Structural Classification of Proteins
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Protein: Immunoglobulin heavy chain variable domain, VH from Engineered (including hybrid species)

SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Immunoglobulin-like beta-sandwich [48725]
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. Superfamily: Immunoglobulin [48726]
    link to SUPERFAMILY database - Superfamily
  5. Family: V set domains (antibody variable domain-like) [48727]
  6. Protein: Immunoglobulin heavy chain variable domain, VH [88543]
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. Species: Engineered (including hybrid species) [88562]
    SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody

PDB Entry Domains:

  1. 1ol0 picpic
    camelized human VH
    complexed with gol, so4
    1. chain a [93296] picpiclink
    2. chain b [93297] picpiclink
  2. 1l7i picpicxrefxrefxref
    part of humanized anti-ERBb2 Fab 2C4
    complexed with so4
    1. region h:1-113 [73656] picpiclink
  3. 1jpt picpicxrefxrefxref
    part of humanized Fab D3H44 against human tissue factor
    1. region h:1-117 [67051] picpiclink
  4. 1jps picpicxrefxrefxrefxref
    part of humanized Fab D3H44 against human tissue factor
    1. region h:1-117 [67045] picpiclink
  5. 1t3f picpicxrefxrefxref
    1. region b:1-118 [112230] picpiclink
  6. 1fgv picpicxref
    part of humanized Fv H52
    1. chain h [19853] picpiclink
  7. 1op3 picpicxrefxrefxref
    part of engineered Fab 2G12
    complexed with box, man
    1. region h:1-115 [87208] picpiclink
    2. region m:1-115 [87214] picpiclink
  8. 1tjg picpicxrefxrefxref
    complexed with egl, ioh, ycm
    1. region h:1-113 [112446] picpiclink
  9. 1tjh picpicxrefxrefxref
    complexed with ace, egl, ioh, nh2, ycm
    1. region h:1-113 [112450] picpiclink
  10. 1tji picpicxrefxrefxref
    complexed with egl, ioh, nh2, ycm
    1. region h:1-113 [112454] picpiclink
  11. 2b1h picpicxref
    automatically matched to d1fgvh_
    1. region h:1-113 [127668] picpiclink
  12. 1ohq picpic
    soluble VH Hel4, resistant to aggregation
    1. chain a [93027] picpiclink
    2. chain b [93028] picpiclink
  13. 2f5b picpicxrefxrefxref
    part of humanized HIV-1 neutralizing Fab 2F5
    1. region h:1-132 [88506] picpiclink
  14. 1gpo picpicxrefxrefxref
    part of Fab M41 (artificial design)
    complexed with so4
    1. region h:1-113 [20225] picpiclink
    2. region i:1-113 [20227] picpiclink
  15. 1u8i picpicxrefxrefxref
    1. region b:1-113 [113134] picpiclink
  16. 2f5a picpicxrefxrefxref
    part of humanized HIV-1 neutralizing Fab 2F5
    1. region h:1-132 [88502] picpiclink
  17. 2pr4 picpicxref
    automatically matched to d2f5ah1
    1. region h:1-132 [139748] picpiclink
  18. 2b0s picpicxref
    automatically matched to d1fgvh_
    complexed with acy, edo
    1. region h:1-113 [127646] picpiclink
  19. 1u8h picpicxrefxrefxref
    1. region b:1-113 [113130] picpiclink
  20. 1u8k picpicxrefxrefxref
    1. region b:1-113 [113142] picpiclink
  21. 1fvc picpicxref
    part of humanized Fv 4D5, herceptin
    1. chain b [19863] picpiclink
    2. chain d [19865] picpiclink
  22. 1u95 picpicxrefxrefxref
    1. region b:1-113 [113230] picpiclink
  23. 1u8j picpicxrefxrefxref
    1. region b:1-113 [113138] picpiclink
  24. 2b1a picpicxref
    automatically matched to d1fgvh_
    1. region h:1-113 [127662] picpiclink
  25. 1om3 picpicxrefxrefxref
    part of engineered Fab 2G12
    1. region h:1-115 [87059] picpiclink
    2. region k:1-115 [87061] picpiclink
  26. 1ad0 picpicxrefxrefxref
    part of humanized Fab A5B7
    1. region b:1-113 [20125] picpiclink
    2. region d:1-113 [20127] picpiclink
  27. 1jv5 picpicxref
    part of an anti-blood group A Fv
    1. chain b [67345] picpiclink
  28. 1u91 picpicxrefxrefxref
    1. region b:1-113 [113218] picpiclink
  29. 1u8q picpicxrefxrefxref
    1. region b:1-113 [113166] picpiclink
  30. 1u92 picpicxrefxrefxref
    1. region b:1-113 [113222] picpiclink
  31. 1u8m picpicxrefxrefxref
    1. region b:1-113 [113150] picpiclink
  32. 1u8n picpicxrefxrefxref
    1. region b:1-113 [113154] picpiclink
  33. 2p8l picpicxref
    automatically matched to d2f5ah1
    1. region b:1-113 [139526] picpiclink
  34. 2h9g picpicxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region b:1-113 [136257] picpiclink
  35. 2h9g picpicxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region h:1-113 [136259] picpiclink
  36. 1pg7 picpicxrefxrefxrefxrefxrefxrefxref
    part of humanized Fab D3H44 against human tissue factor
    1. region h:1-117 [94674] picpiclink
    2. region i:1-117 [94676] picpiclink
  37. 1fvd picpicxrefxrefxref
    part of humanized Fab 4D5, herceptin
    1. region b:1-120 [19867] picpiclink
    2. region d:1-120 [19869] picpiclink
  38. 1u93 picpicxrefxrefxref
    1. region b:1-113 [113226] picpiclink
  39. 1u8l picpicxrefxrefxref
    1. region b:1-113 [113146] picpiclink
  40. 2pw1 picpicxref
    automatically matched to d2f5ah1
    1. region b:1-113 [139758] picpiclink
  41. 2pw2 picpicxref
