Structural Classification of Proteins
Superfamily: DHS-like NAD/FAD-binding domain
binds cofactor molecules in the opposite direction than classical Rossmann fold
uperfamily
Lineage:
Root:
scop
Class:
Alpha and beta proteins (a/b)
[51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold:
DHS-like NAD/FAD-binding domain
[52466]
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
Superfamily:
DHS-like NAD/FAD-binding domain
[52467]
binds cofactor molecules in the opposite direction than classical Rossmann fold
uperfamily
Families:
Deoxyhypusine synthase, DHS
[52468] (1)
Deoxyhypusine synthase, DHS [52469]
Human (Homo sapiens)
[TaxId: 9606]
[52470] (4)
SQ
P49366
1dhs
complexed with nad
chain a
[31727]
1roz
complexed with nad
chain a
[105025]
chain b
[105026]
1rlz
complexed with nad
chain a
[104989]
1rqd
complexed with gc7, nad
chain a
[105059]
chain b
[105060]
C-terminal domain of the electron transfer flavoprotein alpha subunit
[52471] (3)
lacks strand 3; shares the FAD-binding mode with the pyruvate oxidase domain
C-terminal domain of the electron transfer flavoprotein alpha subunit [52472]
Human (Homo sapiens)
[TaxId: 9606]
[52473] (3)
1efv
complexed with amp, fad
region a:208-331
[31728]
2a1u
automatically matched to d1efva2
complexed with amp, fad; mutant
region a:209-331
[126017]
2a1t
automatically matched to d1efva2
complexed with amp, fad; mutant
region r:209-331
[126014]
Paracoccus denitrificans
[TaxId: 266]
[52474] (1)
1efp
complexed with amp, fad
region a:185-308
[31729]
region c:185-308
[31730]
Methylophilus methylotrophus
[TaxId: 17]
[82379] (6)
3cls
automatically matched to d1o96b2
complexed with amp, fad; mutant
region d:196-318
[156759]
1o97
complexed with amp, fad
region d:196-318
[81234]
3clu
automatically matched to d1o96b2
complexed with amp, fad; mutant
region d:196-318
[156765]
3clr
automatically matched to d1o96b2
complexed with amp, fad, po4; mutant
region d:196-318
[156756]
3clt
automatically matched to d1o96b2
complexed with amp, fad; mutant
region d:196-318
[156762]
1o96
complexed with amp, fad
region b:196-318
[81222]
region d:196-318
[81225]
region f:196-318
[81228]
region z:196-318
[81231]
Pyruvate oxidase and decarboxylase, middle domain
[52475] (12)
N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold
Pyruvate oxidase [52476]
binds FAD
Lactobacillus plantarum
[TaxId: 1590]
[52477] (12)
2ez9
automatically matched to d1powa1
complexed with fad, mg, na, tdk; mutant
region a:183-365
[132627]
2ez9
automatically matched to d1powa1
complexed with fad, mg, na, tdk; mutant
region b:183-365
[132630]
2ez8
automatically matched to d1powa1
complexed with fad, mg, na, pyr, tdl; mutant
region a:183-365
[132621]
2ez8
automatically matched to d1powa1
complexed with fad, mg, na, pyr, tdl; mutant
region b:183-365
[132624]
2ez4
automatically matched to d1powa1
complexed with fad, mg, na, po4, tpp; mutant
region a:183-365
[132610]
2ez4
automatically matched to d1powa1
complexed with fad, mg, na, po4, tpp; mutant
region b:183-365
[132613]
2ezu
automatically matched to d1powa1
complexed with fad, htl, mg, na, pyr; mutant
region a:183-365
[132639]
2ezu
automatically matched to d1powa1
complexed with fad, htl, mg, na, pyr; mutant
region b:183-365
[132642]
1pox
complexed with fad, gol, mg, na, tpp; mutant
region a:183-365
[31731]
region b:183-365
[31732]
2ezt
automatically matched to d1powa1
complexed with fad, mg, na, po4, pyr, tdm; mutant
region a:183-365
[132633]
2ezt
automatically matched to d1powa1
complexed with fad, mg, na, po4, pyr, tdm; mutant
region b:183-365
[132636]
1pow
complexed with fad, mg, tpp
region a:183-365
[31733]
region b:183-365
[31734]
Aerococcus viridans
[TaxId: 1377]
[142122] (4)
2dji
automatically matched to 1V5E A:187-363
complexed with fad, so4
region a:187-363
[131544]
1v5e
complexed with fad, so4
region a:187-363
[119844]
1v5f
automatically matched to 1V5E A:187-363
complexed with fad, mg, so4, tpp
region a:187-363
[119847]
1v5g
automatically matched to 1V5E A:187-363
complexed with fad, htl, mg
region a:187-363
[119850]
Pyruvate decarboxylase [52478]
rudiment domain with a variant fold, lacks FAD-binding
Brewer's yeast (Saccharomyces), uvarum strain
[TaxId: 4932]
[52479] (1)
1pyd
complexed with mg, tdp
region a:182-360
[31735]
region b:182-360
[31736]
Baker's yeast (Saccharomyces cerevisiae)
[TaxId: 4932]
[52480] (2)
1pvd
complexed with mg, tpp
region a:182-360
[31737]
region b:182-360
[31738]
1qpb
region a:182-360
[31739]
region b:182-360
[31740]
Zymomonas mobilis
[TaxId: 542]
[52481] (1)
1zpd
complexed with cit, dpx, mg
region a:188-362
[31741]
region b:188-362
[31742]
region e:188-362
[31743]
region f:188-362
[31744]
Indole-3-pyruvate decarboxylase [89637]
Enterobacter cloacae
[TaxId: 550]
[89638] (1)
1ovm
complexed with mg, tpp
region a:181-341
[87461]
region b:181-341
[87464]
region c:181-341
[87467]
region d:181-341
[87470]
Benzoylformate decarboxylase [52482]
Pseudomonas putida
[TaxId: 303]
[52483] (12)
SQ
P20906
1q6z
complexed with ca, mg, tdp; mutant
region a:182-341
[111655]
2fn3
automatically matched to d1bfd_1
complexed with ca, mg, tzd; mutant
region a:182-341
[133803]
1pi3
complexed with ca, mg, tdp; mutant
region a:182-341
[111633]
1po7
complexed with ca, mg, tdp; mutant
region a:182-341
[111636]
1yno
automatically matched to d1bfd_1
complexed with ca, mg, tzd
region a:182-341
[123747]
2fwn
automatically matched to d1bfd_1
complexed with ca, mg, tdp
region a:182-341
[134249]
1bfd
complexed with ca, mg, tpp
region a:182-341
[31745]
2v3w
automatically matched to d1bfda1
complexed with mg, so4, tpp; mutant
region a:182-341
[152465]
2v3w
automatically matched to d1bfda1
complexed with mg, so4, tpp; mutant
region b:182-341
[152468]
2v3w
automatically matched to d1bfda1
complexed with mg, so4, tpp; mutant
region c:182-341
[152471]
2v3w
automatically matched to d1bfda1
complexed with mg, so4, tpp; mutant
region d:182-341
[152474]
1mcz
complexed with mg, rmn, tdp
region a:182-341
[78952]
region b:182-341
[78955]
region c:182-341
[78958]
region d:182-341
[78961]
region e:182-341
[78964]
region f:182-341
[78967]
region g:182-341
[78970]
region h:182-341
[78973]
region i:182-341
[78976]
region j:182-341
[78979]
region k:182-341
[78982]
region l:182-341
[78985]
region m:182-341
[78988]
region n:182-341
[78991]
region o:182-341
[78994]
region p:182-341
[78997]
Acetohydroxyacid synthase catalytic subunit [69463]
Baker's yeast (Saccharomyces cerevisiae)
[TaxId: 4932]
[69464] (6)
SQ
P07342
84-687
1t9b
complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
region a:290-460
[112334]
region b:290-460
[112337]
1t9c
complexed with 1sm, fad, k, mg, p22, p23
region a:290-460
[112340]
region b:290-460
[112343]
1t9d
complexed with 1mm, fad, k, mg, p22, p25, yf1
region a:290-460
[112346]
region b:290-460
[112349]
region c:290-460
[112352]
region d:290-460
[112355]
1t9a
complexed with 1tb, fad, k, mg, p23, yf3, yf4
region a:290-460
[112328]
region b:290-460
[112331]
1jsc
complexed with 2hp, fad, k, mg, tpp
region a:280-460
[67224]
region b:276-458
[67227]
1n0h
complexed with ayd, cie, dtt, fad, k, mg, tpp
region a:277-460
[79734]
region b:278-460
[79737]
Thale cress (Arabidopsis thaliana), chloroplast
[TaxId: 3702]
[142123] (6)
SQ
P17597
281-459
1ybh
complexed with cie, fad, mg, nhe, p22
region a:281-459
[122891]
1yi0
automatically matched to 1YBH A:281-459
complexed with 1sm, fad, mg, nhe, p22
region a:281-459
[123221]
1yhz
automatically matched to 1YBH A:281-459
complexed with 1cs, fad, mg, nhe, p22
region a:281-459
[123218]
1yhy
automatically matched to 1YBH A:281-459
complexed with 1mm, fad, mg, nhe, p22
region a:281-459
[123215]
1yi1
automatically matched to 1YBH A:281-459
complexed with 1tb, fad, mg, nhe, p22
region a:281-459
[123224]
1z8n
automatically matched to 1YBH A:281-459
complexed with 1iq, fad, mg, nhe, tpp
region a:281-459
[124719]
Catabolic acetolactate synthase [102288]
Klebsiella pneumoniae
[TaxId: 573]
[102289] (3)
1ozh
complexed with he3, mg, peg, pig, po4
region a:188-366
[93833]
region b:188-366
[93836]
region c:189-366
[93839]
region d:188-366
[93842]
1ozf
complexed with mg, peg, po4, tpp
region a:188-366
[93821]
region b:188-366
[93824]
1ozg
complexed with he3, mg, peg, po4
region a:188-366
[93827]
region b:188-366
[93830]
Carboxyethylarginine synthase [102290]
Streptomyces clavuligerus
[TaxId: 1901]
[102291] (11)
2iht
automatically matched to d1upaa1
complexed with gol, mg, so4, tpp
region a:198-374
[147685]
2iht
automatically matched to d1upaa1
complexed with gol, mg, so4, tpp
region b:198-374
[147688]
2iht
automatically matched to d1upaa1
complexed with gol, mg, so4, tpp
region c:198-374
[147691]
2iht
automatically matched to d1upaa1
complexed with gol, mg, so4, tpp
region d:198-374
[147694]
2ihu
automatically matched to d1upaa1
complexed with gol, k, mg, tar, tp8, tp9
region a:198-374
[147697]
2ihv
automatically matched to d1upaa1
complexed with gva, k, mg, tpp
region a:198-374
[147700]
2ihv
automatically matched to d1upaa1
complexed with gva, k, mg, tpp
region b:198-374
[147703]
2ihv
automatically matched to d1upaa1
complexed with gva, k, mg, tpp
region d:198-374
[147706]
1upa
complexed with mg, so4, tpp
region a:198-374
[99714]
region b:198-374
[99717]
region c:198-374
[99720]
region d:198-374
[99723]
1upb
complexed with mg, so4, tpp
region a:198-374
[99726]
region b:198-374
[99729]
region c:198-374
[99732]
region d:198-374
[99735]
1upc
complexed with mg, so4, tpp
region a:198-374
[99738]
region b:198-374
[99741]
region c:198-374
[99744]
region d:198-374
[99747]
region e:198-374
[99750]
region f:198-374
[99753]
Oxalyl-CoA decarboxylase [142124]
Oxalobacter formigenes
[TaxId: 847]
[142125] (12)
SQ
P40149
195-369
2ji7
automatically matched to d2c31a1
complexed with adp, b3p, mg, oxt, pge
region a:195-369
[148062]
2ji7
automatically matched to d2c31a1
complexed with adp, b3p, mg, oxt, pge
region b:195-369
[148065]
2c31
complexed with adp, mg, tzd
region a:195-369
[129704]
2c31
automatically matched to 2C31 A:195-369
complexed with adp, mg, tzd
region b:195-369
[129707]
2ji6
automatically matched to d2c31a1
complexed with adp, b3p, mg, oxk, pge, tpw
region a:195-369
[148056]
2ji6
automatically matched to d2c31a1
complexed with adp, b3p, mg, oxk, pge, tpw
region b:195-369
[148059]
2ji9
automatically matched to d2c31a1
complexed with adp, b3p, mg, tpw
region a:195-369
[148074]
2ji9
automatically matched to d2c31a1
complexed with adp, b3p, mg, tpw
region b:195-369
[148077]
2ji8
automatically matched to d2c31a1
complexed with adp, fyn, mg, pge, tpp
region a:195-369
[148068]
2ji8
automatically matched to d2c31a1
complexed with adp, fyn, mg, pge, tpp
region b:195-369
[148071]
2jib
automatically matched to d2c31a1
complexed with adp, coa, mg, pge, tpp
region a:195-369
[148080]
2jib
automatically matched to d2c31a1
complexed with adp, coa, mg, pge, tpp
region b:195-369
[148083]
Transhydrogenase domain III (dIII)
[52484] (3)
binds NADP, shares with the pyruvate oxidase FAD-binding domain a common ADP-binding mode
Transhydrogenase domain III (dIII) [52485]
Human (Homo sapiens)
[TaxId: 9606]
[52486] (4)
1djl
complexed with gol, nap, so4
chain a
[31746]
chain b
[31747]
1u31
automatically matched to d1djla_
complexed with gol, nap, so4
region a:23-204
[119491]
1u31
automatically matched to d1djla_
complexed with gol, nap, so4
region b:23-204
[119492]
1pt9
complexed with gol, so4, tap
chain a
[95097]
chain b
[95098]
Cow (Bos taurus)
[TaxId: 9913]
[52487] (1)
1d4o
chain a
[31748]
Rhodospirillum rubrum
[TaxId: 1085]
[52488] (17)
1pno
complexed with nap
chain a
[94953]
chain b
[94954]
2fsv
complexed with gol, nad, nap; mutant
region c:30-203
[134041]
1u2g
automatically matched to d1pnoa_
complexed with apr, gol, ndp
region c:33-203
[119484]
1pnq
complexed with ndp
chain a
[94955]
chain b
[94956]
2oor
automatically matched to d1pnoa_
complexed with gol, nad, txp
region c:33-202
[139175]
1u28
automatically matched to d1pnoa_
complexed with gol, nad, nap
region c:33-203
[119472]
2oo5
automatically matched to d1pnoa_
complexed with nap, so4, txd
region c:33-203
[139166]
2fr8
automatically matched to d1pnoa_
complexed with nad, nap; mutant
region c:33-203
[133977]
1ptj
complexed with dI component
complexed with gol, nap, snd
chain c
[95103]
1nm5
complexed with dI component
complexed with gol, nad, nap; mutant
chain c
[91972]
1hzz
complexed with dI component
complexed with nad, nap
chain c
[61474]
1u2d
automatically matched to d1pnoa_
complexed with gol, nad, ndp
region c:33-203
[119479]
2frd
automatically matched to d1pnoa_
complexed with nad, nap; mutant
region c:33-203
[133984]
1xlt
automatically matched to d1pnoa_
complexed with na, nad, ndp, suc
region c:291-464
[122126]
1xlt
automatically matched to d1pnoa_
complexed with na, nad, ndp, suc
region f:292-464
[122131]
1xlt
automatically matched to d1pnoa_
complexed with na, nad, ndp, suc
region i:292-464
[122136]
1e3t
complexed with nap
chain a
[31749]
Sir2 family of transcriptional regulators
[63984] (7)
silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain
AF1676, Sir2 homolog (Sir2-AF1?) [63985]
Archaeon Archaeoglobus fulgidus
[TaxId: 2234]
[63986] (6)
1m2k
complexed with apr, zn; mutant
chain a
[84754]
1m2j
complexed with apr, zn; mutant
chain a
[84753]
1m2g
complexed with apr, zn
chain a
[84750]
1m2h
complexed with apr, zn; mutant
chain a
[84751]
1ici
complexed with nad, zn
chain a
[62266]
chain b
[62267]
1m2n
complexed with oad, zn; mutant
chain a
[84756]
chain b
[84757]
AF0112, Sir2 homolog (Sir2-AF2) [82380]
Archaeon Archaeoglobus fulgidus
[TaxId: 2234]
[82381] (7)
1ma3
complexed with an acetylated p53 peptide, chain B
complexed with aly, mes, zn
chain a
[78883]
1s7g
complexed with 1pe, 2pe, apr, egl, nad, p6g, pg4, so4, zn
chain a
[98642]
chain b
[98643]
chain c
[98644]
chain d
[98645]
chain e
[98646]
1yc2
automatically matched to d1ma3a_
complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
region a:1-252
[122903]
1yc2
automatically matched to d1ma3a_
complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
region b:1-252
[122904]
1yc2
automatically matched to d1ma3a_
complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
region c:1-252
[122905]
1yc2
automatically matched to d1ma3a_
complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
region d:2-252
[122906]
1yc2
automatically matched to d1ma3a_
complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
region e:1-250
[122907]
NAD-dependent deacetylase CobB [102292]
Escherichia coli
[TaxId: 562]
[102293] (1)
1s5p
complex with a acetylated substrate peptide, chain B
complexed with zn
chain a
[98569]
Sirt2 histone deacetylase [63987]
Human (Homo sapiens)
[TaxId: 9606]
[63988] (1)
1j8f
complexed with zn
chain a
[62738]
chain b
[62739]
chain c
[62740]
Hst2 [102294]
Baker's yeast (Saccharomyces cerevisiae)
[TaxId: 4932]
[102295] (5)
SQ
P53686
1-293
1q1a
complexed with histone H4 peptide, chain B
complexed with oad, zn2
chain a
[95561]
1szd
complexed with apr, cl, gol, zn
chain a
[106150]
1szc
complexed with cl, cna, gol, zn
chain a
[106149]
1q14
complexed with cl, zn2
chain a
[95537]
1q17
complexed with apr, cl, zn
chain a
[95550]
chain b
[95551]
chain c
[95552]
NAD-dependent deacetylase NpdA [142126]
Thermotoga maritima
[TaxId: 2336]
[142127] (10)
SQ
Q9WYW0
1-245
1yc5
complexed with nca, zn
region a:1-245
[122910]
2h2g
automatically matched to 1YC5 A:1-245
complexed with zn
region a:1-245
[136005]
2h2d
automatically matched to 1YC5 A:1-245
complexed with zn
region a:1-245
[135997]
2h2i
automatically matched to 1YC5 A:1-245
complexed with zn, zpg
region a:1-244
[136007]
3d4b
automatically matched to d1yc5a1
complexed with dzd, zn
region a:1-245
[157291]
2h4f
automatically matched to 1YC5 A:1-245
complexed with nad, zn
region a:1-245
[136073]
2h2h
automatically matched to 1YC5 A:1-245
complexed with zn
region a:1-245
[136006]
2h4j
automatically matched to 1YC5 A:1-245
complexed with nca, oad, zn
region a:1-245
[136076]
2h2f
automatically matched to 1YC5 A:1-245
complexed with zn
region a:1-245
[136004]
3d81
automatically matched to d1yc5a1
complexed with fzn, zn
region a:1-245
[157437]
NAD-dependent deacetylase sirtuin-5 [142128]
Human (Homo sapiens)
[TaxId: 9606]
[142129] (6)
SQ
Q9NXA8
36-302
2b4y
complexed with apr, epe, zn
region a:36-302
[127868]
2b4y
automatically matched to 2B4Y A:36-302
complexed with apr, epe, zn
region b:36-302
[127869]
2b4y
automatically matched to 2B4Y A:36-302
complexed with apr, epe, zn
region c:36-302
[127870]
2b4y
automatically matched to 2B4Y A:36-302
complexed with apr, epe, zn
region d:36-302
[127871]
2nyr
automatically matched to 2B4Y A:36-302
complexed with svr, zn
region a:36-302
[138827]
2nyr
automatically matched to 2B4Y A:36-302
complexed with svr, zn
region b:36-302
[138828]
ACDE2-like
[142130] (1)
Pfam 02552
Acetyl-CoA decarbonylase/synthase complex epsilon subunit 2, ACDE2 [142131]
Archaeoglobus fulgidus
[TaxId: 2234]
[142132] (4)
SQ
O30273
17-174
1ytl
region a:17-174
[124008]
1ytl
automatically matched to 1YTL A:17-174
region b:17-174
[124009]
1ytl
automatically matched to 1YTL A:17-174
region c:18-174
[124010]
1ytl
automatically matched to 1YTL A:17-174
region d:17-174
[124011]
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Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
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