Structural Classification of Proteins
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Family: C1 set domains (antibody constant domain-like)

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Immunoglobulin-like beta-sandwich [48725]
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. Superfamily: Immunoglobulin [48726]
    link to SUPERFAMILY database - Superfamily
  5. Family: C1 set domains (antibody constant domain-like) [48942]

Protein Domains:

  1. Immunoglobulin light chain kappa constant domain, CL-kappa [88566]
    1. Mouse (Mus musculus) [TaxId: 10090] [88567] (347) picpic
      SQ P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: SQ P01637 (Ig kappa chain V-V region T1) and SQ P01837 (Ig kappa chain C region) ! SQ P01837 # KAC_MOUSE Ig kappa chain C region ! SQ P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! SQ P01837 # ! KAC_MOUSE Ig kappa chain C region
    2. Rat (Rattus norvegicus) [TaxId: 10116] [88568] (8) picpic
    3. Human (Homo sapiens) [TaxId: 9606] [88569] (168) picpic
      SQ NA # humanized antibody ! SQ P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody
      including humanized antibodies (chimeric proteins with human constant domains)
    4. synthetic construct [158871] (1) picpic
    5. Escherichia coli [TaxId: 562] [158872] (8) picpic
  2. Immunoglobulin light chain lambda constant domain, CL-lambda [88570]
    1. Mouse (Mus musculus) [TaxId: 10090] [88571] (21) picpic
      SQ Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
    2. Human (Homo sapiens) [TaxId: 9606] [88572] (49) picpic
    3. Hamster (Cricetulus griseus) [TaxId: 10029] [88573] (1) picpic
  3. Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574]
    1. Human (Homo sapiens) [TaxId: 9606] [88575] (256) picpic
      SQ Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! SQ P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
      including humanized antibodies (chimeric proteins with human constant domains)
    2. Mouse (Mus musculus) [TaxId: 10090] [88576] (412) picpic
      SQ P01864 # GCAB_MOUSE Ig gamma-2A chain C region secreted form (B allele) ! SQ P01863 #GCAA_MOUSE Ig gamma-2A chain C region, A allele; 86% sequence identity ! SQ NA # natural chimera; best hits are: SQ P01751 (Ig heavy chain V region B1-8/186-2) and SQ P01864 (Ig gamma-2A chain C region secreted form) ! SQ P01868 # GC1_MOUSE Ig gamma-1 chain C region secreted form ! SQ P01864 # GCAB_MOUSE (P01864) Ig gamma-2A chain C region ! SQ P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ P01863 # GCAA_MOUSE Ig gamma-2A chain C region, A allele ! SQ NA # part of Fab 28 against HIV-1 RT ! SQ P01868 # ! GC1_MOUSE Ig gamma-1 chain C region secreted form
    3. Mouse (Mus musculus), gamma3 [TaxId: 10090] [88577] (8) picpic
      SQ P22436 # GC3_MOUSE (P22436) Ig gamma-3 chain C region
    4. Rat (Rattus norvegicus) [TaxId: 10116] [88578] (6) picpic
    5. Hamster (Cricetulus griseus) [TaxId: 10029] [88579] (1) picpic
    6. Escherichia coli [TaxId: 562] [158873] (3) picpic
    7. synthetic construct [158874] (2) picpic
  4. Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580]
    1. Mouse (Mus musculus) [TaxId: 10090] [88581] (3) picpic
  5. Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582]
    1. Human (Homo sapiens) [TaxId: 9606] [88583] (8) picpic
  6. Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584]
    1. Human (Homo sapiens) [TaxId: 9606] [88585] (34) picpic
      SQ P01857 #118-327 ! SQ P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    2. Mouse (Mus musculus) [TaxId: 10090] [88586] (1) picpic
    3. Mouse (Mus musculus), gamma2 [TaxId: 10090] [88587] (1) picpic
    4. Rat (Rattus norvegicus) [TaxId: 10116] [88588] (2) picpic
  7. Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589]
    1. Human (Homo sapiens) [TaxId: 9606] [88590] (37) picpic
      SQ P01857 #118-327 ! SQ P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    2. Mouse (Mus musculus) [TaxId: 10090] [88591] (2) picpic
    3. Mouse (Mus musculus), gamma2 [TaxId: 10090] [88592] (1) picpic
    4. Rat (Rattus norvegicus) [TaxId: 10116] [88593] (2) picpic
    5. Guinea pig (Cavia porcellus) [TaxId: 10141] [49123] (1) picpic
  8. Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181]
    1. Human (Homo sapiens) [TaxId: 9606] [89182] (3) picpic
  9. Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183]
    1. Human (Homo sapiens) [TaxId: 9606] [89184] (3) picpic
  10. Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594]
    1. Human (Homo sapiens) [TaxId: 9606] [88595] (2) picpic
  11. Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596]
    1. Human (Homo sapiens) [TaxId: 9606] [88597] (3) picpic
  12. Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598]
    1. Human (Homo sapiens) [TaxId: 9606] [88599] (3) picpic
  13. T-cell antigen receptor [49125]
    1. Mouse (Mus musculus), alpha-chain [TaxId: 10090] [49126] (15) picpic
    2. Human (Homo sapiens), alpha-chain [TaxId: 9606] [49127] (24) picpic
    3. Mouse (Mus musculus), beta-chain [TaxId: 10090] [49128] (19) picpic
    4. Human (Homo sapiens), beta-chain [TaxId: 9606] [49129] (39) picpic
    5. Human (Homo sapiens), gamma-chain [TaxId: 9606] [63661] (3) picpic
    6. Human (Homo sapiens), delta-chain [TaxId: 9606] [63662] (3) picpic
  14. beta2-microglobulin [88600]
    1. Cow (Bos taurus) [TaxId: 9913] [48946] (1) picpic
    2. Rat (Rattus norvegicus) [TaxId: 10116] [88601] (6) picpic
    3. Human (Homo sapiens) [TaxId: 9606] [88602] (228) picpic
      SQ P61769 21-119 ! SQ P01884
    4. Mouse (Mus musculus) [TaxId: 10090] [88603] (106) picpic
      SQ P01887
  15. Class I MHC, alpha-3 domain [88604]
    1. Human (Homo sapiens) [TaxId: 9606] [88605] (189) picpic
      SQ P30685 25-300 ! SQ P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor ! SQ P30481 25-300 ! SQ P01892 25-298 ! SQ P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
    2. Mouse (Mus musculus) [TaxId: 10090] [88606] (109) picpic
      SQ P01901 22-299
    3. Rat (Rattus norvegicus), RT1-AA [TaxId: 10116] [88607] (3) picpic
    4. Rhesus monkey (Macaca mulatta) [TaxId: 9544] [158875] (2) picpic
  16. Hemochromatosis protein Hfe, alpha-3 domain [88608]
    1. Human (Homo sapiens) [TaxId: 9606] [88609] (2) picpic
  17. Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965]
    fat depleting factor related to class I MHC
    1. Human (Homo sapiens) [TaxId: 9606] [48966] (7) picpic
      SQ P25311 22-294
  18. Class I MHC homolog, alpha-3 domain [88610]
    gamma, delta T-cell ligand
    1. Human (Homo sapiens), Mic-a [TaxId: 9606] [48968] (2) picpic
    2. Human (Homo sapiens), Mic-b [TaxId: 9606] [74826] (1) picpic
    3. Mouse (Mus musculus), t22 [TaxId: 10090] [88611] (3) picpic
    4. Mouse (Mus musculus), t10 [TaxId: 10090] [101512] (1) picpic
  19. Fc (IgG) receptor, alpha-3 domain [88612]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [88613] (3) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [88614] (1) picpic
  20. CD1, alpha-3 domain [88615]
    1. Mouse (Mus musculus) [TaxId: 10090] [88616] (10) picpic
    2. Human (Homo sapiens), CD1b [TaxId: 9606] [88617] (3) picpic
    3. Human (Homo sapiens), CD1a [TaxId: 9606] [101513] (4) picpic
    4. Human (Homo sapiens), CD1d [TaxId: 9606] [158876] (4) picpic
      SQ P15813 202-295
  21. Class II MHC alpha chain, C-terminal domain [88618]
    1. Human (Homo sapiens), HLA-DM [TaxId: 9606] [88619] (1) picpic
      probably orthologous to the mouse H2-DM
    2. Mouse (Mus musculus), H2-DM [TaxId: 10090] [88620] (1) picpic
      probably orthologous to the human HLA-DM
    3. Human (Homo sapiens), HLA-DR group [TaxId: 9606] [88621] (29) picpic
      SQ P01903 28-207
      probably orthologous to the mouse I-E group
    4. Mouse (Mus musculus), I-E group [TaxId: 10090] [88622] (9) picpic
      probably orthologous to the human HLA-DR group
    5. Human (Homo sapiens), HLA-DQ group [TaxId: 9606] [88623] (3) picpic
      probably orthologous to the mouse I-A group
    6. Mouse (Mus musculus), I-A group [TaxId: 10090] [88624] (39) picpic
      probably orthologous to the human HLA-DQ group
  22. Class II MHC beta chain, C-terminal domain [88625]
    1. Human (Homo sapiens), HLA-DM [TaxId: 9606] [88626] (1) picpic
      probably orthologous to the mouse H2-DM
    2. Mouse (Mus musculus), H2-DM [TaxId: 10090] [88627] (1) picpic
      probably orthologous to the human HLA-DM
    3. Human (Homo sapiens), HLA-DR group [TaxId: 9606] [88628] (48) picpic
      SQ P04229 30-219
      probably orthologous to the mouse I-E group
    4. Mouse (Mus musculus), I-E group [TaxId: 10090] [88629] (9) picpic
      probably orthologous to the human HLA-DR group
    5. Human (Homo sapiens), HLA-DQ group [TaxId: 9606] [88630] (3) picpic
      probably orthologous to the mouse I-A group
    6. Mouse (Mus musculus), I-A group [TaxId: 10090] [88631] (20) picpic
      probably orthologous to the human HLA-DQ group
  23. Immunomodulatory protein m144, alpha-3 domain [110048]
    1. Murine cytomegalovirus [TaxId: 10366] [110049] (2) picpic
      SQ Q69G19 27-263 # 95% sequence identity
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk