Structural Classification of Proteins
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Protein: Immunoglobulin light chain kappa variable domain, VL-kappa from Engineered (including hybrid species)

SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Immunoglobulin-like beta-sandwich [48725]
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. Superfamily: Immunoglobulin [48726]
    link to SUPERFAMILY database - Superfamily
  5. Family: V set domains (antibody variable domain-like) [48727]
  6. Protein: Immunoglobulin light chain kappa variable domain, VL-kappa [88519]
    VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. Species: Engineered (including hybrid species) [88533]
    SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody

PDB Entry Domains:

  1. 1l7i picpicxrefxrefxref
    part of humanized anti-ERBb2 Fab 2C4
    complexed with so4
    1. region l:1-107 [73658] picpiclink
  2. 1jpt picpicxrefxrefxref
    part of humanized Fab D3H44 against human tissue factor
    1. region l:1-107 [67053] picpiclink
  3. 2imn picpic
    VL domain only of humanized antibody MCPC603
    complexed with ace, so4; mutant
    1. chain a [19856] picpiclink
  4. 1jps picpicxrefxrefxrefxref
    part of humanized Fab D3H44 against human tissue factor
    1. region l:1-107 [67047] picpiclink
  5. 1t3f picpicxrefxrefxref
    1. region a:1-108 [112228] picpiclink
  6. 1fgv picpicxref
    part of humanized Fv H52
    1. chain l [19852] picpiclink
  7. 1op3 picpicxrefxrefxref
    part of engineered Fab 2G12
    complexed with box, man
    1. region k:2-107 [87210] picpiclink
    2. region l:2-107 [87212] picpiclink
  8. 1tjg picpicxrefxrefxref
    complexed with egl, ioh, ycm
    1. region l:1-107 [112448] picpiclink
  9. 1tjh picpicxrefxrefxref
    complexed with ace, egl, ioh, nh2, ycm
    1. region l:1-107 [112452] picpiclink
  10. 1tji picpicxrefxrefxref
    complexed with egl, ioh, nh2, ycm
    1. region l:1-107 [112456] picpiclink
  11. 2f5b picpicxrefxrefxref
    part of humanized HIV-1 neutralizing Fab 2F5
    1. region l:1-107 [88508] picpiclink
  12. 1gpo picpicxrefxrefxref
    complexed with so4
    1. region l:1-112 [20224] picpiclink
    2. region m:1-112 [20226] picpiclink
  13. 1u8i picpicxrefxrefxref
    1. region a:1-107 [113132] picpiclink
  14. 2f5a picpicxrefxrefxref
    part of humanized HIV-1 neutralizing Fab 2F5
    1. region l:1-107 [88504] picpiclink
  15. 1u8h picpicxrefxrefxref
    1. region a:1-107 [113128] picpiclink
  16. 1u8k picpicxrefxrefxref
    1. region a:1-107 [113140] picpiclink
  17. 1ivl picpic
    VL domain of synthetic antibody M29B; "reversed" dimerisation mode
    complexed with ipa
    1. chain a [20516] picpiclink
    2. chain b [20517] picpiclink
  18. 1fvc picpicxref
    part of humanized Fv 4D5, herceptin
    1. chain a [19862] picpiclink
    2. chain c [19864] picpiclink
  19. 1u95 picpicxrefxrefxref
    1. region a:1-107 [113228] picpiclink
  20. 1u8j picpicxrefxrefxref
    1. region a:1-107 [113136] picpiclink
  21. 1om3 picpicxrefxrefxref
    part of engineered Fab 2G12
    1. region l:2-107 [87063] picpiclink
    2. region m:2-107 [87065] picpiclink
  22. 1ad0 picpicxrefxrefxref
    part of humanized Fab A5B7
    1. region a:1-107 [20124] picpiclink
    2. region c:1-107 [20126] picpiclink
  23. 1jv5 picpicxref
    part of an anti-blood group A Fv
    1. chain a [67344] picpiclink
  24. 1u8q picpicxrefxrefxref
    1. region a:1-107 [113164] picpiclink
  25. 1u91 picpicxrefxrefxref
    1. region a:1-107 [113216] picpiclink
  26. 1u92 picpicxrefxrefxref
    1. region a:1-107 [113220] picpiclink
  27. 1u8m picpicxrefxrefxref
    1. region a:1-107 [113148] picpiclink
  28. 1u8n picpicxrefxrefxref
    1. region a:1-107 [113152] picpiclink
  29. 1pg7 picpicxrefxrefxrefxrefxrefxrefxref
    part of humanized Fab D3H44 against human tissue factor
    1. region l:1-107 [94678] picpiclink
    2. region m:1-107 [94680] picpiclink
  30. 1fvd picpicxrefxrefxref
    part of humanized Fab 4D5, herceptin
    1. region a:1-107 [19866] picpiclink
    2. region c:1-107 [19868] picpiclink
  31. 1u93 picpicxrefxrefxref
    1. region a:1-107 [113224] picpiclink
  32. 1u8l picpicxrefxrefxref
    1. region a:1-107 [113144] picpiclink
  33. 1ad9 picpicxrefxrefxref
    part of humanized Fab CTM01
    complexed with so4
    1. region l:1-107 [20212] picpiclink
    2. region a:1-107 [20214] picpiclink
  34. 1tzh picpicxrefxrefxrefxref
    1. region a:1-107 [107477] picpiclink
    2. region l:1-107 [107483] picpiclink
  35. 1fve picpicxrefxrefxref
    part of humanized Fab 4D5, herceptin
    1. region a:1-107 [19870] picpiclink
    2. region c:1-107 [19872] picpiclink
  36. 1n8z picpicxrefxrefxrefxrefxref
    part of humanized Fab 4D5, herceptin
    complexed with nag, so4
    1. region a:1-107 [80318] picpiclink
  37. 1mhp picpicxrefxrefxrefxrefxref
    part of humanized anti-alpha1 integrin I-domain Fab
    complexed with mn; mutant
    1. region l:2-106 [84969] picpiclink
  38. 1mhp picpicxrefxrefxrefxrefxref
    part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered
    complexed with mn; mutant
    1. chain y [84972] picpiclink
  39. 1u8o picpicxrefxrefxref
    1. region a:1-107 [113156] picpiclink
  40. 1t04 picpicxrefxrefxref
    1. region a:1-108 [112182] picpiclink
    2. region c:1-108 [112186] picpiclink
  41. 1u8p picpicxrefxrefxref
    1. region a:1-107 [113160] picpiclink
  42. 1b2w picpicxrefxrefxref
    part of a humanized anti-gamma-interferon Fab
    1. region l:1-107 [20306] picpiclink
  43. 2fgw picpicxrefxrefxref
    part of humanized Fab H52
    1. region l:1-108 [19854] picpiclink
  44. 1bvk picpicxrefxref
    part of humanized anti-lysozyme Fv HuLys11
    1. chain a [20278] picpiclink
    2. chain d [20280] picpiclink
  45. 1it9 picpicxrefxrefxref
    part of humanized anti-human Fas Fab HFE7A
    1. region l:1-111 [76785] picpiclink
  46. 1tzi picpicxrefxrefxrefxref
    1. region a:1-107 [107487] picpiclink
  47. 1bvl picpicxref
    part of humanized anti-lysozyme Fv HuLys11
    1. chain b [20283] picpiclink
    2. chain d [20285] picpiclink
  48. 1i9r picpicxrefxrefxrefxref
    part of humanized Fab 5C8 against C40 ligand
    complexed with zn
    1. region l:1-111 [71155] picpiclink
    2. region m:1-111 [71157] picpiclink
    3. region y:1-111 [71161] picpiclink
  49. 1op5 picpicxrefxrefxref
    part of engineered Fab 2G12
    complexed with man, nag
    1. region k:2-107 [87218] picpiclink
    2. region l:2-107 [87220] picpiclink
  50. 1s78 picpicxrefxrefxrefxrefxref
    part of anti-ERBb2 Fab Pertuzumab
    complexed with man, nag
    1. region c:1-107 [98624] picpiclink
    2. region e:1-107 [98628] picpiclink
  51. 1s3k picpicxrefxrefxref
    MQ NA P01857 # artificial chimera
    complexed with fuc, gal, gol, nag
    1. region h:1-119 [105237] picpiclink
  52. 1uj3 picpicxrefxrefxrefxref
    MQ NA P01834 # artificial chimera
    1. region a:1-107 [107888] picpiclink
  53. 1rjl picpicxrefxrefxrefxref
    MQ NA P01837 # artificial chimera
    1. region a:1-107 [111821] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk