Structural Classification of Proteins
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Protein: Immunoglobulin light chain lambda variable domain, VL-lambda from Human (Homo sapiens), cluster 2 [TaxId: 9606]

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Immunoglobulin-like beta-sandwich [48725]
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. Superfamily: Immunoglobulin [48726]
    link to SUPERFAMILY database - Superfamily
  5. Family: V set domains (antibody variable domain-like) [48727]
  6. Protein: Immunoglobulin light chain lambda variable domain, VL-lambda [88534]
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family
  7. Species: Human (Homo sapiens), cluster 2 [TaxId: 9606] [88536]

PDB Entry Domains:

  1. 2rhe picpic
    VL of Bence-Jones protein RHE
    1. chain a [20523] picpiclink
  2. 1rzf picpicxrefxrefxref
    part of anti HIV-1 gp120-reactive Fab E51
    complexed with gol, ioh
    1. region l:2-108 [98152] picpiclink
  3. 2fb4 picpicxrefxrefxref
    part of Fab KOL
    1. region l:1-109 [19846] picpiclink
  4. 1nl0 picpicxrefxrefxrefxref
    part of Fab 10c12 against factor IX Gla domain
    complexed with ca, so4
    1. region l:1-108 [91947] picpiclink
  5. 1bjm picpicxref
    VL dimer of Bence-Jones protein LOC
    1. region a:1-111 [20524] picpiclink
    2. region b:1-111 [20525] picpiclink
  6. 1q1j picpicxrefxrefxref
    part of anti HIV-1 Fab 447-52d
    1. region l:1-108 [95585] picpiclink
    2. region m:1-108 [95587] picpiclink
  7. 3bjl picpicxref
    VL dimer of Bence-Jones protein LOC
    1. region a:1-111 [20526] picpiclink
    2. region b:1-111 [20527] picpiclink
  8. 4bjl picpicxref
    VL dimer of Bence-Jones protein LOC
    1. region a:2-111 [20528] picpiclink
    2. region b:2-111 [20529] picpiclink
  9. 2ig2 picpicxrefxrefxref
    part of antibody KOL; intact protein but only Fab's can be seen in the crystal structure
    1. region l:1-109 [19848] picpiclink
  10. 2j6e picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    complexed with act, bma, cac, cd, ful, gal, man, mpd, nag, ndg, zn
    1. region l:1-108 [145669] picpiclink
  11. 2j6e picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
    automatically matched to 2J6E L:1-108
    complexed with act, bma, cac, cd, ful, gal, man, mpd, nag, ndg, zn
    1. region m:1-108 [145671] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk