Structural Classification of Proteins

Family: Anthrax toxin lethal factor, N- and C-terminal domains

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Zincin-like [55485]
contains mixed beta sheet with connection over free side of the sheet
Superfamily: Metalloproteases ("zincins"), catalytic domain [55486]
uperfamily
Family: Anthrax toxin lethal factor, N- and C-terminal domains [69775]

Protein Domains:

Anthrax toxin lethal factor, N- and C-terminal domains [69776]
duplication: each domain adopts a thermolysin-like fold, but the proteolytic activity resides only in the C-terminal domain
1. Bacillus anthracis [TaxId: 1392] [69777] (12)
  1. 1j7n
    complexed with so4, zn
    1. region a:27-263 [66409]
    2. region a:551-773 [66410]
    3. region b:27-263 [66412]
    4. region b:551-776 [66413]
  2. 1yqy
    automatically matched to d1j7nb2
    complexed with 915, zn
    1. region a:551-776 [123903]
  3. 1zxv
    automatically matched to d1j7na1
    complexed with mfm, zn
    1. region a:27-263 [125797]
  4. 1zxv
    automatically matched to d1j7nb2
    complexed with mfm, zn
    1. region a:551-776 [125798]
  5. 1zxv
    automatically matched to d1j7na1
    complexed with mfm, zn
    1. region b:27-263 [125800]
  6. 1zxv
    automatically matched to d1j7nb2
    complexed with mfm, zn
    1. region b:551-776 [125801]
  7. 1pwu
    complexed with small molecule inhibitor
    complexed with gm6, zn; mutant
    1. region a:30-263 [95244]
    2. region a:551-776 [95245]
    3. region b:33-263 [95247]
    4. region b:551-776 [95248]
  8. 1pwp
    complexed with small molecule inhibitor
    complexed with nsc, zn
    1. region a:30-263 [95232]
    2. region a:551-776 [95233]
    3. region b:31-263 [95235]
    4. region b:551-776 [95236]
  9. 1pwv
    complexed with an optimized peptide substrate (chains C and D) in the presence of zinc
    1. region a:27-263 [95250]
    2. region a:551-776 [95251]
    3. region b:33-263 [95253]
    4. region b:551-776 [95254]
  10. 1pww
    complexed with an optimized peptide substrate (chains C and D) in the presence of zinc
    complexed with zn; mutant
    1. region a:29-263 [95256]
    2. region a:551-776 [95257]
    3. region b:28-263 [95259]
    4. region b:551-776 [95260]
  11. 1pwq
    complexed with small molecule inhibitor
    complexed with sd2, zn
    1. region a:27-263 [95238]
    2. region a:551-776 [95239]
    3. region b:27-263 [95241]
    4. region b:551-776 [95242]
  12. 1jky
    complexed with the n-terminal peptide of mapkk2
    1. region a:29-263 [66817]
    2. region a:551-776 [66818]