Structural Classification of Proteins
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Superfamily: Immunoglobulin

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Immunoglobulin-like beta-sandwich [48725]
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. Superfamily: Immunoglobulin [48726]
    link to SUPERFAMILY database - Superfamily

Families:

  1. V set domains (antibody variable domain-like) [48727] (90)
    1. Immunoglobulin light chain kappa variable domain, VL-kappa [88519]
      VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species
      1. Human (Homo sapiens), cluster 1 [TaxId: 9606] [88520] (18) picpic
      2. Human (Homo sapiens), cluster 2 [TaxId: 9606] [88521] (10) picpic
      3. Human (Homo sapiens), cluster 3.1 [TaxId: 9606] [88522] (10) picpic
      4. Human (Homo sapiens), cluster 3.2 [TaxId: 9606] [88523] (68) picpic
      5. Mouse (Mus musculus), cluster 1.1 [TaxId: 10090] [88524] (128) picpic
        SQ P01631 #KV2G_MOUSE Ig kappa chain V-II region 26-10; 79% sequence identity ! SQ P06310 # KV2F_HUMAN IG KAPPA CHAIN V-II REGION RPMI 6410 PRECURSOR ! SQ P03976 # KV2E_MOUSE (P03976) Ig kappa chain V-II region 17S29.1 ! SQ P01642 21-115 # ! KV2G_MOUSE IG KAPPA CHAIN V-II REGION 26-10
      6. Mouse (Mus musculus), cluster 1.2 [TaxId: 10090] [88525] (36) picpic
      7. Mouse (Mus musculus), cluster 2 [TaxId: 10090] [88526] (34) picpic
      8. Mouse (Mus musculus), cluster 3.1 [TaxId: 10090] [88527] (14) picpic
      9. Mouse (Mus musculus), cluster 3.2 [TaxId: 10090] [88528] (65) picpic
        SQ P04940 # KV6F_MOUSE IG KAPPA CHAIN V-VI REGION NQ2-17.4.1
      10. Mouse (Mus musculus), cluster 3.3 [TaxId: 10090] [88529] (2) picpic
      11. Mouse (Mus musculus), cluster 3.4 [TaxId: 10090] [88530] (6) picpic
      12. Mouse (Mus musculus), cluster 4 [TaxId: 10090] [88531] (189) picpic
        SQ P01645 1-106 # 95% sequense identity; KV5L_MOUSE Ig kappa chain V-V region HP 93G7 ! SQ NA # natural chimera; best hits are: SQ P01637 (Ig kappa chain V-V region T1) and SQ P01837 (Ig kappa chain C region) ! SQ NA # humanized antibody ! SQ NA # part of Fab 28 against HIV-1 RT ! SQ P01642 21-115 # ! KV5I_MOUSE Ig kappa chain V-V region L7 precursor
      13. Rat (Rattus norvegicus) [TaxId: 10116] [88532] (11) picpic
      14. Engineered (including hybrid species) [88533] (53) picpic
        SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody
      15. synthetic construct [158859] (1) picpic
      16. Escherichia coli [TaxId: 562] [158860] (8) picpic
    2. Immunoglobulin light chain lambda variable domain, VL-lambda [88534]
      VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family
      1. Human (Homo sapiens), cluster 1 [TaxId: 9606] [88535] (4) picpic
        SQ NA # Bence-Jones protein JTO ! SQ P06317 # Ig lambda chain V-VI region SUT
      2. Human (Homo sapiens), cluster 2 [TaxId: 9606] [88536] (11) picpic
      3. Human (Homo sapiens), cluster 3.1 [TaxId: 9606] [88537] (3) picpic
      4. Human (Homo sapiens), cluster 3.2 [TaxId: 9606] [88538] (1) picpic
      5. Human (Homo sapiens), cluster 4 [TaxId: 9606] [88539] (23) picpic
      6. Human (Homo sapiens), cluster 5 [TaxId: 9606] [88540] (9) picpic
        SQ Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
      7. Mouse (Mus musculus) [TaxId: 10090] [88541] (35) picpic
      8. Rat (Rattus norvegicus) [TaxId: 10116] [101504] (8) picpic
      9. Hamster (Cricetulus griseus) [TaxId: 10029] [88542] (1) picpic
    3. Immunoglobulin heavy chain variable domain, VH [88543]
      VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
      1. Human (Homo sapiens), cluster 1 [TaxId: 9606] [88544] (47) picpic
      2. Human (Homo sapiens), cluster 2.1 [TaxId: 9606] [88545] (3) picpic
      3. Human (Homo sapiens), cluster 2.2 [TaxId: 9606] [88546] (3) picpic
      4. Human (Homo sapiens), cluster 3 [TaxId: 9606] [88547] (66) picpic
        SQ Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3)
      5. Human (Homo sapiens), cluster 4 [TaxId: 9606] [101505] (4) picpic
      6. Mouse (Mus musculus), cluster 1 [TaxId: 10090] [88548] (51) picpic
        SQ P01796 # ! HV27_MOUSE Ig heavy chain V-III region A4
      7. Mouse (Mus musculus), cluster 2.1 [TaxId: 10090] [88549] (14) picpic
        SQ P18527 # HV56_MOUSE Ig heavy chain V region 914; 90% sequence identity
      8. Mouse (Mus musculus), cluster 2.2 [TaxId: 10090] [88550] (55) picpic
        SQ P01811 # HV41_MOUSE (P01811) Ig heavy chain V region UPC10
      9. Mouse (Mus musculus), cluster 3.1 [TaxId: 10090] [88551] (34) picpic
        SQ NA # natural chimera; best hits are: SQ P01751 (Ig heavy chain V region B1-8/186-2) and SQ P01864 (Ig gamma-2A chain C region secreted form)
      10. Mouse (Mus musculus), cluster 3.2 [TaxId: 10090] [88552] (156) picpic
        SQ P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! SQ P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! SQ P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor
      11. Mouse (Mus musculus), cluster 3.3 [TaxId: 10090] [88553] (1) picpic
      12. Mouse (Mus musculus), cluster 4 [TaxId: 10090] [88554] (35) picpic
        SQ P06327 20-117 # HV52_MOUSE (P06327) Ig heavy chain V region VH558 A1/A4 precursor; 57% sequence identity ! SQ P01631 # KV2G_MOUSE (P01631) Ig kappa chain V-II region 26-10
      13. Mouse (Mus musculus), cluster 5 [TaxId: 10090] [88555] (36) picpic
      14. Mouse (Mus musculus), cluster 6 [TaxId: 10090] [88556] (12) picpic
        SQ NA # part of Fab 28 against HIV-1 RT
      15. Mouse (Mus musculus), cluster 7.1 [TaxId: 10090] [88557] (41) picpic
        SQ P18532 # HV61_MOUSE Ig heavy chain V region 1B43 precursor
      16. Mouse (Mus musculus), cluster 7.2 [TaxId: 10090] [88558] (29) picpic
      17. Mouse (Mus musculus), cluster 7.3 [TaxId: 10090] [88559] (2) picpic
      18. Rat (Rattus norvegicus) [TaxId: 10116] [88560] (17) picpic
      19. Hamster (Cricetulus griseus) [TaxId: 10029] [88561] (1) picpic
      20. Engineered (including hybrid species) [88562] (82) picpic
        SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody
      21. Escherichia coli [TaxId: 562] [158861] (3) picpic
      22. synthetic construct [158862] (2) picpic
    4. Camelid IG heavy chain variable domain, VHh [88563]
      1. Camel (Camelus dromedarius) [TaxId: 9838] [88564] (23) picpic
        SQ NA # camelid antibody
      2. Llama (Lama glama) [TaxId: 9844] [88565] (9) picpic
      3. Homo sapiens [TaxId: 9606] [158863] (2) picpic
    5. T-cell antigen receptor [48933]
      sequences may differ within each classified species
      1. Mouse (Mus musculus), alpha-chain [TaxId: 10090] [48934] (25) picpic
      2. Human (Homo sapiens), alpha-chain [TaxId: 9606] [48935] (21) picpic
      3. Mouse (Mus musculus), beta-chain [TaxId: 10090] [48936] (36) picpic
      4. Human (Homo sapiens), beta-chain [TaxId: 9606] [48937] (52) picpic
      5. Human (Homo sapiens), gamma-chain [TaxId: 9606] [63651] (11) picpic
      6. Human (Homo sapiens), delta-chain [TaxId: 9606] [48938] (4) picpic
    6. Immunoreceptor CTLA-4 (CD152), N-terminal fragment [48939]
      1. Human (Homo sapiens) [TaxId: 9606] [48940] (3) picpic
      2. Mouse (Mus musculus) [TaxId: 10090] [48941] (1) picpic
    7. Myelin membrane adhesion molecule P0 [48728]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [48729] (1) picpic
    8. Myelin oligodendrocyte glycoprotein (MOG) [89174]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [89175] (3) picpic
    9. Coxsackie virus and adenovirus receptor (Car), domain 1 [48730]
      1. Human (Homo sapiens) [TaxId: 9606] [48731] (19) picpic
    10. N-terminal domain of sialoadhesin [48732]
      1. Mouse (Mus musculus) [TaxId: 10090] [48733] (8) picpic
        SQ Q62230 20-130
    11. N-terminal domain of sialic acid binding Ig-like lectin 7 (SIGLEC-7, p75/AIRM1) [89176]
      1. Human (Homo sapiens) [TaxId: 9606] [89177] (6) picpic
    12. NK cell activating receptor NKP44 [89178]
      a triggering partner in natural cytotoxicity
      1. Human (Homo sapiens) [TaxId: 9606] [89179] (1) picpic
    13. TREM-1 (triggering receptor expressed on myeloid cells 1) [101506]
      1. Human (Homo sapiens) [TaxId: 9606] [101507] (2) picpic
        SQ Q9NP99 21-133
      2. Mouse (Mus musculus) [TaxId: 10090] [117037] (1) picpic
        SQ Q9JKE2 25-134
    14. CD8 [48734]
      1. Human (Homo sapiens) [TaxId: 9606] [48735] (2) picpic
      2. Mouse (Mus musculus) [TaxId: 10090] [48736] (6) picpic
      3. Mouse (Mus musculus), beta-chain [TaxId: 10090] [158864] (2) picpic
        SQ P10300 22-136
    15. CD4 V-set domains [48737]
      1. Human (Homo sapiens) [TaxId: 9606] [48738] (27) picpic
      2. Rat (Rattus rattus) [TaxId: 10117] [48739] (1) picpic
    16. CD2, first domain [48740]
      1. Human (Homo sapiens) [TaxId: 9606] [48741] (4) picpic
      2. Rat (Rattus norvegicus) [TaxId: 10116] [48742] (5) picpic
    17. CD2-binding domain of CD58, N-terminal domain [48743]
      1. Human (Homo sapiens) [TaxId: 9606] [48744] (3) picpic
    18. CD80, N-terminal domain [48745]
      a soluble form of b7-1
      1. Human (Homo sapiens) [TaxId: 9606] [48746] (2) picpic
    19. CD86 (b7-2), N-terminal domain [63635]
      1. Human (Homo sapiens) [TaxId: 9606] [63636] (2) picpic
    20. Junction adhesion molecule, JAM, N-terminal domain [48747]
      1. Mouse (Mus musculus) [TaxId: 10090] [48748] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [89180] (1) picpic
    21. Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), N-terminal domain [81942]
      1. Mouse (Mus musculus) [TaxId: 10090] [81943] (1) picpic
    22. Tyrosine-protein kinase receptor tyro3, N-terminal domain [101508]
      1. Human (Homo sapiens) [TaxId: 9606] [101509] (1) picpic
    23. Programmed cell death protein 1, PD1, extracellular domain [101510]
      1. Mouse (Mus musculus) [TaxId: 10090] [101511] (4) picpic
    24. HSV glycoprotein D [63637]
      1. Herpes simplex virus type 1 [TaxId: 10298] [63638] (2) picpic
        elaborated with insertions and N- and C-terminal extensions
    25. Novel antigen receptor (against lysozyme) [110042]
      1. Nurse shark (Ginglymostoma cirratum) [TaxId: 7801] [110043] (7) picpic
        SQ Q8AXI4 # fragment
    26. Novel antigen receptor 12Y-1 [110044]
      1. Spotted wobbegong (Orectolobus maculatus) [TaxId: 168098] [110045] (1) picpic
        SQ Q6X1E7 # fragment
    27. Novel antigen receptor 12Y-2 [110046]
      1. Spotted wobbegong (Orectolobus maculatus) [TaxId: 168098] [110047] (1) picpic
        SQ Q6X1E6 # fragment
    28. Polymeric-immunoglobulin receptor, PIGR [117038]
      1. Human (Homo sapiens) [TaxId: 9606] [117039] (1) picpic
        SQ P01833 20-127 # N-terminal, ligand-binding domain
    29. Alphaherpesvirus glycoprotein E [141008]
      elaborated with insertions and C-terminal extensions
      1. Human herpesvirus 1 [TaxId: 10298] [141009] (4) picpic
        SQ P04488 218-394! SQ P04488 220-390
    30. CD28 [158865]
      T-cell-specific surface glycoprotein
      1. Human (Homo sapiens) [TaxId: 9606] [158866] (1) picpic
        SQ P10747 19-136
    31. Kin of IRRE-like protein 3, KIRREL3 [158867]
      1. Human (Homo sapiens) [TaxId: 9606] [158868] (1) picpic
        SQ Q8IZU9 413-521
    32. B- and T-lymphocyte attenuator CD272 [158869]
      1. Human (Homo sapiens) [TaxId: 9606] [158870] (2) picpic
        SQ Q7Z6A9 34-137
  2. C1 set domains (antibody constant domain-like) [48942] (70)
    1. Immunoglobulin light chain kappa constant domain, CL-kappa [88566]
      1. Mouse (Mus musculus) [TaxId: 10090] [88567] (347) picpic
        SQ P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: SQ P01637 (Ig kappa chain V-V region T1) and SQ P01837 (Ig kappa chain C region) ! SQ P01837 # KAC_MOUSE Ig kappa chain C region ! SQ P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! SQ P01837 # ! KAC_MOUSE Ig kappa chain C region
      2. Rat (Rattus norvegicus) [TaxId: 10116] [88568] (8) picpic
      3. Human (Homo sapiens) [TaxId: 9606] [88569] (168) picpic
        SQ NA # humanized antibody ! SQ P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody
        including humanized antibodies (chimeric proteins with human constant domains)
      4. synthetic construct [158871] (1) picpic
      5. Escherichia coli [TaxId: 562] [158872] (8) picpic
    2. Immunoglobulin light chain lambda constant domain, CL-lambda [88570]
      1. Mouse (Mus musculus) [TaxId: 10090] [88571] (21) picpic
        SQ Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
      2. Human (Homo sapiens) [TaxId: 9606] [88572] (49) picpic
      3. Hamster (Cricetulus griseus) [TaxId: 10029] [88573] (1) picpic
    3. Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574]
      1. Human (Homo sapiens) [TaxId: 9606] [88575] (256) picpic
        SQ Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! SQ P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
        including humanized antibodies (chimeric proteins with human constant domains)
      2. Mouse (Mus musculus) [TaxId: 10090] [88576] (412) picpic
        SQ P01864 # GCAB_MOUSE Ig gamma-2A chain C region secreted form (B allele) ! SQ P01863 #GCAA_MOUSE Ig gamma-2A chain C region, A allele; 86% sequence identity ! SQ NA # natural chimera; best hits are: SQ P01751 (Ig heavy chain V region B1-8/186-2) and SQ P01864 (Ig gamma-2A chain C region secreted form) ! SQ P01868 # GC1_MOUSE Ig gamma-1 chain C region secreted form ! SQ P01864 # GCAB_MOUSE (P01864) Ig gamma-2A chain C region ! SQ P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ P01863 # GCAA_MOUSE Ig gamma-2A chain C region, A allele ! SQ NA # part of Fab 28 against HIV-1 RT ! SQ P01868 # ! GC1_MOUSE Ig gamma-1 chain C region secreted form
      3. Mouse (Mus musculus), gamma3 [TaxId: 10090] [88577] (8) picpic
        SQ P22436 # GC3_MOUSE (P22436) Ig gamma-3 chain C region
      4. Rat (Rattus norvegicus) [TaxId: 10116] [88578] (6) picpic
      5. Hamster (Cricetulus griseus) [TaxId: 10029] [88579] (1) picpic
      6. Escherichia coli [TaxId: 562] [158873] (3) picpic
      7. synthetic construct [158874] (2) picpic
    4. Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580]
      1. Mouse (Mus musculus) [TaxId: 10090] [88581] (3) picpic
    5. Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582]
      1. Human (Homo sapiens) [TaxId: 9606] [88583] (8) picpic
    6. Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584]
      1. Human (Homo sapiens) [TaxId: 9606] [88585] (34) picpic
        SQ P01857 #118-327 ! SQ P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
      2. Mouse (Mus musculus) [TaxId: 10090] [88586] (1) picpic
      3. Mouse (Mus musculus), gamma2 [TaxId: 10090] [88587] (1) picpic
      4. Rat (Rattus norvegicus) [TaxId: 10116] [88588] (2) picpic
    7. Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589]
      1. Human (Homo sapiens) [TaxId: 9606] [88590] (37) picpic
        SQ P01857 #118-327 ! SQ P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
      2. Mouse (Mus musculus) [TaxId: 10090] [88591] (2) picpic
      3. Mouse (Mus musculus), gamma2 [TaxId: 10090] [88592] (1) picpic
      4. Rat (Rattus norvegicus) [TaxId: 10116] [88593] (2) picpic
      5. Guinea pig (Cavia porcellus) [TaxId: 10141] [49123] (1) picpic
    8. Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181]
      1. Human (Homo sapiens) [TaxId: 9606] [89182] (3) picpic
    9. Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183]
      1. Human (Homo sapiens) [TaxId: 9606] [89184] (3) picpic
    10. Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594]
      1. Human (Homo sapiens) [TaxId: 9606] [88595] (2) picpic
    11. Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596]
      1. Human (Homo sapiens) [TaxId: 9606] [88597] (3) picpic
    12. Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598]
      1. Human (Homo sapiens) [TaxId: 9606] [88599] (3) picpic
    13. T-cell antigen receptor [49125]
      1. Mouse (Mus musculus), alpha-chain [TaxId: 10090] [49126] (15) picpic
      2. Human (Homo sapiens), alpha-chain [TaxId: 9606] [49127] (24) picpic
      3. Mouse (Mus musculus), beta-chain [TaxId: 10090] [49128] (19) picpic
      4. Human (Homo sapiens), beta-chain [TaxId: 9606] [49129] (39) picpic
      5. Human (Homo sapiens), gamma-chain [TaxId: 9606] [63661] (3) picpic
      6. Human (Homo sapiens), delta-chain [TaxId: 9606] [63662] (3) picpic
    14. beta2-microglobulin [88600]
      1. Cow (Bos taurus) [TaxId: 9913] [48946] (1) picpic
      2. Rat (Rattus norvegicus) [TaxId: 10116] [88601] (6) picpic
      3. Human (Homo sapiens) [TaxId: 9606] [88602] (228) picpic
        SQ P61769 21-119 ! SQ P01884
      4. Mouse (Mus musculus) [TaxId: 10090] [88603] (106) picpic
        SQ P01887
    15. Class I MHC, alpha-3 domain [88604]
      1. Human (Homo sapiens) [TaxId: 9606] [88605] (189) picpic
        SQ P30685 25-300 ! SQ P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor ! SQ P30481 25-300 ! SQ P01892 25-298 ! SQ P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
      2. Mouse (Mus musculus) [TaxId: 10090] [88606] (109) picpic
        SQ P01901 22-299
      3. Rat (Rattus norvegicus), RT1-AA [TaxId: 10116] [88607] (3) picpic
      4. Rhesus monkey (Macaca mulatta) [TaxId: 9544] [158875] (2) picpic
    16. Hemochromatosis protein Hfe, alpha-3 domain [88608]
      1. Human (Homo sapiens) [TaxId: 9606] [88609] (2) picpic
    17. Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965]
      fat depleting factor related to class I MHC
      1. Human (Homo sapiens) [TaxId: 9606] [48966] (7) picpic
        SQ P25311 22-294
    18. Class I MHC homolog, alpha-3 domain [88610]
      gamma, delta T-cell ligand
      1. Human (Homo sapiens), Mic-a [TaxId: 9606] [48968] (2) picpic
      2. Human (Homo sapiens), Mic-b [TaxId: 9606] [74826] (1) picpic
      3. Mouse (Mus musculus), t22 [TaxId: 10090] [88611] (3) picpic
      4. Mouse (Mus musculus), t10 [TaxId: 10090] [101512] (1) picpic
    19. Fc (IgG) receptor, alpha-3 domain [88612]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [88613] (3) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [88614] (1) picpic
    20. CD1, alpha-3 domain [88615]
      1. Mouse (Mus musculus) [TaxId: 10090] [88616] (10) picpic
      2. Human (Homo sapiens), CD1b [TaxId: 9606] [88617] (3) picpic
      3. Human (Homo sapiens), CD1a [TaxId: 9606] [101513] (4) picpic
      4. Human (Homo sapiens), CD1d [TaxId: 9606] [158876] (4) picpic
        SQ P15813 202-295
    21. Class II MHC alpha chain, C-terminal domain [88618]
      1. Human (Homo sapiens), HLA-DM [TaxId: 9606] [88619] (1) picpic
        probably orthologous to the mouse H2-DM
      2. Mouse (Mus musculus), H2-DM [TaxId: 10090] [88620] (1) picpic
        probably orthologous to the human HLA-DM
      3. Human (Homo sapiens), HLA-DR group [TaxId: 9606] [88621] (29) picpic
        SQ P01903 28-207
        probably orthologous to the mouse I-E group
      4. Mouse (Mus musculus), I-E group [TaxId: 10090] [88622] (9) picpic
        probably orthologous to the human HLA-DR group
      5. Human (Homo sapiens), HLA-DQ group [TaxId: 9606] [88623] (3) picpic
        probably orthologous to the mouse I-A group
      6. Mouse (Mus musculus), I-A group [TaxId: 10090] [88624] (39) picpic
        probably orthologous to the human HLA-DQ group
    22. Class II MHC beta chain, C-terminal domain [88625]
      1. Human (Homo sapiens), HLA-DM [TaxId: 9606] [88626] (1) picpic
        probably orthologous to the mouse H2-DM
      2. Mouse (Mus musculus), H2-DM [TaxId: 10090] [88627] (1) picpic
        probably orthologous to the human HLA-DM
      3. Human (Homo sapiens), HLA-DR group [TaxId: 9606] [88628] (48) picpic
        SQ P04229 30-219
        probably orthologous to the mouse I-E group
      4. Mouse (Mus musculus), I-E group [TaxId: 10090] [88629] (9) picpic
        probably orthologous to the human HLA-DR group
      5. Human (Homo sapiens), HLA-DQ group [TaxId: 9606] [88630] (3) picpic
        probably orthologous to the mouse I-A group
      6. Mouse (Mus musculus), I-A group [TaxId: 10090] [88631] (20) picpic
        probably orthologous to the human HLA-DQ group
    23. Immunomodulatory protein m144, alpha-3 domain [110048]
      1. Murine cytomegalovirus [TaxId: 10366] [110049] (2) picpic
        SQ Q69G19 27-263 # 95% sequence identity
  3. C2 set domains [49142] (10)
    1. Vascular cell adhesion molecule-1 (VCAM-1) [49143]
      1. Human (Homo sapiens) [TaxId: 9606] [49144] (3) picpic
    2. Intercellular cell adhesion molecule-1 (ICAM-1) [49145]
      1. Human (Homo sapiens) [TaxId: 9606] [49146] (8) picpic
    3. Intercellular cell adhesion molecule-2 (ICAM-2) [49147]
      1. Human (Homo sapiens) [TaxId: 9606] [49148] (1) picpic
    4. CD4 C2-set domains [49149]
      1. Human (Homo sapiens) [TaxId: 9606] [49150] (27) picpic
      2. Rat (Rattus rattus) [TaxId: 10117] [49151] (1) picpic
    5. CD2, second domain [49152]
      1. Human (Homo sapiens) [TaxId: 9606] [49153] (1) picpic
      2. Rat (Rattus norvegicus) [TaxId: 10116] [49154] (1) picpic
    6. CD2-binding domain of CD58, second domain [49155]
      1. Human (Homo sapiens) [TaxId: 9606] [49156] (1) picpic
    7. CD80, second domain [49157]
      a soluble form of b7-1
      1. Human (Homo sapiens) [TaxId: 9606] [49158] (2) picpic
    8. Granulocyte colony-stimulating factor (GC-SF) receptor, N-terminal domain [141010]
      1. Human (Homo sapiens) [TaxId: 9606] [141011] (1) picpic
        SQ Q99062 26-119
  4. I set domains [49159] (53)
    1. Vascular cell adhesion molecule-1 (VCAM-1) [49160]
      1. Human (Homo sapiens) [TaxId: 9606] [49161] (3) picpic
    2. Intercellular adhesion molecule-1, ICAM-1 [49162]
      1. Human (Homo sapiens) [TaxId: 9606] [49163] (10) picpic
    3. Intercellular adhesion molecule-2, ICAM-2 [49164]
      1. Human (Homo sapiens) [TaxId: 9606] [49165] (1) picpic
    4. Neural cell adhesion molecule (NCAM) [49166]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [49167] (4) picpic
        Rat and mouse sequences are identical for the two N-terminal modules
      2. Chicken (Gallus gallus) [TaxId: 9031] [63664] (1) picpic
    5. Mucosal addressin cell adhesion molecule-1 (MADCAM-1) [49168]
      1. Human (Homo sapiens) [TaxId: 9606] [49169] (2) picpic
    6. Telokin [49170]
      1. Turkey (Meleagris gallopavo) [TaxId: 9103] [49171] (2) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [141012] (1) picpic
        SQ Q9UIT9 1238-1338
    7. Cardiac myosin binding protein C, different domains [89185]
      1. Human (Homo sapiens) [TaxId: 9606] [89186] (3) picpic
        SQ Q14896 358-451, 641-770
    8. Titin [49172]
      1. Human (Homo sapiens), different modules [TaxId: 9606] [49173] (5) picpic
    9. Twitchin [49174]
      1. Nematode (Caenorhabditis elegans) [TaxId: 6239] [49175] (3) picpic
        different modules
      2. Human (Homo sapiens), Ig repeat 27 [TaxId: 9606] [49176] (2) picpic
    10. Type-1 interleukin-1 receptor [49177]
      duplication: tandem repeat of 3 domains
      1. Human (Homo sapiens) [TaxId: 9606] [49178] (3) picpic
    11. Fibroblast growth factor receptor, FGFR [49179]
      1. Human (Homo sapiens), FGFR1 [TaxId: 9606] [49180] (7) picpic
      2. Human (Homo sapiens), FGFR2a [TaxId: 9606] [49181] (8) picpic
      3. Human (Homo sapiens), FGFR2b [TaxId: 9606] [81955] (1) picpic
      4. Human (Homo sapiens), FGFR3c [TaxId: 9606] [101514] (1) picpic
    12. Hemolin [49182]
      Duplication: tandem repeat of 4 domains, known as L1 domains
      1. Moth (Hyalophora cecropia) [TaxId: 7123] [49183] (1) picpic
    13. Semaphorin 4d Ig-like domain [101515]
      1. Human (Homo sapiens) [TaxId: 9606] [101516] (1) picpic
    14. Axonin-1 [49184]
      tandem repeat of 4 L1 domains
      1. Chicken (Gallus gallus) [TaxId: 9031] [49185] (1) picpic
    15. Perlecan Ig3 domain [69158]
      1. Mouse (Mus musculus) [TaxId: 10090] [69159] (1) picpic
    16. Junction adhesion molecule, JAM, C-terminal domain [49186]
      1. Mouse (Mus musculus) [TaxId: 10090] [49187] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [89187] (1) picpic
    17. Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), C-terminal domain [81956]
      1. Mouse (Mus musculus) [TaxId: 10090] [81957] (1) picpic
    18. Second domain of the Flt-1 receptor [49188]
      1. Human (Homo sapiens) [TaxId: 9606] [49189] (5) picpic
    19. Tyrosine-protein kinase receptor tyro3, second domain [101517]
      1. Human (Homo sapiens) [TaxId: 9606] [101518] (1) picpic
    20. High affinity nerve growth factor receptor TrkA, different domains [49190]
      1. Human (Homo sapiens) [TaxId: 9606] [49191] (7) picpic
    21. Ligand binding domain of trkB receptor [49192]
      1. Human (Homo sapiens) [TaxId: 9606] [49193] (2) picpic
    22. NT3 binding domain of trkC receptor [49194]
      1. Human (Homo sapiens) [TaxId: 9606] [49195] (1) picpic
    23. Fc gamma receptor ectodomain (CD32) [49196]
      possibly an intermediate structure between the I set and FnIII domains
      1. Human (Homo sapiens), IIa [TaxId: 9606] [49197] (2) picpic
      2. Human (Homo sapiens), IIb [TaxId: 9606] [49198] (1) picpic
      3. Human (Homo sapiens), III [TaxId: 9606] [49199] (5) picpic
        SQ O75015 23-189
    24. IgE high affinity receptor alpha subunit [49200]
      possibly an intermediate structure between the I set and FnIII domains
      1. Human (Homo sapiens) [TaxId: 9606] [49201] (7) picpic
        SQ P12319 29-196
    25. Ig alpha Fc receptor, FCARI (CD89) [89188]
      possibly an intermediate structure between the I set and FnIII domains
      1. Human (Homo sapiens) [TaxId: 9606] [89189] (3) picpic
    26. Killer cell inhibitory receptor [49202]
      possibly an intermediate structure between the I set and FnIII domains
      1. Human (Homo sapiens), kir2dl3 [TaxId: 9606] [49203] (2) picpic
      2. Human (Homo sapiens), kir2ds3, CD158j [TaxId: 9606] [89190] (1) picpic
      3. Human (Homo sapiens), p58-cl42 kir [TaxId: 9606] [49204] (2) picpic
      4. Human (Homo sapiens), 2dl2 [TaxId: 9606] [49205] (2) picpic
    27. Ligand binding domain of lir-1 (ilt2) [49206]
      possibly an intermediate structure between the I set and FnIII domains
      1. Human (Homo sapiens) [TaxId: 9606] [49207] (8) picpic
        SQ Q8NHL6 25-218
    28. Ligand binding domain of NK receptor NKp46 [101519]
      possibly an intermediate structure between the I set and FnIII domains
      1. Human (Homo sapiens) [TaxId: 9606] [101520] (2) picpic
    29. The p40 domain of interleukin-12 (IL-12 beta chain), N-terminal domain [63665]
      1. Human (Homo sapiens) [TaxId: 9606] [63666] (7) picpic
    30. Interleukin-6 receptor alpha chain, N-terminal domain [81958]
      1. Human (Homo sapiens) [TaxId: 9606] [81959] (1) picpic
    31. CD3 gamma chain ectodomain fragment [69160]
      possibly an intermediate structure between the I set and FnIII domains
      1. Mouse (Mus musculus) [TaxId: 10090] [69161] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [110050] (1) picpic
        SQ P09693 # CD3G_HUMAN T-cell surface glycoprotein CD3 gamma chain precursor
    32. CD3 epsilon chain ectodomain fragment [69162]
      possibly an intermediate structure between the I set and FnIII domains
      1. Mouse (Mus musculus) [TaxId: 10090] [69163] (2) picpic
        SQ P22646 22-100
      2. Human (Homo sapiens) [TaxId: 9606] [110051] (2) picpic
        SQ P07766 33-123 ! SQ P07766 # CD3E_HUMAN T-cell surface glycoprotein CD3 epsilon chain precursor
      3. Sheep (Ovis aries) [TaxId: 9940] [117040] (1) picpic
        SQ P18438 22-88
    33. B and T lymphocyte attenuator, Btla [117041]
      1. Mouse (Mus musculus) [TaxId: 10090] [117042] (1) picpic
        SQ Q7TSA3 40-143
    34. CD3 delta chain ectodomain fragment [117043]
      1. Human (Homo sapiens) [TaxId: 9606] [117044] (1) picpic
        SQ P04234 23-95
    35. Myosin-binding protein C, slow-type [141013]
      1. Human (Homo sapiens) [TaxId: 9606] [141014] (2) picpic
        SQ Q00872 342-431! SQ Q00872 58-170
    36. Receptor-type tyrosine-protein phosphatase mu [141015]
      1. Human (Homo sapiens) [TaxId: 9606] [141016] (1) picpic
        SQ P28827 184-279
    37. Cervical EMMPRIN [158877]
      contains two Ig-domains in the N-terminal part
      1. Human (Homo sapiens) [TaxId: 9606] [158878] (8) picpic
        SQ Q54A51 103-203! SQ Q54A51 23-102
    38. Ligand binding domain of lir-2 (ilt4) [158879]
      1. Human (Homo sapiens) [TaxId: 9606] [158880] (2) picpic
        SQ Q8N423 120-218! SQ Q8N423 26-109
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk