Structural Classification of Proteins
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Protein: Immunoglobulin heavy chain variable domain, VH from Human (Homo sapiens), cluster 3 [TaxId: 9606]

SQ Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3)

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Immunoglobulin-like beta-sandwich [48725]
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. Superfamily: Immunoglobulin [48726]
    link to SUPERFAMILY database - Superfamily
  5. Family: V set domains (antibody variable domain-like) [48727]
  6. Protein: Immunoglobulin heavy chain variable domain, VH [88543]
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. Species: Human (Homo sapiens), cluster 3 [TaxId: 9606] [88547]
    SQ Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3)

PDB Entry Domains:

  1. 8fab picpicxrefxrefxref
    part of Fab HIL
    1. region b:1-121 [19773] picpiclink
    2. region d:1-121 [19775] picpiclink
  2. 1w72 picpicxrefxrefxrefxrefxrefxref
    complexed with gol
    1. region h:1-113 [114299] picpiclink
    2. region i:1-113 [114301] picpiclink
  3. 2fb4 picpicxrefxrefxref
    part of Fab KOL
    1. region h:1-119 [19847] picpiclink
  4. 2qqn picpicxrefxref
    automatically matched to d1aqkh1
    complexed with edo
    1. region h:1-113 [151224] picpiclink
  5. 1aqk picpicxrefxrefxref
    part of Fab B7-15A2
    1. region h:1-123 [20193] picpiclink
  6. 1nl0 picpicxrefxrefxrefxref
    part of Fab 10c12 against factor IX Gla domain
    complexed with ca, so4
    1. region h:1-113 [91945] picpiclink
  7. 3c08 picpicxref
    automatically matched to d8fabb1
    complexed with so4
    1. region h:2-121 [155809] picpiclink
  8. 1zls picpicxref
    automatically matched to d1aqkh1
    complexed with man
    1. region h:1-112 [125255] picpiclink
  9. 1zlv picpicxrefxref
    automatically matched to d1aqkh1
    complexed with man
    1. region h:1-112 [125262] picpiclink
  10. 1zlv picpicxrefxref
    automatically matched to d1aqkh1
    complexed with man
    1. region m:1-112 [125264] picpiclink
  11. 1y0l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with cl, han
    1. region b:1-113 [122488] picpiclink
  12. 1y0l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with cl, han
    1. region d:1-113 [122492] picpiclink
  13. 1y0l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with cl, han
    1. region f:1-113 [122496] picpiclink
  14. 1y0l picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with cl, han
    1. region h:1-113 [122498] picpiclink
  15. 3cfk picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with b3p, cd, gol; mutant
    1. region b:1-113 [156583] picpiclink
  16. 3cfk picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with b3p, cd, gol; mutant
    1. region d:1-113 [156587] picpiclink
  17. 3cfk picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with b3p, cd, gol; mutant
    1. region f:1-113 [156591] picpiclink
  18. 3cfk picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with b3p, cd, gol; mutant
    1. region h:1-113 [156595] picpiclink
  19. 3cfk picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with b3p, cd, gol; mutant
    1. region i:1-113 [156597] picpiclink
  20. 3cfk picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with b3p, cd, gol; mutant
    1. region k:1-113 [156601] picpiclink
  21. 3cfk picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with b3p, cd, gol; mutant
    1. region n:1-113 [156607] picpiclink
  22. 3cfk picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with b3p, cd, gol; mutant
    1. region p:1-113 [156611] picpiclink
  23. 3cfj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with gol, so4; mutant
    1. region b:1-113 [156567] picpiclink
  24. 3cfj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with gol, so4; mutant
    1. region d:1-113 [156571] picpiclink
  25. 3cfj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with gol, so4; mutant
    1. region f:1-113 [156575] picpiclink
  26. 3cfj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with gol, so4; mutant
    1. region h:1-113 [156577] picpiclink
  27. 1dql picpicxref
    part of IgM Fv MEZ
    1. chain h [19829] picpiclink
  28. 2ghw picpicxrefxrefxrefxref
    complexed with cl
    1. region b:1-117 [145199] picpiclink
  29. 2ghw picpicxrefxrefxrefxref
    automatically matched to 2GHW B:1-117
    complexed with cl
    1. region d:1-117 [145201] picpiclink
  30. 1dee picpicxrefxrefxrefxref
    part of IgM RF 2A2
    1. region b:501-621 [20443] picpiclink
    2. region d:1501-1621 [20445] picpiclink
    3. region f:2501-2621 [20447] picpiclink
  31. 1u6a picpicxrefxrefxref
    automatically matched to d1aqkh1
    1. region h:2-113 [119564] picpiclink
  32. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1deeb1
    complexed with bma, man, nag, so4
    1. region c:1-121 [154774] picpiclink
  33. 3dvg picpicxrefxrefxrefxrefxref
    automatically matched to d1nl0h1
    mutant
    1. region b:2-120 [157890] picpiclink
  34. 3dvn picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1nl0h1
    mutant
    1. region b:2-120 [157896] picpiclink
  35. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1deeb1
    complexed with bma, man, nag, so4
    1. region f:1-121 [154778] picpiclink
  36. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1deeb1
    complexed with bma, man, nag, so4
    1. region h:1-121 [154780] picpiclink
  37. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1deeb1
    complexed with bma, man, nag, so4
    1. region j:1-121 [154784] picpiclink
  38. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1deeb1
    complexed with bma, man, nag, so4
    1. region n:1-121 [154788] picpiclink
  39. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1deeb1
    complexed with bma, man, nag, so4
    1. region q:1-121 [154792] picpiclink
  40. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1deeb1
    complexed with bma, man, nag, so4
    1. region t:1-121 [154796] picpiclink
  41. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1deeb1
    complexed with bma, man, nag, so4
    1. region w:1-121 [154800] picpiclink
  42. 3dvn picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1nl0h1
    mutant
    1. region h:2-120 [157898] picpiclink
  43. 1igm picpicxref
    part of IgM Fv POT
    1. chain h [19827] picpiclink
  44. 1hez picpicxrefxrefxrefxref
    part of IgM RF 2A2
    complexed with imd
    1. region b:1-121 [60985] picpiclink
    2. region d:1-121 [60989] picpiclink
  45. 1dfb picpicxrefxrefxref
    part of Fab 3D6
    1. region h:1-126 [19811] picpiclink
  46. 1y18 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with cl, han; mutant
    1. region b:1-113 [122523] picpiclink
  47. 1y18 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with cl, han; mutant
    1. region d:1-113 [122527] picpiclink
  48. 1y18 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with cl, han; mutant
    1. region f:1-113 [122531] picpiclink
  49. 1y18 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to d1aqkh1
    complexed with cl, han; mutant
    1. region h:1-113 [122533] picpiclink
  50. 2jb5 picpicxref
    automatically matched to d1nl0h1
    complexed with t5c
    1. region h:3-120 [147955] picpiclink
  51. 2oqj picpicxrefxrefxrefxref
    automatically matched to d1aqkh1
    1. region b:1-112 [148984] picpiclink
  52. 2oqj picpicxrefxrefxrefxref
    automatically matched to d1aqkh1
    1. region e:1-112 [148986] picpiclink
  53. 2oqj picpicxrefxrefxrefxref
    automatically matched to d1aqkh1
    1. region h:1-112 [148988] picpiclink
  54. 2oqj picpicxrefxrefxrefxref
    automatically matched to d1aqkh1
    1. region k:1-112 [148990] picpiclink
  55. 3bky picpicxref
    automatically matched to d1w72h1
    1. region h:1-122 [155372] picpiclink
  56. 2jb6 picpicxrefxref
    automatically matched to d1nl0h1
    complexed with t5c
    1. region b:3-120 [147957] picpiclink
  57. 2jb6 picpicxrefxref
    automatically matched to d1nl0h1
    complexed with t5c
    1. region h:3-120 [147959] picpiclink
  58. 1zlw picpicxrefxref
    automatically matched to d1aqkh1
    complexed with bma, man
    1. region h:1-112 [125266] picpiclink
  59. 1zlw picpicxrefxref
    automatically matched to d1aqkh1
    complexed with bma, man
    1. region m:1-112 [125268] picpiclink
  60. 1adq picpicxrefxrefxrefxrefxref
    part of IgM rheumatoid factor Fab
    1. region h:1-113 [20273] picpiclink
  61. 2ig2 picpicxrefxrefxref
    part of antibody KOL; intact protein but only Fab's can be seen in the crystal structure
    1. region h:1-119 [19849] picpiclink
  62. 1zlu picpicxrefxref
    automatically matched to d1aqkh1
    complexed with man
    1. region h:1-112 [125258] picpiclink
  63. 1zlu picpicxrefxref
    automatically matched to d1aqkh1
    complexed with man
    1. region m:1-112 [125260] picpiclink
  64. 3c09 picpicxrefxrefxrefxrefxrefxref
    automatically matched to d8fabb1
    complexed with bma, man, nag
    1. region c:2-121 [155813] picpiclink
  65. 3c09 picpicxrefxrefxrefxrefxrefxref
    automatically matched to d8fabb1
    complexed with bma, man, nag
    1. region h:2-121 [155817] picpiclink
  66. 3b2v picpicxref
    automatically matched to d1deeb1
    complexed with bma, nag, ndg
    1. region h:1-121 [154802] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk