Structural Classification of Proteins
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Protein: Immunoglobulin light chain lambda variable domain, VL-lambda from Human (Homo sapiens), cluster 5 [TaxId: 9606]

SQ Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Immunoglobulin-like beta-sandwich [48725]
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. Superfamily: Immunoglobulin [48726]
    link to SUPERFAMILY database - Superfamily
  5. Family: V set domains (antibody variable domain-like) [48727]
  6. Protein: Immunoglobulin light chain lambda variable domain, VL-lambda [88534]
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family
  7. Species: Human (Homo sapiens), cluster 5 [TaxId: 9606] [88540]
    SQ Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)

PDB Entry Domains:

  1. 8fab picpicxrefxrefxref
    part of Fab HIL
    1. region a:3-105 [19772] picpiclink
    2. region c:3-105 [19774] picpiclink
  2. 1w72 picpicxrefxrefxrefxrefxrefxref
    complexed with gol
    1. region l:1-107 [114303] picpiclink
    2. region m:1-107 [114305] picpiclink
  3. 2dd8 picpicxrefxrefxrefxref
    complexed with nag, po4
    1. region l:3-108 [145075] picpiclink
  4. 2g75 picpicxrefxrefxrefxrefxrefxref
    automatically matched to 2DD8 L:3-108
    1. region b:3-108 [147088] picpiclink
  5. 2g75 picpicxrefxrefxrefxrefxrefxref
    automatically matched to 2DD8 L:3-108
    1. region d:3-108 [147092] picpiclink
  6. 1adq picpicxrefxrefxrefxrefxref
    part of IgM rheumatoid factor Fab
    1. region l:2-107 [20272] picpiclink
  7. 1lil picpicxref
    part of Bence-Jones protein CLE
    1. region a:2-107 [20557] picpiclink
    2. region b:2-107 [20558] picpiclink
  8. 1zvo picpicxrefxref
    automatically matched to d1adql1
    1. region a:3-108 [125710] picpiclink
  9. 1zvo picpicxrefxref
    automatically matched to d1adql1
    1. region b:3-108 [125712] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk