Structural Classification of Proteins

Superfamily: Metalloproteases ("zincins"), catalytic domain

: uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Zincin-like [55485]
contains mixed beta sheet with connection over free side of the sheet
Superfamily: Metalloproteases ("zincins"), catalytic domain [55486]
uperfamily

Families:

Zinc protease [55487] (1)
single domain
Fungal zinc peptidase [64335] (2)
single domain with insertions in the common fold
Thermolysin-like [55490] (4)
includes alpha-helical C-terminal domain characteristic for the family
Leukotriene A4 hydrolase catalytic domain [64338] (1)
adopts thermolysin-like fold
Neutral endopeptidase (neprilysin) [55502] (1)
Neurolysin-like [55505] (6)
combines M2, M3 and M32 families of metalloproteases
the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain
Anthrax toxin lethal factor, N- and C-terminal domains [69775] (1)
Leishmanolysin [55499] (1)
Serralysin-like metalloprotease, catalytic (N-terminal) domain [55508] (4)
characteristic HEXXHXXGXXH motif and Met located near C-terminus
Clostridium neurotoxins, catalytic domain [55512] (4)
Astacin [55516] (1)
Reprolysin-like [55519] (8)
Pfam 01421
TNF-alpha converting enzyme, TACE, catalytic domain [55525] (1)
Matrix metalloproteases, catalytic domain [55528] (15)
Predicted metal-dependent hydrolase [103132] (3)
Pfam 02130; UPF0054; COG0319; MMP-like fold with a different sequence motif in the putative active site
Caur0242-like [160552] (1)
Pfam 10103; DUF2342; there is a characteristic HExxH motif but no metal ion bound to it in the first structure.
TTHA0227-like [160555] (2)
PF06262; DUF1025; minimal zincin fold that retains 3-stranded mixed beta-sheet and contains HExxH motif in the C-terminal helix; no metal ion bound to this motif is observed in the first determined structures