64375)
1. YggX-like [111148] (1)
  uperfamily
L28p-like [143799] (1)
unusual fold consisting of three beta-hairpins, that form a paper clip-like structure, and two helices; could have evolved from a glucocorticoid receptor-like zinc finger domain (scop_cf 57715)
1. L28p-like [143800] (2)
  In early ribosomal structures, L28p has been misinterpreted as L31p. in the Ribosomal protein L28p family, there are sequences containing two CxxC pairs. Threading these sequences into this fold brings the four cysteines in a similar site to the zinc-binding site of glucocorticoid receptor-like zinc fingers. In the Ribosomal protein L31p, there are also members with two CxxC pairs. However, these won't form a putative zinc-binding site in this fold. The L31p family are classified here temporarily, until its true fold is known
  uperfamily
YqaI-like [160712] (1)
dimeric zinc-less 'zinc finger'-like fold; similar to the C-terminal strand-swapped B-box domain (scop_cf 57844)
1. YqaI-like [160713] (1)
Ornithine decarboxylase C-terminal domain [55903] (1)
complex alpha+beta motif
1. Ornithine decarboxylase C-terminal domain [55904] (1)
  uperfamily
Pentein, beta/alpha-propeller [55908] (1)
duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis
1. Pentein [55909] (7)
  uperfamily
Creatinase/aminopeptidase [55919] (1)
duplication: composed of two very similar alpha+beta folds
1. Creatinase/aminopeptidase [55920] (1)
  uperfamily
gpW/gp25-like [160718] (1)
alpha(2)-beta(3); similar to one structural repeat of the Creatinase/aminopeptidase family and the C-terminal subdomain of PanC
1. gpW/gp25-like [160719] (1)
  Contains phage tail lysozyme
Glutamine synthetase/guanido kinase [55930] (1)
duplication: common core consists of two beta-alpha-beta2-alpha repeats
1. Glutamine synthetase/guanido kinase [55931] (5)
  uperfamily
TBP-like [55944] (11)
beta-alpha-beta(4)-alpha
1. TATA-box binding protein-like [55945] (2)
  uperfamily
2. MoaD-related protein, C-terminal domain [103239] (1)
  contains a single copy of this fold
  uperfamily
3. KA1-like [103243] (2)
  contains a single copy of this fold
  uperfamily
4. TT1751-like [103247] (1)
  contains a single copy of this fold decorated with additional structures; forms dimer
  uperfamily
5. Cell-division protein ZipA, C-terminal domain [64383] (1)
  contains a single copy of this fold
  uperfamily
6. Phosphoglucomutase, C-terminal domain [55957] (1)
  contains a single copy of this fold and an extra beta-strand at the C-terminus
  uperfamily
7. Bet v1-like [55961] (10)
  contains a single copy of this fold with a alpha-beta2 insertion after the first helix; there is a cavity between the beta-sheet and the long C-terminal helix
  uperfamily
8. Rbstp2229 protein [111171] (1)
  forms segment-swapped dimers further organized in hexamers
  uperfamily
9. RalF, C-terminal domain [118104] (1)
  contains a single copy of this fold decorated with additional structures
  uperfamily
10. YwmB-like [143842] (1)
  duplication: tandem repeat of two circularly permuted motifs, alpha-beta-alpha-beta(4), assembled as in the TATA-box binding domain; forms a swapped dimer by exchanging the equivalent parts of the C-terminal motifs
  uperfamily
11. YugN-like [160755] (1)
XisI-like [143846] (1)
alpha-beta(4)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order 1234, meander; the open side of beta-sheet provides dimerization interface
1. XisI-like [143847] (1)
  uperfamily
S-adenosylmethionine synthetase [55972] (1)
duplication: consists of 3 similar intertwined domains
structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
1. S-adenosylmethionine synthetase [55973] (1)
  uperfamily
DNA clamp [55978] (1)
contains two helices and two beta sheets
duplication: fold has internal pseudo two-fold symmetry
1. DNA clamp [55979] (2)
  uperfamily
Hypothetical protein TM0160 [103255] (1)
duplication: consists of two beta(3)-alpha(2) structural repeats; single barrel-like beta-sheet
1. Hypothetical protein TM0160 [103256] (1)
  uperfamily
TTHC002-like [160760] (1)
alpha-beta-alpha-beta(3); forms dimer with a single beta-sheet, folded in a barrel-like shape
1. TTHC002-like [160761] (1)
Molybdenum cofactor-binding domain [56002] (1)
beta(2)-alpha-beta-alpha-beta; 2 layers: a/b; mixed sheet: order 1243: crossing loops
1. Molybdenum cofactor-binding domain [56003] (1)
  duplication: consists of 4 structural repeats arranged in 2 lobes
  contains one left-hand beta-alpha-beta unit per lobe
  uperfamily
NE1680-like [160765] (1)
beta(2)-alpha-beta-alpha-beta; 2 layers, a/b; antiparallel sheet, order 3124
1. NE1680-like [160766] (1)
Nitrite and sulphite reductase 4Fe-4S domain-like [56013] (1)
beta-alpha-beta-alpha-beta(3)-alpha(2,3); mixed sheet: order 12345; left-handed crossover connection between strands 1 and 2
1. Nitrite and sulphite reductase 4Fe-4S domain-like [56014] (1)
  duplication: contains two domains of this fold
  uperfamily
DeoB insert domain-like [143855] (1)
alpha-beta-X-beta(2)-alpha-beta(2); 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 2 and 5 are antiparallel to the rest
1. DeoB insert domain-like [143856] (1)
  uperfamily
The spindle assembly checkpoint protein mad2 [56018] (1)
core: alpha(2)-beta(2)-alpha-beta; mixed sheet: order 213
1. The spindle assembly checkpoint protein mad2 [56019] (1)
  N- and C-termini undergo large conformational rearrangement upon ligand binding
  uperfamily
Phospholipase D/nuclease [56023] (1)
beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234
1. Phospholipase D/nuclease [56024] (5)
  uperfamily
CorA soluble domain-like [143864] (1)
beta(2)-alpha-beta-alpha(2)-beta(4)-alpha(3); 3 layers: a/b/a; mixed beta-sheet, order 2137654; strands 3 and 7 are parallel
1. CorA soluble domain-like [143865] (1)
  uperfamily
Monooxygenase (hydroxylase) regulatory protein [56028] (1)
corner-like structure formed by two sheets and filled in with 2-3 helices
1. Monooxygenase (hydroxylase) regulatory protein [56029] (1)
  duplication: consists of two beta-alpha-(beta)-beta(2) motifs; some topological similarity to the ferredoxin-like fold
  uperfamily
PurM C-terminal domain-like [56041] (1)
3 layers: alpha/beta/alpha; partial topological similarity to the ferredoxin-like fold
1. PurM C-terminal domain-like [56042] (1)
  uperfamily
PF0523-like [143869] (1)
beta-alpha-beta-alpha(3)-beta-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order 4132; some similarity to the PurM C-terminal domain-like fold (scop_cf 56041)
1. PF0523-like [143870] (1)
  uperfamily
Chorismate synthase, AroC [103262] (1)
duplication: consists of two DCoH-like beta(2)-alpha-beta(2)-alpha structural repeats; 3 layers, beta/alpha/beta
1. Chorismate synthase, AroC [103263] (1)
  uperfamily
Hsp33 domain [64396] (1)
3 layers: beta/alpha/beta; buried helix
1. Hsp33 domain [64397] (1)
  uperfamily
MTH1598-like [69818] (1)
beta(2)-alpha-beta-alpha-beta(4); 3 layers: beta/alpha/beta; some similarity to the Hsp33 fold
1. MTH1598-like [69819] (1)
  uperfamily
Protein-L-isoaspartyl O-methyltransferase, C-terminal domain [68929] (1)
beta-alpha-beta(4)-alpha-beta(2); 3 layers: beta/alpha/beta; buried helix
1. Protein-L-isoaspartyl O-methyltransferase, C-terminal domain [68930] (1)
  uperfamily
OsmC-like [82783] (1)
swapped dimer of beta(3)-alpha-beta(2)-alpha(2)-beta subunits; mixed beta-sheet; order: 321[4][5][6]; buried helix
1. OsmC-like [82784] (2)
  uperfamily
Hypothetical protein HI1480 [103276] (1)
beta-alpha(4)-beta-alpha-beta; segregated alpha-helical and beta-sheet subdomains; dimeric beta-sheet barrel: n=6, S=10
1. Hypothetical protein HI1480 [103277] (1)
  uperfamily
ERH-like [143874] (1)
beta(2)-alpha(2)-beta(2)-alpha; antiparallel beta-sheet, order:2134; helices are arranged in a bundle rather than packed agains beta-sheet; dimerises via with the formation of a flattened beta-barel: closed n=8, S=10
1. ERH-like [143875] (1)
  uperfamily
Ribosomal protein S8 [56046] (1)
consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a
1. Ribosomal protein S8 [56047] (1)
  uperfamily
Ribosomal protein L6 [56052] (1)
consists of two beta-sheets and one alpha-helix packed around single core
1. Ribosomal protein L6 [56053] (1)
  uperfamily
NE0471 N-terminal domain-like [143879] (1)
beta(3)-alpha(n)-beta(3)-alpha; the two meander beta-sheets and helices are packed against the same core
1. NE0471 N-terminal domain-like [143880] (1)
  uperfamily
Lp2179-like [160799] (1)
beta(2)-alpha-beta(4)-alpha-beta; contains two antiparallel beta-sheets (orders: 127 and 3456) packed against the longer C-terminal helix
1. Lp2179-like [160800] (1)
RGC domain-like [143884] (1)
consists of two beta-sheets and four helices eclosing a cental cavity
1. RGC domain-like [143885] (1)
  uperfamily
Smc hinge domain [75552] (1)
consists of 2 different alpha+beta subdomains; forms subdomain-swapped dimers
1. Smc hinge domain [75553] (1)
  uperfamily
DNA mismatch repair protein MutL [118115] (1)
consists of two different alpha+beta (sub)domains; d1: [beta(3)-alpha-(insert of d2)-alpha(2)-beta; 2 layers, a/b; antiparallel sheet, order: 1234]; d2: [beta-alpha-beta(2)-alpha(2); 2 layers, a/b; antiparallel sheet, order: 132]
1. DNA mismatch repair protein MutL [118116] (1)
  uperfamily
ATP-grasp [56058] (2)
Consists of two subdomains with different alpha+beta folds
shares functional and structural similarities with the PIPK and protein kinase superfamilies
1. Glutathione synthetase ATP-binding domain-like [56059] (9)
  uperfamily
2. DNA ligase/mRNA capping enzyme, catalytic domain [56091] (4)
  has a circularly permuted topology
  uperfamily
SAICAR synthase-like [56103] (1)
consists of two alpha+beta subdomains
1. SAICAR synthase-like [56104] (3)
  shares functional and structural similarities with the ATP-grasp fold and protein kinase superfamilies
  uperfamily
Protein kinase-like (PK-like) [56111] (1)
consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
1. Protein kinase-like (PK-like) [56112] (7)
  shares functional and structural similarities with the ATP-grasp fold and PIPK
  uperfamily
FAD-binding/transporter-associated domain-like [56175] (1)
consists of two alpha+beta subdomains
1. FAD-binding/transporter-associated domain-like [56176] (4)
  uperfamily
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain [56193] (1)
consists of two alpha+beta subdomains
1. Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain [56194] (1)
  uperfamily
Methenyltetrahydromethanopterin cyclohydrolase [56198] (1)
consists of two alpha+beta subdomains
1. Methenyltetrahydromethanopterin cyclohydrolase [56199] (1)
  uperfamily
Prim-pol domain [56746] (1)
consists of two alpha+beta domains
1. Prim-pol domain [56747] (3)
  uperfamily
Hect, E3 ligase catalytic domain [56203] (1)
consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit; conformational flexibility of domain orientation
1. Hect, E3 ligase catalytic domain [56204] (1)
  uperfamily
Nitrile hydratase alpha chain [56208] (1)
4 layers a/b/b/a; inside is a sandwich of two 2-stranded beta-sheets
1. Nitrile hydratase alpha chain [56209] (1)
  duplication: contains two structural repeats
  uperfamily
4'-phosphopantetheinyl transferase [56213] (1)
beta-alpha(3)-beta(2) motif
1. 4'-phosphopantetheinyl transferase [56214] (2)
  possibly related to the IspF (d.79.5) and YjgF-like superfamilies (d.79.1)
  uperfamily
DNase I-like [56218] (1)
contains beta-sandwich; duplication of alpha+beta motif
1. DNase I-like [56219] (3)
  uperfamily
Aldehyde ferredoxin oxidoreductase, N-terminal domain [56227] (1)
contains sandwich; duplication of alpha+beta motif with single mixed sheet
motif: beta(2)-alpha-beta(3)-alpha-beta; strand order 216345, strands 1 and 6 are parallel
1. Aldehyde ferredoxin oxidoreductase, N-terminal domain [56228] (1)
  uperfamily
Ntn hydrolase-like [56234] (2)
4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
1. N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (7)
  N-terminal residue provides two catalytic groups, nucleophile and proton donor
  uperfamily
2. Archaeal IMP cyclohydrolase PurO [75569] (1)
  has a putative active site in the same topological location as the Ntn hydrolase but lacks the N-terminal nucleophile
  uperfamily
DmpA/ArgJ-like [56265] (1)
duplication of beta(3)-alpha-beta-alpha motif; 4 layers: alpha/beta/beta/alpha
1. DmpA/ArgJ-like [56266] (2)
  convergent similarity to the Ntn amidohydrolases
  uperfamily
Pyruvoyl-dependent histidine and arginine decarboxylases [56270] (1)
duplication of beta-alpha-beta(2) motif; 4 layers: alpha/beta/beta/alpha; contains "silk" beta-sandwich
1. Pyruvoyl-dependent histidine and arginine decarboxylases [56271] (2)
  two chains result from self-processing single-chain precursor; form heterohexamer
  uperfamily
S-adenosylmethionine decarboxylase [56275] (1)
duplication of beta-alpha-beta(4)-alpha-beta-alpha-beta(2) motif; 4 layers a/b/b/a; antiparallel beta-sheets: order 23451687
1. S-adenosylmethionine decarboxylase [56276] (2)
  uperfamily
Metallo-hydrolase/oxidoreductase [56280] (1)
duplication of beta(4)-alpha-beta-alpha motif; 4 layers a/b/b/a; mixed beta-sheets
1. Metallo-hydrolase/oxidoreductase [56281] (14)
  uperfamily
PP2C-like [81607] (1)
4 layers: alpha/beta/beta/alpha; antiparallel beta sheets
1. PP2C-like [81606] (1)
  contain binuclear metal (Mn) centre
  uperfamily
Metallo-dependent phosphatases [56299] (1)
4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
1. Metallo-dependent phosphatases [56300] (12)
  different families of this superfamily are groupped in a single Pfam family, Pfam 00149
  uperfamily
Carbon-nitrogen hydrolase [56316] (1)
4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication
1. Carbon-nitrogen hydrolase [56317] (2)
  Pfam 00795; some topological similarities to the metallo-dependent phosphatases and DNase I-like nucleases
  uperfamily
CNF1/YfiH-like putative cysteine hydrolases [64437] (1)
4 layers: alpha/beta/beta/alpha; mixed beta sheets
1. CNF1/YfiH-like putative cysteine hydrolases [64438] (3)
  uperfamily
ADC synthase [56321] (1)
duplication: contains four repeats of alpha-beta(2)-beta motif arranged in a 4 layer core structure: alpha/beta/beta/alpha; orthogonally packed beta-sheets
1. ADC synthase [56322] (1)
  the active site is formed by additional structures inserted into the core structure
  uperfamily
Sulfolobus fructose-1,6-bisphosphatase-like [111248] (1)
4 layers: a/b/b/a; antiparallel beta sheets; similarities to ferredoxin-like fold (scop_cf 54861) in the N-terminal part (1-120) and to the Bacterial S-adenosylmethionine decarboxylase subunit (scop_fa 997656) in the C-terminal part (121-340)
1. Sulfolobus fructose-1,6-bisphosphatase-like [111249] (1)
  uperfamily
LDH C-terminal domain-like [56326] (1)
unusual fold, defines family
1. LDH C-terminal domain-like [56327] (2)
  uperfamily
DNA breaking-rejoining enzymes [56348] (1)
core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
1. DNA breaking-rejoining enzymes [56349] (2)
  uperfamily
Replication modulator SeqA, C-terminal DNA-binding domain [82807] (1)
consists of seven alpha-helices and three-stranded beta-sheet
1. Replication modulator SeqA, C-terminal DNA-binding domain [82808] (1)
  uperfamily
SMAD MH1 domain [56365] (1)
consists of four alpha-helices and three beta-ribbons
1. SMAD MH1 domain [56366] (1)
  uperfamily
YopH tyrosine phosphatase N-terminal domain [64448] (1)
consists of four alpha-helices and two beta-hairpins
1. YopH tyrosine phosphatase N-terminal domain [64449] (1)
  uperfamily
Rotavirus NSP2 fragment, N-terminal domain [75573] (1)
consists of six alpha-helices and two beta-hairpins
1. Rotavirus NSP2 fragment, N-terminal domain [75574] (1)
  uperfamily
Rv2827c C-terminal domain-like [160886] (1)
multihelical array flanked by two three-stranded mixed beta-sheets
1. Rv2827c C-terminal domain-like [160887] (1)
Phosphoprotein oligomerization domain-like [160891] (1)
intertwinned homodimer of beta(2)-alpha-beta(2) motifs; 3 layers: b/a/b; each antiparallel beta-sheet is formed by the N-terminal beta-hairpin of one subunit and the C-terminal beta-hairpin of the other subunit; order 1243
1. Phosphoprotein oligomerization domain-like [160892] (1)
Taf5 N-terminal domain-like [160896] (1)
multihelical cluster with a C-terminal beta-alpha(2)-beta motif; one central buried helix; parallel beta-ribbon
1. Taf5 N-terminal domain-like [160897] (1)
Jann2411-like [160903] (1)
unusual fold; consists of seven alpha-helices and three beta-hairpins
1. Jann2411-like [160904] (1)
ATP12-like [160908] (1)
contains an N-terminal beta-sheet that forms a beta-triangle structure; the remainder is a multihelical array of long and short helices
1. ATP12-like [160909] (1)
Ribosome inactivating proteins (RIP) [56370] (1)
contains mixed beta-sheet
1. Ribosome inactivating proteins (RIP) [56371] (2)
  uperfamily
ADP-ribosylation [56398] (1)
unusual fold
1. ADP-ribosylation [56399] (7)
  uperfamily
Peptide deformylase [56419] (1)
alpha-beta(5)-alpha; 3 layers: a/b/a; meander beta-sheet wraps around the C-terminal alpha-helix
1. Peptide deformylase [56420] (1)
  nickel-dependent enzyme
  uperfamily
LCCL domain [69847] (1)
unusual fold
1. LCCL domain [69848] (1)
  uperfamily
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [56424] (1)
unusual fold
1. Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [56425] (1)
  uperfamily
C-type lectin-like [56435] (1)
unusual fold
1. C-type lectin-like [56436] (8)
  uperfamily
Hemolytic lectin CEL-III, C-terminal domain [111264] (1)
unusual fold
1. Hemolytic lectin CEL-III, C-terminal domain [111265] (1)
  uperfamily
SRCR-like [56486] (2)
unusual fold; disulfide-rich; core: beta-x-alpha-beta-loop-beta
1. SRCR-like [56487] (2)
  uperfamily
2. A heparin-binding domain [56491] (1)
  uperfamily
Fibrinogen C-terminal domain-like [56495] (1)
unusual fold
1. Fibrinogen C-terminal domain-like [56496] (1)
  uperfamily
gp120 core [56501] (1)
unusual fold
1. gp120 core [56502] (1)
  uperfamily
Methionine synthase activation domain-like [56506] (1)
unusual fold; core: beta-alpha(2)-beta(2)-alpha(2)-beta-alpha-beta; antiparallel beta-sheet: order 12354
1. Methionine synthase activation domain-like [56507] (2)
  uperfamily
UbiD C-terminal domain-like [143967] (1)
alpha-beta(2)-alpha-beta-alpha-beta(2); 3 layers, a/b/a; mixed beta-sheet, order: 12354, strands 2,3 and 5 are parallel to each other
1. UbiD C-terminal domain-like [143968] (1)
  uperfamily
Hypothetical protein TM0875 [90063] (1)
unusual fold; core: beta(2)-loop-beta(2)-alpha-beta; mixed beta-sheet: order 51243; parallel strands 2 and 4
1. Hypothetical protein TM0875 [90064] (1)
  uperfamily
Metal cation-transporting ATPase, ATP-binding domain N [81661] (1)
unusual fold; core: beta-alpha(2)-beta(3)-alpha(2)-beta(2); 6-stranded antiparallel beta-sheet, order: 165432
1. Metal cation-transporting ATPase, ATP-binding domain N [81660] (1)
  uperfamily
Suppressor of Fused, N-terminal domain [103358] (1)
unusual fold; bifurcated beta-sheet; left-handed beta-alpha-beta unit
1. Suppressor of Fused, N-terminal domain [103359] (1)
  uperfamily
Nitric oxide (NO) synthase oxygenase domain [56511] (1)
unusual fold
1. Nitric oxide (NO) synthase oxygenase domain [56512] (1)
  uperfamily
Penicillin binding protein dimerisation domain [56518] (1)
unusual fold
1. Penicillin binding protein dimerisation domain [56519] (1)
  uperfamily
Oxidoreductase molybdopterin-binding domain [56523] (1)
unusual fold; contains 3 layers of beta-sheet structure and a beta-grasp like motif
1. Oxidoreductase molybdopterin-binding domain [56524] (1)
  uperfamily
FAH [56528] (1)
unusual fold; contains 3 layers of beta-sheet structure
1. FAH [56529] (1)
  uperfamily
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [56533] (1)
unusual fold
1. Aromatic aminoacid monoxygenases, catalytic and oligomerization domains [56534] (1)
  uperfamily
Substrate-binding domain of HMG-CoA reductase [56541] (1)
unusual fold
1. Substrate-binding domain of HMG-CoA reductase [56542] (1)
  uperfamily
Argininosuccinate synthetase, C-terminal domain [69863] (1)
unusual fold
1. Argininosuccinate synthetase, C-terminal domain [69864] (1)
  uperfamily
Hypothetical protein PH1602 [103364] (1)
complex alpha+beta fold; contains a region of similarity to the ferredoxin-like fold
1. Hypothetical protein PH1602 [103365] (1)
  uperfamily
IlvD/EDD N-terminal domain-like [143974] (1)
contains a large cluster of helices and a mixed beta-sheet of 4 strands; order 2134, strands 3 and 4 are parallel
1. IlvD/EDD N-terminal domain-like [143975] (1)
  uperfamily
DNA methylase specificity domain [116733] (1)
comprises the N-terminal, double beta-helix like structure and C-terminal alpha-hairpin
1. DNA methylase specificity domain [116734] (2)
  uperfamily
GCM domain [90072] (1)
consists of two different alpha+beta subdomains; 2 zinc-binding sites
1. GCM domain [90073] (1)
  DNA-binding domain
  uperfamily
Conserved core of transcriptional regulatory protein vp16 [56547] (1)
unusual fold
1. Conserved core of transcriptional regulatory protein vp16 [56548] (1)
  uperfamily
Insert subdomain of RNA polymerase alpha subunit [56552] (1)
unusual fold; contains a left-handed beta-alpha-beta unit
1. Insert subdomain of RNA polymerase alpha subunit [56553] (1)
  uperfamily
Baseplate structural protein gp11 [56557] (1)
unusual fold; trimer
1. Baseplate structural protein gp11 [56558] (1)
  uperfamily
Receptor-binding domain of short tail fibre protein gp12 [88873] (1)
unusual fold; trimer
1. Receptor-binding domain of short tail fibre protein gp12 [88874] (1)
  uperfamily
Outer capsid protein sigma 3 [64464] (1)
unusual fold
1. Outer capsid protein sigma 3 [64465] (1)
  uperfamily
Phosphoprotein M1, C-terminal domain [118172] (1)
consists of 6 helices and one beta-hairpin
1. Phosphoprotein M1, C-terminal domain [118173] (1)
  uperfamily
L,D-transpeptidase pre-catalytic domain-like [143984] (1)
unusual fold, made of four helices and four 2-3 stranded beta-sheets
1. L,D-transpeptidase pre-catalytic domain-like [143985] (1)
  uperfamily
YbiA-like [143989] (1)
consists of six alpha-helices and two two-stranded beta-sheets
1. YbiA-like [143990] (1)
  uperfamily
NinB [103369] (1)
unusual fold; intertwined dimer; consists of two different structural domains
1. NinB [103370] (1)
  uperfamily
AF2331-like [143994] (1)
interlocked dimer of beta-alpha-beta(2)-alpha-beta-(alpha) subunits; 3 layers: b/b/a
1. AF2331-like [143995] (1)
  uperfamily
SSo0622-like [111277] (1)
alpha(2)-beta(2)-alpha-beta-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel beta-sheet: order 21354; strands 1,3 and 5 and the C-terminal helix are longer than other secondary structures
1. SSo0622-like [111278] (1)
  the dimer, formed in the crystals, is a probable biological unit
  uperfamily
Putative modulator of DNA gyrase, PmbA/TldD [111282] (1)
consists of two different alpha+beta domains; d1: [duplication of alpha-beta(3)-alpha motif; 2 layers: a/b; antiparallel beta-sheet, order: 321456; strands 1, 2, 4 and 5 are twice longer than other secondary structures]; d2 [ complex fold; contains beta-barrel (n=5, S=10)]
1. Putative modulator of DNA gyrase, PmbA/TldD [111283] (1)
  uperfamily
PSTPO5379-like [160919] (1)
complex fold; consists of two alpha+beta subdomains, one is inserted in the other
1. PSTPO5379-like [160920] (1)
PG1388-like [160924] (1)
consists of 2 alpha+beta subdomains, each having a meander beta-sheet; d1: alpha(2)-beta(7); d2: alpha(2)-beta(2)-alpha(2)-beta(2)
1. PG1388-like [160925] (1)
Oxysterol-binding protein-like [143999] (1)
core: large meander beta-sheet of 12 strands wrapped around the N-terminal (distorted) alpha-hairpin; some similarity to transmembrane beta-barrel proteins
1. Oxysterol-binding protein-like [144000] (1)
  uperfamily
ORC1-binding domain [144004] (1)
complex fold, composed of an alpha hairpin, meander beta-sheet and a five-stranded barrel of unusual topology
1. ORC1-binding domain [144005] (1)
  uperfamily
CofE-like [144009] (1)
consists of two different domains; d1: beta-alpha-beta-alpha-beta(2)-alpha-beta, mixed sheet of 5 strands, order:15234, strands 2 and 3 are parralel; d2 is inserted in d1 after strand 2 and comprises a helix-turn-helix motif and two 3-stranded sheets
1. CofE-like [144010] (1)
  uperfamily
Peptidoglycan deacetylase N-terminal noncatalytic region [144014] (1)
consists of two different domains, d1: [alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; mixed beta-sheet, order 12345, strands 2 and 3 are parallel to each other with a left-handed crossover connection], d2: alpha-beta(3)-alpha; 2 layers; antiparallel beta-sheet, order 123]
1. Peptidoglycan deacetylase N-terminal noncatalytic region [144015] (1)
  uperfamily
Non-globular alpha+beta subunits of globular proteins [56567] (1)
not a true fold
1. Non-globular alpha+beta subunits of globular proteins [56568] (3)
  not a true superfamily
  uperfamily