    automatically matched to d2f5ah1
    1. region b:1-113 [139760] picpiclink
  42. 2nyy picpicxrefxrefxref
    automatically matched to d1mhph1
    complexed with ca, zn
    1. region d:2-118 [138831] picpiclink
  43. 1ad9 picpicxrefxrefxref
    part of humanized Fab CTM01
    complexed with so4
    1. region h:1-113 [20213] picpiclink
    2. region b:1-113 [20215] picpiclink
  44. 1fve picpicxrefxrefxref
    part of humanized Fab 4D5, herceptin
    1. region b:1-120 [19871] picpiclink
    2. region d:1-120 [19873] picpiclink
  45. 1tzh picpicxrefxrefxrefxref
    1. region b:1-113 [107479] picpiclink
    2. region h:1-113 [107481] picpiclink
  46. 2p8m picpicxref
    automatically matched to d2f5ah1
    1. region b:1-113 [139528] picpiclink
  47. 2p8p picpicxref
    automatically matched to d2f5ah1
    complexed with nh2
    1. region b:1-113 [139530] picpiclink
  48. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region b:1-120 [133579] picpiclink
  49. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region d:1-120 [133581] picpiclink
  50. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region f:1-120 [133583] picpiclink
  51. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region h:1-120 [133585] picpiclink
  52. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region i:1-120 [133587] picpiclink
  53. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region k:1-120 [133589] picpiclink
  54. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region n:1-120 [133591] picpiclink
  55. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region p:1-120 [133593] picpiclink
  56. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region r:1-120 [133595] picpiclink
  57. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region t:1-120 [133597] picpiclink
  58. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region v:1-120 [133599] picpiclink
  59. 2fjf picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1fvcb_
    1. region x:1-120 [133601] picpiclink
  60. 1n8z picpicxrefxrefxrefxrefxref
    part of humanized Fab 4D5, herceptin
    complexed with nag, so4
    1. region b:1-120 [80320] picpiclink
  61. 1mhp picpicxrefxrefxrefxrefxref
    part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered
    complexed with mn; mutant
    1. chain x [84971] picpiclink
  62. 1mhp picpicxrefxrefxrefxrefxref
    part of humanized anti-alpha1 integrin I-domain Fab
    complexed with mn; mutant
    1. region h:1-118 [84967] picpiclink
  63. 1u8o picpicxrefxrefxref
    1. region b:1-113 [113158] picpiclink
  64. 2agj picpicxrefxrefxref
    annotated as human, this domain has greater sequence similarity to mouse VH domains
    complexed with nag
    1. region h:1-120 [144806] picpiclink
  65. 2fjg picpicxrefxrefxrefxref
    automatically matched to d1fvcb_
    complexed with so4
    1. region b:1-120 [133603] picpiclink
  66. 2fjg picpicxrefxrefxrefxref
    automatically matched to d1fvcb_
    complexed with so4
    1. region h:1-120 [133605] picpiclink
  67. 1t04 picpicxrefxrefxref
    1. region b:1-118 [112184] picpiclink
    2. region d:1-118 [112188] picpiclink
  68. 1u8p picpicxrefxrefxref
    1. region b:1-113 [113162] picpiclink
  69. 1b2w picpicxrefxrefxref
    part of a humanized anti-gamma-interferon Fab
    1. region h:1-117 [20307] picpiclink
  70. 2fgw picpicxrefxrefxref
    part of humanized Fab H52
    1. region h:1-124 [19855] picpiclink
  71. 1bvk picpicxrefxref
    part of humanized anti-lysozyme Fv HuLys11
    1. chain b [20279] picpiclink
    2. chain e [20281] picpiclink
  72. 1it9 picpicxrefxrefxref
    part of humanized anti-human Fas Fab HFE7A
    1. region h:1-121 [76783] picpiclink
  73. 1tzi picpicxrefxrefxrefxref
    1. region b:1-113 [107489] picpiclink
  74. 1bvl picpicxref
    part of humanized anti-lysozyme Fv HuLys11
    1. chain a [20282] picpiclink
    2. chain c [20284] picpiclink
  75. 2nz9 picpicxrefxrefxrefxrefxrefxref
    automatically matched to d1mhph1
    complexed with ca, zn
    1. region d:2-118 [138842] picpiclink
  76. 2nz9 picpicxrefxrefxrefxrefxrefxref
    automatically matched to d1mhph1
    complexed with ca, zn
    1. region f:2-118 [138846] picpiclink
  77. 1i9r picpicxrefxrefxrefxref
    complexed with zn
    1. region h:1-118 [71151] picpiclink
    2. region k:1-118 [71153] picpiclink
    3. region x:1-118 [71159] picpiclink
  78. 1op5 picpicxrefxrefxref
    part of engineered Fab 2G12
    complexed with man, nag
    1. region h:1-115 [87216] picpiclink
    2. region m:1-115 [87222] picpiclink
  79. 1vhp picpic
    camelized monomeric VH
    1. chain a [20504] picpiclink
  80. 1s78 picpicxrefxrefxrefxrefxref
    part of anti-ERBb2 Fab Pertuzumab
    complexed with man, nag
    1. region d:1-113 [98626] picpiclink
    2. region f:1-113 [98630] picpiclink
  81. 1uj3 picpicxrefxrefxrefxref
    MQ NA P01857 # artificial chimera
    1. region b:301-417 [107890] picpiclink
  82. 1rjl picpicxrefxrefxrefxref
    MQ NA P01864 # artificial chimera
    1. region b:1-120 [111823] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk