Superfamily: ACT-like

regulatory domain linked to a wide range of metabolic enzymes
uperfamily

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b) [53931]
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: Ferredoxin-like [54861]
   alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
4. Superfamily: ACT-like [55021]
   regulatory domain linked to a wide range of metabolic enzymes
   uperfamily

Families:

1. Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [55022] (2)
2. Allosteric threonine deaminase C-terminal domain [55025] (1)
3. Phenylalanine metabolism regulatory domain [55028] (2)
4. Nickel responsive regulator NikR, C-terminal domain [102999] (2)
5. Glycine cleavage system transcriptional repressor [110980] (1)
   tandem repeat of two ACT-like domains; swapped domain dimer
6. IlvH-like [143376] (3)
   Duplication: tandem repeat of two ACT-like domains; dimer, the N- and C-terminal domains have different dimerisation modes
7. SP0238-like [143381] (1)
   stand-alone protein; dimer, the dimerization interface is formed by parallel packing of the subunit beta-sheets
8. Atu0741-like [143384] (1)
   duplication: tandem repeat of two ACT-like domains; contains strand invasion of extra N-terminal strand into the C-terminal domain beta-sheet; dimerizes with the formation of orthogonally packed intersubunit beta-sheets
9. VC0802-like [143387] (1)
   duplication: tandem repeat of two ACT-like domains; contains circular permutation (the C-terminal strand replacement with extra N-terminal strand); dimerizes with the formation of orthogonally packed intersubunit beta-sheets
10. Aspartokinase allosteric domain-like [143390] (3)
    duplication: tandem repeat of two ACT-like domains; similar subunit and oligomeric structures to the VC0802-like family
11. BT0572-like [143395] (1)
    duplication: tandem repeat of two ACT-like domains; dimerizes with the formation of orthogonally packed intersubunit beta-sheets
12. AF1403 N-terminal domain-like [143398] (1)
    dimerizes with the formation of a single intersubunit beta-sheet
13. NIL domain-like [160322] (4)
    Pfam 09383
14. TM1266-like [160329] (1)
    PfamB 015436; stand-alone tetrameric protein; there are single beta-sheet dimers, whose beta-sheets are packed in parallel fasion in the tetramer

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk